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P27798

- CALR_CAEEL

UniProt

P27798 - CALR_CAEEL

Protein

Calreticulin

Gene

crt-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei105 – 1051CarbohydrateBy similarity
    Binding sitei107 – 1071CarbohydrateBy similarity
    Binding sitei124 – 1241CarbohydrateBy similarity
    Binding sitei131 – 1311CarbohydrateBy similarity
    Binding sitei312 – 3121CarbohydrateBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: WormBase

    GO - Biological processi

    1. defecation Source: WormBase
    2. endoplasmic reticulum unfolded protein response Source: WormBase
    3. hemidesmosome assembly Source: WormBase
    4. multicellular organismal reproductive process Source: WormBase
    5. programmed cell death Source: WormBase
    6. protein folding Source: InterPro
    7. response to ethanol Source: WormBase
    8. response to heat Source: WormBase

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    Calcium, Lectin, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_183107. Calnexin/calreticulin cycle.
    REACT_222921. Scavenging by Class F Receptors.
    REACT_34502. ATF6-alpha activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calreticulin
    Gene namesi
    Name:crt-1
    ORF Names:Y38A10A.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiY38A10A.5; CE21562; WBGene00000802; crt-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 395380CalreticulinPRO_0000004180Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi101 ↔ 133By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP27798.

    2D gel databases

    World-2DPAGE0020:P27798.

    Interactioni

    Protein-protein interaction databases

    BioGridi44045. 7 interactions.
    DIPiDIP-25701N.
    IntActiP27798. 4 interactions.
    MINTiMINT-226928.
    STRINGi6239.Y38A10A.5.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP27798.
    SMRiP27798. Positions 17-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati186 – 197121-1Add
    BLAST
    Repeati205 – 216121-2Add
    BLAST
    Repeati222 – 233121-3Add
    BLAST
    Repeati239 – 250121-4Add
    BLAST
    Repeati254 – 264112-1Add
    BLAST
    Repeati268 – 278112-2Add
    BLAST
    Repeati282 – 292112-3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni? – 192N-domain
    Regioni186 – 250654 X approximate repeatsAdd
    BLAST
    Regioni193 – 301109P-domainAdd
    BLAST
    Regioni254 – 292393 X approximate repeatsAdd
    BLAST
    Regioni302 – 39594C-domainAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi392 – 3954Prevents secretion from ERPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi332 – 39059Asp/Glu/Lys-richAdd
    BLAST

    Domaini

    Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity By similarity.By similarity
    The interaction with glycans occurs through a binding site in the globular lectin domain.By similarity
    The zinc binding sites are localized to the N-domain.By similarity

    Sequence similaritiesi

    Belongs to the calreticulin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG305105.
    GeneTreeiENSGT00430000030841.
    HOGENOMiHOG000192435.
    InParanoidiP27798.
    KOiK08057.
    OMAiVKLFPDG.
    OrthoDBiEOG77126Z.
    PhylomeDBiP27798.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR001580. Calret/calnex.
    IPR018124. Calret/calnex_CS.
    IPR009169. Calreticulin.
    IPR009033. Calreticulin/calnexin_P_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view]
    PANTHERiPTHR11073. PTHR11073. 1 hit.
    PfamiPF00262. Calreticulin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002356. Calreticulin. 1 hit.
    PRINTSiPR00626. CALRETICULIN.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF63887. SSF63887. 1 hit.
    PROSITEiPS00803. CALRETICULIN_1. 1 hit.
    PS00804. CALRETICULIN_2. 1 hit.
    PS00805. CALRETICULIN_REPEAT. 3 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27798-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLCLLAIV AVVSAEVYFK EEFNDASWEK RWVQSKHKDD FGAFKLSAGK    50
    FFDVESRDQG IQTSQDAKFY SRAAKFDKDF SNKGKTLVIQ YTVKHEQGID 100
    CGGGYVKVMR ADADLGDFHG ETPYNVMFGP DICGPTRRVH VILNYKGENK 150
    LIKKEITCKS DELTHLYTLI LNSDNTYEVK IDGESAQTGS LEEDWDLLPA 200
    KKIKDPDAKK PEDWDEREYI DDAEDAKPED WEKPEHIPDP DAKKPEDWDD 250
    EMDGEWEPPM IDNPEYKGEW KPKQIKNPAY KGKWIHPEIE NPEYTPDDEL 300
    YSYESWGAIG FDLWQVKSGT IFDNIIITDS VEEAEAHAAE TFDKLKTVEK 350
    EKKEKADEET RKAEEEARKK AEEEKEAKKD DDEEEKEEEE GHDEL 395
    Length:395
    Mass (Da):45,616
    Last modified:August 1, 1992 - v1
    Checksum:i35CA7D2EC1D56B03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59589 Genomic DNA. Translation: CAA42159.1.
    FO081168 Genomic DNA. Translation: CCD69629.1.
    PIRiS25851.
    RefSeqiNP_504575.1. NM_072174.3.
    UniGeneiCel.4918.

    Genome annotation databases

    EnsemblMetazoaiY38A10A.5.1; Y38A10A.5.1; WBGene00000802.
    Y38A10A.5.2; Y38A10A.5.2; WBGene00000802.
    GeneIDi178997.
    KEGGicel:CELE_Y38A10A.5.
    UCSCiY38A10A.5.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59589 Genomic DNA. Translation: CAA42159.1 .
    FO081168 Genomic DNA. Translation: CCD69629.1 .
    PIRi S25851.
    RefSeqi NP_504575.1. NM_072174.3.
    UniGenei Cel.4918.

    3D structure databases

    ProteinModelPortali P27798.
    SMRi P27798. Positions 17-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44045. 7 interactions.
    DIPi DIP-25701N.
    IntActi P27798. 4 interactions.
    MINTi MINT-226928.
    STRINGi 6239.Y38A10A.5.1.

    2D gel databases

    World-2DPAGE 0020:P27798.

    Proteomic databases

    PaxDbi P27798.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y38A10A.5.1 ; Y38A10A.5.1 ; WBGene00000802 .
    Y38A10A.5.2 ; Y38A10A.5.2 ; WBGene00000802 .
    GeneIDi 178997.
    KEGGi cel:CELE_Y38A10A.5.
    UCSCi Y38A10A.5.1. c. elegans.

    Organism-specific databases

    CTDi 178997.
    WormBasei Y38A10A.5 ; CE21562 ; WBGene00000802 ; crt-1.

    Phylogenomic databases

    eggNOGi NOG305105.
    GeneTreei ENSGT00430000030841.
    HOGENOMi HOG000192435.
    InParanoidi P27798.
    KOi K08057.
    OMAi VKLFPDG.
    OrthoDBi EOG77126Z.
    PhylomeDBi P27798.

    Enzyme and pathway databases

    Reactomei REACT_183107. Calnexin/calreticulin cycle.
    REACT_222921. Scavenging by Class F Receptors.
    REACT_34502. ATF6-alpha activates chaperone genes.

    Miscellaneous databases

    NextBioi 903464.
    PROi P27798.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR001580. Calret/calnex.
    IPR018124. Calret/calnex_CS.
    IPR009169. Calreticulin.
    IPR009033. Calreticulin/calnexin_P_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    [Graphical view ]
    PANTHERi PTHR11073. PTHR11073. 1 hit.
    Pfami PF00262. Calreticulin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002356. Calreticulin. 1 hit.
    PRINTSi PR00626. CALRETICULIN.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF63887. SSF63887. 1 hit.
    PROSITEi PS00803. CALRETICULIN_1. 1 hit.
    PS00804. CALRETICULIN_2. 1 hit.
    PS00805. CALRETICULIN_REPEAT. 3 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A C. elegans gene encodes a protein homologous to mammalian calreticulin."
      Smith M.J.
      DNA Seq. 2:235-240(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiCALR_CAEEL
    AccessioniPrimary (citable) accession number: P27798
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3