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Protein

Protein lyl-1

Gene

Lyl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • B cell differentiation Source: UniProtKB
  • blood vessel maturation Source: UniProtKB
  • definitive hemopoiesis Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lyl-1
Alternative name(s):
Lymphoblastic leukemia-derived sequence 1
Gene namesi
Name:Lyl1
Synonyms:Lyl-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96891. Lyl1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272631 – 278Protein lyl-1Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP27792.
PeptideAtlasiP27792.
PRIDEiP27792.

PTM databases

iPTMnetiP27792.
PhosphoSitePlusiP27792.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034041.
CleanExiMM_LYL1.
GenevisibleiP27792. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046010.

Structurei

3D structure databases

ProteinModelPortaliP27792.
SMRiP27792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 201bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG094957.
InParanoidiP27792.
KOiK15604.
OMAiIKMEQTA.
OrthoDBiEOG091G0ESI.
PhylomeDBiP27792.
TreeFamiTF315153.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

P27792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT
60 70 80 90 100
CTPWLPPGVP VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA
110 120 130 140 150
VHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHSELDLA DGHQPQKVAR
160 170 180 190 200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF
210 220 230 240 250
LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH RVEAARSQPV
260 270
LPGDCDGDPN GSVRPIKLEQ TSLSPEVR
Length:278
Mass (Da):30,142
Last modified:April 14, 2009 - v2
Checksum:i83582AAF03C1C832
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → G in CAA40870 (PubMed:2000219).Curated1
Sequence conflicti7R → G in CAJ18375 (Ref. 3) Curated1
Sequence conflicti7R → G in EDL10953 (Ref. 6) Curated1
Sequence conflicti7R → G in AAH05736 (PubMed:15489334).Curated1
Sequence conflicti34P → L in CAA40870 (PubMed:2000219).Curated1
Sequence conflicti34P → L in EDL10953 (Ref. 6) Curated1
Sequence conflicti34P → L in AAH05736 (PubMed:15489334).Curated1
Sequence conflicti111S → R in CAA38896 (PubMed:2067848).Curated1
Sequence conflicti239G → E in CAA40870 (PubMed:2000219).Curated1
Sequence conflicti239G → E in EDL10953 (Ref. 6) Curated1
Sequence conflicti239G → E in AAH05736 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57687 mRNA. Translation: CAA40870.1.
X55055 Genomic DNA. Translation: CAA38896.1.
CT010167 mRNA. Translation: CAJ18375.1.
AK076114 mRNA. Translation: BAC36194.1.
AC145556 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL10953.1.
BC005736 mRNA. Translation: AAH05736.1.
CCDSiCCDS22476.1.
PIRiS16678.
RefSeqiNP_032561.2. NM_008535.2.
XP_006530807.1. XM_006530744.2.
UniGeneiMm.4925.

Genome annotation databases

EnsembliENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041.
GeneIDi17095.
KEGGimmu:17095.
UCSCiuc009mnb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57687 mRNA. Translation: CAA40870.1.
X55055 Genomic DNA. Translation: CAA38896.1.
CT010167 mRNA. Translation: CAJ18375.1.
AK076114 mRNA. Translation: BAC36194.1.
AC145556 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL10953.1.
BC005736 mRNA. Translation: AAH05736.1.
CCDSiCCDS22476.1.
PIRiS16678.
RefSeqiNP_032561.2. NM_008535.2.
XP_006530807.1. XM_006530744.2.
UniGeneiMm.4925.

3D structure databases

ProteinModelPortaliP27792.
SMRiP27792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046010.

PTM databases

iPTMnetiP27792.
PhosphoSitePlusiP27792.

Proteomic databases

PaxDbiP27792.
PeptideAtlasiP27792.
PRIDEiP27792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041.
GeneIDi17095.
KEGGimmu:17095.
UCSCiuc009mnb.1. mouse.

Organism-specific databases

CTDi4066.
MGIiMGI:96891. Lyl1.

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG094957.
InParanoidiP27792.
KOiK15604.
OMAiIKMEQTA.
OrthoDBiEOG091G0ESI.
PhylomeDBiP27792.
TreeFamiTF315153.

Miscellaneous databases

PROiPR:P27792.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034041.
CleanExiMM_LYL1.
GenevisibleiP27792. MM.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLYL1_MOUSE
AccessioniPrimary (citable) accession number: P27792
Secondary accession number(s): Q4FK84, Q8BPE2, Q923F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 14, 2009
Last modified: May 10, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.