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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi357 – 364ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:SCO3879
ORF Names:SCH18.16c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142711 – 656Chromosomal replication initiator protein DnaAAdd BLAST656

Proteomic databases

PRIDEiP27902

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3879

Structurei

3D structure databases

ProteinModelPortaliP27902
SMRiP27902
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
HOGENOMiHOG000235658
InParanoidiP27902
KOiK02313
OMAiFPERDPY
OrthoDBiPOG091H02FF
PhylomeDBiP27902

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

P27902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVPADLAA VWPRVLEQLL GEGRGQGVES KDEHWIRRCQ PLALVADTAL
60 70 80 90 100
LAVPNEFAKG VLEGRLAPIV SETLSRECGR PIRIAITVDD TAGEPAGPAP
110 120 130 140 150
QAPQSPPSRP QHRYEEPELP APGQGGREEY RDRDEYEGYG RNRADQLPTA
160 170 180 190 200
RPAYPQEYQR PEPGSWPRPA QQDDYGWQQQ RLGFPERDPY ASPNQEPYGQ
210 220 230 240 250
EPPPPYSHEN RTSYQQDYRP QPPERPSYDA QRGDYEQARG EYEQPRGDYD
260 270 280 290 300
KPRGDYDQQR GDYDQRGPRR DLPEPPPGSG HVHRGGPVGP GPATGAPGPL
310 320 330 340 350
AAQPAPATGP GEPTARLNPK YLFDTFVIGA SNRFAHAAAV AVAEAPAKAY
360 370 380 390 400
NPLFIYGESG LGKTHLLHAI GHYARSLYPG TRVRYVSSEE FTNEFINSIR
410 420 430 440 450
DGKGDSFRKR YREMDILLVD DIQFLADKES TQEEFFHTFN TLHNANKQIV
460 470 480 490 500
LSSDRPPKQL VTLEDRLRNR FEWGLITDVQ PPELETRIAI LRKKAVQEQL
510 520 530 540 550
NAPPEVLEFI ASRISRNIRE LEGALIRVTA FASLNRQPVD LGLTEIVLKD
560 570 580 590 600
LIPGGEDSAP EITSTAIMGA TADYFGLTVE DLCGTSRGRA LVTARQIAMY
610 620 630 640 650
LCRELTDLSL PKIGALFGGR DHTTVMHADR KIRNLMAERR SIYNQVTELT

NRIKNG
Length:656
Mass (Da):73,183
Last modified:August 1, 1992 - v1
Checksum:i6C1D5C0193D3C92B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187159 Genomic DNA Translation: AAA26734.1
AL939118 Genomic DNA Translation: CAD55464.1
PIRiA41870
RefSeqiNP_733620.1, NC_003888.3
WP_011029287.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAD55464; CAD55464; CAD55464
GeneIDi1099315
KEGGisco:SCO3879
PATRICifig|100226.15.peg.3952

Similar proteinsi

Entry informationi

Entry nameiDNAA_STRCO
AccessioniPrimary (citable) accession number: P27902
Secondary accession number(s): Q9KXX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health