##gff-version 3 P27915 UniProtKB Chain 1 3390 . . . ID=PRO_0000405221;Note=Genome polyprotein P27915 UniProtKB Chain 1 100 . . . ID=PRO_0000037989;Note=Capsid protein C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Propeptide 101 114 . . . ID=PRO_0000037990;Note=ER anchor for the capsid protein C%2C removed in mature form by serine protease NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 115 280 . . . ID=PRO_0000308293;Note=Protein prM;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 115 205 . . . ID=PRO_0000308294;Note=Peptide pr;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 206 280 . . . ID=PRO_0000037991;Note=Small envelope protein M;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 281 773 . . . ID=PRO_0000037992;Note=Envelope protein E;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 774 1125 . . . ID=PRO_0000037993;Note=Non-structural protein 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 1126 1343 . . . ID=PRO_0000037994;Note=Non-structural protein 2A;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 1344 1473 . . . ID=PRO_0000037995;Note=Serine protease subunit NS2B;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 1474 2092 . . . ID=PRO_0000037996;Note=Serine protease NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 2093 2219 . . . ID=PRO_0000037997;Note=Non-structural protein 4A;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Peptide 2220 2242 . . . ID=PRO_0000308296;Note=Peptide 2k;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 2243 2490 . . . ID=PRO_0000037998;Note=Non-structural protein 4B;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Chain 2491 3390 . . . ID=PRO_0000037999;Note=RNA-directed RNA polymerase NS5;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Topological domain 1 100 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 101 118 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 119 243 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 244 264 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 265 265 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 266 280 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 281 723 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 724 744 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 745 750 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 751 771 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 772 1193 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 1194 1218 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 1219 1224 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 1225 1243 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 1244 1267 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 1268 1288 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 1289 1289 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 1290 1308 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 1309 1315 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 1316 1336 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 1337 1344 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 1345 1365 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 1366 1368 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 1369 1389 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 1390 1443 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Intramembrane 1444 1464 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 1465 2146 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 2147 2167 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 2168 2169 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Intramembrane 2170 2190 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 2191 2191 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 2192 2212 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 2213 2227 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 2228 2248 . . . Note=Helical%3B Note%3DSignal for NS4B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498 P27915 UniProtKB Topological domain 2249 2273 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Intramembrane 2274 2294 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 2295 2305 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Intramembrane 2306 2326 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 2327 2346 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 2347 2367 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 2368 2412 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 2413 2433 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 2434 2458 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Transmembrane 2459 2479 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Topological domain 2480 3390 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Domain 1474 1651 . . . Note=Peptidase S7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00860 P27915 UniProtKB Domain 1654 1810 . . . Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P27915 UniProtKB Domain 1821 1986 . . . Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542 P27915 UniProtKB Domain 2492 2753 . . . Note=MRNA cap 0-1 NS5-type MT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Domain 3018 3168 . . . Note=RdRp catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00539 P27915 UniProtKB Region 1 15 . . . Note=Interaction with host EXOC1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Region 37 72 . . . Note=Hydrophobic%3B homodimerization of capsid protein C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Region 378 391 . . . Note=Fusion peptide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14336 P27915 UniProtKB Region 1396 1435 . . . Note=Interacts with and activates NS3 protease;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00859 P27915 UniProtKB Region 1658 1661 . . . Note=Important for RNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14340 P27915 UniProtKB Motif 1758 1761 . . . Note=DEAH box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P27915 UniProtKB Motif 2567 2570 . . . Note=SUMO-interacting motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Active site 1524 1524 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00860 P27915 UniProtKB Active site 1548 1548 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00860 P27915 UniProtKB Active site 1608 1608 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00860 P27915 UniProtKB Active site 2551 2551 . . . Note=For 2'-O-MTase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P27915 UniProtKB Active site 2636 2636 . . . Note=For 2'-O-MTase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P27915 UniProtKB Active site 2670 2670 . . . Note=For 2'-O-MTase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P27915 UniProtKB Active site 2706 2706 . . . Note=For 2'-O-MTase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P27915 UniProtKB Binding site 1667 1674 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P27915 UniProtKB Binding site 2546 2546 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2576 2576 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2577 2577 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2594 2594 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2595 2595 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2621 2621 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2622 2622 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2637 2637 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2708 2708 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Binding site 2927 2927 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26895240;Dbxref=PMID:26895240 P27915 UniProtKB Binding site 2931 2931 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26895240;Dbxref=PMID:26895240 P27915 UniProtKB Binding site 2936 2936 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26895240;Dbxref=PMID:26895240 P27915 UniProtKB Binding site 2939 2939 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26895240;Dbxref=PMID:26895240 P27915 UniProtKB Binding site 3202 3202 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26895240;Dbxref=PMID:26895240 P27915 UniProtKB Binding site 3218 3218 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26895240;Dbxref=PMID:26895240 P27915 UniProtKB Binding site 3337 3337 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P27915 UniProtKB Site 100 101 . . . Note=Cleavage%3B by viral protease NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 114 115 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 205 206 . . . Note=Cleavage%3B by host furin;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P29990,ECO:0000255 P27915 UniProtKB Site 280 281 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 773 774 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 1125 1126 . . . Note=Cleavage%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 1343 1344 . . . Note=Cleavage%3B by viral protease NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 1473 1474 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 1931 1931 . . . Note=Involved in NS3 ATPase and RTPase activities;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P27915 UniProtKB Site 1934 1934 . . . Note=Involved in NS3 ATPase and RTPase activities;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P27915 UniProtKB Site 2092 2093 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 2219 2220 . . . Note=Cleavage%3B by viral protease NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 2242 2243 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 2490 2491 . . . Note=Cleavage%3B by viral protease NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P27915 UniProtKB Site 2504 2504 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2507 2507 . . . Note=MRNA cap binding%3B via carbonyl oxygen;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2508 2508 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2510 2510 . . . Note=MRNA cap binding%3B via carbonyl oxygen;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2515 2515 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2519 2519 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2551 2551 . . . Note=Essential for 2'-O-methyltransferase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2636 2636 . . . Note=Essential for 2'-O-methyltransferase and N-7 methyltransferase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2640 2640 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2670 2670 . . . Note=Essential for 2'-O-methyltransferase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2701 2701 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2703 2703 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Site 2706 2706 . . . Note=Essential for 2'-O-methyltransferase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P27915 UniProtKB Modified residue 2546 2546 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03314 P27915 UniProtKB Glycosylation 183 183 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27915 UniProtKB Glycosylation 347 347 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:15613349;Dbxref=PMID:15613349 P27915 UniProtKB Glycosylation 433 433 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:15613349;Dbxref=PMID:15613349 P27915 UniProtKB Glycosylation 903 903 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498 P27915 UniProtKB Glycosylation 980 980 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498 P27915 UniProtKB Glycosylation 1132 1132 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498 P27915 UniProtKB Glycosylation 1188 1188 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498 P27915 UniProtKB Glycosylation 2300 2300 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498 P27915 UniProtKB Glycosylation 2304 2304 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498 P27915 UniProtKB Glycosylation 2456 2456 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00498 P27915 UniProtKB Disulfide bond 283 310 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 340 401 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 354 385 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 372 396 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 463 563 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 580 611 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 777 788 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 828 916 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 952 996 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 1053 1102 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 1064 1086 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Disulfide bond 1085 1089 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P17763 P27915 UniProtKB Mutagenesis 2623 2623 . . . Note=No effect on N7 methylase activity%3B 35%25 loss of 2'-O methylase activity. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21147775;Dbxref=PMID:21147775 P27915 UniProtKB Mutagenesis 2638 2638 . . . Note=70%25 loss of N7 methylase activity%3B 60%25 loss of 2'-O methylase activity. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21147775;Dbxref=PMID:21147775 P27915 UniProtKB Mutagenesis 2650 2650 . . . Note=40%25 loss of N7 methylase activity%3B No effect on loss of 2'-O methylase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21147775;Dbxref=PMID:21147775 P27915 UniProtKB Mutagenesis 2653 2653 . . . Note=40%25 loss of N7 methylase activity%3B No effect on loss of 2'-O methylase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21147775;Dbxref=PMID:21147775 P27915 UniProtKB Mutagenesis 2672 2672 . . . Note=No effect on N7 methylase activity%3B 80%25 loss of 2'-O methylase activity. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21147775;Dbxref=PMID:21147775 P27915 UniProtKB Turn 282 285 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UZG P27915 UniProtKB Beta strand 287 293 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Helix 295 297 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 299 314 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 321 330 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 334 352 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Helix 363 365 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 367 380 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Turn 381 384 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 389 409 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Helix 412 414 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 415 423 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 434 436 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UZG P27915 UniProtKB Beta strand 438 446 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 448 453 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Turn 454 456 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 457 464 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 474 479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 482 487 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Helix 488 492 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 498 502 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3S P27915 UniProtKB Beta strand 503 505 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UZG P27915 UniProtKB Helix 512 515 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 516 519 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 521 524 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 527 530 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Helix 535 541 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 543 553 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 555 557 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 560 570 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Turn 573 576 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3S P27915 UniProtKB Beta strand 577 579 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UZG P27915 UniProtKB Beta strand 584 586 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Beta strand 594 596 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1UZG P27915 UniProtKB Beta strand 598 604 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Beta strand 610 612 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Beta strand 615 618 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Beta strand 628 631 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Beta strand 635 637 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Beta strand 639 641 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A3T P27915 UniProtKB Beta strand 643 648 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Beta strand 651 661 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Beta strand 665 671 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3VTT P27915 UniProtKB Helix 2499 2509 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2512 2518 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Turn 2519 2522 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2524 2527 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2529 2536 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2548 2557 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2565 2570 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2576 2581 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2587 2593 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2611 2613 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2614 2617 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2622 2624 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2631 2635 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2644 2658 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2659 2661 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2666 2672 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2677 2690 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2693 2695 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2707 2712 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Helix 2717 2730 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Turn 2731 2733 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI P27915 UniProtKB Beta strand 2740 2743 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EHI