P27917 (APOC3_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein C-III
Short name=Apo-CIII
Short name=ApoC-III

Alternative name(s):
Apolipoprotein C3

Gene names

Name:

APOC3

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Subcellular location	Secreted.
Tissue specificity	Mainly VLDL and also in HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
Sequence similarities	Belongs to the apolipoprotein C3 family.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism Lipid transport Transport
Cellular component	Chylomicron Secreted VLDL
Domain	Signal
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara cholesterol efflux Inferred from electronic annotation. Source: Compara cholesterol homeostasis Inferred from electronic annotation. Source: Compara cholesterol metabolic process Inferred from electronic annotation. Source: Compara chylomicron remnant clearance Inferred from electronic annotation. Source: Compara high-density lipoprotein particle remodeling Inferred from electronic annotation. Source: Compara lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro negative regulation of cholesterol import Inferred from electronic annotation. Source: Compara negative regulation of fatty acid biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of high-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara negative regulation of lipoprotein lipase activity Inferred from electronic annotation. Source: Compara negative regulation of low-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara negative regulation of receptor-mediated endocytosis Inferred from electronic annotation. Source: Compara negative regulation of triglyceride catabolic process Inferred from electronic annotation. Source: Compara negative regulation of very-low-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara phospholipid efflux Inferred from electronic annotation. Source: Compara regulation of Cdc42 protein signal transduction Inferred from electronic annotation. Source: Compara triglyceride catabolic process Inferred from electronic annotation. Source: Compara triglyceride homeostasis Inferred from electronic annotation. Source: Compara triglyceride mobilization Inferred from electronic annotation. Source: Compara
Cellular_component	chylomicron Inferred from electronic annotation. Source: UniProtKB-KW intermediate-density lipoprotein particle Inferred from electronic annotation. Source: Compara spherical high-density lipoprotein particle Inferred from electronic annotation. Source: Compara very-low-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipase inhibitor activity Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 96	73	Apolipoprotein C-III		PRO_0000002034
Regions
	Region	68 – 96	29	Lipid-binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27917 [UniParc]. Last modified October 1, 1993. Version 2. Checksum: E4AC07F58C8A4DB2	FASTA	96	10,704
	10 20 30 40 50 60 MQPRVLLVAG LLVLLACAQA IEAEDTSLLD KMQDYVKQAT RTAQDALTSV KESEVAQQAR 70 80 90 GWVTDSISSL KDYWSTFKGK FTDFWDYTPK PEPSSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the apolipoprotein AI and CIII genes in the domestic pig." Birchbauer A., Knipping G., Juritsch B., Aschauer H., Zechner R. Genomics 15:643-652(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome 7:509-517(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.
[3]	"Sequences and expression of the porcine apolipoprotein A-I and C-III mRNAs." Trieu V.N., Hasler-Rapacz J., Rapacz J., Black D.D. Gene 123:173-179(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-96, PROTEIN SEQUENCE OF 34-58. Tissue: Liver.
[4]	Hasler-Rapacz J.O., Chaudhary R., Chowdhary B.P., Trieu V.N., Jackson K., Gustavsson I., Rapacz J. Submitted (OCT-1995) to UniProtKB Cited for: PROTEIN SEQUENCE OF 24-96.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00627 Genomic DNA. Translation: AAA30993.1. F14536 mRNA. Translation: CAA23113.1. M84133 mRNA. No translation available. M84134 Genomic DNA. No translation available.
PIR	B46018.
RefSeq	NP_001002801.1. NM_001002801.1.
UniGene	Ssc.53685. Ssc.96102.
3D structure databases
ProteinModelPortal	P27917.
SMR	P27917. Positions 22-96.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000015993.
Proteomic databases
PaxDb	P27917.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000016435; ENSSSCP00000015993; ENSSSCG00000015069.
GeneID	406187.
KEGG	ssc:406187.
Organism-specific databases
CTD	345.
Phylogenomic databases
eggNOG	NOG39866.
GeneTree	ENSGT00390000015395.
HOGENOM	HOG000247042.
HOVERGEN	HBG050549.
KO	K08759.
OMA	SLKDYWS.
OrthoDB	EOG4WDDDG.
Gene expression databases
ArrayExpress	P27917.
Family and domain databases
InterPro	IPR008403. Apo-CIII. [Graphical view]
PANTHER	PTHR14225. PTHR14225. 1 hit.
Pfam	PF05778. Apo-CIII. 1 hit. [Graphical view]
ProDom	PD010414. Apo-CIII. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

APOC3_PIG

Accession

Primary (citable) accession number: P27917
Secondary accession number(s): Q29208

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	October 1, 1993
Last modified:	April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program