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Protein

Trichome differentiation protein GL1

Gene

GL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in leaves. Together with TTG1 and GL3, promotes trichome formation and endoreplication. Regulates the production of a signal that induces hair (trichome) precursor cells on leaf primordia to differentiate. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes (By similarity).By similarity5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi39 – 63H-T-H motifPROSITE-ProRule annotationAdd BLAST25
DNA bindingi91 – 114H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cell fate specification Source: TAIR
  • gibberellic acid mediated signaling pathway Source: TAIR
  • jasmonic acid mediated signaling pathway Source: TAIR
  • regulation of protein localization Source: TAIR
  • regulation of trichome morphogenesis Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • trichome differentiation Source: TAIR
  • trichome patterning Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Trichome differentiation protein GL11 Publication
Alternative name(s):
Myb-related protein 0
Short name:
AtMYB0
Protein GLABRA 11 Publication
Protein GLABROUS 11 Publication
R2R3-MYB transcription factor GL11 Publication
Gene namesi
Name:GL11 Publication
Synonyms:MYB0
Ordered Locus Names:At3g27920Imported
ORF Names:K16N12.17Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G27920.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

  • Note: Detected in trichome nucleus.

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi100G → R in gl1-65; few trichomes on leaf margins, cauline leaves, and stems. 1 Publication1
Mutagenesisi182 – 228Missing in gl1-323; few trichomes on leaf margins, cauline leaves. 1 PublicationAdd BLAST47
Mutagenesisi202 – 228Missing in gl1-2; reduced trichome density, truncated trichomes. 1 PublicationAdd BLAST27

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001970711 – 228Trichome differentiation protein GL1Add BLAST228

Proteomic databases

PaxDbiP27900.

Expressioni

Tissue specificityi

Expressed in leaves, stems and flowers (PubMed:11437443). Expressed in trichome cells and in leaf primordia (PubMed:9625690).2 Publications

Developmental stagei

Ubiquitous in young leaves primordia. Becomes more prominent in developing trichome cells but disappears progressively when trichomes begin to initiate branches.1 Publication

Inductioni

Up-regulated by gibberellins (PubMed:9625690). May be regulated by GEBP and GEBP-like proteins (PubMed:12535344).2 Publications

Gene expression databases

ExpressionAtlasiP27900. baseline and differential.
GenevisibleiP27900. AT.

Interactioni

Subunit structurei

Homodimer and heterodimer with MYB82 (PubMed:24803498). Interacts directly with GL3 and BHLH2. Part of a complex made of GL1, GL3 or BHLH2, and TTG1. Interacts also with BHLH2/EGL3/MYC146 and BHLH12/MYC1. Interacts with MYB82 (PubMed:24803498).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GL3Q9FN695EBI-1543742,EBI-533348

Protein-protein interaction databases

BioGridi7745. 10 interactors.
DIPiDIP-38476N.
IntActiP27900. 5 interactors.
STRINGi3702.AT3G27920.1.

Structurei

3D structure databases

ProteinModelPortaliP27900.
SMRiP27900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 63HTH myb-type 1PROSITE-ProRule annotationAdd BLAST53
Domaini64 – 118HTH myb-type 2PROSITE-ProRule annotationAdd BLAST55

Sequence similaritiesi

Contains 2 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
InParanoidiP27900.
KOiK09422.
OMAiGQWNRIV.
OrthoDBiEOG09360LV2.
PhylomeDBiP27900.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIRRRDEKE NQEYKKGLWT VEEDNILMDY VLNHGTGQWN RIVRKTGLKR
60 70 80 90 100
CGKSCRLRWM NYLSPNVNKG NFTEQEEDLI IRLHKLLGNR WSLIAKRVPG
110 120 130 140 150
RTDNQVKNYW NTHLSKKLVG DYSSAVKTTG EDDDSPPSLF ITAATPSSCH
160 170 180 190 200
HQQENIYENI AKSFNGVVSA SYEDKPKQEL AQKDVLMATT NDPSHYYGNN
210 220
ALWVHDDDFE LSSLVMMNFA SGDVEYCL
Length:228
Mass (Da):26,339
Last modified:October 18, 2001 - v2
Checksum:i822A8646F446F6B9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti130 – 132GED → VEE in strain: cv. Can-0. 3
Natural varianti148Missing in strain: cv. Kas-1, cv. Ms-0. 1 Publication1
Natural varianti149C → R in strain: cv. Aa-0, cv. An-1, cv. Bur-0, cv. Can-0, cv. Es-0, cv. Gr-1, cv. Hi-0, cv. Ita-0, cv. Kas-1, cv. Ms-0, cv. Mt-0, cv. Nd-0, cv. No-0, cv. Oy-0, cv. RLD, cv. Tsu-0, cv. Wassilewskija and cv. Yo-0. 1 Publication1
Natural varianti176P → R in strain: cv. Di-0 and cv. Landsberg erecta. 1 Publication1
Natural varianti222 – 224GDV → SDI in strain: cv. Aa-0, cv. An-1, cv. Bur-0, cv. Can-0, cv. Es-0, cv. Gr-1, cv. Hi-0, cv. Ita-0, cv. Kas-1, cv. Ms-0, cv. Mt-0, cv. Nd-0, cv. No-0, cv. Oy-0, cv. RLD, cv. Tsu-0, cv. Wassilewskija and cv. Yo-0. 3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M79448 Genomic DNA. Translation: AAC97387.1.
L22786 Genomic DNA. Translation: AAC97388.1.
AB006078 Genomic DNA. Translation: BAA86879.1.
AJ243899 Genomic DNA. Translation: CAB97484.1.
AJ243900 Genomic DNA. Translation: CAB97485.1.
AF263690 Genomic DNA. Translation: AAL01215.1.
AF263691 Genomic DNA. Translation: AAL01216.1.
AF263692 Genomic DNA. Translation: AAL01217.1.
AF263693 Genomic DNA. Translation: AAL01218.1.
AF263694 Genomic DNA. Translation: AAL01219.1.
AF263695 Genomic DNA. Translation: AAL01220.1.
AF263696 Genomic DNA. Translation: AAL01221.1.
AF263697 Genomic DNA. Translation: AAL01222.1.
AF263698 Genomic DNA. Translation: AAL01223.1.
AF263699 Genomic DNA. Translation: AAL01224.1.
AF263700 Genomic DNA. Translation: AAL01225.1.
AF263701 Genomic DNA. Translation: AAL01226.1.
AF263702 Genomic DNA. Translation: AAL01227.1.
AF263703 Genomic DNA. Translation: AAL01228.1.
AF263704 Genomic DNA. Translation: AAL01229.1.
AF263705 Genomic DNA. Translation: AAL01230.1.
AF263706 Genomic DNA. Translation: AAL01231.1.
AF263707 Genomic DNA. Translation: AAL01232.1.
AF263708 Genomic DNA. Translation: AAL01233.1.
AF263709 Genomic DNA. Translation: AAL01234.1.
AF263710 Genomic DNA. Translation: AAL01235.1.
AF263711 Genomic DNA. Translation: AAL01236.1.
AF263712 Genomic DNA. Translation: AAL01237.1.
AF263713 Genomic DNA. Translation: AAL01238.1.
AF263714 Genomic DNA. Translation: AAL01239.1.
AF263715 Genomic DNA. Translation: AAL01240.1.
AF263718 Genomic DNA. Translation: AAL01243.1.
AF263719 Genomic DNA. Translation: AAL01244.1.
AF495524 mRNA. Translation: AAM14620.1.
AY519590 mRNA. Translation: AAS10060.1.
AP000371 Genomic DNA. Translation: BAB02538.1.
CP002686 Genomic DNA. Translation: AEE77380.1.
PIRiA39289. TVMUG1.
RefSeqiNP_189430.1. NM_113708.2.
UniGeneiAt.42881.

Genome annotation databases

EnsemblPlantsiAT3G27920.1; AT3G27920.1; AT3G27920.
GeneIDi822415.
GrameneiAT3G27920.1; AT3G27920.1; AT3G27920.
KEGGiath:AT3G27920.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

More to it than meets the finger - Issue 120 of August 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M79448 Genomic DNA. Translation: AAC97387.1.
L22786 Genomic DNA. Translation: AAC97388.1.
AB006078 Genomic DNA. Translation: BAA86879.1.
AJ243899 Genomic DNA. Translation: CAB97484.1.
AJ243900 Genomic DNA. Translation: CAB97485.1.
AF263690 Genomic DNA. Translation: AAL01215.1.
AF263691 Genomic DNA. Translation: AAL01216.1.
AF263692 Genomic DNA. Translation: AAL01217.1.
AF263693 Genomic DNA. Translation: AAL01218.1.
AF263694 Genomic DNA. Translation: AAL01219.1.
AF263695 Genomic DNA. Translation: AAL01220.1.
AF263696 Genomic DNA. Translation: AAL01221.1.
AF263697 Genomic DNA. Translation: AAL01222.1.
AF263698 Genomic DNA. Translation: AAL01223.1.
AF263699 Genomic DNA. Translation: AAL01224.1.
AF263700 Genomic DNA. Translation: AAL01225.1.
AF263701 Genomic DNA. Translation: AAL01226.1.
AF263702 Genomic DNA. Translation: AAL01227.1.
AF263703 Genomic DNA. Translation: AAL01228.1.
AF263704 Genomic DNA. Translation: AAL01229.1.
AF263705 Genomic DNA. Translation: AAL01230.1.
AF263706 Genomic DNA. Translation: AAL01231.1.
AF263707 Genomic DNA. Translation: AAL01232.1.
AF263708 Genomic DNA. Translation: AAL01233.1.
AF263709 Genomic DNA. Translation: AAL01234.1.
AF263710 Genomic DNA. Translation: AAL01235.1.
AF263711 Genomic DNA. Translation: AAL01236.1.
AF263712 Genomic DNA. Translation: AAL01237.1.
AF263713 Genomic DNA. Translation: AAL01238.1.
AF263714 Genomic DNA. Translation: AAL01239.1.
AF263715 Genomic DNA. Translation: AAL01240.1.
AF263718 Genomic DNA. Translation: AAL01243.1.
AF263719 Genomic DNA. Translation: AAL01244.1.
AF495524 mRNA. Translation: AAM14620.1.
AY519590 mRNA. Translation: AAS10060.1.
AP000371 Genomic DNA. Translation: BAB02538.1.
CP002686 Genomic DNA. Translation: AEE77380.1.
PIRiA39289. TVMUG1.
RefSeqiNP_189430.1. NM_113708.2.
UniGeneiAt.42881.

3D structure databases

ProteinModelPortaliP27900.
SMRiP27900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi7745. 10 interactors.
DIPiDIP-38476N.
IntActiP27900. 5 interactors.
STRINGi3702.AT3G27920.1.

Proteomic databases

PaxDbiP27900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G27920.1; AT3G27920.1; AT3G27920.
GeneIDi822415.
GrameneiAT3G27920.1; AT3G27920.1; AT3G27920.
KEGGiath:AT3G27920.

Organism-specific databases

TAIRiAT3G27920.

Phylogenomic databases

eggNOGiKOG0048. Eukaryota.
COG5147. LUCA.
InParanoidiP27900.
KOiK09422.
OMAiGQWNRIV.
OrthoDBiEOG09360LV2.
PhylomeDBiP27900.

Miscellaneous databases

PROiP27900.

Gene expression databases

ExpressionAtlasiP27900. baseline and differential.
GenevisibleiP27900. AT.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGL1_ARATH
AccessioniPrimary (citable) accession number: P27900
Secondary accession number(s): Q39109
, Q53YQ0, Q93V34, Q93VW0, Q93WP0, Q947R6, Q9LF81, Q9LF82, Q9ST42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 18, 2001
Last modified: November 30, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.