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P27798

- CALR_CAEEL

UniProt

P27798 - CALR_CAEEL

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Protein

Calreticulin

Gene

crt-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051CarbohydrateBy similarity
Binding sitei107 – 1071CarbohydrateBy similarity
Binding sitei124 – 1241CarbohydrateBy similarity
Binding sitei131 – 1311CarbohydrateBy similarity
Binding sitei312 – 3121CarbohydrateBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: WormBase
  2. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. defecation Source: WormBase
  2. endoplasmic reticulum unfolded protein response Source: WormBase
  3. hemidesmosome assembly Source: WormBase
  4. multicellular organismal reproductive process Source: WormBase
  5. programmed cell death Source: WormBase
  6. protein folding Source: InterPro
  7. response to ethanol Source: WormBase
  8. response to heat Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Calcium, Lectin, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_183107. Calnexin/calreticulin cycle.
REACT_222921. Scavenging by Class F Receptors.
REACT_34502. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Calreticulin
Gene namesi
Name:crt-1
ORF Names:Y38A10A.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiY38A10A.5; CE21562; WBGene00000802; crt-1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 395380CalreticulinPRO_0000004180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi101 ↔ 133By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP27798.

2D gel databases

World-2DPAGE0020:P27798.

Interactioni

Protein-protein interaction databases

BioGridi44045. 7 interactions.
DIPiDIP-25701N.
IntActiP27798. 4 interactions.
MINTiMINT-226928.
STRINGi6239.Y38A10A.5.1.

Structurei

3D structure databases

ProteinModelPortaliP27798.
SMRiP27798. Positions 17-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati186 – 197121-1Add
BLAST
Repeati205 – 216121-2Add
BLAST
Repeati222 – 233121-3Add
BLAST
Repeati239 – 250121-4Add
BLAST
Repeati254 – 264112-1Add
BLAST
Repeati268 – 278112-2Add
BLAST
Repeati282 – 292112-3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni? – 192N-domain
Regioni186 – 250654 X approximate repeatsAdd
BLAST
Regioni193 – 301109P-domainAdd
BLAST
Regioni254 – 292393 X approximate repeatsAdd
BLAST
Regioni302 – 39594C-domainAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi392 – 3954Prevents secretion from ERPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi332 – 39059Asp/Glu/Lys-richAdd
BLAST

Domaini

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).By similarity
The interaction with glycans occurs through a binding site in the globular lectin domain.By similarity
The zinc binding sites are localized to the N-domain.By similarity

Sequence similaritiesi

Belongs to the calreticulin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG305105.
GeneTreeiENSGT00430000030841.
HOGENOMiHOG000192435.
InParanoidiP27798.
KOiK08057.
OMAiVKLFPDG.
OrthoDBiEOG77126Z.
PhylomeDBiP27798.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFiPIRSF002356. Calreticulin. 1 hit.
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27798 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSLCLLAIV AVVSAEVYFK EEFNDASWEK RWVQSKHKDD FGAFKLSAGK
60 70 80 90 100
FFDVESRDQG IQTSQDAKFY SRAAKFDKDF SNKGKTLVIQ YTVKHEQGID
110 120 130 140 150
CGGGYVKVMR ADADLGDFHG ETPYNVMFGP DICGPTRRVH VILNYKGENK
160 170 180 190 200
LIKKEITCKS DELTHLYTLI LNSDNTYEVK IDGESAQTGS LEEDWDLLPA
210 220 230 240 250
KKIKDPDAKK PEDWDEREYI DDAEDAKPED WEKPEHIPDP DAKKPEDWDD
260 270 280 290 300
EMDGEWEPPM IDNPEYKGEW KPKQIKNPAY KGKWIHPEIE NPEYTPDDEL
310 320 330 340 350
YSYESWGAIG FDLWQVKSGT IFDNIIITDS VEEAEAHAAE TFDKLKTVEK
360 370 380 390
EKKEKADEET RKAEEEARKK AEEEKEAKKD DDEEEKEEEE GHDEL
Length:395
Mass (Da):45,616
Last modified:August 1, 1992 - v1
Checksum:i35CA7D2EC1D56B03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59589 Genomic DNA. Translation: CAA42159.1.
FO081168 Genomic DNA. Translation: CCD69629.1.
PIRiS25851.
RefSeqiNP_504575.1. NM_072174.3.
UniGeneiCel.4918.

Genome annotation databases

EnsemblMetazoaiY38A10A.5.1; Y38A10A.5.1; WBGene00000802.
Y38A10A.5.2; Y38A10A.5.2; WBGene00000802.
GeneIDi178997.
KEGGicel:CELE_Y38A10A.5.
UCSCiY38A10A.5.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59589 Genomic DNA. Translation: CAA42159.1 .
FO081168 Genomic DNA. Translation: CCD69629.1 .
PIRi S25851.
RefSeqi NP_504575.1. NM_072174.3.
UniGenei Cel.4918.

3D structure databases

ProteinModelPortali P27798.
SMRi P27798. Positions 17-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44045. 7 interactions.
DIPi DIP-25701N.
IntActi P27798. 4 interactions.
MINTi MINT-226928.
STRINGi 6239.Y38A10A.5.1.

2D gel databases

World-2DPAGE 0020:P27798.

Proteomic databases

PaxDbi P27798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y38A10A.5.1 ; Y38A10A.5.1 ; WBGene00000802 .
Y38A10A.5.2 ; Y38A10A.5.2 ; WBGene00000802 .
GeneIDi 178997.
KEGGi cel:CELE_Y38A10A.5.
UCSCi Y38A10A.5.1. c. elegans.

Organism-specific databases

CTDi 178997.
WormBasei Y38A10A.5 ; CE21562 ; WBGene00000802 ; crt-1.

Phylogenomic databases

eggNOGi NOG305105.
GeneTreei ENSGT00430000030841.
HOGENOMi HOG000192435.
InParanoidi P27798.
KOi K08057.
OMAi VKLFPDG.
OrthoDBi EOG77126Z.
PhylomeDBi P27798.

Enzyme and pathway databases

Reactomei REACT_183107. Calnexin/calreticulin cycle.
REACT_222921. Scavenging by Class F Receptors.
REACT_34502. ATF6-alpha activates chaperone genes.

Miscellaneous databases

NextBioi 903464.
PROi P27798.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR013320. ConA-like_dom.
[Graphical view ]
PANTHERi PTHR11073. PTHR11073. 1 hit.
Pfami PF00262. Calreticulin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002356. Calreticulin. 1 hit.
PRINTSi PR00626. CALRETICULIN.
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEi PS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A C. elegans gene encodes a protein homologous to mammalian calreticulin."
    Smith M.J.
    DNA Seq. 2:235-240(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCALR_CAEEL
AccessioniPrimary (citable) accession number: P27798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3