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Protein

Protein RarD

Gene

rarD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11466-MONOMER.
ECOL316407:JW5589-MONOMER.

Protein family/group databases

TCDBi2.A.7.7.2. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RarD
Gene namesi
Name:rarD
Ordered Locus Names:b3819, JW5589
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11466. rarD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Topological domaini35 – 37PeriplasmicSequence analysis3
Transmembranei38 – 60HelicalSequence analysisAdd BLAST23
Topological domaini61 – 72CytoplasmicSequence analysisAdd BLAST12
Transmembranei73 – 95HelicalSequence analysisAdd BLAST23
Topological domaini96 – 99PeriplasmicSequence analysis4
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23
Topological domaini123 – 128CytoplasmicSequence analysis6
Transmembranei129 – 146HelicalSequence analysisAdd BLAST18
Topological domaini147 – 149PeriplasmicSequence analysis3
Transmembranei150 – 167HelicalSequence analysisAdd BLAST18
Topological domaini168 – 179CytoplasmicSequence analysisAdd BLAST12
Transmembranei180 – 197HelicalSequence analysisAdd BLAST18
Topological domaini198 – 211PeriplasmicSequence analysisAdd BLAST14
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23
Topological domaini235 – 238CytoplasmicSequence analysis4
Transmembranei239 – 261HelicalSequence analysisAdd BLAST23
Topological domaini262 – 270PeriplasmicSequence analysis9
Transmembranei271 – 290HelicalSequence analysisAdd BLAST20
Topological domaini291 – 296CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001081521 – 296Protein RarDAdd BLAST296

Proteomic databases

PaxDbiP27844.
PRIDEiP27844.

Interactioni

Protein-protein interaction databases

BioGridi4261790. 11 interactors.
STRINGi511145.b3819.

Structurei

3D structure databases

ProteinModelPortaliP27844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 145EamAAdd BLAST128

Sequence similaritiesi

Belongs to the EamA transporter family.Curated
Contains 1 EamA domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105FR1. Bacteria.
COG2962. LUCA.
HOGENOMiHOG000262547.
InParanoidiP27844.
KOiK05786.
OMAiIWAVNNN.
PhylomeDBiP27844.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR004626. RarD.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00688. rarD. 1 hit.

Sequencei

Sequence statusi: Complete.

P27844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKQTRQGV LLALAAYFIW GIAPAYFKLI YYVPADEILT HRVIWSFFFM
60 70 80 90 100
VVLMSICRQW SYLKTLIQTP QKIFMLAVSA VLIGGNWLLF IWAVNNHHML
110 120 130 140 150
EASLGYFINP LVNIVLGMIF LGERFRRMQW LAVILAICGV LVQLWTFGSL
160 170 180 190 200
PIIALGLAFS FAFYGLVRKK IAVEAQTGML IETMWLLPVA AIYLFAIADS
210 220 230 240 250
STSHMGQNPM SLNLLLIAAG IVTTVPLLCF TAAATRLRLS TLGFFQYIGP
260 270 280 290
TLMFLLAVTF YGEKPGADKM VTFAFIWVAL AIFVMDAIYT QRRTSK
Length:296
Mass (Da):33,283
Last modified:April 1, 1993 - v2
Checksum:iE4E462C1E154912D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102A → R in AAA67615 (PubMed:1379743).Curated1
Sequence conflicti123 – 124ER → DG in AAA67615 (PubMed:1379743).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02122 Genomic DNA. Translation: AAD15041.1.
M87049 Genomic DNA. Translation: AAA67615.1.
U00096 Genomic DNA. Translation: AAT48220.1.
AP009048 Genomic DNA. Translation: BAE77482.1.
PIRiS30709.
S30746.
RefSeqiWP_000339104.1. NZ_LN832404.1.
YP_026262.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48220; AAT48220; b3819.
BAE77482; BAE77482; BAE77482.
GeneIDi948330.
KEGGiecj:JW5589.
eco:b3819.
PATRICi32123139. VBIEscCol129921_3935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02122 Genomic DNA. Translation: AAD15041.1.
M87049 Genomic DNA. Translation: AAA67615.1.
U00096 Genomic DNA. Translation: AAT48220.1.
AP009048 Genomic DNA. Translation: BAE77482.1.
PIRiS30709.
S30746.
RefSeqiWP_000339104.1. NZ_LN832404.1.
YP_026262.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP27844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261790. 11 interactors.
STRINGi511145.b3819.

Protein family/group databases

TCDBi2.A.7.7.2. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbiP27844.
PRIDEiP27844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48220; AAT48220; b3819.
BAE77482; BAE77482; BAE77482.
GeneIDi948330.
KEGGiecj:JW5589.
eco:b3819.
PATRICi32123139. VBIEscCol129921_3935.

Organism-specific databases

EchoBASEiEB1434.
EcoGeneiEG11466. rarD.

Phylogenomic databases

eggNOGiENOG4105FR1. Bacteria.
COG2962. LUCA.
HOGENOMiHOG000262547.
InParanoidiP27844.
KOiK05786.
OMAiIWAVNNN.
PhylomeDBiP27844.

Enzyme and pathway databases

BioCyciEcoCyc:EG11466-MONOMER.
ECOL316407:JW5589-MONOMER.

Miscellaneous databases

PROiP27844.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR004626. RarD.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00688. rarD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRARD_ECOLI
AccessioniPrimary (citable) accession number: P27844
Secondary accession number(s): Q2M8C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.