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Protein

Protein CyaY

Gene

cyaY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ferric iron binding Source: EcoCyc
  • ferrous iron binding Source: EcoCyc

GO - Biological processi

  • iron-sulfur cluster assembly Source: EcoliWiki
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11653-MONOMER.
ECOL316407:JW3779-MONOMER.
MetaCyc:EG11653-MONOMER.

Protein family/group databases

TCDBi9.B.21.2.1. the frataxin (frataxin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CyaY
Gene namesi
Name:cyaY
Ordered Locus Names:b3807, JW3779
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11653. cyaY.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Cells are not affected in cellular iron content and sensitivity to oxidants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Protein CyaYPRO_0000193936Add
BLAST

Proteomic databases

PaxDbiP27838.

Interactioni

Protein-protein interaction databases

BioGridi4260671. 113 interactions.
DIPiDIP-9356N.
IntActiP27838. 2 interactions.
STRINGi511145.b3807.

Structurei

Secondary structure

1
106
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 2220Combined sources
Beta strandi26 – 283Combined sources
Beta strandi31 – 355Combined sources
Beta strandi38 – 425Combined sources
Beta strandi48 – 547Combined sources
Turni55 – 584Combined sources
Beta strandi59 – 635Combined sources
Beta strandi68 – 747Combined sources
Beta strandi77 – 804Combined sources
Turni81 – 833Combined sources
Helixi87 – 9913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EW4X-ray1.40A1-106[»]
1SOYNMR-A1-106[»]
2EFFX-ray1.80A1-106[»]
2P1XX-ray1.42A1-106[»]
ProteinModelPortaliP27838.
SMRiP27838. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27838.

Family & Domainsi

Sequence similaritiesi

Belongs to the frataxin family.Curated

Phylogenomic databases

eggNOGiENOG4105XQ6. Bacteria.
COG1965. LUCA.
HOGENOMiHOG000190728.
InParanoidiP27838.
KOiK06202.
OMAiLHQIWVA.
OrthoDBiEOG6GXTXM.
PhylomeDBiP27838.

Family and domain databases

Gene3Di3.30.920.10. 1 hit.
HAMAPiMF_00142. CyaY.
InterProiIPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
[Graphical view]
PANTHERiPTHR16821. PTHR16821. 1 hit.
PfamiPF01491. Frataxin_Cyay. 1 hit.
[Graphical view]
SMARTiSM01219. Frataxin_Cyay. 1 hit.
[Graphical view]
SUPFAMiSSF55387. SSF55387. 1 hit.
TIGRFAMsiTIGR03421. FeS_CyaY. 1 hit.
PROSITEiPS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDSEFHRLA DQLWLTIEER LDDWDGDSDI DCEINGGVLT ITFENGSKII
60 70 80 90 100
INRQEPLHQV WLATKQGGYH FDLKGDEWIC DRSGETFWDL LEQAATQQAG

ETVSFR
Length:106
Mass (Da):12,231
Last modified:August 1, 1992 - v1
Checksum:i03EA6F330A48F711
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66782 Genomic DNA. Translation: CAA47281.1.
M87049 Genomic DNA. Translation: AAA67603.1.
U00096 Genomic DNA. Translation: AAC76810.1.
AP009048 Genomic DNA. Translation: BAE77494.1.
PIRiS30697.
RefSeqiNP_418251.1. NC_000913.3.
WP_000999947.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76810; AAC76810; b3807.
BAE77494; BAE77494; BAE77494.
GeneIDi947754.
KEGGiecj:JW3779.
eco:b3807.
PATRICi32123113. VBIEscCol129921_3922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66782 Genomic DNA. Translation: CAA47281.1.
M87049 Genomic DNA. Translation: AAA67603.1.
U00096 Genomic DNA. Translation: AAC76810.1.
AP009048 Genomic DNA. Translation: BAE77494.1.
PIRiS30697.
RefSeqiNP_418251.1. NC_000913.3.
WP_000999947.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EW4X-ray1.40A1-106[»]
1SOYNMR-A1-106[»]
2EFFX-ray1.80A1-106[»]
2P1XX-ray1.42A1-106[»]
ProteinModelPortaliP27838.
SMRiP27838. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260671. 113 interactions.
DIPiDIP-9356N.
IntActiP27838. 2 interactions.
STRINGi511145.b3807.

Protein family/group databases

TCDBi9.B.21.2.1. the frataxin (frataxin) family.

Proteomic databases

PaxDbiP27838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76810; AAC76810; b3807.
BAE77494; BAE77494; BAE77494.
GeneIDi947754.
KEGGiecj:JW3779.
eco:b3807.
PATRICi32123113. VBIEscCol129921_3922.

Organism-specific databases

EchoBASEiEB1606.
EcoGeneiEG11653. cyaY.

Phylogenomic databases

eggNOGiENOG4105XQ6. Bacteria.
COG1965. LUCA.
HOGENOMiHOG000190728.
InParanoidiP27838.
KOiK06202.
OMAiLHQIWVA.
OrthoDBiEOG6GXTXM.
PhylomeDBiP27838.

Enzyme and pathway databases

BioCyciEcoCyc:EG11653-MONOMER.
ECOL316407:JW3779-MONOMER.
MetaCyc:EG11653-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP27838.
PROiP27838.

Family and domain databases

Gene3Di3.30.920.10. 1 hit.
HAMAPiMF_00142. CyaY.
InterProiIPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
[Graphical view]
PANTHERiPTHR16821. PTHR16821. 1 hit.
PfamiPF01491. Frataxin_Cyay. 1 hit.
[Graphical view]
SMARTiSM01219. Frataxin_Cyay. 1 hit.
[Graphical view]
SUPFAMiSSF55387. SSF55387. 1 hit.
TIGRFAMsiTIGR03421. FeS_CyaY. 1 hit.
PROSITEiPS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete nucleotide sequence of the adenylate cyclase gene of Escherichia coli."
    Aiba H., Mori K., Tanaka M., Ooi T., Roy A., Danchin A.
    Nucleic Acids Res. 12:9427-9440(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
    Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
    Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. "Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes."
    Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.
    Science 257:771-778(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Phylogeny of adenylyl cyclases."
    Danchin A.
    Adv. Second Messenger Phosphoprotein Res. 27:109-162(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Knock-out of the cyaY gene in Escherichia coli does not affect cellular iron content and sensitivity to oxidants."
    Li D.S., Ohshima K., Jiralerspong S., Bojanowski M.W., Pandolfo M.
    FEBS Lett. 456:13-16(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  8. "Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family."
    Cho S.-J., Lee M.G., Yang J.K., Lee J.Y., Song H.K., Suh S.W.
    Proc. Natl. Acad. Sci. U.S.A. 97:8932-8937(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).

Entry informationi

Entry nameiCYAY_ECOLI
AccessioniPrimary (citable) accession number: P27838
Secondary accession number(s): Q2M8B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: May 11, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.