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P27792

- LYL1_MOUSE

UniProt

P27792 - LYL1_MOUSE

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Protein

Protein lyl-1

Gene

Lyl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB

GO - Biological processi

  1. B cell differentiation Source: UniProtKB
  2. blood vessel maturation Source: UniProtKB
  3. definitive hemopoiesis Source: UniProtKB
  4. positive regulation of transcription, DNA-templated Source: UniProtKB
  5. regulation of transcription, DNA-templated Source: UniProtKB
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lyl-1
Alternative name(s):
Lymphoblastic leukemia-derived sequence 1
Gene namesi
Name:Lyl1
Synonyms:Lyl-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:96891. Lyl1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Protein lyl-1PRO_0000127263Add
BLAST

Proteomic databases

PRIDEiP27792.

PTM databases

PhosphoSiteiP27792.

Expressioni

Gene expression databases

BgeeiP27792.
CleanExiMM_LYL1.
GenevestigatoriP27792.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Structurei

3D structure databases

ProteinModelPortaliP27792.
SMRiP27792. Positions 147-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 20153bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG307510.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000113414.
HOVERGENiHBG094957.
InParanoidiP27792.
KOiK15604.
OMAiIKMEQTA.
OrthoDBiEOG7SN8DF.
PhylomeDBiP27792.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27792-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT
60 70 80 90 100
CTPWLPPGVP VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA
110 120 130 140 150
VHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHSELDLA DGHQPQKVAR
160 170 180 190 200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF
210 220 230 240 250
LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH RVEAARSQPV
260 270
LPGDCDGDPN GSVRPIKLEQ TSLSPEVR
Length:278
Mass (Da):30,142
Last modified:April 14, 2009 - v2
Checksum:i83582AAF03C1C832
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71R → G in CAA40870. (PubMed:2000219)Curated
Sequence conflicti7 – 71R → G in CAJ18375. 1 PublicationCurated
Sequence conflicti7 – 71R → G in EDL10953. 1 PublicationCurated
Sequence conflicti7 – 71R → G in AAH05736. (PubMed:15489334)Curated
Sequence conflicti34 – 341P → L in CAA40870. (PubMed:2000219)Curated
Sequence conflicti34 – 341P → L in EDL10953. 1 PublicationCurated
Sequence conflicti34 – 341P → L in AAH05736. (PubMed:15489334)Curated
Sequence conflicti111 – 1111S → R in CAA38896. (PubMed:2067848)Curated
Sequence conflicti239 – 2391G → E in CAA40870. (PubMed:2000219)Curated
Sequence conflicti239 – 2391G → E in EDL10953. 1 PublicationCurated
Sequence conflicti239 – 2391G → E in AAH05736. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57687 mRNA. Translation: CAA40870.1.
X55055 Genomic DNA. Translation: CAA38896.1.
CT010167 mRNA. Translation: CAJ18375.1.
AK076114 mRNA. Translation: BAC36194.1.
AC145556 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL10953.1.
BC005736 mRNA. Translation: AAH05736.1.
CCDSiCCDS22476.1.
PIRiS16678.
RefSeqiNP_032561.2. NM_008535.2.
XP_006530807.1. XM_006530744.1.
UniGeneiMm.4925.

Genome annotation databases

EnsembliENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041.
GeneIDi17095.
KEGGimmu:17095.
UCSCiuc009mnb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57687 mRNA. Translation: CAA40870.1 .
X55055 Genomic DNA. Translation: CAA38896.1 .
CT010167 mRNA. Translation: CAJ18375.1 .
AK076114 mRNA. Translation: BAC36194.1 .
AC145556 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL10953.1 .
BC005736 mRNA. Translation: AAH05736.1 .
CCDSi CCDS22476.1.
PIRi S16678.
RefSeqi NP_032561.2. NM_008535.2.
XP_006530807.1. XM_006530744.1.
UniGenei Mm.4925.

3D structure databases

ProteinModelPortali P27792.
SMRi P27792. Positions 147-208.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P27792.

Proteomic databases

PRIDEi P27792.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037165 ; ENSMUSP00000046010 ; ENSMUSG00000034041 .
GeneIDi 17095.
KEGGi mmu:17095.
UCSCi uc009mnb.1. mouse.

Organism-specific databases

CTDi 4066.
MGIi MGI:96891. Lyl1.

Phylogenomic databases

eggNOGi NOG307510.
GeneTreei ENSGT00760000119097.
HOGENOMi HOG000113414.
HOVERGENi HBG094957.
InParanoidi P27792.
KOi K15604.
OMAi IKMEQTA.
OrthoDBi EOG7SN8DF.
PhylomeDBi P27792.
TreeFami TF315153.

Miscellaneous databases

NextBioi 291236.
PROi P27792.
SOURCEi Search...

Gene expression databases

Bgeei P27792.
CleanExi MM_LYL1.
Genevestigatori P27792.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system."
    Visvader J., Begley C.G., Adams J.M.
    Oncogene 6:187-194(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene."
    Kuo S.S., Mellentin J.D., Copeland N.G., Gilbert D.J., Jenkins N.A., Cleary M.L.
    Oncogene 6:961-968(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BIOA.
    Tissue: Liver.
  3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiLYL1_MOUSE
AccessioniPrimary (citable) accession number: P27792
Secondary accession number(s): Q4FK84, Q8BPE2, Q923F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3