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Protein

Interleukin-1 receptor type 2

Gene

IL1R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.4 Publications

GO - Molecular functioni

  • interleukin-1, Type II, blocking receptor activity Source: InterPro
  • interleukin-1 receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115590-MONOMER.
ReactomeiR-HSA-446652. Interleukin-1 signaling.
SIGNORiP27930.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 2
Short name:
IL-1R-2
Short name:
IL-1RT-2
Short name:
IL-1RT2
Alternative name(s):
CD121 antigen-like family member B
CDw121b
IL-1 type II receptor
Interleukin-1 receptor beta
Short name:
IL-1R-beta
Interleukin-1 receptor type II
CD_antigen: CD121b
Cleaved into the following 2 chains:
Interleukin-1 receptor type 2, membrane form
Short name:
mIL-1R2
Short name:
mIL-1RII
Interleukin-1 receptor type 2, soluble form
Short name:
sIL-1R2
Short name:
sIL-1RII
Gene namesi
Name:IL1R2
Synonyms:IL1RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5994. IL1R2.

Subcellular locationi

Isoform Short :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 343ExtracellularSequence analysisAdd BLAST330
Transmembranei344 – 369HelicalSequence analysisAdd BLAST26
Topological domaini370 – 398CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7850.
OpenTargetsiENSG00000115590.
PharmGKBiPA29810.

Polymorphism and mutation databases

BioMutaiIL1R2.
DMDMi124310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Sequence analysisAdd BLAST13
ChainiPRO_000001543914 – 398Interleukin-1 receptor type 2, membrane formAdd BLAST385
ChainiPRO_000041534814 – ?Interleukin-1 receptor type 2, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 116PROSITE-ProRule annotation1 Publication
Disulfide bondi50 ↔ 108PROSITE-ProRule annotation1 Publication
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)1 Publication1
Disulfide bondi152 ↔ 207PROSITE-ProRule annotation1 Publication
Glycosylationi219N-linked (GlcNAc...)1 Publication1
Disulfide bondi258 ↔ 326PROSITE-ProRule annotation1 Publication
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP27930.
PeptideAtlasiP27930.
PRIDEiP27930.

PTM databases

iPTMnetiP27930.
PhosphoSitePlusiP27930.

Expressioni

Gene expression databases

BgeeiENSG00000115590.
CleanExiHS_IL1R2.
ExpressionAtlasiP27930. baseline and differential.
GenevisibleiP27930. HS.

Organism-specific databases

HPAiHPA027597.
HPA027598.

Interactioni

Subunit structurei

Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.1 Publication

Protein-protein interaction databases

BioGridi113605. 39 interactors.
DIPiDIP-61267N.
IntActiP27930. 4 interactors.
STRINGi9606.ENSP00000330959.

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 33Combined sources5
Beta strandi38 – 41Combined sources4
Beta strandi47 – 49Combined sources3
Beta strandi70 – 73Combined sources4
Beta strandi82 – 84Combined sources3
Beta strandi86 – 89Combined sources4
Beta strandi92 – 98Combined sources7
Beta strandi104 – 107Combined sources4
Beta strandi110 – 112Combined sources3
Beta strandi115 – 126Combined sources12
Helixi130 – 132Combined sources3
Helixi133 – 136Combined sources4
Beta strandi138 – 143Combined sources6
Beta strandi148 – 151Combined sources4
Turni156 – 158Combined sources3
Beta strandi161 – 163Combined sources3
Beta strandi170 – 173Combined sources4
Beta strandi181 – 185Combined sources5
Beta strandi189 – 196Combined sources8
Helixi199 – 201Combined sources3
Beta strandi203 – 210Combined sources8
Beta strandi219 – 229Combined sources11
Beta strandi260 – 265Combined sources6
Beta strandi271 – 279Combined sources9
Beta strandi281 – 285Combined sources5
Beta strandi287 – 289Combined sources3
Beta strandi301 – 303Combined sources3
Beta strandi305 – 308Combined sources4
Beta strandi325 – 330Combined sources6
Beta strandi333 – 335Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O4OX-ray3.30C14-343[»]
ProteinModelPortaliP27930.
SMRiP27930.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27930.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 124Ig-like C2-type 1Add BLAST107
Domaini134 – 223Ig-like C2-type 2Add BLAST90
Domaini237 – 349Ig-like C2-type 3Add BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni329 – 343Contains proteolytic cleavage siteCuratedAdd BLAST15

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCQ. Eukaryota.
ENOG410YQDP. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113036.
HOVERGENiHBG052104.
InParanoidiP27930.
KOiK04387.
OMAiRQEYSEN.
OrthoDBiEOG091G077L.
PhylomeDBiP27930.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR004074. IL-1_rcpt_I/II-typ.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P27930-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRLYVLVMG VSAFTLQPAA HTGAARSCRF RGRHYKREFR LEGEPVALRC
60 70 80 90 100
PQVPYWLWAS VSPRINLTWH KNDSARTVPG EEETRMWAQD GALWLLPALQ
110 120 130 140 150
EDSGTYVCTT RNASYCDKMS IELRVFENTD AFLPFISYPQ ILTLSTSGVL
160 170 180 190 200
VCPDLSEFTR DKTDVKIQWY KDSLLLDKDN EKFLSVRGTT HLLVHDVALE
210 220 230 240 250
DAGYYRCVLT FAHEGQQYNI TRSIELRIKK KKEETIPVII SPLKTISASL
260 270 280 290 300
GSRLTIPCKV FLGTGTPLTT MLWWTANDTH IESAYPGGRV TEGPRQEYSE
310 320 330 340 350
NNENYIEVPL IFDPVTREDL HMDFKCVVHN TLSFQTLRTT VKEASSTFSW
360 370 380 390
GIVLAPLSLA FLVLGGIWMH RRCKHRTGKA DGLTVLWPHH QDFQSYPK
Length:398
Mass (Da):45,421
Last modified:August 1, 1992 - v1
Checksum:i2C2A03ADA6F3AC5B
GO
Isoform Short (identifier: P27930-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     297-398: Missing.

Show »
Length:296
Mass (Da):33,622
Checksum:i581AA026BB7DACD5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123L → F in AAD00242 (PubMed:8702856).Curated1
Sequence conflicti171K → R in AAD00242 (PubMed:8702856).Curated1
Sequence conflicti199L → Q in AAD00242 (PubMed:8702856).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019132181E → K.1 PublicationCorresponds to variant rs28385682dbSNPEnsembl.1
Natural variantiVAR_019133292E → K.1 PublicationCorresponds to variant rs3218976dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042222297 – 398Missing in isoform Short. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59770 mRNA. Translation: CAA42441.1.
U64094 mRNA. Translation: AAB05878.1.
U74649 mRNA. Translation: AAD00242.1.
AY124010 Genomic DNA. Translation: AAM64221.1.
AC007165 Genomic DNA. Translation: AAK52072.1.
CH471127 Genomic DNA. Translation: EAX01800.1.
CH471127 Genomic DNA. Translation: EAX01801.1.
CH471127 Genomic DNA. Translation: EAX01802.1.
CH471127 Genomic DNA. Translation: EAX01803.1.
BC039031 mRNA. Translation: AAH39031.1.
CCDSiCCDS2054.1. [P27930-1]
CCDS58719.1. [P27930-2]
PIRiS17428.
RefSeqiNP_001248348.1. NM_001261419.1. [P27930-2]
NP_004624.1. NM_004633.3. [P27930-1]
XP_006712797.1. XM_006712734.3. [P27930-1]
XP_011510106.1. XM_011511804.2. [P27930-1]
UniGeneiHs.25333.

Genome annotation databases

EnsembliENST00000332549; ENSP00000330959; ENSG00000115590. [P27930-1]
ENST00000393414; ENSP00000377066; ENSG00000115590. [P27930-1]
ENST00000441002; ENSP00000414611; ENSG00000115590. [P27930-2]
GeneIDi7850.
KEGGihsa:7850.
UCSCiuc002tbm.4. human. [P27930-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59770 mRNA. Translation: CAA42441.1.
U64094 mRNA. Translation: AAB05878.1.
U74649 mRNA. Translation: AAD00242.1.
AY124010 Genomic DNA. Translation: AAM64221.1.
AC007165 Genomic DNA. Translation: AAK52072.1.
CH471127 Genomic DNA. Translation: EAX01800.1.
CH471127 Genomic DNA. Translation: EAX01801.1.
CH471127 Genomic DNA. Translation: EAX01802.1.
CH471127 Genomic DNA. Translation: EAX01803.1.
BC039031 mRNA. Translation: AAH39031.1.
CCDSiCCDS2054.1. [P27930-1]
CCDS58719.1. [P27930-2]
PIRiS17428.
RefSeqiNP_001248348.1. NM_001261419.1. [P27930-2]
NP_004624.1. NM_004633.3. [P27930-1]
XP_006712797.1. XM_006712734.3. [P27930-1]
XP_011510106.1. XM_011511804.2. [P27930-1]
UniGeneiHs.25333.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O4OX-ray3.30C14-343[»]
ProteinModelPortaliP27930.
SMRiP27930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113605. 39 interactors.
DIPiDIP-61267N.
IntActiP27930. 4 interactors.
STRINGi9606.ENSP00000330959.

PTM databases

iPTMnetiP27930.
PhosphoSitePlusiP27930.

Polymorphism and mutation databases

BioMutaiIL1R2.
DMDMi124310.

Proteomic databases

PaxDbiP27930.
PeptideAtlasiP27930.
PRIDEiP27930.

Protocols and materials databases

DNASUi7850.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332549; ENSP00000330959; ENSG00000115590. [P27930-1]
ENST00000393414; ENSP00000377066; ENSG00000115590. [P27930-1]
ENST00000441002; ENSP00000414611; ENSG00000115590. [P27930-2]
GeneIDi7850.
KEGGihsa:7850.
UCSCiuc002tbm.4. human. [P27930-1]

Organism-specific databases

CTDi7850.
DisGeNETi7850.
GeneCardsiIL1R2.
HGNCiHGNC:5994. IL1R2.
HPAiHPA027597.
HPA027598.
MIMi147811. gene.
neXtProtiNX_P27930.
OpenTargetsiENSG00000115590.
PharmGKBiPA29810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJCQ. Eukaryota.
ENOG410YQDP. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113036.
HOVERGENiHBG052104.
InParanoidiP27930.
KOiK04387.
OMAiRQEYSEN.
OrthoDBiEOG091G077L.
PhylomeDBiP27930.
TreeFamiTF325519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115590-MONOMER.
ReactomeiR-HSA-446652. Interleukin-1 signaling.
SIGNORiP27930.

Miscellaneous databases

EvolutionaryTraceiP27930.
GeneWikiiInterleukin_1_receptor,_type_II.
GenomeRNAii7850.
PROiP27930.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115590.
CleanExiHS_IL1R2.
ExpressionAtlasiP27930. baseline and differential.
GenevisibleiP27930. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR004074. IL-1_rcpt_I/II-typ.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1R2_HUMAN
AccessioniPrimary (citable) accession number: P27930
Secondary accession number(s): D3DVJ5, Q6LCE6, Q9UE68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 2, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.