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Protein

Protein RarD

Gene

rarD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG11466-MONOMER

Protein family/group databases

TCDBi2.A.7.7.2 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RarD
Gene namesi
Name:rarD
Ordered Locus Names:b3819, JW5589
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11466 rarD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Topological domaini35 – 37PeriplasmicSequence analysis3
Transmembranei38 – 60HelicalSequence analysisAdd BLAST23
Topological domaini61 – 72CytoplasmicSequence analysisAdd BLAST12
Transmembranei73 – 95HelicalSequence analysisAdd BLAST23
Topological domaini96 – 99PeriplasmicSequence analysis4
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23
Topological domaini123 – 128CytoplasmicSequence analysis6
Transmembranei129 – 146HelicalSequence analysisAdd BLAST18
Topological domaini147 – 149PeriplasmicSequence analysis3
Transmembranei150 – 167HelicalSequence analysisAdd BLAST18
Topological domaini168 – 179CytoplasmicSequence analysisAdd BLAST12
Transmembranei180 – 197HelicalSequence analysisAdd BLAST18
Topological domaini198 – 211PeriplasmicSequence analysisAdd BLAST14
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23
Topological domaini235 – 238CytoplasmicSequence analysis4
Transmembranei239 – 261HelicalSequence analysisAdd BLAST23
Topological domaini262 – 270PeriplasmicSequence analysis9
Transmembranei271 – 290HelicalSequence analysisAdd BLAST20
Topological domaini291 – 296CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001081521 – 296Protein RarDAdd BLAST296

Proteomic databases

PaxDbiP27844
PRIDEiP27844

Interactioni

Protein-protein interaction databases

BioGridi4261790, 13 interactors
STRINGi316385.ECDH10B_4010

Structurei

3D structure databases

ProteinModelPortaliP27844
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 145EamAAdd BLAST128

Sequence similaritiesi

Belongs to the EamA transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105FR1 Bacteria
COG2962 LUCA
HOGENOMiHOG000262547
InParanoidiP27844
KOiK05786
OMAiIWAVNNN
PhylomeDBiP27844

Family and domain databases

InterProiView protein in InterPro
IPR000620 EamA_dom
IPR004626 RarD
PANTHERiPTHR22911:SF41 PTHR22911:SF41, 1 hit
PfamiView protein in Pfam
PF00892 EamA, 2 hits
TIGRFAMsiTIGR00688 rarD, 1 hit

Sequencei

Sequence statusi: Complete.

P27844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKQTRQGV LLALAAYFIW GIAPAYFKLI YYVPADEILT HRVIWSFFFM
60 70 80 90 100
VVLMSICRQW SYLKTLIQTP QKIFMLAVSA VLIGGNWLLF IWAVNNHHML
110 120 130 140 150
EASLGYFINP LVNIVLGMIF LGERFRRMQW LAVILAICGV LVQLWTFGSL
160 170 180 190 200
PIIALGLAFS FAFYGLVRKK IAVEAQTGML IETMWLLPVA AIYLFAIADS
210 220 230 240 250
STSHMGQNPM SLNLLLIAAG IVTTVPLLCF TAAATRLRLS TLGFFQYIGP
260 270 280 290
TLMFLLAVTF YGEKPGADKM VTFAFIWVAL AIFVMDAIYT QRRTSK
Length:296
Mass (Da):33,283
Last modified:April 1, 1993 - v2
Checksum:iE4E462C1E154912D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102A → R in AAA67615 (PubMed:1379743).Curated1
Sequence conflicti123 – 124ER → DG in AAA67615 (PubMed:1379743).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02122 Genomic DNA Translation: AAD15041.1
M87049 Genomic DNA Translation: AAA67615.1
U00096 Genomic DNA Translation: AAT48220.1
AP009048 Genomic DNA Translation: BAE77482.1
PIRiS30709
S30746
RefSeqiWP_000339104.1, NZ_LN832404.1
YP_026262.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48220; AAT48220; b3819
BAE77482; BAE77482; BAE77482
GeneIDi948330
KEGGiecj:JW5589
eco:b3819
PATRICifig|1411691.4.peg.2888

Similar proteinsi

Entry informationi

Entry nameiRARD_ECOLI
AccessioniPrimary (citable) accession number: P27844
Secondary accession number(s): Q2M8C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 1, 1993
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health