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Protein

Probable transport protein YifK

Gene

yifK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable amino-acid or metabolite transport protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YIFK-MONOMER.
ECOL316407:JW5595-MONOMER.

Protein family/group databases

TCDBi2.A.3.1.15. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transport protein YifK
Gene namesi
Name:yifK
Ordered Locus Names:b3795, JW5595
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11459. yifK.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Topological domaini38 – 392PeriplasmicSequence analysis
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Topological domaini61 – 9636CytoplasmicSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence analysisAdd
BLAST
Topological domaini118 – 1225PeriplasmicSequence analysis
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Topological domaini144 – 15512CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 20024PeriplasmicSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Topological domaini222 – 24322CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Topological domaini265 – 27713PeriplasmicSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence analysisAdd
BLAST
Topological domaini299 – 33234CytoplasmicSequence analysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence analysisAdd
BLAST
Topological domaini354 – 3596PeriplasmicSequence analysis
Transmembranei360 – 38021HelicalSequence analysisAdd
BLAST
Topological domaini381 – 40020CytoplasmicSequence analysisAdd
BLAST
Transmembranei401 – 42121HelicalSequence analysisAdd
BLAST
Topological domaini422 – 4298PeriplasmicSequence analysis
Transmembranei430 – 45021HelicalSequence analysisAdd
BLAST
Topological domaini451 – 46111CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Probable transport protein YifKPRO_0000054218Add
BLAST

Proteomic databases

PaxDbiP27837.
PRIDEiP27837.

Interactioni

Protein-protein interaction databases

BioGridi4261339. 150 interactions.
STRINGi511145.b3795.

Structurei

3D structure databases

ProteinModelPortaliP27837.
SMRiP27837. Positions 17-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261849.
InParanoidiP27837.
KOiK03293.
OMAiMFAYLAV.
OrthoDBiEOG6HQSQM.
PhylomeDBiP27837.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNKPELQR GLEARHIELI ALGGTIGVGL FMGAASTLKW AGPSVLLAYI
60 70 80 90 100
IAGLFVFFIM RSMGEMLFLE PVTGSFAVYA HRYMSPFFGY LTAWSYWFMW
110 120 130 140 150
MAVGISEITA IGVYVQFWFP EMAQWIPALI AVALVALANL AAVRLYGEIE
160 170 180 190 200
FWFAMIKVTT IIVMIVIGLG VIFFGFGNGG QSIGFSNLTE HGGFFAGGWK
210 220 230 240 250
GFLTALCIVV ASYQGVELIG ITAGEAKNPQ VTLRSAVGKV LWRILIFYVG
260 270 280 290 300
AIFVIVTIFP WNEIGSNGSP FVLTFAKIGI TAAAGIINFV VLTAALSGCN
310 320 330 340 350
SGMYSCGRML YALAKNRQLP AAMAKVSRHG VPVAGVAVSI AILLIGSCLN
360 370 380 390 400
YIIPNPQRVF VYVYSASVLP GMVPWFVILI SQLRFRRAHK AAIASHPFRS
410 420 430 440 450
ILFPWANYVT MAFLICVLIG MYFNEDTRMS LFVGIIFMLA VTAIYKVFGL
460
NRHGKAHKLE E
Length:461
Mass (Da):50,399
Last modified:October 11, 2004 - v4
Checksum:i62EE13158BC8EE3A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 752GS → VA in AAA67595 (PubMed:1379743).Curated
Sequence conflicti346 – 3494GSCL → AHAW in AAA67595 (PubMed:1379743).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA. Translation: AAA67595.1.
U00096 Genomic DNA. Translation: AAT48216.1.
AP009048 Genomic DNA. Translation: BAE77502.1.
PIRiH65183.
RefSeqiWP_000774731.1. NZ_LN832404.1.
YP_026258.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48216; AAT48216; b3795.
BAE77502; BAE77502; BAE77502.
GeneIDi945400.
KEGGiecj:JW5595.
eco:b3795.
PATRICi32123087. VBIEscCol129921_3913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA. Translation: AAA67595.1.
U00096 Genomic DNA. Translation: AAT48216.1.
AP009048 Genomic DNA. Translation: BAE77502.1.
PIRiH65183.
RefSeqiWP_000774731.1. NZ_LN832404.1.
YP_026258.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP27837.
SMRiP27837. Positions 17-444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261339. 150 interactions.
STRINGi511145.b3795.

Protein family/group databases

TCDBi2.A.3.1.15. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP27837.
PRIDEiP27837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48216; AAT48216; b3795.
BAE77502; BAE77502; BAE77502.
GeneIDi945400.
KEGGiecj:JW5595.
eco:b3795.
PATRICi32123087. VBIEscCol129921_3913.

Organism-specific databases

EchoBASEiEB1428.
EcoGeneiEG11459. yifK.

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261849.
InParanoidiP27837.
KOiK03293.
OMAiMFAYLAV.
OrthoDBiEOG6HQSQM.
PhylomeDBiP27837.

Enzyme and pathway databases

BioCyciEcoCyc:YIFK-MONOMER.
ECOL316407:JW5595-MONOMER.

Miscellaneous databases

PROiP27837.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes."
    Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.
    Science 257:771-778(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 68 AND 74-75.
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: SEQUENCE REVISION TO 68 AND 346-349.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYIFK_ECOLI
AccessioniPrimary (citable) accession number: P27837
Secondary accession number(s): P76756, Q2M8A4, Q6BEZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 11, 2004
Last modified: February 17, 2016
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.