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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi357 – 3648ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:SCO3879
ORF Names:SCH18.16c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 656656Chromosomal replication initiator protein DnaAPRO_0000114271Add
BLAST

Proteomic databases

PRIDEiP27902.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3879.

Structurei

3D structure databases

ProteinModelPortaliP27902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235658.
InParanoidiP27902.
KOiK02313.
OMAiFPERDPY.
OrthoDBiPOG091H02FF.
PhylomeDBiP27902.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVPADLAA VWPRVLEQLL GEGRGQGVES KDEHWIRRCQ PLALVADTAL
60 70 80 90 100
LAVPNEFAKG VLEGRLAPIV SETLSRECGR PIRIAITVDD TAGEPAGPAP
110 120 130 140 150
QAPQSPPSRP QHRYEEPELP APGQGGREEY RDRDEYEGYG RNRADQLPTA
160 170 180 190 200
RPAYPQEYQR PEPGSWPRPA QQDDYGWQQQ RLGFPERDPY ASPNQEPYGQ
210 220 230 240 250
EPPPPYSHEN RTSYQQDYRP QPPERPSYDA QRGDYEQARG EYEQPRGDYD
260 270 280 290 300
KPRGDYDQQR GDYDQRGPRR DLPEPPPGSG HVHRGGPVGP GPATGAPGPL
310 320 330 340 350
AAQPAPATGP GEPTARLNPK YLFDTFVIGA SNRFAHAAAV AVAEAPAKAY
360 370 380 390 400
NPLFIYGESG LGKTHLLHAI GHYARSLYPG TRVRYVSSEE FTNEFINSIR
410 420 430 440 450
DGKGDSFRKR YREMDILLVD DIQFLADKES TQEEFFHTFN TLHNANKQIV
460 470 480 490 500
LSSDRPPKQL VTLEDRLRNR FEWGLITDVQ PPELETRIAI LRKKAVQEQL
510 520 530 540 550
NAPPEVLEFI ASRISRNIRE LEGALIRVTA FASLNRQPVD LGLTEIVLKD
560 570 580 590 600
LIPGGEDSAP EITSTAIMGA TADYFGLTVE DLCGTSRGRA LVTARQIAMY
610 620 630 640 650
LCRELTDLSL PKIGALFGGR DHTTVMHADR KIRNLMAERR SIYNQVTELT

NRIKNG
Length:656
Mass (Da):73,183
Last modified:August 1, 1992 - v1
Checksum:i6C1D5C0193D3C92B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187159 Genomic DNA. Translation: AAA26734.1.
AL939118 Genomic DNA. Translation: CAD55464.1.
PIRiA41870.
RefSeqiNP_733620.1. NC_003888.3.
WP_011029287.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAD55464; CAD55464; CAD55464.
GeneIDi1099315.
KEGGisco:SCO3879.
PATRICi23737542. VBIStrCoe124346_3952.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187159 Genomic DNA. Translation: AAA26734.1.
AL939118 Genomic DNA. Translation: CAD55464.1.
PIRiA41870.
RefSeqiNP_733620.1. NC_003888.3.
WP_011029287.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP27902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3879.

Proteomic databases

PRIDEiP27902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD55464; CAD55464; CAD55464.
GeneIDi1099315.
KEGGisco:SCO3879.
PATRICi23737542. VBIStrCoe124346_3952.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235658.
InParanoidiP27902.
KOiK02313.
OMAiFPERDPY.
OrthoDBiPOG091H02FF.
PhylomeDBiP27902.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_STRCO
AccessioniPrimary (citable) accession number: P27902
Secondary accession number(s): Q9KXX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.