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Protein

40S ribosomal protein S2

Gene

Rps2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein complex binding Source: RGD
  • RNA binding Source: InterPro
  • structural constituent of ribosome Source: RGD

GO - Biological processi

  • formation of translation preinitiation complex Source: RGD
  • response to ethanol Source: RGD
  • ribosomal small subunit assembly Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S2
Gene namesi
Name:Rps2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619887. Rps2.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: RGD
  • intracellular ribonucleoprotein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 29329240S ribosomal protein S2PRO_0000131675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei263 – 2631N6-acetyllysineBy similarity
Modified residuei264 – 2641PhosphoserineBy similarity
Modified residuei275 – 2751N6-acetyllysineBy similarity
Modified residuei281 – 2811PhosphoserineBy similarity

Post-translational modificationi

Citrullinated by PADI4 in the Arg/Gly-rich region.By similarity
Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

PaxDbiP27952.
PRIDEiP27952.

PTM databases

iPTMnetiP27952.
PhosphoSiteiP27952.

Expressioni

Gene expression databases

GenevisibleiP27952. RN.

Interactioni

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi249832. 2 interactions.
IntActiP27952. 2 interactions.
MINTiMINT-4566642.
STRINGi10116.ENSRNOP00000019508.

Structurei

3D structure databases

ProteinModelPortaliP27952.
SMRiP27952. Positions 59-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 1131-1
Repeati12 – 1431-2
Repeati15 – 1731-3
Repeati22 – 2542-1
Repeati26 – 2942-2
Repeati34 – 3523-1
Repeati36 – 3723-2
Repeati38 – 3923-3
Repeati40 – 4123-4
Repeati42 – 4323-5
Repeati44 – 4523-6
Repeati46 – 4723-7
Repeati48 – 4923-8
Repeati51 – 5223-9
Domaini102 – 16564S5 DRBMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 1793 X 3 AA tandem repeats of G-G-P
Regioni22 – 2982 X 4 AA tandem repeats of R-G-G-F
Regioni34 – 52199 X 2 AA tandem repeats of R-GAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 5332Arg/Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S5P family.Curated
Contains 1 S5 DRBM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001433.
HOGENOMiHOG000072596.
HOVERGENiHBG000437.
InParanoidiP27952.
KOiK02981.
OMAiHTYGFLT.
OrthoDBiEOG7P5T1Q.
PhylomeDBiP27952.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDAGAAGG PGGPGGPGLG GRGGFRGGFG SGLRGRGRGR GRGRGRGRGA
60 70 80 90 100
RGGKAEDKEW IPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA
110 120 130 140 150
SLKDEVLKIM PVQKQTRAGQ RTRFKAFVAI GDYNGHVGLG VKCSKEVATA
160 170 180 190 200
IRGAIILAKL SIVPVRRGYW GNKIGKPHTV PCKVTGRCGS VLVRLIPAPR
210 220 230 240 250
GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT FDAISKTYSY
260 270 280 290
LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT
Length:293
Mass (Da):31,231
Last modified:August 1, 1992 - v1
Checksum:i9092DB564AA624C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57432 mRNA. Translation: CAA40679.1.
BC098726 mRNA. Translation: AAH98726.1.
PIRiS18828. R3RTS2.
RefSeqiNP_114026.3. NM_031838.3.
UniGeneiRn.2115.
Rn.220062.

Genome annotation databases

EnsembliENSRNOT00000019508; ENSRNOP00000019508; ENSRNOG00000014179.
GeneIDi83789.
KEGGirno:83789.
UCSCiRGD:619887. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57432 mRNA. Translation: CAA40679.1.
BC098726 mRNA. Translation: AAH98726.1.
PIRiS18828. R3RTS2.
RefSeqiNP_114026.3. NM_031838.3.
UniGeneiRn.2115.
Rn.220062.

3D structure databases

ProteinModelPortaliP27952.
SMRiP27952. Positions 59-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249832. 2 interactions.
IntActiP27952. 2 interactions.
MINTiMINT-4566642.
STRINGi10116.ENSRNOP00000019508.

PTM databases

iPTMnetiP27952.
PhosphoSiteiP27952.

Proteomic databases

PaxDbiP27952.
PRIDEiP27952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019508; ENSRNOP00000019508; ENSRNOG00000014179.
GeneIDi83789.
KEGGirno:83789.
UCSCiRGD:619887. rat.

Organism-specific databases

CTDi6187.
RGDi619887. Rps2.

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001433.
HOGENOMiHOG000072596.
HOVERGENiHBG000437.
InParanoidiP27952.
KOiK02981.
OMAiHTYGFLT.
OrthoDBiEOG7P5T1Q.
PhylomeDBiP27952.

Miscellaneous databases

PROiP27952.

Gene expression databases

GenevisibleiP27952. RN.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of rat ribosomal protein S2. A ribosomal protein with arginine-glycine tandem repeats and RGGF motifs that are associated with nucleolar localization and binding to ribonucleic acids."
    Suzuki K., Olvera J., Wool I.G.
    J. Biol. Chem. 266:20007-20010(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 111-128.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiRS2_RAT
AccessioniPrimary (citable) accession number: P27952
Secondary accession number(s): Q4G062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.