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P27889

- HNF1B_MOUSE

UniProt

P27889 - HNF1B_MOUSE

Protein

Hepatocyte nuclear factor 1-beta

Gene

Hnf1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (04 Apr 2003)
      Previous versions | rss
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    Functioni

    Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi231 – 31181Homeobox; HNF1-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. protein heterodimerization activity Source: MGI
    4. protein homodimerization activity Source: UniProtKB
    5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    6. sequence-specific DNA binding Source: InterPro
    7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    8. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. branching morphogenesis of an epithelial tube Source: MGI
    3. embryonic digestive tract morphogenesis Source: MGI
    4. endocrine pancreas development Source: UniProtKB
    5. endodermal cell fate specification Source: MGI
    6. endoderm development Source: MGI
    7. endoderm formation Source: MGI
    8. epithelial cell proliferation Source: MGI
    9. epithelium development Source: MGI
    10. genitalia development Source: UniProtKB
    11. hepatoblast differentiation Source: MGI
    12. hindbrain development Source: MGI
    13. inner cell mass cell differentiation Source: MGI
    14. insulin secretion Source: MGI
    15. kidney development Source: UniProtKB
    16. kidney morphogenesis Source: MGI
    17. liver development Source: MGI
    18. mesonephric duct development Source: MGI
    19. mesonephric duct formation Source: MGI
    20. mesonephric tubule development Source: MGI
    21. negative regulation of apoptotic process Source: MGI
    22. negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Source: MGI
    23. negative regulation of mesenchymal cell apoptotic process involved in metanephros development Source: MGI
    24. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    25. nephric duct development Source: MGI
    26. nephric duct formation Source: MGI
    27. positive regulation of gene expression Source: MGI
    28. positive regulation of transcription, DNA-templated Source: UniProtKB
    29. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    30. positive regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
    31. pronephric nephron tubule development Source: Ensembl
    32. regulation of branch elongation involved in ureteric bud branching Source: MGI
    33. regulation of endodermal cell fate specification Source: MGI
    34. regulation of pronephros size Source: Ensembl
    35. regulation of Wnt signaling pathway Source: MGI
    36. response to glucose Source: MGI
    37. transcription from RNA polymerase II promoter Source: GOC
    38. ureteric bud elongation Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_208465. Regulation of gene expression in early pancreatic precursor cells.
    REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte nuclear factor 1-beta
    Short name:
    HNF-1-beta
    Short name:
    HNF-1B
    Alternative name(s):
    Homeoprotein LFB3
    Transcription factor 2
    Short name:
    TCF-2
    Gene namesi
    Name:Hnf1b
    Synonyms:Hnf-1b, Tcf2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98505. Hnf1b.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Hepatocyte nuclear factor 1-betaPRO_0000049122Add
    BLAST

    Proteomic databases

    MaxQBiP27889.
    PaxDbiP27889.
    PRIDEiP27889.

    PTM databases

    PhosphoSiteiP27889.

    Expressioni

    Gene expression databases

    ArrayExpressiP27889.
    BgeeiP27889.
    CleanExiMM_HNF1B.
    GenevestigatoriP27889.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Can form homodimer or heterodimer with HNF1-alpha.

    Protein-protein interaction databases

    BioGridi204003. 5 interactions.
    IntActiP27889. 1 interaction.
    MINTiMINT-4097641.

    Structurei

    3D structure databases

    ProteinModelPortaliP27889.
    SMRiP27889. Positions 91-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3131DimerizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HNF1 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG79356.
    GeneTreeiENSGT00730000110937.
    HOVERGENiHBG005980.
    InParanoidiQ5NC37.
    KOiK08034.
    OMAiMYTHKQE.
    OrthoDBiEOG769ZJ9.
    PhylomeDBiP27889.
    TreeFamiTF320327.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR006899. HNF-1_N.
    IPR023219. HNF1_dimer_dom.
    IPR006897. HNF1b_C.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view]
    PfamiPF04814. HNF-1_N. 1 hit.
    PF04812. HNF-1B_C. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF100957. SSF100957. 1 hit.
    SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P27889-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVSKLTSLQQ ELLSALLSSG VTKEVLIQAL EELLPSPNFG VKLETLPLSP    50
    GSGADLDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT 100
    EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL 150
    SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD 200
    QLLFLFPEFS QQNQGPGQSE DTCSEPTNKK MRRNRFKWGP ASQQILYQAY 250
    DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF 300
    ANRRKEEAFR QKLAMDAYSS NQTHNLNPLL THGSPHHQPS SSPPNKMSGV 350
    RYNQPGNNEV TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHSLLSPDS 400
    KMQITVSGGG LPPVSTLTNI HSLSHHNPQQ SQNLIMTPLS GVMAIAQSLN 450
    TSQAQGVPVI NSVASSLAAL QPVQFSQQLH SPHQQPLMQQ SPGSHMAQQP 500
    FMAAVTQLQN SHMYAHKQEP PQYSHTSRFP SAMVVTDTSS INTLTSMSSS 550
    KQCPLQAW 558
    Length:558
    Mass (Da):61,588
    Last modified:April 4, 2003 - v2
    Checksum:iD4F2BC92B64374A6
    GO
    Isoform 2 (identifier: P27889-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         183-208: Missing.

    Show »
    Length:532
    Mass (Da):58,644
    Checksum:iA7AD8DBD40D40E4F
    GO
    Isoform 3 (identifier: P27889-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:435
    Mass (Da):48,336
    Checksum:i8885C6A5474F7786
    GO
    Isoform 4 (identifier: P27889-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: Missing.
         183-208: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:409
    Mass (Da):45,392
    Checksum:i4B8FDE392F0D55CC
    GO

    Sequence cautioni

    The sequence BAB31632.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671N → S in BAB31632. (PubMed:16141072)Curated
    Sequence conflicti423 – 4297LSHHNPQ → THSPPQSP in CAA39358. (PubMed:1673925)Curated
    Sequence conflicti520 – 5212PP → HT in CAA39358. (PubMed:1673925)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti222 – 2221T → A in strain: NSY. 2 Publications

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 123123Missing in isoform 3 and isoform 4. 2 PublicationsVSP_007099Add
    BLAST
    Alternative sequencei183 – 20826Missing in isoform 2 and isoform 4. 2 PublicationsVSP_007100Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55842 mRNA. Translation: CAA39358.1.
    AB008174 mRNA. Translation: BAA77718.1.
    AB008175 mRNA. Translation: BAA77719.1.
    AB008176 mRNA. Translation: BAA77720.1.
    AB008177 mRNA. Translation: BAA77721.1.
    AB052659 mRNA. Translation: BAB60814.1.
    AK004837 mRNA. Translation: BAB23604.1.
    AK019258 mRNA. Translation: BAB31632.2. Different initiation.
    AL669868 Genomic DNA. Translation: CAI35313.1.
    BC025189 mRNA. Translation: AAH25189.1.
    CCDSiCCDS25179.1. [P27889-1]
    CCDS70271.1. [P27889-2]
    CCDS70272.1. [P27889-3]
    PIRiA39633.
    RefSeqiNP_001278197.1. NM_001291268.1. [P27889-2]
    NP_001278198.1. NM_001291269.1. [P27889-3]
    NP_033356.2. NM_009330.3. [P27889-1]
    XP_006532859.1. XM_006532796.1. [P27889-3]
    UniGeneiMm.7226.

    Genome annotation databases

    EnsembliENSMUST00000021016; ENSMUSP00000021016; ENSMUSG00000020679. [P27889-1]
    ENSMUST00000108113; ENSMUSP00000103748; ENSMUSG00000020679. [P27889-3]
    ENSMUST00000108114; ENSMUSP00000103749; ENSMUSG00000020679. [P27889-2]
    GeneIDi21410.
    KEGGimmu:21410.
    UCSCiuc007kpx.1. mouse. [P27889-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55842 mRNA. Translation: CAA39358.1 .
    AB008174 mRNA. Translation: BAA77718.1 .
    AB008175 mRNA. Translation: BAA77719.1 .
    AB008176 mRNA. Translation: BAA77720.1 .
    AB008177 mRNA. Translation: BAA77721.1 .
    AB052659 mRNA. Translation: BAB60814.1 .
    AK004837 mRNA. Translation: BAB23604.1 .
    AK019258 mRNA. Translation: BAB31632.2 . Different initiation.
    AL669868 Genomic DNA. Translation: CAI35313.1 .
    BC025189 mRNA. Translation: AAH25189.1 .
    CCDSi CCDS25179.1. [P27889-1 ]
    CCDS70271.1. [P27889-2 ]
    CCDS70272.1. [P27889-3 ]
    PIRi A39633.
    RefSeqi NP_001278197.1. NM_001291268.1. [P27889-2 ]
    NP_001278198.1. NM_001291269.1. [P27889-3 ]
    NP_033356.2. NM_009330.3. [P27889-1 ]
    XP_006532859.1. XM_006532796.1. [P27889-3 ]
    UniGenei Mm.7226.

    3D structure databases

    ProteinModelPortali P27889.
    SMRi P27889. Positions 91-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204003. 5 interactions.
    IntActi P27889. 1 interaction.
    MINTi MINT-4097641.

    PTM databases

    PhosphoSitei P27889.

    Proteomic databases

    MaxQBi P27889.
    PaxDbi P27889.
    PRIDEi P27889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021016 ; ENSMUSP00000021016 ; ENSMUSG00000020679 . [P27889-1 ]
    ENSMUST00000108113 ; ENSMUSP00000103748 ; ENSMUSG00000020679 . [P27889-3 ]
    ENSMUST00000108114 ; ENSMUSP00000103749 ; ENSMUSG00000020679 . [P27889-2 ]
    GeneIDi 21410.
    KEGGi mmu:21410.
    UCSCi uc007kpx.1. mouse. [P27889-1 ]

    Organism-specific databases

    CTDi 6928.
    MGIi MGI:98505. Hnf1b.

    Phylogenomic databases

    eggNOGi NOG79356.
    GeneTreei ENSGT00730000110937.
    HOVERGENi HBG005980.
    InParanoidi Q5NC37.
    KOi K08034.
    OMAi MYTHKQE.
    OrthoDBi EOG769ZJ9.
    PhylomeDBi P27889.
    TreeFami TF320327.

    Enzyme and pathway databases

    Reactomei REACT_208465. Regulation of gene expression in early pancreatic precursor cells.
    REACT_222486. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.

    Miscellaneous databases

    NextBioi 300688.
    PROi P27889.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P27889.
    Bgeei P27889.
    CleanExi MM_HNF1B.
    Genevestigatori P27889.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR006899. HNF-1_N.
    IPR023219. HNF1_dimer_dom.
    IPR006897. HNF1b_C.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view ]
    Pfami PF04814. HNF-1_N. 1 hit.
    PF04812. HNF-1B_C. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF100957. SSF100957. 1 hit.
    SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia."
      de Simone V., de Magistris L., Lazzaro L., Gerstner J., Monaci P., Nicosia A., Cortese R.
      EMBO J. 10:1435-1443(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait."
      Ueda H., Ikegami H., Kawaguchi Y., Fujisawa T., Yamato E., Shibata M., Ogihara T.
      Diabetes 48:1168-1174(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-222.
      Strain: C3H and NSY.
      Tissue: Kidney.
    3. "Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice."
      Yamada K., Ikegami H., Kawaguchi Y., Fujisawa T., Hotta M., Ueda H., Shintani M., Nojima K., Kawabata Y., Ono M., Nishino M., Itoi M., Babaya N., Shibata M., Makino S., Ogihara T.
      Endocr. J. 48:241-247(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-222.
      Strain: C3H, NOD and NSY.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Strain: C57BL/6J.
      Tissue: Embryo and Liver.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Kidney.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiHNF1B_MOUSE
    AccessioniPrimary (citable) accession number: P27889
    Secondary accession number(s): Q5NC37
    , Q8R162, Q9CS26, Q9R1W1, Q9R1W2, Q9WTL5, Q9WTL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: April 4, 2003
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3