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Protein

Probable transport protein YifK

Gene

yifK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable amino-acid or metabolite transport protein.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YIFK-MONOMER.
ECOL316407:JW5595-MONOMER.

Protein family/group databases

TCDBi2.A.3.1.15. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transport protein YifK
Gene namesi
Name:yifK
Ordered Locus Names:b3795, JW5595
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11459. yifK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 39PeriplasmicSequence analysis2
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 96CytoplasmicSequence analysisAdd BLAST36
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 122PeriplasmicSequence analysis5
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 155CytoplasmicSequence analysisAdd BLAST12
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 200PeriplasmicSequence analysisAdd BLAST24
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 243CytoplasmicSequence analysisAdd BLAST22
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 277PeriplasmicSequence analysisAdd BLAST13
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 332CytoplasmicSequence analysisAdd BLAST34
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 359PeriplasmicSequence analysis6
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 400CytoplasmicSequence analysisAdd BLAST20
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 429PeriplasmicSequence analysis8
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 461CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542181 – 461Probable transport protein YifKAdd BLAST461

Proteomic databases

PaxDbiP27837.
PRIDEiP27837.

Interactioni

Protein-protein interaction databases

BioGridi4261339. 150 interactors.
STRINGi511145.b3795.

Structurei

3D structure databases

ProteinModelPortaliP27837.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261849.
InParanoidiP27837.
KOiK03293.
OMAiETRMSLF.
PhylomeDBiP27837.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNKPELQR GLEARHIELI ALGGTIGVGL FMGAASTLKW AGPSVLLAYI
60 70 80 90 100
IAGLFVFFIM RSMGEMLFLE PVTGSFAVYA HRYMSPFFGY LTAWSYWFMW
110 120 130 140 150
MAVGISEITA IGVYVQFWFP EMAQWIPALI AVALVALANL AAVRLYGEIE
160 170 180 190 200
FWFAMIKVTT IIVMIVIGLG VIFFGFGNGG QSIGFSNLTE HGGFFAGGWK
210 220 230 240 250
GFLTALCIVV ASYQGVELIG ITAGEAKNPQ VTLRSAVGKV LWRILIFYVG
260 270 280 290 300
AIFVIVTIFP WNEIGSNGSP FVLTFAKIGI TAAAGIINFV VLTAALSGCN
310 320 330 340 350
SGMYSCGRML YALAKNRQLP AAMAKVSRHG VPVAGVAVSI AILLIGSCLN
360 370 380 390 400
YIIPNPQRVF VYVYSASVLP GMVPWFVILI SQLRFRRAHK AAIASHPFRS
410 420 430 440 450
ILFPWANYVT MAFLICVLIG MYFNEDTRMS LFVGIIFMLA VTAIYKVFGL
460
NRHGKAHKLE E
Length:461
Mass (Da):50,399
Last modified:October 11, 2004 - v4
Checksum:i62EE13158BC8EE3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74 – 75GS → VA in AAA67595 (PubMed:1379743).Curated2
Sequence conflicti346 – 349GSCL → AHAW in AAA67595 (PubMed:1379743).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA. Translation: AAA67595.1.
U00096 Genomic DNA. Translation: AAT48216.1.
AP009048 Genomic DNA. Translation: BAE77502.1.
PIRiH65183.
RefSeqiWP_000774731.1. NZ_LN832404.1.
YP_026258.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48216; AAT48216; b3795.
BAE77502; BAE77502; BAE77502.
GeneIDi945400.
KEGGiecj:JW5595.
eco:b3795.
PATRICi32123087. VBIEscCol129921_3913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA. Translation: AAA67595.1.
U00096 Genomic DNA. Translation: AAT48216.1.
AP009048 Genomic DNA. Translation: BAE77502.1.
PIRiH65183.
RefSeqiWP_000774731.1. NZ_LN832404.1.
YP_026258.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP27837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261339. 150 interactors.
STRINGi511145.b3795.

Protein family/group databases

TCDBi2.A.3.1.15. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP27837.
PRIDEiP27837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48216; AAT48216; b3795.
BAE77502; BAE77502; BAE77502.
GeneIDi945400.
KEGGiecj:JW5595.
eco:b3795.
PATRICi32123087. VBIEscCol129921_3913.

Organism-specific databases

EchoBASEiEB1428.
EcoGeneiEG11459. yifK.

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261849.
InParanoidiP27837.
KOiK03293.
OMAiETRMSLF.
PhylomeDBiP27837.

Enzyme and pathway databases

BioCyciEcoCyc:YIFK-MONOMER.
ECOL316407:JW5595-MONOMER.

Miscellaneous databases

PROiP27837.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYIFK_ECOLI
AccessioniPrimary (citable) accession number: P27837
Secondary accession number(s): P76756, Q2M8A4, Q6BEZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.