Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P27792 (LYL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein lyl-1
Alternative name(s):
Lymphoblastic leukemia-derived sequence 1
Gene names
Name:Lyl1
Synonyms:Lyl-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Protein lyl-1
PRO_0000127263

Regions

Domain149 – 20153bHLH

Experimental info

Sequence conflict71R → G in CAA40870. Ref.1
Sequence conflict71R → G in CAJ18375. Ref.3
Sequence conflict71R → G in EDL10953. Ref.6
Sequence conflict71R → G in AAH05736. Ref.7
Sequence conflict341P → L in CAA40870. Ref.1
Sequence conflict341P → L in EDL10953. Ref.6
Sequence conflict341P → L in AAH05736. Ref.7
Sequence conflict1111S → R in CAA38896. Ref.2
Sequence conflict2391G → E in CAA40870. Ref.1
Sequence conflict2391G → E in EDL10953. Ref.6
Sequence conflict2391G → E in AAH05736. Ref.7

Sequences

Sequence LengthMass (Da)Tools
P27792 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: 83582AAF03C1C832

FASTA27830,142
        10         20         30         40         50         60 
MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT CTPWLPPGVP 

        70         80         90        100        110        120 
VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA VHYHPHPFLN SVYIGPAGPF 

       130        140        150        160        170        180 
SIFPNSRLKR RPSHSELDLA DGHQPQKVAR RVFTNSRERW RQQHVNGAFA ELRKLLPTHP 

       190        200        210        220        230        240 
PDRKLSKNEV LRLAMKYIGF LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH 

       250        260        270 
RVEAARSQPV LPGDCDGDPN GSVRPIKLEQ TSLSPEVR 

« Hide

References

« Hide 'large scale' references
[1]"Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system."
Visvader J., Begley C.G., Adams J.M.
Oncogene 6:187-194(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure, chromosome mapping, and expression of the mouse Lyl-1 gene."
Kuo S.S., Mellentin J.D., Copeland N.G., Gilbert D.J., Jenkins N.A., Cleary M.L.
Oncogene 6:961-968(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BIOA.
Tissue: Liver.
[3]"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[5]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[6]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57687 mRNA. Translation: CAA40870.1.
X55055 Genomic DNA. Translation: CAA38896.1.
CT010167 mRNA. Translation: CAJ18375.1.
AK076114 mRNA. Translation: BAC36194.1.
AC145556 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL10953.1.
BC005736 mRNA. Translation: AAH05736.1.
CCDSCCDS22476.1.
PIRS16678.
RefSeqNP_032561.2. NM_008535.2.
XP_006530807.1. XM_006530744.1.
UniGeneMm.4925.

3D structure databases

ProteinModelPortalP27792.
SMRP27792. Positions 147-208.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP27792.

Proteomic databases

PRIDEP27792.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041.
GeneID17095.
KEGGmmu:17095.
UCSCuc009mnb.1. mouse.

Organism-specific databases

CTD4066.
MGIMGI:96891. Lyl1.

Phylogenomic databases

eggNOGNOG307510.
GeneTreeENSGT00730000110586.
HOGENOMHOG000113414.
HOVERGENHBG094957.
InParanoidQ4FK84.
KOK15604.
OMAIKMEQTA.
OrthoDBEOG7SN8DF.
PhylomeDBP27792.
TreeFamTF315153.

Gene expression databases

BgeeP27792.
CleanExMM_LYL1.
GenevestigatorP27792.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291236.
PROP27792.
SOURCESearch...

Entry information

Entry nameLYL1_MOUSE
AccessionPrimary (citable) accession number: P27792
Secondary accession number(s): Q4FK84, Q8BPE2, Q923F0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 14, 2009
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot