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P27900

- GL1_ARATH

UniProt

P27900 - GL1_ARATH

Protein

Trichome differentiation protein GL1

Gene

GL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (18 Oct 2001)
      Previous versions | rss
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    Functioni

    Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in leaves. Together with TTG1 and GL3, promotes trichome formation and endoreplication. Regulates the production of a signal that induces hair (trichome) precursor cells on leaf primordia to differentiate. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi39 – 6325H-T-H motifPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi91 – 11424H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: TAIR
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: TAIR

    GO - Biological processi

    1. cell fate specification Source: TAIR
    2. gibberellic acid mediated signaling pathway Source: TAIR
    3. regulation of protein localization Source: TAIR
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. trichome patterning Source: TAIR

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trichome differentiation protein GL1
    Alternative name(s):
    Myb-related protein 0
    Short name:
    AtMYB0
    Protein GLABRA 1
    Protein GLABROUS 1
    R2R3-MYB transcription factor GL1
    Gene namesi
    Name:GL1
    Synonyms:MYB0
    Ordered Locus Names:At3g27920
    ORF Names:K16N12.17
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G27920.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation
    Note: Detected in trichome nucleus.

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi100 – 1001G → R in gl1-65; few trichomes on leaf margins, cauline leaves, and stems. 2 Publications
    Mutagenesisi182 – 22847Missing in gl1-323; few trichomes on leaf margins, cauline leaves. 1 PublicationAdd
    BLAST
    Mutagenesisi202 – 22827Missing in gl1-2; reduced trichome density, truncated trichomes. 1 PublicationAdd
    BLAST

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Trichome differentiation protein GL1PRO_0000197071Add
    BLAST

    Proteomic databases

    PRIDEiP27900.

    Expressioni

    Tissue specificityi

    Expressed in leaves, stems and flowers.1 Publication

    Developmental stagei

    Ubiquitous in young leaves primordia. Becomes more prominent in developing trichome cells but disappears progressively when trichomes begin to initiate branches.1 Publication

    Gene expression databases

    GenevestigatoriP27900.

    Interactioni

    Subunit structurei

    Interacts directly with GL3 and BHLH2. Part of a complex made of GL1, GL3 or BHLH2, and TTG1. Interacts also with BHLH2/EGL3/MYC146 and BHLH12/MYC1.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GL3Q9FN695EBI-1543742,EBI-533348

    Protein-protein interaction databases

    BioGridi7745. 6 interactions.
    IntActiP27900. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP27900.
    SMRiP27900. Positions 16-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 6353HTH myb-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini64 – 11855HTH myb-type 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5147.
    InParanoidiP27900.
    KOiK09422.
    OMAiYENIAKS.
    PhylomeDBiP27900.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    InterProiIPR009057. Homeodomain-like.
    IPR017930. Myb_dom.
    IPR001005. SANT/Myb.
    [Graphical view]
    PfamiPF00249. Myb_DNA-binding. 2 hits.
    [Graphical view]
    SMARTiSM00717. SANT. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51294. HTH_MYB. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27900-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIRRRDEKE NQEYKKGLWT VEEDNILMDY VLNHGTGQWN RIVRKTGLKR    50
    CGKSCRLRWM NYLSPNVNKG NFTEQEEDLI IRLHKLLGNR WSLIAKRVPG 100
    RTDNQVKNYW NTHLSKKLVG DYSSAVKTTG EDDDSPPSLF ITAATPSSCH 150
    HQQENIYENI AKSFNGVVSA SYEDKPKQEL AQKDVLMATT NDPSHYYGNN 200
    ALWVHDDDFE LSSLVMMNFA SGDVEYCL 228
    Length:228
    Mass (Da):26,339
    Last modified:October 18, 2001 - v2
    Checksum:i822A8646F446F6B9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1323GED → VEE in strain: cv. Can-0.
    Natural varianti148 – 1481Missing in strain: cv. Kas-1, cv. Ms-0. 1 Publication
    Natural varianti149 – 1491C → R in strain: cv. Aa-0, cv. An-1, cv. Bur-0, cv. Can-0, cv. Es-0, cv. Gr-1, cv. Hi-0, cv. Ita-0, cv. Kas-1, cv. Ms-0, cv. Mt-0, cv. Nd-0, cv. No-0, cv. Oy-0, cv. RLD, cv. Tsu-0, cv. Wassilewskija and cv. Yo-0. 1 Publication
    Natural varianti176 – 1761P → R in strain: cv. Di-0 and cv. Landsberg erecta. 1 Publication
    Natural varianti222 – 2243GDV → SDI in strain: cv. Aa-0, cv. An-1, cv. Bur-0, cv. Can-0, cv. Es-0, cv. Gr-1, cv. Hi-0, cv. Ita-0, cv. Kas-1, cv. Ms-0, cv. Mt-0, cv. Nd-0, cv. No-0, cv. Oy-0, cv. RLD, cv. Tsu-0, cv. Wassilewskija and cv. Yo-0.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M79448 Genomic DNA. Translation: AAC97387.1.
    L22786 Genomic DNA. Translation: AAC97388.1.
    AB006078 Genomic DNA. Translation: BAA86879.1.
    AJ243899 Genomic DNA. Translation: CAB97484.1.
    AJ243900 Genomic DNA. Translation: CAB97485.1.
    AF263690 Genomic DNA. Translation: AAL01215.1.
    AF263691 Genomic DNA. Translation: AAL01216.1.
    AF263692 Genomic DNA. Translation: AAL01217.1.
    AF263693 Genomic DNA. Translation: AAL01218.1.
    AF263694 Genomic DNA. Translation: AAL01219.1.
    AF263695 Genomic DNA. Translation: AAL01220.1.
    AF263696 Genomic DNA. Translation: AAL01221.1.
    AF263697 Genomic DNA. Translation: AAL01222.1.
    AF263698 Genomic DNA. Translation: AAL01223.1.
    AF263699 Genomic DNA. Translation: AAL01224.1.
    AF263700 Genomic DNA. Translation: AAL01225.1.
    AF263701 Genomic DNA. Translation: AAL01226.1.
    AF263702 Genomic DNA. Translation: AAL01227.1.
    AF263703 Genomic DNA. Translation: AAL01228.1.
    AF263704 Genomic DNA. Translation: AAL01229.1.
    AF263705 Genomic DNA. Translation: AAL01230.1.
    AF263706 Genomic DNA. Translation: AAL01231.1.
    AF263707 Genomic DNA. Translation: AAL01232.1.
    AF263708 Genomic DNA. Translation: AAL01233.1.
    AF263709 Genomic DNA. Translation: AAL01234.1.
    AF263710 Genomic DNA. Translation: AAL01235.1.
    AF263711 Genomic DNA. Translation: AAL01236.1.
    AF263712 Genomic DNA. Translation: AAL01237.1.
    AF263713 Genomic DNA. Translation: AAL01238.1.
    AF263714 Genomic DNA. Translation: AAL01239.1.
    AF263715 Genomic DNA. Translation: AAL01240.1.
    AF263718 Genomic DNA. Translation: AAL01243.1.
    AF263719 Genomic DNA. Translation: AAL01244.1.
    AF495524 mRNA. Translation: AAM14620.1.
    AY519590 mRNA. Translation: AAS10060.1.
    AP000371 Genomic DNA. Translation: BAB02538.1.
    CP002686 Genomic DNA. Translation: AEE77380.1.
    PIRiA39289. TVMUG1.
    RefSeqiNP_189430.1. NM_113708.1.
    UniGeneiAt.42881.

    Genome annotation databases

    EnsemblPlantsiAT3G27920.1; AT3G27920.1; AT3G27920.
    GeneIDi822415.
    KEGGiath:AT3G27920.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    More to it than meets the finger - Issue 120 of August 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M79448 Genomic DNA. Translation: AAC97387.1 .
    L22786 Genomic DNA. Translation: AAC97388.1 .
    AB006078 Genomic DNA. Translation: BAA86879.1 .
    AJ243899 Genomic DNA. Translation: CAB97484.1 .
    AJ243900 Genomic DNA. Translation: CAB97485.1 .
    AF263690 Genomic DNA. Translation: AAL01215.1 .
    AF263691 Genomic DNA. Translation: AAL01216.1 .
    AF263692 Genomic DNA. Translation: AAL01217.1 .
    AF263693 Genomic DNA. Translation: AAL01218.1 .
    AF263694 Genomic DNA. Translation: AAL01219.1 .
    AF263695 Genomic DNA. Translation: AAL01220.1 .
    AF263696 Genomic DNA. Translation: AAL01221.1 .
    AF263697 Genomic DNA. Translation: AAL01222.1 .
    AF263698 Genomic DNA. Translation: AAL01223.1 .
    AF263699 Genomic DNA. Translation: AAL01224.1 .
    AF263700 Genomic DNA. Translation: AAL01225.1 .
    AF263701 Genomic DNA. Translation: AAL01226.1 .
    AF263702 Genomic DNA. Translation: AAL01227.1 .
    AF263703 Genomic DNA. Translation: AAL01228.1 .
    AF263704 Genomic DNA. Translation: AAL01229.1 .
    AF263705 Genomic DNA. Translation: AAL01230.1 .
    AF263706 Genomic DNA. Translation: AAL01231.1 .
    AF263707 Genomic DNA. Translation: AAL01232.1 .
    AF263708 Genomic DNA. Translation: AAL01233.1 .
    AF263709 Genomic DNA. Translation: AAL01234.1 .
    AF263710 Genomic DNA. Translation: AAL01235.1 .
    AF263711 Genomic DNA. Translation: AAL01236.1 .
    AF263712 Genomic DNA. Translation: AAL01237.1 .
    AF263713 Genomic DNA. Translation: AAL01238.1 .
    AF263714 Genomic DNA. Translation: AAL01239.1 .
    AF263715 Genomic DNA. Translation: AAL01240.1 .
    AF263718 Genomic DNA. Translation: AAL01243.1 .
    AF263719 Genomic DNA. Translation: AAL01244.1 .
    AF495524 mRNA. Translation: AAM14620.1 .
    AY519590 mRNA. Translation: AAS10060.1 .
    AP000371 Genomic DNA. Translation: BAB02538.1 .
    CP002686 Genomic DNA. Translation: AEE77380.1 .
    PIRi A39289. TVMUG1.
    RefSeqi NP_189430.1. NM_113708.1.
    UniGenei At.42881.

    3D structure databases

    ProteinModelPortali P27900.
    SMRi P27900. Positions 16-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 7745. 6 interactions.
    IntActi P27900. 5 interactions.

    Proteomic databases

    PRIDEi P27900.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G27920.1 ; AT3G27920.1 ; AT3G27920 .
    GeneIDi 822415.
    KEGGi ath:AT3G27920.

    Organism-specific databases

    GeneFarmi 924. 100.
    TAIRi AT3G27920.

    Phylogenomic databases

    eggNOGi COG5147.
    InParanoidi P27900.
    KOi K09422.
    OMAi YENIAKS.
    PhylomeDBi P27900.

    Gene expression databases

    Genevestigatori P27900.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    InterProi IPR009057. Homeodomain-like.
    IPR017930. Myb_dom.
    IPR001005. SANT/Myb.
    [Graphical view ]
    Pfami PF00249. Myb_DNA-binding. 2 hits.
    [Graphical view ]
    SMARTi SM00717. SANT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51294. HTH_MYB. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A myb gene required for leaf trichome differentiation in Arabidopsis is expressed in stipules."
      Oppenheimer D.G., Herman P.L., Sivakumaran S., Esch J.J., Marks M.D.
      Cell 67:483-493(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Characterization of a weak allele of the GL1 gene of Arabidopsis thaliana."
      Esch J.J., Oppenheimer D.G., Marks M.D.
      Plant Mol. Biol. 24:203-207(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF 182-GLN--LEU-228 AND 202-LEU--LEU-228.
    3. "Nucleotide sequence of the GLABROUS1 gene of Arabidopsis thaliana ecotype Columbia."
      Shikazono N., Tanaka A., Yokota Y., Watanabe H., Tano S.
      DNA Seq. 9:177-181(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    4. "Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular analysis of the candidate gene GLABROUS1."
      Hauser M.-T., Harr B., Schloetterer C.
      Mol. Biol. Evol. 18:1754-1763(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF GLY-100, VARIANTS 130-VAL--GLU-132; SER-148 DEL; ARG-149; ARG-176 AND 222-SER--ILE-224.
      Strain: cv. Aa-0, cv. An-1, cv. Ba-1, cv. Bla-1, cv. Bur-0, cv. Can-0, cv. Columbia, cv. Di-0, cv. Es-0, cv. Gr-1, cv. Hi-0, cv. Ita-0, cv. Kas-1, cv. Kon, cv. Landsberg erecta, cv. Ms-0, cv. Mt-0, cv. Nd-0, cv. No-0, cv. Oy-0, cv. RLD, cv. Sha, cv. Te-0, cv. Tsu-0, cv. Wassilewskija and cv. Yo-0.
    5. "The R2R3-MYB gene family in Arabidopsis thaliana."
      Stracke R., Werber M., Weisshaar B.
      Curr. Opin. Plant Biol. 4:447-456(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
      Strain: cv. Columbia.
    6. "The MYB transcription factor family in Arabidopsis: a genome-wide cloning and expression pattern analysis."
      Qu L.-J., Gu H.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
      Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
      DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    8. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    9. "GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1."
      Payne C.T., Zhang F., Lloyd A.M.
      Genetics 156:1349-1362(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GL3.
    10. "Ectopic expression of the Arabidopsis AtMYB23 gene induces differentiation of trichome cells."
      Kirik V., Schnittger A., Radchuk V., Adler K., Huelskamp M., Baeumlein H.
      Dev. Biol. 235:366-377(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
      Strain: cv. Landsberg erecta.
      Tissue: Silique.
    11. "TRIPTYCHON and CAPRICE mediate lateral inhibition during trichome and root hair patterning in Arabidopsis."
      Schellmann S., Schnittger A., Kirik V., Wada T., Okada K., Beermann A., Thumfahrt J., Juergens G., Huelskamp M.
      EMBO J. 21:5036-5046(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: cv. Columbia.
      Tissue: Root.
    12. "A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis."
      Zhang F., Gonzalez A., Zhao M., Payne C.T., Lloyd A.M.
      Development 130:4859-4869(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BHLH2.
    13. "A contradictory GLABRA3 allele helps define gene interactions controlling trichome development in Arabidopsis."
      Esch J.J., Chen M., Sanders M., Hillestad M., Ndkium S., Idelkope B., Neizer J., Marks M.D.
      Development 130:5885-5894(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GL3, SUBCELLULAR LOCATION.
    14. "Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins."
      Zimmermann I.M., Heim M.A., Weisshaar B., Uhrig J.F.
      Plant J. 40:22-34(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BHLH2 AND BHLH12.
    15. "Functional diversification of MYB23 and GL1 genes in trichome morphogenesis and initiation."
      Kirik V., Lee M.M., Wester K., Herrmann U., Zheng Z., Oppenheimer D., Schiefelbein J., Hulskamp M.
      Development 132:1477-1485(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GL3, DEVELOPMENTAL STAGE.
    16. "The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family."
      Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X., Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H., Qu L.-J.
      Plant Mol. Biol. 60:107-124(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiGL1_ARATH
    AccessioniPrimary (citable) accession number: P27900
    Secondary accession number(s): Q39109
    , Q53YQ0, Q93V34, Q93VW0, Q93WP0, Q947R6, Q9LF81, Q9LF82, Q9ST42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: October 18, 2001
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3