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Protein

Sorbitol dehydrogenase

Gene

Sord

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.By similarity

Caution

PubMed:8223590 reports a cDNA predicted to encode a protein with an extended N-terminus but there is no further evidence for the existence of such a protein.Curated

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Zinc; catalyticBy similarity1
Binding sitei51SubstrateBy similarity1
Metal bindingi70Zinc; catalyticBy similarity1
Metal bindingi71Zinc; catalyticBy similarity1
Binding sitei156SubstrateBy similarity1
Binding sitei299SubstrateBy similarity1
Binding sitei300SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • flagellated sperm motility Source: UniProtKB
  • fructose biosynthetic process Source: RGD
  • L-xylitol catabolic process Source: RGD
  • L-xylitol metabolic process Source: RGD
  • response to cadmium ion Source: RGD
  • response to copper ion Source: RGD
  • response to drug Source: RGD
  • response to hormone Source: RGD
  • response to nutrient levels Source: RGD
  • response to osmotic stress Source: RGD
  • sorbitol catabolic process Source: RGD
  • sorbitol metabolic process Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5652227 Fructose biosynthesis
R-RNO-5661270 Catabolism of glucuronate to xylulose-5-phosphate
SABIO-RKiP27867

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase
Gene namesi
Name:Sord
Synonyms:Sdh1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3734 Sord

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000008842 – 357Sorbitol dehydrogenaseAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei169PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP27867
PRIDEiP27867

PTM databases

iPTMnetiP27867
PhosphoSitePlusiP27867

Expressioni

Gene expression databases

BgeeiENSRNOG00000017291
GenevisibleiP27867 RN

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

  • identical protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023350

Chemistry databases

BindingDBiP27867

Structurei

3D structure databases

ProteinModelPortaliP27867
SMRiP27867
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0024 Eukaryota
COG1063 LUCA
GeneTreeiENSGT00550000074781
HOGENOMiHOG000294670
HOVERGENiHBG005484
InParanoidiP27867
KOiK00008
OMAiGVFHNTP
OrthoDBiEOG091G0AQY
PhylomeDBiP27867
TreeFamiTF313060

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAKGENL SLVVHGPGDI RLENYPIPEL GPNDVLLKMH SVGICGSDVH
60 70 80 90 100
YWEHGRIGDF VVKKPMVLGH EAAGTVTKVG PMVKHLKPGD RVAIEPGVPR
110 120 130 140 150
EIDEFCKIGR YNLTPSIFFC ATPPDDGNLC RFYKHSADFC YKLPDSVTFE
160 170 180 190 200
EGALIEPLSV GIYACRRGSV SLGNKVLVCG AGPIGIVTLL VAKAMGASQV
210 220 230 240 250
VVIDLSASRL AKAKEVGADF TIQVAKETPH DIAKKVESVL GSKPEVTIEC
260 270 280 290 300
TGAESSVQTG IYATHSGGTL VVVGMGPEMI NLPLVHAAVR EVDIKGVFRY
310 320 330 340 350
CNTWPMAVSM LASKTLNVKP LVTHRFPLEK AVEAFETAKK GLGLKVMIKC

DPNDQNP
Length:357
Mass (Da):38,235
Last modified:July 10, 2007 - v4
Checksum:iE6F535775EF73D36
GO

Sequence cautioni

The sequence CAA52670 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti259T → D in CAA41761 (PubMed:2050152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59037 mRNA Translation: CAA41761.1
X74593 mRNA Translation: CAA52670.1 Different initiation.
BC088398 mRNA Translation: AAH88398.2
BC098919 mRNA Translation: AAH98919.2
BC128707 mRNA Translation: AAI28708.2
PIRiS38363 S16132
RefSeqiNP_058748.2, NM_017052.2
UniGeneiRn.11334

Genome annotation databases

EnsembliENSRNOT00000023350; ENSRNOP00000023350; ENSRNOG00000017291
GeneIDi24788
KEGGirno:24788
UCSCiRGD:3734 rat

Similar proteinsi

Entry informationi

Entry nameiDHSO_RAT
AccessioniPrimary (citable) accession number: P27867
Secondary accession number(s): A2VCV9, Q4FZY4, Q5I0F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health