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P27786

- CP17A_MOUSE

UniProt

P27786 - CP17A_MOUSE

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

Cyp17a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

Heme group.By similarity

Enzyme regulationi

Regulated predominantly by intracellular cAMP levels.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi441 – 4411Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: MGI

GO - Biological processi

  1. adrenal gland development Source: Ensembl
  2. biphenyl metabolic process Source: Ensembl
  3. cellular response to antibiotic Source: Ensembl
  4. cellular response to gonadotropin stimulus Source: Ensembl
  5. cellular response to lipopolysaccharide Source: Ensembl
  6. dibenzo-p-dioxin metabolic process Source: Ensembl
  7. glucocorticoid biosynthetic process Source: MGI
  8. hippocampus development Source: Ensembl
  9. hormone biosynthetic process Source: UniProtKB
  10. Leydig cell differentiation Source: Ensembl
  11. ovulation Source: Ensembl
  12. phenol-containing compound metabolic process Source: Ensembl
  13. phthalate metabolic process Source: Ensembl
  14. positive regulation of steroid hormone biosynthetic process Source: Ensembl
  15. progesterone metabolic process Source: UniProtKB
  16. response to acetate Source: Ensembl
  17. response to cAMP Source: Ensembl
  18. response to cytokine Source: Ensembl
  19. response to drug Source: Ensembl
  20. response to fungicide Source: Ensembl
  21. response to herbicide Source: Ensembl
  22. response to insecticide Source: Ensembl
  23. response to ionizing radiation Source: Ensembl
  24. response to methylmercury Source: Ensembl
  25. response to nutrient levels Source: Ensembl
  26. response to retinoic acid Source: Ensembl
  27. response to steroid hormone Source: Ensembl
  28. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_207160. Glucocorticoid biosynthesis.
REACT_220332. Androgen biosynthesis.
REACT_227038. Endogenous sterols.
UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:Cyp17a1
Synonyms:Cyp17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:88586. Cyp17a1.

Subcellular locationi

Membrane Curated

GO - Cellular componenti

  1. axon Source: MGI
  2. endoplasmic reticulum Source: Ensembl
  3. membrane Source: UniProtKB-KW
  4. mitochondrion Source: MGI
  5. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051935Add
BLAST

Proteomic databases

PaxDbiP27786.
PRIDEiP27786.

PTM databases

PhosphoSiteiP27786.

Expressioni

Gene expression databases

BgeeiP27786.
ExpressionAtlasiP27786. baseline and differential.
GenevestigatoriP27786.

Structurei

3D structure databases

ProteinModelPortaliP27786.
SMRiP27786. Positions 34-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP27786.
KOiK00512.
OMAiILAYFFW.
OrthoDBiEOG7RBZ85.
PhylomeDBiP27786.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27786-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWELVGLLLL ILAYFFWPKS KTPNAKFPRS LPFLPLVGSL PFLPRRGHMH
60 70 80 90 100
ANFFKLQEKY GPIYSLRLGT TTAVIVGHYQ LAREVLVKKG KEFSGRPQMV
110 120 130 140 150
TLGLLSDQGK GVAFADSSSS WQLHRKLVFS TFSLFRDDQK LEKMICQEAN
160 170 180 190 200
SLCDLILTYD GESRDLSTLI FKSVINIICT ICFNISFENK DPILTTIQTF
210 220 230 240 250
TEGIVDVLGH SDLVDIFPWL KIFPNKNLEM IKEHTKIREK TLVEMFEKCK
260 270 280 290 300
EKFNSESLSS LTDILIQAKM NAENNNTGEG QDPSVFSDKH ILVTVGDIFG
310 320 330 340 350
AGIETTSSVL NWILAFLVHN PEVKRKIQKE IDQYVGFSRT PSFNDRTHLL
360 370 380 390 400
MLEATIREVL RIRPVAPLLI PHKANIDSSI GEFAIPKDTH VIINLWALHH
410 420 430 440 450
DKNEWDQPDR FMPERFLDPT GSHLITPTPS YLPFGAGPRS CIGEALARQE
460 470 480 490 500
LFIFMALLLQ RFDFDVSDDK QLPCLVGDPK VVFLIDPFKV KITVRQAWKD

AQVEVST
Length:507
Mass (Da):57,638
Last modified:August 1, 1992 - v1
Checksum:iC0916193356EFEBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64863 mRNA. Translation: AAA39877.1.
CCDSiCCDS29882.1.
PIRiA39072.
RefSeqiNP_031835.3. NM_007809.3.
UniGeneiMm.1262.

Genome annotation databases

EnsembliENSMUST00000026012; ENSMUSP00000026012; ENSMUSG00000003555.
GeneIDi13074.
KEGGimmu:13074.
UCSCiuc008hua.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64863 mRNA. Translation: AAA39877.1 .
CCDSi CCDS29882.1.
PIRi A39072.
RefSeqi NP_031835.3. NM_007809.3.
UniGenei Mm.1262.

3D structure databases

ProteinModelPortali P27786.
SMRi P27786. Positions 34-502.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P27786.

Proteomic databases

PaxDbi P27786.
PRIDEi P27786.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026012 ; ENSMUSP00000026012 ; ENSMUSG00000003555 .
GeneIDi 13074.
KEGGi mmu:13074.
UCSCi uc008hua.2. mouse.

Organism-specific databases

CTDi 1586.
MGIi MGI:88586. Cyp17a1.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi P27786.
KOi K00512.
OMAi ILAYFFW.
OrthoDBi EOG7RBZ85.
PhylomeDBi P27786.
TreeFami TF105095.

Enzyme and pathway databases

UniPathwayi UPA00062 .
Reactomei REACT_207160. Glucocorticoid biosynthesis.
REACT_220332. Androgen biosynthesis.
REACT_227038. Endogenous sterols.

Miscellaneous databases

NextBioi 283012.
PROi P27786.
SOURCEi Search...

Gene expression databases

Bgeei P27786.
ExpressionAtlasi P27786. baseline and differential.
Genevestigatori P27786.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, characterization, and chromosomal mapping of mouse P450 17 alpha-hydroxylase/C17-20 lyase."
    Youngblood G.L., Sartorius C., Taylor B.A., Payne A.H.
    Genomics 10:270-275(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP17A_MOUSE
AccessioniPrimary (citable) accession number: P27786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3