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Protein

Interleukin-1 receptor type 2

Gene

Il1r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).By similarity2 Publications

GO - Molecular functioni

  • interleukin-1, Type II, blocking receptor activity Source: InterPro
  • interleukin-1 binding Source: MGI
  • interleukin-1 receptor activity Source: MGI

GO - Biological processi

  • negative regulation of cytokine production involved in inflammatory response Source: MGI
  • negative regulation of interleukin-1 alpha secretion Source: MGI
  • negative regulation of interleukin-1-mediated signaling pathway Source: MGI
  • negative regulation of protein processing Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 2
Short name:
IL-1R-2
Short name:
IL-1RT-2
Short name:
IL-1RT2
Alternative name(s):
CD121 antigen-like family member B
IL-1 type II receptor
Interleukin-1 receptor beta
Short name:
IL-1R-beta
Interleukin-1 receptor type II
CD_antigen: CD121b
Cleaved into the following 2 chains:
Interleukin-1 receptor type 2, membrane form
Short name:
mIL-1R2
Short name:
mIL-1RII
Interleukin-1 receptor type 2, soluble form
Short name:
sIL-1R2
Short name:
sIL-1RII
Gene namesi
Name:Il1r2
Synonyms:Il-1r2, Il1rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96546 Il1r2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 355ExtracellularSequence analysisAdd BLAST342
Transmembranei356 – 381HelicalSequence analysisAdd BLAST26
Topological domaini382 – 410CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Sequence analysisAdd BLAST13
ChainiPRO_000001544014 – 410Interleukin-1 receptor type 2, membrane formAdd BLAST397
ChainiPRO_000041534914 – ?Interleukin-1 receptor type 2, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 128PROSITE-ProRule annotation
Disulfide bondi64 ↔ 120PROSITE-ProRule annotation
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 219PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi270 ↔ 338PROSITE-ProRule annotation
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP27931
PeptideAtlasiP27931
PRIDEiP27931

PTM databases

iPTMnetiP27931
PhosphoSitePlusiP27931

Expressioni

Tissue specificityi

Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1.1 Publication

Gene expression databases

BgeeiENSMUSG00000026073
CleanExiMM_IL1R2
ExpressionAtlasiP27931 baseline and differential
GenevisibleiP27931 MM

Interactioni

Subunit structurei

Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.By similarity

GO - Molecular functioni

  • interleukin-1 binding Source: MGI

Protein-protein interaction databases

BioGridi200626, 1 interactor
IntActiP27931, 1 interactor
MINTiP27931
STRINGi10090.ENSMUSP00000027243

Structurei

3D structure databases

ProteinModelPortaliP27931
SMRiP27931
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 136Ig-like C2-type 1Add BLAST102
Domaini146 – 237Ig-like C2-type 2Add BLAST92
Domaini249 – 357Ig-like C2-type 3Add BLAST109

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCQ Eukaryota
ENOG410YQDP LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000113036
HOVERGENiHBG052104
InParanoidiP27931
KOiK04387
OMAiRQEYSEN
OrthoDBiEOG091G077L
PhylomeDBiP27931
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR004077 IL-1_rcpt_II-typ
IPR013151 Immunoglobulin
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PRINTSiPR01539 INTRLEUKN1R2
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFILLVLVTG VSAFTTPTVV HTGKVSESPI TSEKPTVHGD NCQFRGREFK
60 70 80 90 100
SELRLEGEPV VLRCPLAPHS DISSSSHSFL TWSKLDSSQL IPRDEPRMWV
110 120 130 140 150
KGNILWILPA VQQDSGTYIC TFRNASHCEQ MSVELKVFKN TEASLPHVSY
160 170 180 190 200
LQISALSTTG LLVCPDLKEF ISSNADGKIQ WYKGAILLDK GNKEFLSAGD
210 220 230 240 250
PTRLLISNTS MDDAGYYRCV MTFTYNGQEY NITRNIELRV KGTTTEPIPV
260 270 280 290 300
IISPLETIPA SLGSRLIVPC KVFLGTGTSS NTIVWWLANS TFISAAYPRG
310 320 330 340 350
RVTEGLHHQY SENDENYVEV SLIFDPVTRE DLHTDFKCVA SNPRSSQSLH
360 370 380 390 400
TTVKEVSSTF SWSIALAPLS LIILVVGAIW MRRRCKRRAG KTYGLTKLRT
410
DNQDFPSSPN
Length:410
Mass (Da):45,645
Last modified:August 1, 1992 - v1
Checksum:i923DFC27C70AF604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59769 mRNA Translation: CAA42440.1
CCDSiCCDS14909.1
RefSeqiNP_034685.1, NM_010555.4
XP_011236739.1, XM_011238437.2
XP_011236740.1, XM_011238438.2
XP_011236741.1, XM_011238439.2
XP_011236742.1, XM_011238440.2
UniGeneiMm.1349

Genome annotation databases

EnsembliENSMUST00000027243; ENSMUSP00000027243; ENSMUSG00000026073
GeneIDi16178
KEGGimmu:16178
UCSCiuc007atu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIL1R2_MOUSE
AccessioniPrimary (citable) accession number: P27931
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health