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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

Cyp17a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

hemeBy similarity

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi441 – 4411Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: MGI

GO - Biological processi

  1. adrenal gland development Source: Ensembl
  2. biphenyl metabolic process Source: Ensembl
  3. cellular response to antibiotic Source: Ensembl
  4. cellular response to gonadotropin stimulus Source: Ensembl
  5. cellular response to lipopolysaccharide Source: Ensembl
  6. dibenzo-p-dioxin metabolic process Source: Ensembl
  7. glucocorticoid biosynthetic process Source: MGI
  8. hippocampus development Source: Ensembl
  9. hormone biosynthetic process Source: UniProtKB
  10. Leydig cell differentiation Source: Ensembl
  11. ovulation Source: Ensembl
  12. phenol-containing compound metabolic process Source: Ensembl
  13. phthalate metabolic process Source: Ensembl
  14. positive regulation of steroid hormone biosynthetic process Source: Ensembl
  15. progesterone metabolic process Source: UniProtKB
  16. response to acetate Source: Ensembl
  17. response to cAMP Source: Ensembl
  18. response to cytokine Source: Ensembl
  19. response to drug Source: Ensembl
  20. response to fungicide Source: Ensembl
  21. response to herbicide Source: Ensembl
  22. response to insecticide Source: Ensembl
  23. response to ionizing radiation Source: Ensembl
  24. response to methylmercury Source: Ensembl
  25. response to nutrient levels Source: Ensembl
  26. response to retinoic acid Source: Ensembl
  27. response to steroid hormone Source: Ensembl
  28. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_281686. Endogenous sterols.
REACT_297756. Glucocorticoid biosynthesis.
REACT_305222. Androgen biosynthesis.
UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:Cyp17a1
Synonyms:Cyp17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:88586. Cyp17a1.

Subcellular locationi

  1. Membrane Curated

GO - Cellular componenti

  1. axon Source: MGI
  2. endoplasmic reticulum Source: Ensembl
  3. membrane Source: UniProtKB-SubCell
  4. mitochondrion Source: MGI
  5. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051935Add
BLAST

Proteomic databases

PaxDbiP27786.
PRIDEiP27786.

PTM databases

PhosphoSiteiP27786.

Expressioni

Gene expression databases

BgeeiP27786.
ExpressionAtlasiP27786. baseline and differential.
GenevestigatoriP27786.

Structurei

3D structure databases

ProteinModelPortaliP27786.
SMRiP27786. Positions 34-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP27786.
KOiK00512.
OMAiILAYFFW.
OrthoDBiEOG7RBZ85.
PhylomeDBiP27786.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWELVGLLLL ILAYFFWPKS KTPNAKFPRS LPFLPLVGSL PFLPRRGHMH
60 70 80 90 100
ANFFKLQEKY GPIYSLRLGT TTAVIVGHYQ LAREVLVKKG KEFSGRPQMV
110 120 130 140 150
TLGLLSDQGK GVAFADSSSS WQLHRKLVFS TFSLFRDDQK LEKMICQEAN
160 170 180 190 200
SLCDLILTYD GESRDLSTLI FKSVINIICT ICFNISFENK DPILTTIQTF
210 220 230 240 250
TEGIVDVLGH SDLVDIFPWL KIFPNKNLEM IKEHTKIREK TLVEMFEKCK
260 270 280 290 300
EKFNSESLSS LTDILIQAKM NAENNNTGEG QDPSVFSDKH ILVTVGDIFG
310 320 330 340 350
AGIETTSSVL NWILAFLVHN PEVKRKIQKE IDQYVGFSRT PSFNDRTHLL
360 370 380 390 400
MLEATIREVL RIRPVAPLLI PHKANIDSSI GEFAIPKDTH VIINLWALHH
410 420 430 440 450
DKNEWDQPDR FMPERFLDPT GSHLITPTPS YLPFGAGPRS CIGEALARQE
460 470 480 490 500
LFIFMALLLQ RFDFDVSDDK QLPCLVGDPK VVFLIDPFKV KITVRQAWKD

AQVEVST
Length:507
Mass (Da):57,638
Last modified:August 1, 1992 - v1
Checksum:iC0916193356EFEBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64863 mRNA. Translation: AAA39877.1.
CCDSiCCDS29882.1.
PIRiA39072.
RefSeqiNP_031835.3. NM_007809.3.
UniGeneiMm.1262.

Genome annotation databases

EnsembliENSMUST00000026012; ENSMUSP00000026012; ENSMUSG00000003555.
GeneIDi13074.
KEGGimmu:13074.
UCSCiuc008hua.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64863 mRNA. Translation: AAA39877.1.
CCDSiCCDS29882.1.
PIRiA39072.
RefSeqiNP_031835.3. NM_007809.3.
UniGeneiMm.1262.

3D structure databases

ProteinModelPortaliP27786.
SMRiP27786. Positions 34-502.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP27786.

Proteomic databases

PaxDbiP27786.
PRIDEiP27786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026012; ENSMUSP00000026012; ENSMUSG00000003555.
GeneIDi13074.
KEGGimmu:13074.
UCSCiuc008hua.2. mouse.

Organism-specific databases

CTDi1586.
MGIiMGI:88586. Cyp17a1.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP27786.
KOiK00512.
OMAiILAYFFW.
OrthoDBiEOG7RBZ85.
PhylomeDBiP27786.
TreeFamiTF105095.

Enzyme and pathway databases

UniPathwayiUPA00062.
ReactomeiREACT_281686. Endogenous sterols.
REACT_297756. Glucocorticoid biosynthesis.
REACT_305222. Androgen biosynthesis.

Miscellaneous databases

NextBioi283012.
PROiP27786.
SOURCEiSearch...

Gene expression databases

BgeeiP27786.
ExpressionAtlasiP27786. baseline and differential.
GenevestigatoriP27786.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation, characterization, and chromosomal mapping of mouse P450 17 alpha-hydroxylase/C17-20 lyase."
    Youngblood G.L., Sartorius C., Taylor B.A., Payne A.H.
    Genomics 10:270-275(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP17A_MOUSE
AccessioniPrimary (citable) accession number: P27786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 29, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.