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P27792

- LYL1_MOUSE

UniProt

P27792 - LYL1_MOUSE

Protein

Protein lyl-1

Gene

Lyl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB

    GO - Biological processi

    1. B cell differentiation Source: UniProtKB
    2. blood vessel maturation Source: UniProtKB
    3. definitive hemopoiesis Source: UniProtKB
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. regulation of transcription, DNA-templated Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lyl-1
    Alternative name(s):
    Lymphoblastic leukemia-derived sequence 1
    Gene namesi
    Name:Lyl1
    Synonyms:Lyl-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:96891. Lyl1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Protein lyl-1PRO_0000127263Add
    BLAST

    Proteomic databases

    PRIDEiP27792.

    PTM databases

    PhosphoSiteiP27792.

    Expressioni

    Gene expression databases

    BgeeiP27792.
    CleanExiMM_LYL1.
    GenevestigatoriP27792.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Structurei

    3D structure databases

    ProteinModelPortaliP27792.
    SMRiP27792. Positions 147-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini149 – 20153bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG307510.
    GeneTreeiENSGT00730000110586.
    HOGENOMiHOG000113414.
    HOVERGENiHBG094957.
    InParanoidiQ4FK84.
    KOiK15604.
    OMAiIKMEQTA.
    OrthoDBiEOG7SN8DF.
    PhylomeDBiP27792.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27792-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT    50
    CTPWLPPGVP VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA 100
    VHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHSELDLA DGHQPQKVAR 150
    RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF 200
    LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH RVEAARSQPV 250
    LPGDCDGDPN GSVRPIKLEQ TSLSPEVR 278
    Length:278
    Mass (Da):30,142
    Last modified:April 14, 2009 - v2
    Checksum:i83582AAF03C1C832
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71R → G in CAA40870. (PubMed:2000219)Curated
    Sequence conflicti7 – 71R → G in CAJ18375. 1 PublicationCurated
    Sequence conflicti7 – 71R → G in EDL10953. 1 PublicationCurated
    Sequence conflicti7 – 71R → G in AAH05736. (PubMed:15489334)Curated
    Sequence conflicti34 – 341P → L in CAA40870. (PubMed:2000219)Curated
    Sequence conflicti34 – 341P → L in EDL10953. 1 PublicationCurated
    Sequence conflicti34 – 341P → L in AAH05736. (PubMed:15489334)Curated
    Sequence conflicti111 – 1111S → R in CAA38896. (PubMed:2067848)Curated
    Sequence conflicti239 – 2391G → E in CAA40870. (PubMed:2000219)Curated
    Sequence conflicti239 – 2391G → E in EDL10953. 1 PublicationCurated
    Sequence conflicti239 – 2391G → E in AAH05736. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57687 mRNA. Translation: CAA40870.1.
    X55055 Genomic DNA. Translation: CAA38896.1.
    CT010167 mRNA. Translation: CAJ18375.1.
    AK076114 mRNA. Translation: BAC36194.1.
    AC145556 Genomic DNA. No translation available.
    CH466525 Genomic DNA. Translation: EDL10953.1.
    BC005736 mRNA. Translation: AAH05736.1.
    CCDSiCCDS22476.1.
    PIRiS16678.
    RefSeqiNP_032561.2. NM_008535.2.
    XP_006530807.1. XM_006530744.1.
    UniGeneiMm.4925.

    Genome annotation databases

    EnsembliENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041.
    GeneIDi17095.
    KEGGimmu:17095.
    UCSCiuc009mnb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57687 mRNA. Translation: CAA40870.1 .
    X55055 Genomic DNA. Translation: CAA38896.1 .
    CT010167 mRNA. Translation: CAJ18375.1 .
    AK076114 mRNA. Translation: BAC36194.1 .
    AC145556 Genomic DNA. No translation available.
    CH466525 Genomic DNA. Translation: EDL10953.1 .
    BC005736 mRNA. Translation: AAH05736.1 .
    CCDSi CCDS22476.1.
    PIRi S16678.
    RefSeqi NP_032561.2. NM_008535.2.
    XP_006530807.1. XM_006530744.1.
    UniGenei Mm.4925.

    3D structure databases

    ProteinModelPortali P27792.
    SMRi P27792. Positions 147-208.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P27792.

    Proteomic databases

    PRIDEi P27792.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037165 ; ENSMUSP00000046010 ; ENSMUSG00000034041 .
    GeneIDi 17095.
    KEGGi mmu:17095.
    UCSCi uc009mnb.1. mouse.

    Organism-specific databases

    CTDi 4066.
    MGIi MGI:96891. Lyl1.

    Phylogenomic databases

    eggNOGi NOG307510.
    GeneTreei ENSGT00730000110586.
    HOGENOMi HOG000113414.
    HOVERGENi HBG094957.
    InParanoidi Q4FK84.
    KOi K15604.
    OMAi IKMEQTA.
    OrthoDBi EOG7SN8DF.
    PhylomeDBi P27792.
    TreeFami TF315153.

    Miscellaneous databases

    NextBioi 291236.
    PROi P27792.
    SOURCEi Search...

    Gene expression databases

    Bgeei P27792.
    CleanExi MM_LYL1.
    Genevestigatori P27792.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system."
      Visvader J., Begley C.G., Adams J.M.
      Oncogene 6:187-194(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene."
      Kuo S.S., Mellentin J.D., Copeland N.G., Gilbert D.J., Jenkins N.A., Cleary M.L.
      Oncogene 6:961-968(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BIOA.
      Tissue: Liver.
    3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiLYL1_MOUSE
    AccessioniPrimary (citable) accession number: P27792
    Secondary accession number(s): Q4FK84, Q8BPE2, Q923F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3