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Reviewed, UniProtKB/Swiss-Prot P27915 (POLG_DEN3P)

Last modified February 9, 2010. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Genome polyprotein
Cleaved into the following 14 chains:
    1- Recommended name:
            Protein C
        Alternative name(s):
            Core protein
            Capsid protein
    2- Recommended name:
            prM
    3- Recommended name:
            Peptide pr
    4- Recommended name:
            Small envelope protein M
        Alternative name(s):
            Matrix protein
    5- Recommended name:
            Envelope protein E
    6- Recommended name:
            Non-structural protein 1
                Short name=NS1
    7- Recommended name:
            Non-structural protein 2A
                Short name=NS2A
    8- Recommended name:
            Non-structural protein 2A-alpha
                Short name=NS2A-alpha
    9- Recommended name:
            Serine protease subunit NS2B
        Alternative name(s):
            Non-structural protein 2B
            Flavivirin protease NS2B regulatory subunit
    10- Recommended name:
            Serine protease/NTPase/helicase NS3
              EC=3.4.21.91
              EC=3.6.1.15
              EC=3.6.1.-
        Alternative name(s):
            Flavivirin protease NS3 catalytic subunit
            Non-structural protein 3
    11- Recommended name:
            Non-structural protein 4A
                Short name=NS4A
    12- Recommended name:
            Peptide 2k
    13- Recommended name:
            Non-structural protein 4B
                Short name=NS4B
    14- Recommended name:
            Methyltransferase/RNA-directed RNA polymerase NS5
              EC=2.7.7.48
              EC=2.1.1.56
              EC=2.1.1.57
        Alternative name(s):
            Non-structural protein 5
OrganismDengue virus type 3 (strain Philippines/H87/1956) (DENV-3) [Complete proteome]
Taxonomic identifier408870 [NCBI]
Taxonomic lineageViruses › ssRNA positive-strand viruses, no DNA stage › Flaviviridae › Flavivirus › Dengue virus group
Virus hostErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Diceromyia [TaxID: 53539]
Aedimorphus [TaxID: 53540]
Stegomyia [TaxID: 53541]

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Protein attributes

Sequence length3390 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function. NS5 may play a role in the viral RNA replication. The NS2B/NS3 protease complex processes the viral polyprotein.

Catalytic activity

Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

NTP + H2O = NDP + phosphate.

S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.

S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA.

Subunit structure

NS3 and NS2B form a heterodimer. NS3 is the catalytic subunit, whereas NS2B strongly stimulates the latter By similarity.

Subcellular location

Protein C: Virion Potential. Host membrane; Single-pass membrane protein Potential.

Small envelope protein M: Virion Potential. Host membrane; Single-pass membrane protein Potential.

Envelope protein E: Virion Potential. Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 4A: Host membrane; Single-pass membrane protein Potential.

Non-structural protein 4B: Host membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins By similarity.

Miscellaneous

The virion of this virus is a nucleocapsid covered by a lipoprotein envelope. The envelope contains two proteins: the protein M and glycoprotein E. The nucleocapsid is a complex of protein C and mRNA. In immature particles, there are 60 icosaedrally organized trimeric spikes on the surface. Each spike consists of three heterodimers of envelope protein M precursor (prM) and envelope protein E By similarity.

Sequence similarities

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 1 peptidase S7 domain.

Contains 1 RdRp catalytic domain.

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Ontologies

Keywords
   Biological processRNA replication
   Cellular componentCapsid protein
Core protein
Envelope protein
Host membrane
Membrane
Virion
   DomainTransmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
Methyltransferase
Nucleotidyltransferase
RNA-directed RNA polymerase
Transferase
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processRNA metabolic process

Inferred from electronic annotation. Source: InterPro

methylation

Inferred from electronic annotation. Source: InterPro

transcription, RNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

viral genome replication

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

viral nucleocapsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

double-stranded RNA binding

Inferred from electronic annotation. Source: InterPro

mRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: EC

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 100100Protein C By similarity
PRO_0000037989
Propeptide101 – 11414ER anchor for the protein C, removed in mature form by serine protease NS3 By similarity
PRO_0000037990
Chain115 – 280166prM By similarity
PRO_0000308293
Chain115 – 20591Peptide pr By similarity
PRO_0000308294
Chain206 – 28075Small envelope protein M By similarity
PRO_0000037991
Chain281 – 773493Envelope protein E By similarity
PRO_0000037992
Chain774 – 1125352Non-structural protein 1 By similarity
PRO_0000037993
Chain1126 – 1343218Non-structural protein 2A By similarity
PRO_0000037994
Chain1126 – 1313188Non-structural protein 2A-alpha By similarity
PRO_0000308295
Chain1344 – 1473130Serine protease subunit NS2B By similarity
PRO_0000037995
Chain1474 – 2092619Serine protease/NTPase/helicase NS3 By similarity
PRO_0000037996
Chain2093 – 2219127Non-structural protein 4A By similarity
PRO_0000037997
Peptide2220 – 224223Peptide 2k By similarity
PRO_0000308296
Chain2243 – 2490248Non-structural protein 4B By similarity
PRO_0000037998
Chain2491 – 3390900Methyltransferase/RNA-directed RNA polymerase NS5 By similarity
PRO_0000037999

Regions

Topological domain1 – 101101Cytoplasmic Potential
Transmembrane102 – 12221 Potential
Topological domain123 – 238116Extracellular Potential
Transmembrane239 – 25921 Potential
Topological domain260 – 2656Cytoplasmic Potential
Transmembrane266 – 28621 Potential
Topological domain287 – 723437Extracellular Potential
Transmembrane724 – 74421 Potential
Topological domain745 – 7506Cytoplasmic Potential
Transmembrane751 – 77121 Potential
Topological domain772 – 1154383Extracellular Potential
Transmembrane1155 – 117521 Potential
Topological domain1176 – 1445270Cytoplasmic Potential
Transmembrane1446 – 146621 Potential
Topological domain1467 – 2191725Lumenal Potential
Transmembrane2192 – 221221 Potential
Topological domain2213 – 22197Cytoplasmic Potential
Transmembrane2220 – 223920 Potential
Topological domain2240 – 2346107Lumenal Potential
Transmembrane2347 – 236721 Potential
Topological domain2368 – 241245Cytoplasmic Potential
Transmembrane2413 – 243321 Potential
Topological domain2434 – 245825Lumenal Potential
Transmembrane2459 – 247921 Potential
Topological domain2480 – 3390911Cytoplasmic Potential
Domain1654 – 1810157Helicase ATP-binding
Domain1820 – 1987168Helicase C-terminal
Domain3018 – 3168151RdRp catalytic
Nucleotide binding1667 – 16748ATP Potential
Motif1758 – 17614DEAH box By similarity

Sites

Active site15241Charge relay system; for serine protease NS3 activity By similarity
Active site15481Charge relay system; for serine protease NS3 activity By similarity
Active site16081Charge relay system; for serine protease NS3 activity By similarity
Active site25511For 2'-O-methyltransferase activity By similarity
Active site26361For 2'-O-methyltransferase and N-7 methyltransferase activity By similarity
Active site26701For 2'-O-methyltransferase activity By similarity
Active site27061For 2'-O-methyltransferase activity By similarity
Site100 – 1012Cleavage; by serine protease NS3 By similarity
Site114 – 1152Cleavage; by host signal peptidase By similarity
Site205 – 2062Cleavage; by host furin By similarity
Site280 – 2812Cleavage; by host signal peptidase By similarity
Site773 – 7742Cleavage; by host signal peptidase By similarity
Site1125 – 11262Cleavage; by host By similarity
Site1313 – 13142Cleavage; by serine protease NS3 By similarity
Site1343 – 13442Cleavage; by serine protease NS3 By similarity
Site1473 – 14742Cleavage; by serine protease NS3 By similarity
Site2092 – 20932Cleavage; by serine protease NS3 By similarity
Site2219 – 22202Cleavage; by host signal peptidase By similarity
Site2242 – 22432Cleavage; by serine protease NS3 By similarity
Site2490 – 24912Cleavage; by serine protease NS3 By similarity

Amino acid modifications

Glycosylation1831N-linked (GlcNAc...); by host Potential
Glycosylation3471N-linked (GlcNAc...); by host Potential
Glycosylation4331N-linked (GlcNAc...); by host Potential
Glycosylation9031N-linked (GlcNAc...); by host Potential
Glycosylation9801N-linked (GlcNAc...); by host Potential
Glycosylation11321N-linked (GlcNAc...); by host Potential
Glycosylation16611N-linked (GlcNAc...); by host Potential
Glycosylation23001N-linked (GlcNAc...); by host Potential
Glycosylation23041N-linked (GlcNAc...); by host Potential
Glycosylation24561N-linked (GlcNAc...); by host Potential
Disulfide bond283 ↔ 310 By similarity
Disulfide bond340 ↔ 401 By similarity
Disulfide bond354 ↔ 385 By similarity
Disulfide bond372 ↔ 396 By similarity
Disulfide bond463 ↔ 563 By similarity
Disulfide bond580 ↔ 611 By similarity

Secondary structure

1 ................................................................................ 3390
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P27915-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 666E8F70F1E1756E

FASTA3,390378,063
        10         20         30         40         50         60 
MNNQRKKTGK PSINMLKRVR NRVSTGSQLA KRFSRGLLNG QGPMKLVMAF IAFLRFLAIP 

        70         80         90        100        110        120 
PTAGVLARWG TFKKSGAIKV LKGFKKEISN MLSIINKRKK TSLCLMMMLP ATLAFHLTSR 

       130        140        150        160        170        180 
DGEPRMIVGK NERGKSLLFK TASGINMCTL IAMDLGEMCD DTVTYKCPHI TEVEPEDIDC 

       190        200        210        220        230        240 
WCNLTSTWVT YGTCNQAGEH RRDKRSVALA PHVGMGLDTR TQTWMSAEGA WRQVEKVETW 

       250        260        270        280        290        300 
ALRHPGFTIL ALFLAHYIGT SLTQKVVIFI LLMLVTPSMT MRCVGVGNRD FVEGLSGATW 

       310        320        330        340        350        360 
VDVVLEHGGC VTTMAKNKPT LDIELQKTEA TQLATLRKLC IEGKITNITT DSRCPTQGEA 

       370        380        390        400        410        420 
ILPEEQDQNY VCKHTYVDRG WGNGCGLFGK GSLVTCAKFQ CLESIEGKVV QHENLKYTVI 

       430        440        450        460        470        480 
ITVHTGDQHQ VGNETQGVTA EITSQASTAE AILPEYGTLG LECSPRTGLD FNEMILLTMK 

       490        500        510        520        530        540 
NKAWMVHRQW FFDLPLPWTS GATTKTPTWN RKELLVTFKN AHAKKQEVVV LGSQEGAMHT 

       550        560        570        580        590        600 
ALTGATEIQT SGGTSIFAGH LKCRLKMDKL KLKGMSYAMC LNTFVLKKEV SETQHGTILI 

       610        620        630        640        650        660 
KVEYKGEDAP CKIPFSTEDG QGKAHNGRLI TANPVVTKKE EPVNIEAEPP FGESNIVIGI 

       670        680        690        700        710        720 
GDKALKINWY RKGSSIGKMF EATARGARRM AILGDTAWDF GSVGGVLNSL GKMVHQIFGS 

       730        740        750        760        770        780 
AYTALFSGVS WIMKIGIGVL LTWIGLNSKN TSMSFSCIAI GIITLYLGVV VQADMGCVIN 

       790        800        810        820        830        840 
WKGKELKCGS GIFVTNEVHT WTEQYKFQAD SPKRVATAIA GAWENGVCGI RSTTRMENLL 

       850        860        870        880        890        900 
WKQIANELNY ILWENDIKLT VVVGDITGVL EQGKRTLTPQ PMELKYSWKT WGLAKIVTAE 

       910        920        930        940        950        960 
TQNSSFIIDG PSTPECPSAS RAWNVWEVED YGFGVFTTNI WLKLREVYTQ LCDHRLMSAA 

       970        980        990       1000       1010       1020 
VKDERAVHAD MGYWIESQKN GSWKLEKASL IEVKTCTWPK SHTLWSNGVL ESDMIIPKSL 

      1030       1040       1050       1060       1070       1080 
AGPISQHNHR PGYHTQTAGP WHLGKLELDF NYCEGTTVVI SENCGTRGPS LRTTTVSGKL 

      1090       1100       1110       1120       1130       1140 
IHEWCCRSCT LPPLRYMGED GCWYGMEIRP INEKEENMVK SLASAGSGKV DNFTMGVLCL 

      1150       1160       1170       1180       1190       1200 
AILFEEVMRG KFGKKHMIAG VLFTFVLLLS GQITWRGMAH TLIMIGSNAS DRMGMGVTYL 

      1210       1220       1230       1240       1250       1260 
ALIATFKIQP FLALGFFLRK LTSRENLLLG VGLAMAATLR LPEDIEQMAN GIALGLMALK 

      1270       1280       1290       1300       1310       1320 
LITQFETYQL WTALVSLTCS NTIFTLTVAW RTATLILAGI SLLPVCQSSS MRKTDWLPMT 

      1330       1340       1350       1360       1370       1380 
VAAMGVPPLP LFIFSLKDTL KRRSWPLNEG VMAVGLVSIL ASSLLRNDVP MAGPLVAGGL 

      1390       1400       1410       1420       1430       1440 
LIACYVITGT SADLTVEKAA DVTWEEEAEQ TGVSHNLMIT VDDDGTMRIK DDETENILTV 

      1450       1460       1470       1480       1490       1500 
LLKTALLIVS GIFPYSIPAT MLVWHTWQKQ TQRSGVLWDV PSPPETQKAE LEEGVYRIKQ 

      1510       1520       1530       1540       1550       1560 
QGIFGKTQVG VGVQKEGVFH TMWHVTRGAV LTHNGKRLEP NWASVKKDLI SYGGGWRLSA 

      1570       1580       1590       1600       1610       1620 
QWQKGEEVQV IAVEPGKNPK NFQTMPGIFQ TTTGEIGAIA LDFKPGTSGS PIINREGKVV 

      1630       1640       1650       1660       1670       1680 
GLYGNGVVTK NGGYVSGIAQ TNAEPDGPTP ELEEEMFKKR NLTIMDLHPG SGKTRKYLPA 

      1690       1700       1710       1720       1730       1740 
IVREAIKRRL RTLILAPTRV VAAEMEEAMK GLPIRYQTTA TKSEHTGREI VDLMCHATFT 

      1750       1760       1770       1780       1790       1800 
MRLLSPVRVP NYNLIIMDEA HFTDPASIAA RGYISTRVGM GEAAAIFMTA TPPGTADAFP 

      1810       1820       1830       1840       1850       1860 
QSNAPIQDEE RDIPERSWNS GNEWITDFVG KTVWFVPSIK AGNVIANCLR KNGKKVIQLS 

      1870       1880       1890       1900       1910       1920 
RKTFDTEYQK TKLNDWDFVV TTDISEMGAN FIADRVIDPR RCLKPVILTD GPERVILAGP 

      1930       1940       1950       1960       1970       1980 
MPVTVASAAQ RRGRVGRNPQ KENDQYIFMG QPLNKDEDHA HWTEAKMLLD NINTPEGIIP 

      1990       2000       2010       2020       2030       2040 
ALFEPEREKS AAIDGEYRLK GESRKTFVEL MRRGDLPVWL AHKVASEGIK YTDRKWCFDG 

      2050       2060       2070       2080       2090       2100 
ERNNQILEEN MDVEIWTKEG EKKKLRPRWL DARTYSDPLA LKEFKDFAAG RKSIALDLVT 

      2110       2120       2130       2140       2150       2160 
EIGRVPSHLA HRTRNALDNL VMLHTSEHGG RAYRHAVEEL PETMETLLLL GLMILLTGGA 

      2170       2180       2190       2200       2210       2220 
MLFLISGKGI GKTSIGLICV IASSGMLWMA DVPLQWIASA IVLEFFMMVL LIPEPEKQRT 

      2230       2240       2250       2260       2270       2280 
PQDNQLAYVV IGILTLAAIV AANEMGLLET TKRDLGMSKE PGVVSPTSYL DVDLHPASAW 

      2290       2300       2310       2320       2330       2340 
TLYAVATTVI TPMLRHTIEN STANVSLAAI ANQAVVLMGL DKGWPISKMD LGVPLLALGC 

      2350       2360       2370       2380       2390       2400 
YSQVNPLTLI AAVLLLVTHY AIIGPGLQAK ATREAQKRTA AGIMKNPTVD GIMTIDLDPV 

      2410       2420       2430       2440       2450       2460 
IYDSKFEKQL GQVMLLVLCA VQLLLMRTSW ALCEVLTLAT GPITTLWEGS PGKFWNTTIA 

      2470       2480       2490       2500       2510       2520 
VSMANIFRGS YLAGAGLALS IMKSVGTGKR GTGSQGETLG EKWKKKLNQL SRKEFDLYKK 

      2530       2540       2550       2560       2570       2580 
SGITEVDRTE AKEGLKRGEI THHAVSRGSA KLQWFVERNM VIPEGRVIDL GCGRGGWSYY 

      2590       2600       2610       2620       2630       2640 
CAGLKKVTEV RGYTKGGPGH EEPVPMSTYG WNIVKLMSGK DVFYLPPEKC DTLLCDIGES 

      2650       2660       2670       2680       2690       2700 
SPSPTVEESR TIRVLKMVEP WLKNNQFCIK VLNPYMPTVI EHLERLQRKH GGMLVRNPLS 

      2710       2720       2730       2740       2750       2760 
RNSTHEMYWI SNGTGNIVSS VNMVSRLLLN RFTMTHRRPT IEKDVDLGAG TRHVNAEPET 

      2770       2780       2790       2800       2810       2820 
PNMDVIGERI KRIKEEHSST WHYDDENPYK TWAYHGSYEV KATGSASSMI NGVVKLLTKP 

      2830       2840       2850       2860       2870       2880 
WDVVPMVTQM AMTDTTPFGQ QRVFKEKVDT RTPRPMPGTR KVMEITAEWL WRTLGRNKRP 

      2890       2900       2910       2920       2930       2940 
RLCTREEFTK KVRTNAAMGA VFTEENQWDS ARAAVEDEEF WKLVDREREL HKLGKCGSCV 

      2950       2960       2970       2980       2990       3000 
YNMMGKREKK LGEFGKAKGS RAIWYMWLGA RYLEFEALGF LNEDHWFSRE NSYSGVEGEG 

      3010       3020       3030       3040       3050       3060 
LHKLGYILRD ISKIPGGAMY ADDTAGWDTR ITEDDLHNEE KITQQMDPEH RQLANAIFKL 

      3070       3080       3090       3100       3110       3120 
TYQNKVVKVQ RPTPKGTVMD IISRKDQRGS GQVGTYGLNT FTNMEAQLIR QMEGEGVLSK 

      3130       3140       3150       3160       3170       3180 
ADLENPHPLE KKITQWLETK GVERLKRMAI SGDDCVVKPI DDRFANALLA LNDMGKVRKD 

      3190       3200       3210       3220       3230       3240 
IPQWQPSKGW HDWQQVPFCS HHFHELIMKD GRKLVVPCRP QDELIGRARI SQGAGWSLRE 

      3250       3260       3270       3280       3290       3300 
TACLGKAYAQ MWTLMYFHRR DLRLASNAIC SAVPVHWVPT SRTTWSIHAH HQWMTTEDML 

      3310       3320       3330       3340       3350       3360 
TVWNRVWIED NPWMEDKTPV TTWEDVPYLG KREDQWCGSL IGLTSRATWA QNILTAIQQV 

      3370       3380       3390 
RSLIGNEEFL DYMPSMKRFR KEEESEGAIW

« Hide

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References

[1]"Complete nucleotide sequence of dengue type 3 virus genome RNA."
Osatomi K., Sumiyoshi H.
Virology 176:643-647(1990) [PubMed: 2345967] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PARTIAL PROTEIN SEQUENCE.
[2]"Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein."
Modis Y., Ogata S., Clements D., Harrison S.C.
J. Virol. 79:1223-1231(2005) [PubMed: 15613349] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 281-672.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M93130 Genomic RNA. Translation: AAA99437.1.
PIRGNWVD3. A34774.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UZGX-ray3.60A/B281-672[»]
2J7UX-ray1.85A2762-3390[»]
2J7WX-ray2.60A2762-3390[»]
ModBaseSearch...

Family and domain databases

InterProIPR014001. DEAD-like_N.
IPR001650. DNA/RNA_helicase_C.
IPR000069. Env_glycoprot_M_flavivir.
IPR013754. Flav_glyE_dim.
IPR001122. Flavi_capsidC.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flv_glyE_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011999. GlycoprotE_cen/dimer_Flavivir.
IPR011998. GlycoprotE_cen/dimer_vir.
IPR014021. Helicase_SF1/SF2_ATP-bd.
IPR014756. Ig_E-set.
IPR001850. Peptidase_S7.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_RrmJ/FtsJ.
IPR009003. Ser/Cys_Pept_Trypsin-like.
[Graphical view]
Gene3DG3DSA:2.60.98.10. Flav_glyE_dim. 1 hit.
G3DSA:2.60.40.350. Flv_glyE_Ig-like. 1 hit.
PfamPF01003. Flavi_capsid. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
PROSITEPS00690. DEAH_ATP_HELICASE. False negative.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePOLG_DEN3P
AccessionPrimary (citable) accession number: P27915
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 9, 2010
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents