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Protein

Hepatocyte nuclear factor 1-beta

Gene

Hnf1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi231 – 311Homeobox; HNF1-typePROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • branching morphogenesis of an epithelial tube Source: MGI
  • circadian regulation of gene expression Source: Ensembl
  • embryonic digestive tract morphogenesis Source: MGI
  • endocrine pancreas development Source: UniProtKB
  • endodermal cell fate specification Source: MGI
  • endoderm development Source: MGI
  • endoderm formation Source: MGI
  • epithelial cell proliferation Source: MGI
  • epithelium development Source: MGI
  • genitalia development Source: UniProtKB
  • hepatoblast differentiation Source: MGI
  • hepatocyte differentiation Source: Ensembl
  • hindbrain development Source: MGI
  • inner cell mass cell differentiation Source: MGI
  • insulin secretion Source: MGI
  • kidney development Source: MGI
  • kidney morphogenesis Source: MGI
  • liver development Source: MGI
  • mesonephric duct development Source: MGI
  • mesonephric duct formation Source: MGI
  • mesonephric tubule development Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Source: MGI
  • negative regulation of mesenchymal cell apoptotic process involved in metanephros development Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • nephric duct development Source: MGI
  • nephric duct formation Source: MGI
  • Notch signaling pathway Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription initiation from RNA polymerase II promoter Source: MGI
  • pronephric nephron tubule development Source: MGI
  • pronephros development Source: MGI
  • protein-DNA complex assembly Source: Ensembl
  • regulation of branch elongation involved in ureteric bud branching Source: MGI
  • regulation of endodermal cell fate specification Source: MGI
  • regulation of pronephros size Source: MGI
  • regulation of Wnt signaling pathway Source: MGI
  • response to drug Source: Ensembl
  • response to glucose Source: MGI
  • response to organic cyclic compound Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
  • ureteric bud elongation Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-210744. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
R-MMU-210747. Regulation of gene expression in early pancreatic precursor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 1-beta
Short name:
HNF-1-beta
Short name:
HNF-1B
Alternative name(s):
Homeoprotein LFB3
Transcription factor 2
Short name:
TCF-2
Gene namesi
Name:Hnf1b
Synonyms:Hnf-1b, Tcf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98505. Hnf1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491221 – 558Hepatocyte nuclear factor 1-betaAdd BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP27889.
PeptideAtlasiP27889.
PRIDEiP27889.

PTM databases

iPTMnetiP27889.
PhosphoSitePlusiP27889.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020679.
CleanExiMM_HNF1B.
ExpressionAtlasiP27889. baseline and differential.
GenevisibleiP27889. MM.

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimer or heterodimer with HNF1-alpha.

GO - Molecular functioni

  • protein complex binding Source: Ensembl
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi204003. 5 interactors.
IntActiP27889. 1 interactor.
MINTiMINT-4097641.
STRINGi10090.ENSMUSP00000021016.

Structurei

3D structure databases

ProteinModelPortaliP27889.
SMRiP27889.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 31DimerizationBy similarityAdd BLAST31

Sequence similaritiesi

Belongs to the HNF1 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiENOG410IFA0. Eukaryota.
ENOG410ZZZ0. LUCA.
GeneTreeiENSGT00860000133745.
HOVERGENiHBG005980.
InParanoidiP27889.
KOiK08034.
OMAiQQPFMAT.
OrthoDBiEOG091G052F.
PhylomeDBiP27889.
TreeFamiTF320327.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR006899. HNF-1_N.
IPR023219. HNF1_dimer_dom.
IPR006897. HNF1b_C.
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
PfamiView protein in Pfam
PF04814. HNF-1_N. 1 hit.
PF04812. HNF-1B_C. 1 hit.
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF100957. SSF100957. 1 hit.
SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P27889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSKLTSLQQ ELLSALLSSG VTKEVLIQAL EELLPSPNFG VKLETLPLSP
60 70 80 90 100
GSGADLDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT
110 120 130 140 150
EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL
160 170 180 190 200
SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD
210 220 230 240 250
QLLFLFPEFS QQNQGPGQSE DTCSEPTNKK MRRNRFKWGP ASQQILYQAY
260 270 280 290 300
DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF
310 320 330 340 350
ANRRKEEAFR QKLAMDAYSS NQTHNLNPLL THGSPHHQPS SSPPNKMSGV
360 370 380 390 400
RYNQPGNNEV TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHSLLSPDS
410 420 430 440 450
KMQITVSGGG LPPVSTLTNI HSLSHHNPQQ SQNLIMTPLS GVMAIAQSLN
460 470 480 490 500
TSQAQGVPVI NSVASSLAAL QPVQFSQQLH SPHQQPLMQQ SPGSHMAQQP
510 520 530 540 550
FMAAVTQLQN SHMYAHKQEP PQYSHTSRFP SAMVVTDTSS INTLTSMSSS

KQCPLQAW
Length:558
Mass (Da):61,588
Last modified:April 4, 2003 - v2
Checksum:iD4F2BC92B64374A6
GO
Isoform 2 (identifier: P27889-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-208: Missing.

Show »
Length:532
Mass (Da):58,644
Checksum:iA7AD8DBD40D40E4F
GO
Isoform 3 (identifier: P27889-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:435
Mass (Da):48,336
Checksum:i8885C6A5474F7786
GO
Isoform 4 (identifier: P27889-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.
     183-208: Missing.

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):45,392
Checksum:i4B8FDE392F0D55CC
GO

Sequence cautioni

The sequence BAB31632 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67N → S in BAB31632 (PubMed:16141072).Curated1
Sequence conflicti423 – 429LSHHNPQ → THSPPQSP in CAA39358 (PubMed:1673925).Curated7
Sequence conflicti520 – 521PP → HT in CAA39358 (PubMed:1673925).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti222T → A in strain: NSY. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0070991 – 123Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST123
Alternative sequenceiVSP_007100183 – 208Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55842 mRNA. Translation: CAA39358.1.
AB008174 mRNA. Translation: BAA77718.1.
AB008175 mRNA. Translation: BAA77719.1.
AB008176 mRNA. Translation: BAA77720.1.
AB008177 mRNA. Translation: BAA77721.1.
AB052659 mRNA. Translation: BAB60814.1.
AK004837 mRNA. Translation: BAB23604.1.
AK019258 mRNA. Translation: BAB31632.2. Different initiation.
AL669868 Genomic DNA. Translation: CAI35313.1.
BC025189 mRNA. Translation: AAH25189.1.
CCDSiCCDS25179.1. [P27889-1]
CCDS70271.1. [P27889-2]
CCDS70272.1. [P27889-3]
PIRiA39633.
RefSeqiNP_001278197.1. NM_001291268.1. [P27889-2]
NP_001278198.1. NM_001291269.1. [P27889-3]
NP_033356.2. NM_009330.3. [P27889-1]
XP_006532859.1. XM_006532796.3. [P27889-3]
UniGeneiMm.7226.

Genome annotation databases

EnsembliENSMUST00000021016; ENSMUSP00000021016; ENSMUSG00000020679. [P27889-1]
ENSMUST00000108113; ENSMUSP00000103748; ENSMUSG00000020679. [P27889-3]
ENSMUST00000108114; ENSMUSP00000103749; ENSMUSG00000020679. [P27889-2]
GeneIDi21410.
KEGGimmu:21410.
UCSCiuc007kpx.2. mouse. [P27889-1]
uc007kpy.2. mouse. [P27889-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHNF1B_MOUSE
AccessioniPrimary (citable) accession number: P27889
Secondary accession number(s): Q5NC37
, Q8R162, Q9CS26, Q9R1W1, Q9R1W2, Q9WTL5, Q9WTL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 4, 2003
Last modified: September 27, 2017
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families