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P27949

- UBC_ASFB7

UniProt

P27949 - UBC_ASFB7

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Protein
Ubiquitin-conjugating enzyme E2
Gene
UBC, BA71V-144, I215L
Organism
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Performs the second step in the ubiquitination reaction that targets specifically a protein for degradation via the proteasome By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Name:UBC
Ordered Locus Names:BA71V-144
ORF Names:I215L
OrganismiAfrican swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)
Taxonomic identifieri10498 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostiOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000000624: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Ubiquitin-conjugating enzyme E2
PRO_0000082591Add
BLAST

Expressioni

Inductioni

Mainly late in infection.

Keywords - Developmental stagei

Late protein

Structurei

3D structure databases

ProteinModelPortaliP27949.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 21533Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27949-1 [UniParc]FASTAAdd to Basket

« Hide

MVSRFLIAEY RHLIENPSEN FKISVNENNI TEWDVILRGP PDTLYEGGLF    50
KAKVAFPPEY PYAPPKLTFT SEMWHPNIYP DGRLCISILH GDNAEEQGMT 100
WSPAQKIDTI LLSVISLLNE PNPDSPANVD AAKSYRKYVY KEDLESYPME 150
VKKTVKKSLD ECSPEDIEYF KNAASNVPPI PSDAYEDECE EMEDDTYILT 200
YDDDEEEEDE EMDDE 215
Length:215
Mass (Da):24,737
Last modified:August 1, 1992 - v1
Checksum:i3488BEC687E67727
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M77121 Genomic DNA. Translation: AAA42704.1.
U18466 Genomic DNA. Translation: AAA65370.1.
PIRiF39448. UQXFAS.
RefSeqiNP_042834.1. NC_001659.1.

Genome annotation databases

GeneIDi1488905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M77121 Genomic DNA. Translation: AAA42704.1 .
U18466 Genomic DNA. Translation: AAA65370.1 .
PIRi F39448. UQXFAS.
RefSeqi NP_042834.1. NC_001659.1.

3D structure databases

ProteinModelPortali P27949.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1488905.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes homologous to ubiquitin-conjugating proteins and eukaryotic transcription factor SII in African swine fever virus."
    Rodriguez J.M., Salas M.L., Vinuela E.
    Virology 186:40-52(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the complete nucleotide sequence of African swine fever virus."
    Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C., Rodriguez J.F., Vinuela E.
    Virology 208:249-278(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUBC_ASFB7
AccessioniPrimary (citable) accession number: P27949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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