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P27949 (UBC_ASFB7) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene names
Name:UBC
Ordered Locus Names:BA71V-144
ORF Names:I215L
OrganismAfrican swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) [Reference proteome]
Taxonomic identifier10498 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Performs the second step in the ubiquitination reaction that targets specifically a protein for degradation via the proteasome By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Induction

Mainly late in infection.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Developmental stageLate protein
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Ubiquitin-conjugating enzyme E2
PRO_0000082591

Regions

Compositional bias183 – 21533Asp/Glu-rich (acidic)

Sites

Active site851Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P27949 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 3488BEC687E67727

FASTA21524,737
        10         20         30         40         50         60 
MVSRFLIAEY RHLIENPSEN FKISVNENNI TEWDVILRGP PDTLYEGGLF KAKVAFPPEY 

        70         80         90        100        110        120 
PYAPPKLTFT SEMWHPNIYP DGRLCISILH GDNAEEQGMT WSPAQKIDTI LLSVISLLNE 

       130        140        150        160        170        180 
PNPDSPANVD AAKSYRKYVY KEDLESYPME VKKTVKKSLD ECSPEDIEYF KNAASNVPPI 

       190        200        210 
PSDAYEDECE EMEDDTYILT YDDDEEEEDE EMDDE 

« Hide

References

« Hide 'large scale' references
[1]"Genes homologous to ubiquitin-conjugating proteins and eukaryotic transcription factor SII in African swine fever virus."
Rodriguez J.M., Salas M.L., Vinuela E.
Virology 186:40-52(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the complete nucleotide sequence of African swine fever virus."
Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C., Rodriguez J.F., Vinuela E.
Virology 208:249-278(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M77121 Genomic DNA. Translation: AAA42704.1.
U18466 Genomic DNA. Translation: AAA65370.1.
PIRUQXFAS. F39448.
RefSeqNP_042834.1. NC_001659.1.

3D structure databases

ProteinModelPortalP27949.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1488905.

Phylogenomic databases

ProtClustDBCLSP2510037.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBC_ASFB7
AccessionPrimary (citable) accession number: P27949
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways