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Protein

40S ribosomal protein S2

Gene

Rps2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein complex binding Source: RGD
  • RNA binding Source: InterPro
  • structural constituent of ribosome Source: RGD

GO - Biological processi

  • cellular response to interleukin-4 Source: Ensembl
  • formation of translation preinitiation complex Source: RGD
  • response to ethanol Source: RGD
  • ribosomal small subunit assembly Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S2
Gene namesi
Name:Rps2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619887. Rps2.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: RGD
  • intracellular ribonucleoprotein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001316752 – 29340S ribosomal protein S2Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei252PhosphothreonineBy similarity1
Modified residuei263N6-acetyllysineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei270PhosphothreonineBy similarity1
Modified residuei275N6-acetyllysine; alternateBy similarity1
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei281PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4 in the Arg/Gly-rich region.By similarity
Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP27952.
PRIDEiP27952.

PTM databases

iPTMnetiP27952.
PhosphoSitePlusiP27952.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014179.
GenevisibleiP27952. RN.

Interactioni

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

BioGridi249832. 2 interactors.
IntActiP27952. 2 interactors.
MINTiMINT-4566642.
STRINGi10116.ENSRNOP00000019508.

Structurei

3D structure databases

ProteinModelPortaliP27952.
SMRiP27952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 111-13
Repeati12 – 141-23
Repeati15 – 171-33
Repeati22 – 252-14
Repeati26 – 292-24
Repeati34 – 353-12
Repeati36 – 373-22
Repeati38 – 393-32
Repeati40 – 413-42
Repeati42 – 433-52
Repeati44 – 453-62
Repeati46 – 473-72
Repeati48 – 493-82
Repeati51 – 523-92
Domaini102 – 165S5 DRBMPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 173 X 3 AA tandem repeats of G-G-P9
Regioni22 – 292 X 4 AA tandem repeats of R-G-G-F8
Regioni34 – 529 X 2 AA tandem repeats of R-GAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 53Arg/Gly-richAdd BLAST32

Sequence similaritiesi

Belongs to the ribosomal protein S5P family.Curated
Contains 1 S5 DRBM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001433.
HOGENOMiHOG000072596.
HOVERGENiHBG000437.
InParanoidiP27952.
KOiK02981.
OMAiKEADCDA.
OrthoDBiEOG091G0LPC.
PhylomeDBiP27952.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDAGAAGG PGGPGGPGLG GRGGFRGGFG SGLRGRGRGR GRGRGRGRGA
60 70 80 90 100
RGGKAEDKEW IPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA
110 120 130 140 150
SLKDEVLKIM PVQKQTRAGQ RTRFKAFVAI GDYNGHVGLG VKCSKEVATA
160 170 180 190 200
IRGAIILAKL SIVPVRRGYW GNKIGKPHTV PCKVTGRCGS VLVRLIPAPR
210 220 230 240 250
GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT FDAISKTYSY
260 270 280 290
LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT
Length:293
Mass (Da):31,231
Last modified:August 1, 1992 - v1
Checksum:i9092DB564AA624C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57432 mRNA. Translation: CAA40679.1.
BC098726 mRNA. Translation: AAH98726.1.
PIRiS18828. R3RTS2.
RefSeqiNP_114026.3. NM_031838.3.
UniGeneiRn.2115.
Rn.220062.

Genome annotation databases

EnsembliENSRNOT00000019508; ENSRNOP00000019508; ENSRNOG00000014179.
GeneIDi83789.
KEGGirno:83789.
UCSCiRGD:619887. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57432 mRNA. Translation: CAA40679.1.
BC098726 mRNA. Translation: AAH98726.1.
PIRiS18828. R3RTS2.
RefSeqiNP_114026.3. NM_031838.3.
UniGeneiRn.2115.
Rn.220062.

3D structure databases

ProteinModelPortaliP27952.
SMRiP27952.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249832. 2 interactors.
IntActiP27952. 2 interactors.
MINTiMINT-4566642.
STRINGi10116.ENSRNOP00000019508.

PTM databases

iPTMnetiP27952.
PhosphoSitePlusiP27952.

Proteomic databases

PaxDbiP27952.
PRIDEiP27952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019508; ENSRNOP00000019508; ENSRNOG00000014179.
GeneIDi83789.
KEGGirno:83789.
UCSCiRGD:619887. rat.

Organism-specific databases

CTDi6187.
RGDi619887. Rps2.

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001433.
HOGENOMiHOG000072596.
HOVERGENiHBG000437.
InParanoidiP27952.
KOiK02981.
OMAiKEADCDA.
OrthoDBiEOG091G0LPC.
PhylomeDBiP27952.

Miscellaneous databases

PROiP27952.

Gene expression databases

BgeeiENSRNOG00000014179.
GenevisibleiP27952. RN.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS2_RAT
AccessioniPrimary (citable) accession number: P27952
Secondary accession number(s): Q4G062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.