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Protein

Killer cell lectin-like receptor subfamily B member 1A

Gene

Klrb1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a stimulatory role on natural killer (NK) cell cytotoxicity.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily B member 1A
Short name:
NKR-P1A
Alternative name(s):
CD161 antigen-like family member A
Lymphocyte antigen 55A
Short name:
Ly-55A
NKR-P1.7
Natural killer cell surface protein P1-2
Short name:
NKR-P1 2
CD_antigen: CD161a
Gene namesi
Name:Klrb1a
Synonyms:Ly55, Ly55a, Nkrp1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107540. Klrb1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini67 – 227ExtracellularSequence analysisAdd BLAST161

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466751 – 227Killer cell lectin-like receptor subfamily B member 1AAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 105PROSITE-ProRule annotation1 Publication
Disulfide bondi122 ↔ 210PROSITE-ProRule annotation1 Publication
Disulfide bondi189 ↔ 202PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP27811.
PRIDEiP27811.

Expressioni

Tissue specificityi

Expressed in natural killer cells.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032512.

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi99 – 101Combined sources3
Beta strandi104 – 108Combined sources5
Helixi115 – 124Combined sources10
Helixi135 – 145Combined sources11
Beta strandi148 – 150Combined sources3
Beta strandi152 – 159Combined sources8
Turni160 – 163Combined sources4
Beta strandi164 – 167Combined sources4
Helixi175 – 178Combined sources4
Beta strandi187 – 193Combined sources7
Beta strandi196 – 201Combined sources6
Beta strandi206 – 213Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M94NMR-A89-227[»]
3M9ZX-ray1.70A89-227[»]
3T3AX-ray2.30A/B89-227[»]
ProteinModelPortaliP27811.
SMRiP27811.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27811.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 212C-type lectinPROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 34LCK-binding motifBy similarity4

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOVERGENiHBG052267.
InParanoidiP27811.
KOiK06543.
PhylomeDBiP27811.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTARVYFGL KPPRTPGAWH ESPPSLPPDA CRCPRSHRLA LKLSCAGLIL
60 70 80 90 100
LVVTLIGMSV LVRVLIQKPS IEKCYVLIQE NLNKTTDCSA KLECPQDWLS
110 120 130 140 150
HRDKCFHVSH VSNTWEEGLV DCDGKGATLM LIQDQEELRF LLDSIKEKYN
160 170 180 190 200
SFWIGLRYTL PDMNWKWING STLNSDVLKI TDDTENDSCA AISGDKVTFE
210 220
SCNSDNRWIC QKELYHETLS NYVGYGH
Length:227
Mass (Da):25,782
Last modified:January 9, 2007 - v2
Checksum:iB8283253E076C673
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39L → S in AAA39822 (PubMed:1880421).Curated1
Sequence conflicti39L → S in CAA45971 (PubMed:1517565).Curated1
Sequence conflicti56I → T in CAA45976 (PubMed:1517565).Curated1
Sequence conflicti110H → Q in AAA39822 (PubMed:1880421).Curated1
Sequence conflicti110H → Q in AAA39366 (PubMed:1680927).Curated1
Sequence conflicti110H → Q in AAK39102 (PubMed:10229823).Curated1
Sequence conflicti110H → Q in AAK83003 (PubMed:11685472).Curated1
Sequence conflicti110H → Q in AAI20708 (PubMed:15489334).Curated1
Sequence conflicti117E → K in AAK39101 (PubMed:10229823).Curated1
Sequence conflicti168I → L in CAA45976 (PubMed:1517565).Curated1
Sequence conflicti182D → G in AAA39822 (PubMed:1880421).Curated1
Sequence conflicti182D → G in AAA39366 (PubMed:1680927).Curated1
Sequence conflicti182D → G in AAK39102 (PubMed:10229823).Curated1
Sequence conflicti182D → G in AAK83003 (PubMed:11685472).Curated1
Sequence conflicti182D → G in AAI20708 (PubMed:15489334).Curated1
Sequence conflicti217E → D in AAK39101 (PubMed:10229823).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77676 mRNA. Translation: AAA39822.1.
M77753 mRNA. Translation: AAA39366.1.
X64716
, X64717, X64718, X64724 Genomic DNA. Translation: CAA45971.1.
X64723 mRNA. Translation: CAA45976.1.
AF354261 mRNA. Translation: AAK39101.1.
AF354262 mRNA. Translation: AAK39102.1.
AF285840, AF285839 Genomic DNA. Translation: AAK83003.1.
DQ143102 Genomic DNA. Translation: ABA43353.1.
DQ237927 mRNA. Translation: ABB72025.1.
BC120707 mRNA. Translation: AAI20708.1.
PIRiA46467.
RefSeqiNP_001153374.1. NM_001159902.1.
NP_034867.3. NM_010737.3.
UniGeneiMm.16729.

Genome annotation databases

GeneIDi17057.
KEGGimmu:17057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77676 mRNA. Translation: AAA39822.1.
M77753 mRNA. Translation: AAA39366.1.
X64716
, X64717, X64718, X64724 Genomic DNA. Translation: CAA45971.1.
X64723 mRNA. Translation: CAA45976.1.
AF354261 mRNA. Translation: AAK39101.1.
AF354262 mRNA. Translation: AAK39102.1.
AF285840, AF285839 Genomic DNA. Translation: AAK83003.1.
DQ143102 Genomic DNA. Translation: ABA43353.1.
DQ237927 mRNA. Translation: ABB72025.1.
BC120707 mRNA. Translation: AAI20708.1.
PIRiA46467.
RefSeqiNP_001153374.1. NM_001159902.1.
NP_034867.3. NM_010737.3.
UniGeneiMm.16729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M94NMR-A89-227[»]
3M9ZX-ray1.70A89-227[»]
3T3AX-ray2.30A/B89-227[»]
ProteinModelPortaliP27811.
SMRiP27811.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032512.

Proteomic databases

PaxDbiP27811.
PRIDEiP27811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17057.
KEGGimmu:17057.

Organism-specific databases

CTDi17057.
MGIiMGI:107540. Klrb1a.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOVERGENiHBG052267.
InParanoidiP27811.
KOiK06543.
PhylomeDBiP27811.

Miscellaneous databases

EvolutionaryTraceiP27811.
PROiP27811.
SOURCEiSearch...

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLRBA_MOUSE
AccessioniPrimary (citable) accession number: P27811
Secondary accession number(s): Q1AG01
, Q1WJB8, Q61972, Q61973, Q91V25, Q925G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.