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Protein

Protein RarD

Gene

rarD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11466-MONOMER.
ECOL316407:JW5589-MONOMER.

Protein family/group databases

TCDBi2.A.7.7.2. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RarD
Gene namesi
Name:rarD
Ordered Locus Names:b3819, JW5589
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11466. rarD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3423HelicalSequence analysisAdd
BLAST
Topological domaini35 – 373PeriplasmicSequence analysis
Transmembranei38 – 6023HelicalSequence analysisAdd
BLAST
Topological domaini61 – 7212CytoplasmicSequence analysisAdd
BLAST
Transmembranei73 – 9523HelicalSequence analysisAdd
BLAST
Topological domaini96 – 994PeriplasmicSequence analysis
Transmembranei100 – 12223HelicalSequence analysisAdd
BLAST
Topological domaini123 – 1286CytoplasmicSequence analysis
Transmembranei129 – 14618HelicalSequence analysisAdd
BLAST
Topological domaini147 – 1493PeriplasmicSequence analysis
Transmembranei150 – 16718HelicalSequence analysisAdd
BLAST
Topological domaini168 – 17912CytoplasmicSequence analysisAdd
BLAST
Transmembranei180 – 19718HelicalSequence analysisAdd
BLAST
Topological domaini198 – 21114PeriplasmicSequence analysisAdd
BLAST
Transmembranei212 – 23423HelicalSequence analysisAdd
BLAST
Topological domaini235 – 2384CytoplasmicSequence analysis
Transmembranei239 – 26123HelicalSequence analysisAdd
BLAST
Topological domaini262 – 2709PeriplasmicSequence analysis
Transmembranei271 – 29020HelicalSequence analysisAdd
BLAST
Topological domaini291 – 2966CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Protein RarDPRO_0000108152Add
BLAST

Proteomic databases

PaxDbiP27844.

Interactioni

Protein-protein interaction databases

BioGridi4261790. 11 interactions.
STRINGi511145.b3819.

Structurei

3D structure databases

ProteinModelPortaliP27844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 145128EamAAdd
BLAST

Sequence similaritiesi

Belongs to the EamA transporter family.Curated
Contains 1 EamA domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105FR1. Bacteria.
COG2962. LUCA.
HOGENOMiHOG000262547.
InParanoidiP27844.
KOiK05786.
OMAiIWAVNNN.
OrthoDBiEOG6RG013.
PhylomeDBiP27844.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR004626. RarD.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00688. rarD. 1 hit.

Sequencei

Sequence statusi: Complete.

P27844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKQTRQGV LLALAAYFIW GIAPAYFKLI YYVPADEILT HRVIWSFFFM
60 70 80 90 100
VVLMSICRQW SYLKTLIQTP QKIFMLAVSA VLIGGNWLLF IWAVNNHHML
110 120 130 140 150
EASLGYFINP LVNIVLGMIF LGERFRRMQW LAVILAICGV LVQLWTFGSL
160 170 180 190 200
PIIALGLAFS FAFYGLVRKK IAVEAQTGML IETMWLLPVA AIYLFAIADS
210 220 230 240 250
STSHMGQNPM SLNLLLIAAG IVTTVPLLCF TAAATRLRLS TLGFFQYIGP
260 270 280 290
TLMFLLAVTF YGEKPGADKM VTFAFIWVAL AIFVMDAIYT QRRTSK
Length:296
Mass (Da):33,283
Last modified:April 1, 1993 - v2
Checksum:iE4E462C1E154912D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021A → R in AAA67615 (PubMed:1379743).Curated
Sequence conflicti123 – 1242ER → DG in AAA67615 (PubMed:1379743).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02122 Genomic DNA. Translation: AAD15041.1.
M87049 Genomic DNA. Translation: AAA67615.1.
U00096 Genomic DNA. Translation: AAT48220.1.
AP009048 Genomic DNA. Translation: BAE77482.1.
PIRiS30709.
S30746.
RefSeqiWP_000339104.1. NZ_LN832404.1.
YP_026262.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48220; AAT48220; b3819.
BAE77482; BAE77482; BAE77482.
GeneIDi948330.
KEGGiecj:JW5589.
eco:b3819.
PATRICi32123139. VBIEscCol129921_3935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02122 Genomic DNA. Translation: AAD15041.1.
M87049 Genomic DNA. Translation: AAA67615.1.
U00096 Genomic DNA. Translation: AAT48220.1.
AP009048 Genomic DNA. Translation: BAE77482.1.
PIRiS30709.
S30746.
RefSeqiWP_000339104.1. NZ_LN832404.1.
YP_026262.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP27844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261790. 11 interactions.
STRINGi511145.b3819.

Protein family/group databases

TCDBi2.A.7.7.2. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbiP27844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48220; AAT48220; b3819.
BAE77482; BAE77482; BAE77482.
GeneIDi948330.
KEGGiecj:JW5589.
eco:b3819.
PATRICi32123139. VBIEscCol129921_3935.

Organism-specific databases

EchoBASEiEB1434.
EcoGeneiEG11466. rarD.

Phylogenomic databases

eggNOGiENOG4105FR1. Bacteria.
COG2962. LUCA.
HOGENOMiHOG000262547.
InParanoidiP27844.
KOiK05786.
OMAiIWAVNNN.
OrthoDBiEOG6RG013.
PhylomeDBiP27844.

Enzyme and pathway databases

BioCyciEcoCyc:EG11466-MONOMER.
ECOL316407:JW5589-MONOMER.

Miscellaneous databases

PROiP27844.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR004626. RarD.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00688. rarD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ohmori H.
    Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes."
    Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.
    Science 257:771-778(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: SEQUENCE REVISION.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiRARD_ECOLI
AccessioniPrimary (citable) accession number: P27844
Secondary accession number(s): Q2M8C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 1, 1993
Last modified: January 20, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.