P27951 (BAG_STRAG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
IgA FC receptor

Alternative name(s):
Beta antigen
Short name=B antigen

Gene names

Name:

bag

Organism

Streptococcus agalactiae

Taxonomic identifier

1311 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	1164 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted › cell wall; Peptidoglycan-anchor Potential.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell wall Secreted
Domain	Immunoglobulin domain Signal
Molecular function	Receptor
PTM	Peptidoglycan-anchor
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Ref.1
	Chain	38 – 1135	1098	IgA FC receptor		PRO_0000005595
	Propeptide	1136 – 1164	29	Removed by sortase Potential		PRO_0000005596
Regions
	Domain	434 – 534	101	Ig-like
	Region	199 – 438	240	IgA-binding Potential
	Region	439 – 826	388	IgA-binding Potential
	Motif	1132 – 1136	5	LPXTG sorting signal Potential
	Compositional bias	827 – 944	118	Pro-rich
Amino acid modifications
	Modified residue	1135	1	Pentaglycyl murein peptidoglycan amidated threonine Potential

Sequences

	Sequence		Length	Mass (Da)
	P27951 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 65DE94AF720A5474	FASTA	1,164	131,052
	10 20 30 40 50 60 MFKSNYERKM RYSIRKFSVG VASVAVASLF MGSVAHASEL VKDDSVKTTE VAAKPYPSMA 70 80 90 100 110 120 QTDQGNNSSS SELETTKMEI PTTDIKKAVE PVEKTAGETS ATDTGKREKQ LQQWKNNLKN 130 140 150 160 170 180 DVDNTILSHE QKNEFKTKID ETNDSDALLE LENQFNETNR LLHIKQHEEV EKDKKAKQQK 190 200 210 220 230 240 TLKQSDTKVD LSNIDKELNH QKSQVEKMAE QKGITNEDKD SMLKKIEDIR KQAQQADKKE 250 260 270 280 290 300 DAEVKVREEL GKLFSSTKAG LDQEIQEHVK KETSSEENTQ KVDEHYANSL QNLAQKSLEE 310 320 330 340 350 360 LDKATTNEQA TQVKNQFLEN AQKLKEIQPL IKETNVKLYK AMSESLEQVE KELKHNSEAN 370 380 390 400 410 420 LEDLVAKSKE IVREYEGKLN QSKNLPELKQ LEEEAHSKLK QVVEDFRKKF KTSEQVTPKK 430 440 450 460 470 480 RVKRDLAANE NNQQKIELTV SPENITVYEG EDVKFTVTAK SDSKTTLDFS DLLTKYNPSV 490 500 510 520 530 540 SDRISTNYKT NTDNHKIAEI TIKNLKLNES QTVTLKAKDD SGNVVEKTFT ITVQKKEEKQ 550 560 570 580 590 600 VPKTPEQKDS KTEEKVPQEP KSNDKNQLQE LIKSAQQELE KLEKAIKELM EQPEIPSNPE 610 620 630 640 650 660 YGIQKSIWES QKEPIQEAIT SFKKIIGDSS SKYYTEHYFN KYKSDFMNYQ LHAQMEMLTR 670 680 690 700 710 720 KVVQYMNKYP DNAEIKKIFE SDMKRTKEDN YGSLENDALK GYFEKYFLTP FNKIKQIVDD 730 740 750 760 770 780 LDKKVEQDQP APIPENSEMD QAKEKAKIAV SKYMSKVLDG VHQHLQKKNN SKIVDLFKEL 790 800 810 820 830 840 EAIKQQTIFD IDNAKTEVEI DNLVHDAFSK MNATVAKFQK GLETNTPETP DTPKIPELPQ 850 860 870 880 890 900 APDTPQAPDT PHVPESPKAP EAPRVPESPK TPEAPHVPES PKAPEAPRVP ESPKTPEAPH 910 920 930 940 950 960 VPESPKTPEA PKIPEPPKTP DVPKLPDVPK LPDVPKLPDA PKLPDGLNKV GQAVFTSTDG 970 980 990 1000 1010 1020 NTKVTVVFDK PTDADKLHLK EVTTKELADK IAHKTGGGTV RVFDLSLSKG GKETHVNGER 1030 1040 1050 1060 1070 1080 TVRLALGQTG SDVHVYHVKE NGDLERIPSK VENGQVVFKT NHFSLFAIKT LSKDQNVTPP 1090 1100 1110 1120 1130 1140 KQTKPSTQGS QVEIAESQTG KFQSKAANHK ALATGNETVA KGNPTSTTEK KLPYTGVASN 1150 1160 LVLEIMGLLG LIGTSFIAMK RRKS

References

[1]	"The IgA-binding beta antigen of the c protein complex of Group B streptococci: sequence determination of its gene and detection of two binding regions." Jerlstroem P.G., Chhatwal G.S., Timmis K.N. Mol. Microbiol. 5:843-849(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 38-48. Strain: LA239.
[2]	"Members of the immunoglobulin superfamily in bacteria." Bateman A., Eddy S.R., Chothia C. Protein Sci. 5:1939-1942(1996) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF IG-LIKE DOMAIN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X59771 Genomic DNA. Translation: CAA42442.1.
PIR	FCSOAG. S15330.
3D structure databases
ProteinModelPortal	P27951.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG5523.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR005877. Gpos_YSIRK. IPR019948. Gram-positive_anchor. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR019931. LPXTG-motif_cell_wall_anchor. IPR007756. RICH. [Graphical view]
Pfam	PF00746. Gram_pos_anchor. 1 hit. PF05062. RICH. 1 hit. PF04650. YSIRK_signal. 1 hit. [Graphical view]
ProDom	PD008292. RICH. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00409. IG. 1 hit. [Graphical view]
TIGRFAMs	TIGR01167. LPXTG_anchor. 1 hit. TIGR01168. YSIRK_signal. 1 hit.
PROSITE	PS50847. GRAM_POS_ANCHORING. 1 hit. PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BAG_STRAG

Accession

Primary (citable) accession number: P27951

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program