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Protein

Interleukin-1 receptor type 2

Gene

Il1r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).By similarity2 Publications

GO - Molecular functioni

  • interleukin-1, Type II, blocking receptor activity Source: InterPro
  • interleukin-1 binding Source: MGI
  • interleukin-1 receptor activity Source: MGI

GO - Biological processi

  • negative regulation of cytokine production involved in inflammatory response Source: MGI
  • negative regulation of interleukin-1 alpha secretion Source: MGI
  • negative regulation of interleukin-1-mediated signaling pathway Source: MGI
  • negative regulation of protein processing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-446652. Interleukin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 2
Short name:
IL-1R-2
Short name:
IL-1RT-2
Short name:
IL-1RT2
Alternative name(s):
CD121 antigen-like family member B
IL-1 type II receptor
Interleukin-1 receptor beta
Short name:
IL-1R-beta
Interleukin-1 receptor type II
CD_antigen: CD121b
Cleaved into the following 2 chains:
Interleukin-1 receptor type 2, membrane form
Short name:
mIL-1R2
Short name:
mIL-1RII
Interleukin-1 receptor type 2, soluble form
Short name:
sIL-1R2
Short name:
sIL-1RII
Gene namesi
Name:Il1r2
Synonyms:Il-1r2, Il1rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96546. Il1r2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 355342ExtracellularSequence analysisAdd
BLAST
Transmembranei356 – 38126HelicalSequence analysisAdd
BLAST
Topological domaini382 – 41029CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular region Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313Sequence analysisAdd
BLAST
Chaini14 – 410397Interleukin-1 receptor type 2, membrane formPRO_0000015440Add
BLAST
Chaini14 – ?Interleukin-1 receptor type 2, soluble formPRO_0000415349

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 128PROSITE-ProRule annotation
Disulfide bondi64 ↔ 120PROSITE-ProRule annotation
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi164 ↔ 219PROSITE-ProRule annotation
Glycosylationi208 – 2081N-linked (GlcNAc...)1 Publication
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi270 ↔ 338PROSITE-ProRule annotation
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP27931.
PeptideAtlasiP27931.
PRIDEiP27931.

PTM databases

iPTMnetiP27931.
PhosphoSiteiP27931.

Expressioni

Tissue specificityi

Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1.1 Publication

Gene expression databases

BgeeiP27931.
CleanExiMM_IL1R2.
ExpressionAtlasiP27931. baseline and differential.
GenevisibleiP27931. MM.

Interactioni

Subunit structurei

Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.By similarity

GO - Molecular functioni

  • interleukin-1 binding Source: MGI

Protein-protein interaction databases

BioGridi200626. 1 interaction.
IntActiP27931. 1 interaction.
MINTiMINT-4098585.
STRINGi10090.ENSMUSP00000027243.

Structurei

3D structure databases

ProteinModelPortaliP27931.
SMRiP27931. Positions 42-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 136102Ig-like C2-type 1Add
BLAST
Domaini146 – 23792Ig-like C2-type 2Add
BLAST
Domaini249 – 357109Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCQ. Eukaryota.
ENOG410YQDP. LUCA.
HOGENOMiHOG000113036.
HOVERGENiHBG052104.
InParanoidiP27931.
KOiK04387.
OMAiRQEYSEN.
OrthoDBiEOG77HDDW.
PhylomeDBiP27931.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFILLVLVTG VSAFTTPTVV HTGKVSESPI TSEKPTVHGD NCQFRGREFK
60 70 80 90 100
SELRLEGEPV VLRCPLAPHS DISSSSHSFL TWSKLDSSQL IPRDEPRMWV
110 120 130 140 150
KGNILWILPA VQQDSGTYIC TFRNASHCEQ MSVELKVFKN TEASLPHVSY
160 170 180 190 200
LQISALSTTG LLVCPDLKEF ISSNADGKIQ WYKGAILLDK GNKEFLSAGD
210 220 230 240 250
PTRLLISNTS MDDAGYYRCV MTFTYNGQEY NITRNIELRV KGTTTEPIPV
260 270 280 290 300
IISPLETIPA SLGSRLIVPC KVFLGTGTSS NTIVWWLANS TFISAAYPRG
310 320 330 340 350
RVTEGLHHQY SENDENYVEV SLIFDPVTRE DLHTDFKCVA SNPRSSQSLH
360 370 380 390 400
TTVKEVSSTF SWSIALAPLS LIILVVGAIW MRRRCKRRAG KTYGLTKLRT
410
DNQDFPSSPN
Length:410
Mass (Da):45,645
Last modified:August 1, 1992 - v1
Checksum:i923DFC27C70AF604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59769 mRNA. Translation: CAA42440.1.
CCDSiCCDS14909.1.
RefSeqiNP_034685.1. NM_010555.4.
XP_011236739.1. XM_011238437.1.
XP_011236740.1. XM_011238438.1.
XP_011236741.1. XM_011238439.1.
XP_011236742.1. XM_011238440.1.
UniGeneiMm.1349.

Genome annotation databases

EnsembliENSMUST00000027243; ENSMUSP00000027243; ENSMUSG00000026073.
GeneIDi16178.
KEGGimmu:16178.
UCSCiuc007atu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59769 mRNA. Translation: CAA42440.1.
CCDSiCCDS14909.1.
RefSeqiNP_034685.1. NM_010555.4.
XP_011236739.1. XM_011238437.1.
XP_011236740.1. XM_011238438.1.
XP_011236741.1. XM_011238439.1.
XP_011236742.1. XM_011238440.1.
UniGeneiMm.1349.

3D structure databases

ProteinModelPortaliP27931.
SMRiP27931. Positions 42-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200626. 1 interaction.
IntActiP27931. 1 interaction.
MINTiMINT-4098585.
STRINGi10090.ENSMUSP00000027243.

PTM databases

iPTMnetiP27931.
PhosphoSiteiP27931.

Proteomic databases

PaxDbiP27931.
PeptideAtlasiP27931.
PRIDEiP27931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027243; ENSMUSP00000027243; ENSMUSG00000026073.
GeneIDi16178.
KEGGimmu:16178.
UCSCiuc007atu.2. mouse.

Organism-specific databases

CTDi7850.
MGIiMGI:96546. Il1r2.

Phylogenomic databases

eggNOGiENOG410IJCQ. Eukaryota.
ENOG410YQDP. LUCA.
HOGENOMiHOG000113036.
HOVERGENiHBG052104.
InParanoidiP27931.
KOiK04387.
OMAiRQEYSEN.
OrthoDBiEOG77HDDW.
PhylomeDBiP27931.
TreeFamiTF325519.

Enzyme and pathway databases

ReactomeiR-MMU-446652. Interleukin-1 signaling.

Miscellaneous databases

ChiTaRSiIl1r2. mouse.
PROiP27931.
SOURCEiSearch...

Gene expression databases

BgeeiP27931.
CleanExiMM_IL1R2.
ExpressionAtlasiP27931. baseline and differential.
GenevisibleiP27931. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types."
    McMahan C.J., Slack J.L., Mosley B., Cosman D., Lupton S.D., Brunton L.L., Grubin C.E., Wignall J.M., Jenkins N.A., Brannan C.I., Copeland N.G., Huebner K., Croce C.M., Cannizzarro L.A., Benjamin D., Dower S.K., Spriggs M.K., Sims J.E.
    EMBO J. 10:2821-2832(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4."
    Colotta F., Re F., Muzio M., Bertini R., Polentarutti N., Sironi M., Giri J.G., Dower S.K., Sims J.E., Mantovani A.
    Science 261:472-475(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS DECOY RECEPTOR.
  3. "Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor."
    Malinowsky D., Lundkvist J., Laye S., Bartfai T.
    FEBS Lett. 429:299-302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-208.
    Strain: C57BL/6J.
    Tissue: Plasma.
  5. "Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist."
    Smeets R.L., Joosten L.A., Arntz O.J., Bennink M.B., Takahashi N., Carlsen H., Martin M.U., van den Berg W.B., van de Loo F.A.
    Arthritis Rheum. 52:2202-2211(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiIL1R2_MOUSE
AccessioniPrimary (citable) accession number: P27931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 6, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.