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Protein

Protein CyaY

Gene

cyaY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ferric iron binding Source: EcoCyc
  • ferrous iron binding Source: EcoCyc

GO - Biological processi

  • iron-sulfur cluster assembly Source: EcoliWiki
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG11653-MONOMER.
ECOL316407:JW3779-MONOMER.
MetaCyc:EG11653-MONOMER.

Protein family/group databases

TCDBi9.B.21.2.1. the frataxin (frataxin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CyaY
Gene namesi
Name:cyaY
Ordered Locus Names:b3807, JW3779
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11653. cyaY.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Cells are not affected in cellular iron content and sensitivity to oxidants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Protein CyaYPRO_0000193936Add
BLAST

Proteomic databases

PaxDbiP27838.

Interactioni

Protein-protein interaction databases

BioGridi4260671. 113 interactions.
DIPiDIP-9356N.
IntActiP27838. 2 interactions.
STRINGi511145.b3807.

Structurei

Secondary structure

1
106
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 2220Combined sources
Beta strandi26 – 283Combined sources
Beta strandi31 – 355Combined sources
Beta strandi38 – 425Combined sources
Beta strandi48 – 547Combined sources
Turni55 – 584Combined sources
Beta strandi59 – 635Combined sources
Beta strandi68 – 747Combined sources
Beta strandi77 – 804Combined sources
Turni81 – 833Combined sources
Helixi87 – 9913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EW4X-ray1.40A1-106[»]
1SOYNMR-A1-106[»]
2EFFX-ray1.80A1-106[»]
2P1XX-ray1.42A1-106[»]
ProteinModelPortaliP27838.
SMRiP27838. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27838.

Family & Domainsi

Sequence similaritiesi

Belongs to the frataxin family.Curated

Phylogenomic databases

eggNOGiENOG4105XQ6. Bacteria.
COG1965. LUCA.
HOGENOMiHOG000190728.
InParanoidiP27838.
KOiK06202.
OMAiLHQIWVA.
PhylomeDBiP27838.

Family and domain databases

Gene3Di3.30.920.10. 1 hit.
HAMAPiMF_00142. CyaY. 1 hit.
InterProiIPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
[Graphical view]
PANTHERiPTHR16821. PTHR16821. 1 hit.
PfamiPF01491. Frataxin_Cyay. 1 hit.
[Graphical view]
SMARTiSM01219. Frataxin_Cyay. 1 hit.
[Graphical view]
SUPFAMiSSF55387. SSF55387. 1 hit.
TIGRFAMsiTIGR03421. FeS_CyaY. 1 hit.
PROSITEiPS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDSEFHRLA DQLWLTIEER LDDWDGDSDI DCEINGGVLT ITFENGSKII
60 70 80 90 100
INRQEPLHQV WLATKQGGYH FDLKGDEWIC DRSGETFWDL LEQAATQQAG

ETVSFR
Length:106
Mass (Da):12,231
Last modified:August 1, 1992 - v1
Checksum:i03EA6F330A48F711
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66782 Genomic DNA. Translation: CAA47281.1.
M87049 Genomic DNA. Translation: AAA67603.1.
U00096 Genomic DNA. Translation: AAC76810.1.
AP009048 Genomic DNA. Translation: BAE77494.1.
PIRiS30697.
RefSeqiNP_418251.1. NC_000913.3.
WP_000999947.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76810; AAC76810; b3807.
BAE77494; BAE77494; BAE77494.
GeneIDi947754.
KEGGiecj:JW3779.
eco:b3807.
PATRICi32123113. VBIEscCol129921_3922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66782 Genomic DNA. Translation: CAA47281.1.
M87049 Genomic DNA. Translation: AAA67603.1.
U00096 Genomic DNA. Translation: AAC76810.1.
AP009048 Genomic DNA. Translation: BAE77494.1.
PIRiS30697.
RefSeqiNP_418251.1. NC_000913.3.
WP_000999947.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EW4X-ray1.40A1-106[»]
1SOYNMR-A1-106[»]
2EFFX-ray1.80A1-106[»]
2P1XX-ray1.42A1-106[»]
ProteinModelPortaliP27838.
SMRiP27838. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260671. 113 interactions.
DIPiDIP-9356N.
IntActiP27838. 2 interactions.
STRINGi511145.b3807.

Protein family/group databases

TCDBi9.B.21.2.1. the frataxin (frataxin) family.

Proteomic databases

PaxDbiP27838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76810; AAC76810; b3807.
BAE77494; BAE77494; BAE77494.
GeneIDi947754.
KEGGiecj:JW3779.
eco:b3807.
PATRICi32123113. VBIEscCol129921_3922.

Organism-specific databases

EchoBASEiEB1606.
EcoGeneiEG11653. cyaY.

Phylogenomic databases

eggNOGiENOG4105XQ6. Bacteria.
COG1965. LUCA.
HOGENOMiHOG000190728.
InParanoidiP27838.
KOiK06202.
OMAiLHQIWVA.
PhylomeDBiP27838.

Enzyme and pathway databases

BioCyciEcoCyc:EG11653-MONOMER.
ECOL316407:JW3779-MONOMER.
MetaCyc:EG11653-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP27838.
PROiP27838.

Family and domain databases

Gene3Di3.30.920.10. 1 hit.
HAMAPiMF_00142. CyaY. 1 hit.
InterProiIPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
[Graphical view]
PANTHERiPTHR16821. PTHR16821. 1 hit.
PfamiPF01491. Frataxin_Cyay. 1 hit.
[Graphical view]
SMARTiSM01219. Frataxin_Cyay. 1 hit.
[Graphical view]
SUPFAMiSSF55387. SSF55387. 1 hit.
TIGRFAMsiTIGR03421. FeS_CyaY. 1 hit.
PROSITEiPS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYAY_ECOLI
AccessioniPrimary (citable) accession number: P27838
Secondary accession number(s): Q2M8B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.