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P27798 (CALR_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calreticulin
Gene names
Name:crt-1
ORF Names:Y38A10A.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen.

Domain

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.

The interaction with glycans occurs through a binding site in the globular lectin domain By similarity.

The zinc binding sites are localized to the N-domain By similarity.

Sequence similarities

Belongs to the calreticulin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 395380Calreticulin
PRO_0000004180

Regions

Repeat186 – 197121-1
Repeat205 – 216121-2
Repeat222 – 233121-3
Repeat239 – 250121-4
Repeat254 – 264112-1
Repeat268 – 278112-2
Repeat282 – 292112-3
Region186 – 250654 X approximate repeats
Region? – 192N-domain
Region193 – 301109P-domain
Region254 – 292393 X approximate repeats
Region302 – 39594C-domain
Motif392 – 3954Prevents secretion from ER By similarity
Compositional bias332 – 39059Asp/Glu/Lys-rich

Sites

Binding site1051Carbohydrate By similarity
Binding site1071Carbohydrate By similarity
Binding site1241Carbohydrate By similarity
Binding site1311Carbohydrate By similarity
Binding site3121Carbohydrate By similarity

Amino acid modifications

Disulfide bond101 ↔ 133 By similarity

Sequences

Sequence LengthMass (Da)Tools
P27798 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 35CA7D2EC1D56B03

FASTA39545,616
        10         20         30         40         50         60 
MKSLCLLAIV AVVSAEVYFK EEFNDASWEK RWVQSKHKDD FGAFKLSAGK FFDVESRDQG 

        70         80         90        100        110        120 
IQTSQDAKFY SRAAKFDKDF SNKGKTLVIQ YTVKHEQGID CGGGYVKVMR ADADLGDFHG 

       130        140        150        160        170        180 
ETPYNVMFGP DICGPTRRVH VILNYKGENK LIKKEITCKS DELTHLYTLI LNSDNTYEVK 

       190        200        210        220        230        240 
IDGESAQTGS LEEDWDLLPA KKIKDPDAKK PEDWDEREYI DDAEDAKPED WEKPEHIPDP 

       250        260        270        280        290        300 
DAKKPEDWDD EMDGEWEPPM IDNPEYKGEW KPKQIKNPAY KGKWIHPEIE NPEYTPDDEL 

       310        320        330        340        350        360 
YSYESWGAIG FDLWQVKSGT IFDNIIITDS VEEAEAHAAE TFDKLKTVEK EKKEKADEET 

       370        380        390 
RKAEEEARKK AEEEKEAKKD DDEEEKEEEE GHDEL 

« Hide

References

« Hide 'large scale' references
[1]"A C. elegans gene encodes a protein homologous to mammalian calreticulin."
Smith M.J.
DNA Seq. 2:235-240(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59589 Genomic DNA. Translation: CAA42159.1.
FO081168 Genomic DNA. Translation: CCD69629.1.
PIRS25851.
RefSeqNP_504575.1. NM_072174.3.
UniGeneCel.4918.

3D structure databases

ProteinModelPortalP27798.
SMRP27798. Positions 17-361.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44045. 7 interactions.
DIPDIP-25701N.
IntActP27798. 4 interactions.
MINTMINT-226928.
STRING6239.Y38A10A.5.1.

2D gel databases

World-2DPAGE0020:P27798.

Proteomic databases

PaxDbP27798.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaY38A10A.5.1; Y38A10A.5.1; WBGene00000802.
Y38A10A.5.2; Y38A10A.5.2; WBGene00000802.
GeneID178997.
KEGGcel:CELE_Y38A10A.5.
UCSCY38A10A.5.1. c. elegans.

Organism-specific databases

CTD178997.
WormBaseY38A10A.5; CE21562; WBGene00000802; crt-1.

Phylogenomic databases

eggNOGNOG305105.
GeneTreeENSGT00430000030841.
HOGENOMHOG000192435.
InParanoidP27798.
KOK08057.
OMAVKLFPDG.
OrthoDBEOG77126Z.
PhylomeDBP27798.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PANTHERPTHR11073. PTHR11073. 1 hit.
PfamPF00262. Calreticulin. 1 hit.
[Graphical view]
PIRSFPIRSF002356. Calreticulin. 1 hit.
PRINTSPR00626. CALRETICULIN.
SUPFAMSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEPS00803. CALRETICULIN_1. 1 hit.
PS00804. CALRETICULIN_2. 1 hit.
PS00805. CALRETICULIN_REPEAT. 3 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio903464.
PROP27798.

Entry information

Entry nameCALR_CAEEL
AccessionPrimary (citable) accession number: P27798
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 11, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase