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Protein

Protein lyl-1

Gene

Lyl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB

GO - Biological processi

  1. B cell differentiation Source: UniProtKB
  2. blood vessel maturation Source: UniProtKB
  3. definitive hemopoiesis Source: UniProtKB
  4. positive regulation of transcription, DNA-templated Source: UniProtKB
  5. regulation of transcription, DNA-templated Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lyl-1
Alternative name(s):
Lymphoblastic leukemia-derived sequence 1
Gene namesi
Name:Lyl1
Synonyms:Lyl-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96891. Lyl1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Protein lyl-1PRO_0000127263Add
BLAST

Proteomic databases

PRIDEiP27792.

PTM databases

PhosphoSiteiP27792.

Expressioni

Gene expression databases

BgeeiP27792.
CleanExiMM_LYL1.
GenevestigatoriP27792.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Structurei

3D structure databases

ProteinModelPortaliP27792.
SMRiP27792. Positions 147-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 20153bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG307510.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG094957.
InParanoidiP27792.
KOiK15604.
OMAiIKMEQTA.
OrthoDBiEOG7SN8DF.
PhylomeDBiP27792.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT
60 70 80 90 100
CTPWLPPGVP VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA
110 120 130 140 150
VHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHSELDLA DGHQPQKVAR
160 170 180 190 200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF
210 220 230 240 250
LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH RVEAARSQPV
260 270
LPGDCDGDPN GSVRPIKLEQ TSLSPEVR
Length:278
Mass (Da):30,142
Last modified:April 14, 2009 - v2
Checksum:i83582AAF03C1C832
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71R → G in CAA40870 (PubMed:2000219).Curated
Sequence conflicti7 – 71R → G in CAJ18375 (Ref. 3) Curated
Sequence conflicti7 – 71R → G in EDL10953 (Ref. 6) Curated
Sequence conflicti7 – 71R → G in AAH05736 (PubMed:15489334).Curated
Sequence conflicti34 – 341P → L in CAA40870 (PubMed:2000219).Curated
Sequence conflicti34 – 341P → L in EDL10953 (Ref. 6) Curated
Sequence conflicti34 – 341P → L in AAH05736 (PubMed:15489334).Curated
Sequence conflicti111 – 1111S → R in CAA38896 (PubMed:2067848).Curated
Sequence conflicti239 – 2391G → E in CAA40870 (PubMed:2000219).Curated
Sequence conflicti239 – 2391G → E in EDL10953 (Ref. 6) Curated
Sequence conflicti239 – 2391G → E in AAH05736 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57687 mRNA. Translation: CAA40870.1.
X55055 Genomic DNA. Translation: CAA38896.1.
CT010167 mRNA. Translation: CAJ18375.1.
AK076114 mRNA. Translation: BAC36194.1.
AC145556 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL10953.1.
BC005736 mRNA. Translation: AAH05736.1.
CCDSiCCDS22476.1.
PIRiS16678.
RefSeqiNP_032561.2. NM_008535.2.
XP_006530807.1. XM_006530744.2.
UniGeneiMm.4925.

Genome annotation databases

EnsembliENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041.
GeneIDi17095.
KEGGimmu:17095.
UCSCiuc009mnb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57687 mRNA. Translation: CAA40870.1.
X55055 Genomic DNA. Translation: CAA38896.1.
CT010167 mRNA. Translation: CAJ18375.1.
AK076114 mRNA. Translation: BAC36194.1.
AC145556 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL10953.1.
BC005736 mRNA. Translation: AAH05736.1.
CCDSiCCDS22476.1.
PIRiS16678.
RefSeqiNP_032561.2. NM_008535.2.
XP_006530807.1. XM_006530744.2.
UniGeneiMm.4925.

3D structure databases

ProteinModelPortaliP27792.
SMRiP27792. Positions 147-208.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP27792.

Proteomic databases

PRIDEiP27792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041.
GeneIDi17095.
KEGGimmu:17095.
UCSCiuc009mnb.1. mouse.

Organism-specific databases

CTDi4066.
MGIiMGI:96891. Lyl1.

Phylogenomic databases

eggNOGiNOG307510.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG094957.
InParanoidiP27792.
KOiK15604.
OMAiIKMEQTA.
OrthoDBiEOG7SN8DF.
PhylomeDBiP27792.
TreeFamiTF315153.

Miscellaneous databases

NextBioi291236.
PROiP27792.
SOURCEiSearch...

Gene expression databases

BgeeiP27792.
CleanExiMM_LYL1.
GenevestigatoriP27792.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system."
    Visvader J., Begley C.G., Adams J.M.
    Oncogene 6:187-194(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene."
    Kuo S.S., Mellentin J.D., Copeland N.G., Gilbert D.J., Jenkins N.A., Cleary M.L.
    Oncogene 6:961-968(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BIOA.
    Tissue: Liver.
  3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiLYL1_MOUSE
AccessioniPrimary (citable) accession number: P27792
Secondary accession number(s): Q4FK84, Q8BPE2, Q923F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 14, 2009
Last modified: April 1, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.