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Protein

Microtubule-associated protein 4

Gene

MAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-neuronal microtubule-associated protein. Promotes microtubule assembly.1 Publication

GO - Molecular functioni

  • microtubule binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB
  • structural molecule activity Source: ProtInc

GO - Biological processi

  • cell division Source: MGI
  • establishment of spindle orientation Source: MGI
  • microtubule sliding Source: MGI
  • mitotic spindle organization Source: MGI
  • negative regulation of non-motile cilium assembly Source: GO_Central
  • neuron projection development Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000047849-MONOMER.
SIGNORiP27816.

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 4
Short name:
MAP-4
Gene namesi
Name:MAP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6862. MAP4.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: GO_Central
  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: ProtInc
  • microtubule cytoskeleton Source: HPA
  • mitotic spindle Source: MGI
  • neuron projection Source: GO_Central
  • plasma membrane Source: HPA
  • postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi696S → E: No change in microtubule binding; no change in microtubule polymerization activity. 1 Publication1
Mutagenesisi787S → E: No change in microtubule binding; reduced microtubule polymerization activity. 1 Publication1

Organism-specific databases

DisGeNETi4134.
OpenTargetsiENSG00000047849.
PharmGKBiPA30608.

Chemistry databases

DrugBankiDB01248. Docetaxel.
DB01229. Paclitaxel.

Polymorphism and mutation databases

BioMutaiMAP4.
DMDMi269849673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000727512 – 1152Microtubule-associated protein 4Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei5PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei253PhosphoserineBy similarity1
Cross-linki269Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei280PhosphoserineCombined sources1
Modified residuei282PhosphothreonineCombined sources1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei380PhosphothreonineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei442PhosphothreonineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1
Modified residuei521PhosphothreonineCombined sources1
Modified residuei526PhosphothreonineCombined sources1
Modified residuei571PhosphothreonineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei585PhosphothreonineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei643PhosphoserineBy similarity1
Modified residuei687PhosphothreonineBy similarity1
Modified residuei696PhosphoserineCombined sources1 Publication1
Modified residuei713PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1 Publication1
Modified residuei797PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei827PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1
Modified residuei928PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1
Modified residuei942PhosphothreonineCombined sources1
Modified residuei1000PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1151PhosphoserineCombined sources1
Isoform 4 (identifier: P27816-4)
Modified residuei28PhosphothreonineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Isoform 3 (identifier: P27816-3)
Modified residuei337PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Isoform 5 (identifier: P27816-5)
Modified residuei803PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP27816.
MaxQBiP27816.
PaxDbiP27816.
PeptideAtlasiP27816.
PRIDEiP27816.

PTM databases

iPTMnetiP27816.
PhosphoSitePlusiP27816.
SwissPalmiP27816.

Miscellaneous databases

PMAP-CutDBP27816.

Expressioni

Gene expression databases

BgeeiENSG00000047849.
CleanExiHS_MAP4.
ExpressionAtlasiP27816. baseline and differential.
GenevisibleiP27816. HS.

Organism-specific databases

HPAiHPA038149.
HPA038150.

Interactioni

Subunit structurei

Interacts with SEPT2; this interaction impedes tubulin-binding. Interacts with TRAF3IP1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-715255,EBI-389883

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110306. 60 interactors.
IntActiP27816. 26 interactors.
MINTiMINT-1425668.
STRINGi9606.ENSP00000353375.

Structurei

3D structure databases

ProteinModelPortaliP27816.
SMRiP27816.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati248 – 2611Add BLAST14
Repeati262 – 2752Add BLAST14
Repeati276 – 2893Add BLAST14
Repeati290 – 3034Add BLAST14
Repeati304 – 3175Add BLAST14
Repeati318 – 3316Add BLAST14
Repeati332 – 3457Add BLAST14
Repeati346 – 3518; truncated6
Repeati352 – 37726 residues 1Add BLAST26
Repeati378 – 40326 residues 2Add BLAST26
Repeati408 – 4219Add BLAST14
Repeati422 – 43310Add BLAST12
Repeati434 – 44711Add BLAST14
Repeati448 – 46112Add BLAST14
Repeati462 – 47513Add BLAST14
Repeati476 – 48914Add BLAST14
Repeati490 – 50315Add BLAST14
Repeati504 – 51716Add BLAST14
Repeati532 – 54517Add BLAST14
Repeati923 – 953Tau/MAP 1Add BLAST31
Repeati992 – 1022Tau/MAP 2Add BLAST31
Repeati1023 – 1053Tau/MAP 3Add BLAST31
Repeati1054 – 1085Tau/MAP 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 54517 X 14 AA tandem repeatsAdd BLAST298

Sequence similaritiesi

Contains 4 Tau/MAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IG6M. Eukaryota.
ENOG4111J07. LUCA.
GeneTreeiENSGT00530000063491.
HOGENOMiHOG000139406.
HOVERGENiHBG006323.
InParanoidiP27816.
KOiK10431.
PhylomeDBiP27816.
TreeFamiTF316358.

Family and domain databases

InterProiIPR027324. MAP2/MAP4/Tau.
IPR027323. MAP4.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 2 hits.
PTHR11501:SF16. PTHR11501:SF16. 2 hits.
PfamiPF00418. Tubulin-binding. 4 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 4 hits.
PS51491. TAU_MAP_2. 4 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P27816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL
60 70 80 90 100
LDVDEKTGNS ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP
110 120 130 140 150
TEFLEEKMAY QEYPNSQNWP EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA
160 170 180 190 200
DLVFPSSATA DTSIFAGQND PLKDSYGMSP CNTAVVPQGW SVEALNSPHS
210 220 230 240 250
ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE IMMGLKTTDM
260 270 280 290 300
APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM
310 320 330 340 350
ALVKDMELPT EKEVALVKDV RWPTETDVSS AKNVVLPTET EVAPAKDVTL
360 370 380 390 400
LKETERASPI KMDLAPSKDM GPPKENKKET ERASPIKMDL APSKDMGPPK
410 420 430 440 450
ENKIVPAKDL VLLSEIEVAQ ANDIISSTEI SSAEKVALSS ETEVALARDM
460 470 480 490 500
TLPPETNVIL TKDKALPLEA EVAPVKDMAQ LPETEIAPAK DVAPSTVKEV
510 520 530 540 550
GLLKDMSPLS ETEMALGKDV TPPPETEVVL IKNVCLPPEM EVALTEDQVP
560 570 580 590 600
ALKTEAPLAK DGVLTLANNV TPAKDVPPLS ETEATPVPIK DMEIAQTQKG
610 620 630 640 650
ISEDSHLESL QDVGQSAAPT FMISPETVTG TGKKCSLPAE EDSVLEKLGE
660 670 680 690 700
RKPCNSQPSE LSSETSGIAR PEEGRPVVSG TGNDITTPPN KELPPSPEKK
710 720 730 740 750
TKPLATTQPA KTSTSKAKTQ PTSLPKQPAP TTIGGLNKKP MSLASGLVPA
760 770 780 790 800
APPKRPAVAS ARPSILPSKD VKPKPIADAK APEKRASPSK PASAPASRSG
810 820 830 840 850
SKSTQTVAKT TTAAAVASTG PSSRSPSTLL PKKPTAIKTE GKPAEVKKMT
860 870 880 890 900
AKSVPADLSR PKSTSTSSMK KTTTLSGTAP AAGVVPSRVK ATPMPSRPST
910 920 930 940 950
TPFIDKKPTS AKPSSTTPRL SRLATNTSAP DLKNVRSKVG STENIKHQPG
960 970 980 990 1000
GGRAKVEKKT EAAATTRKPE SNAVTKTAGP IASAQKQPAG KVQIVSKKVS
1010 1020 1030 1040 1050
YSHIQSKCGS KDNIKHVPGG GNVQIQNKKV DISKVSSKCG SKANIKHKPG
1060 1070 1080 1090 1100
GGDVKIESQK LNFKEKAQAK VGSLDNVGHL PAGGAVKTEG GGSEAPLCPG
1110 1120 1130 1140 1150
PPAGEEPAIS EAAPEAGAPT SASGLNGHPT LSGGGDQREA QTLDSQIQET

SI
Length:1,152
Mass (Da):121,005
Last modified:November 24, 2009 - v3
Checksum:i061A69AC18593339
GO
Isoform 2 (identifier: P27816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-730: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:979
Mass (Da):102,906
Checksum:i04F3054281DA91E7
GO
Isoform 3 (identifier: P27816-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     152-437: LVFPSSATAD...TEISSAEKVA → MSLSDKQTAS...IRDHDKELEK
     441-631: ETEVALARDM...MISPETVTGT → TEEAVLNQAP...EKQPGQTALA
     635-666: CSLPAEEDSVLEKLGERKPCNSQPSELSSETS → EIEVTATQSTPSFLFEKPPRD
     703-716: PLATTQPAKTSTSK → VGARMVVIFYCHNF
     717-1152: Missing.

Show »
Length:539
Mass (Da):58,557
Checksum:i6B67BBE02C4F946D
GO
Isoform 4 (identifier: P27816-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     83-221: LLANGGHGVE...PPQPTAVPLE → METTGDQGIE...VKEGDSFPDT
     225-271: EIEMASEERP...KDMALATKTE → NGQEIAPAQI...AVVPSTSTGG
     275-666: AKDMESPTKL...QPSELSSETS → PITTAIETVN...QERHKQLKSA
     939-953: Missing.

Show »
Length:872
Mass (Da):91,154
Checksum:i777E25AE88E22090
GO
Isoform 5 (identifier: P27816-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-666: WPTETDVSSA...QPSELSSETS → LPEPKDKILE...QERHKQLKSA
     954-1022: Missing.
     1151-1152: SI → N

Show »
Length:809
Mass (Da):85,252
Checksum:iF259E4B688F2B44F
GO
Isoform 6 (identifier: P27816-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1088-1152: TEGGGSEAPL...LDSQIQETSI → IETYRLTFRA...VLGPLSRAVH

Note: No experimental confirmation available.
Show »
Length:1,135
Mass (Da):119,958
Checksum:i9FDE4697ADAD05D5
GO
Isoform 7 (identifier: P27816-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-99: GS → EA
     100-1152: Missing.

Note: No experimental confirmation available.
Show »
Length:99
Mass (Da):10,441
Checksum:i2D295214DAA6FB37
GO

Sequence cautioni

The sequence BAD92614 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160A → R in AAA59553 (PubMed:1718985).Curated1
Sequence conflicti319D → G in CAH18346 (PubMed:17974005).Curated1
Sequence conflicti1109I → V in CAH18346 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03956623R → Q.Corresponds to variant rs11711953dbSNPEnsembl.1
Natural variantiVAR_039567366P → L.Corresponds to variant rs13097415dbSNPEnsembl.1
Natural variantiVAR_039568367S → P.Corresponds to variant rs13096947dbSNPEnsembl.1
Natural variantiVAR_039569409D → G.Corresponds to variant rs13076542dbSNPEnsembl.1
Natural variantiVAR_020361427S → Y.1 PublicationCorresponds to variant rs1060407dbSNPEnsembl.1
Natural variantiVAR_020362441E → Q.Corresponds to variant rs2230169dbSNPEnsembl.1
Natural variantiVAR_039570628V → I.Combined sources1 PublicationCorresponds to variant rs1137524dbSNPEnsembl.1
Natural variantiVAR_039571994I → V.Corresponds to variant rs35736893dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0320651 – 151Missing in isoform 3. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_0320661 – 82Missing in isoform 4. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_03206783 – 221LLANG…AVPLE → METTGDQGIEGMAYMDENRN ITFTCPRTPSELINKSSPLE VLGSAACEKLPTPTPQVVKE GDSFPDT in isoform 4. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_04324098 – 99GS → EA in isoform 7. 1 Publication2
Alternative sequenceiVSP_043241100 – 1152Missing in isoform 7. 1 PublicationAdd BLAST1053
Alternative sequenceiVSP_032068152 – 437LVFPS…AEKVA → MSLSDKQTASLTAAYGQLSK GKPAECRMDSPKEISQAGFE WQRTEGKLNEIGLNVSMDGQ PKDGLVKNASFLEQNKLCFF EGKLDKELSIEMQDKDCQEA SGHLESRYVISETCHPLEGN SVHQKTSEFHLGLIEGPDKN KTIPVQGKVAGKNGLETKSQ SDLDFPGAADIPTRYVKEQE TSVWNPSFHPVAQGSLGSRE ATPGEMENSITPGCPVIGVV NDNSEQLKCESPLLVSLAHP APIIEHSPTTIPPITMVFTQ EHLNASCHIRDHDKELEK in isoform 3. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_032069225 – 271EIEMA…ATKTE → NGQEIAPAQISKSLMVDNYT KDGVPGQERPKGPSAVVPST STGG in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_032070275 – 666AKDME…SSETS → PITTAIETVNIHGDHSLKNK AELADSMKNEAGIDEGHVIG ESESVHSGASKHSVEKVTEL AKGHLLPGVPVEDQSLPGEA RALEGYADRGNFPAHPVNEE KETKEGSVAVQIPDLLEDKA QKLSFCEDQNAQDRNSKGSD SLNKKVDLTLLSPKSENDKL KEISLACKITELESVSLPTP EIQSDFLHSKVEAPPSEVAD TLVIMTASKGVRLPEPKDKI LETPQKMTEKSESKTPGEGK KEDKSRMAEPMKGYMRPTKS RGLTPLLPKSTIQEQERHKQ LKSA in isoform 4. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_032071322 – 666WPTET…SSETS → LPEPKDKILETPQKMTEKSE SKTPGEGKKEDKSRMAEPMK GYMRPTKSRGLTPLLPKSTI QEQERHKQLKSA in isoform 5. 1 PublicationAdd BLAST345
Alternative sequenceiVSP_032072441 – 631ETEVA…TVTGT → TEEAVLNQAPQQKKAVRRAL SECSHLSVPPAVNLADKYPE LPAREEPSSGLLPPPSSPMP SPTPGKLGAPAMKRSMTVGE EQTASYKLSPGKLPILSTKE IPPFICEEPVAKKREELAHF SNSSSNSGKKELGTAGLYLH SKLEQIPEGSSKEKGQEDFS ETRIDSCSQVCQRGEKQPGQ TALA in isoform 3. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_003200558 – 730Missing in isoform 2. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_032073635 – 666CSLPA…SSETS → EIEVTATQSTPSFLFEKPPR D in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_032074703 – 716PLATT…TSTSK → VGARMVVIFYCHNF in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_032075717 – 1152Missing in isoform 3. 1 PublicationAdd BLAST436
Alternative sequenceiVSP_032076939 – 953Missing in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_032077954 – 1022Missing in isoform 5. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_0320781088 – 1152TEGGG…QETSI → IETYRLTFRANARARTDHGA DIVSRPPHFPGGPNSGSRVL GPLSRAVH in isoform 6. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_0320791151 – 1152SI → N in isoform 5. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64571 mRNA. Translation: AAA59553.1.
U19727 mRNA. Translation: AAA67361.1.
AK054696 mRNA. Translation: BAB70795.1.
AK125245 mRNA. Translation: BAC86099.1.
AB209377 mRNA. Translation: BAD92614.1. Different initiation.
AC124916 Genomic DNA. No translation available.
AC139667 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64839.1.
BC008715 mRNA. Translation: AAH08715.1.
BC012794 mRNA. Translation: AAH12794.1.
BC015149 mRNA. Translation: AAH15149.1.
BC051843 mRNA. Translation: AAH51843.1.
CR749544 mRNA. Translation: CAH18346.1.
CCDSiCCDS33750.1. [P27816-1]
CCDS46818.1. [P27816-6]
CCDS46821.1. [P27816-7]
PIRiA41206. A33183.
RefSeqiNP_001127836.1. NM_001134364.1. [P27816-6]
NP_002366.2. NM_002375.4. [P27816-1]
NP_112147.2. NM_030885.3. [P27816-7]
UniGeneiHs.517949.

Genome annotation databases

EnsembliENST00000360240; ENSP00000353375; ENSG00000047849. [P27816-1]
ENST00000395734; ENSP00000379083; ENSG00000047849. [P27816-6]
ENST00000434267; ENSP00000402767; ENSG00000047849. [P27816-7]
ENST00000439356; ENSP00000397414; ENSG00000047849. [P27816-7]
GeneIDi4134.
KEGGihsa:4134.
UCSCiuc003csb.3. human. [P27816-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64571 mRNA. Translation: AAA59553.1.
U19727 mRNA. Translation: AAA67361.1.
AK054696 mRNA. Translation: BAB70795.1.
AK125245 mRNA. Translation: BAC86099.1.
AB209377 mRNA. Translation: BAD92614.1. Different initiation.
AC124916 Genomic DNA. No translation available.
AC139667 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64839.1.
BC008715 mRNA. Translation: AAH08715.1.
BC012794 mRNA. Translation: AAH12794.1.
BC015149 mRNA. Translation: AAH15149.1.
BC051843 mRNA. Translation: AAH51843.1.
CR749544 mRNA. Translation: CAH18346.1.
CCDSiCCDS33750.1. [P27816-1]
CCDS46818.1. [P27816-6]
CCDS46821.1. [P27816-7]
PIRiA41206. A33183.
RefSeqiNP_001127836.1. NM_001134364.1. [P27816-6]
NP_002366.2. NM_002375.4. [P27816-1]
NP_112147.2. NM_030885.3. [P27816-7]
UniGeneiHs.517949.

3D structure databases

ProteinModelPortaliP27816.
SMRiP27816.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110306. 60 interactors.
IntActiP27816. 26 interactors.
MINTiMINT-1425668.
STRINGi9606.ENSP00000353375.

Chemistry databases

DrugBankiDB01248. Docetaxel.
DB01229. Paclitaxel.

PTM databases

iPTMnetiP27816.
PhosphoSitePlusiP27816.
SwissPalmiP27816.

Polymorphism and mutation databases

BioMutaiMAP4.
DMDMi269849673.

Proteomic databases

EPDiP27816.
MaxQBiP27816.
PaxDbiP27816.
PeptideAtlasiP27816.
PRIDEiP27816.

Protocols and materials databases

DNASUi4134.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360240; ENSP00000353375; ENSG00000047849. [P27816-1]
ENST00000395734; ENSP00000379083; ENSG00000047849. [P27816-6]
ENST00000434267; ENSP00000402767; ENSG00000047849. [P27816-7]
ENST00000439356; ENSP00000397414; ENSG00000047849. [P27816-7]
GeneIDi4134.
KEGGihsa:4134.
UCSCiuc003csb.3. human. [P27816-1]

Organism-specific databases

CTDi4134.
DisGeNETi4134.
GeneCardsiMAP4.
HGNCiHGNC:6862. MAP4.
HPAiHPA038149.
HPA038150.
MIMi157132. gene.
neXtProtiNX_P27816.
OpenTargetsiENSG00000047849.
PharmGKBiPA30608.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG6M. Eukaryota.
ENOG4111J07. LUCA.
GeneTreeiENSGT00530000063491.
HOGENOMiHOG000139406.
HOVERGENiHBG006323.
InParanoidiP27816.
KOiK10431.
PhylomeDBiP27816.
TreeFamiTF316358.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000047849-MONOMER.
SIGNORiP27816.

Miscellaneous databases

ChiTaRSiMAP4. human.
GeneWikiiMAP4.
GenomeRNAii4134.
PMAP-CutDBP27816.
PROiP27816.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000047849.
CleanExiHS_MAP4.
ExpressionAtlasiP27816. baseline and differential.
GenevisibleiP27816. HS.

Family and domain databases

InterProiIPR027324. MAP2/MAP4/Tau.
IPR027323. MAP4.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 2 hits.
PTHR11501:SF16. PTHR11501:SF16. 2 hits.
PfamiPF00418. Tubulin-binding. 4 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 4 hits.
PS51491. TAU_MAP_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAP4_HUMAN
AccessioniPrimary (citable) accession number: P27816
Secondary accession number(s): Q13082
, Q59FT2, Q68D74, Q6ZUW9, Q86V26, Q96A76, Q96NS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.