P27786 (CP17A_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 109.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Steroid 17-alpha-hydroxylase/17,20 lyase EC=1.14.99.9 EC=4.1.2.30 Alternative name(s): 17-alpha-hydroxyprogesterone aldolase CYPXVII Cytochrome P450 17A1 Cytochrome P450-C17 Short name=Cytochrome P450c17 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus![]() |
Protein attributes
| Sequence length | 507 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. |
| Catalytic activity | A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O. 17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde. |
| Cofactor | Heme group By similarity. |
| Enzyme regulation | Regulated predominantly by intracellular cAMP levels. |
| Pathway | |
| Subcellular location | Membrane Potential. |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "Isolation, characterization, and chromosomal mapping of mouse P450 17 alpha-hydroxylase/C17-20 lyase." Youngblood G.L., Sartorius C., Taylor B.A., Payne A.H. Genomics 10:270-275(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M64863 mRNA. Translation: AAA39877.1. |
| IPI | IPI00119940. |
| PIR | A39072. |
| RefSeq | NP_031835.3. NM_007809.3. |
| UniGene | Mm.1262. |
3D structure databases | |
| ProteinModelPortal | P27786. |
| SMR | P27786. Positions 34-502. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P27786. |
Proteomic databases | |
| PaxDb | P27786. |
| PRIDE | P27786. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000026012; ENSMUSP00000026012; ENSMUSG00000003555. |
| GeneID | 13074. |
| KEGG | mmu:13074. |
Organism-specific databases | |
| CTD | 1586. |
| MGI | MGI:88586. Cyp17a1. |
Phylogenomic databases | |
| eggNOG | COG2124. |
| HOGENOM | HOG000036991. |
| HOVERGEN | HBG106944. |
| InParanoid | P27786. |
| KO | K00512. |
| OMA | ILAYFFW. |
| OrthoDB | EOG4W9J45. |
Enzyme and pathway databases | |
| UniPathway | UPA00062. |
Gene expression databases | |
| ArrayExpress | P27786. |
| Bgee | P27786. |
| Genevestigator | P27786. |
| GermOnline | ENSMUSG00000003555. Mus musculus. |
Family and domain databases | |
| Gene3D | 1.10.630.10. 1 hit. |
| InterPro | IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view] |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00463. EP450I. PR00385. P450. |
| SUPFAM | SSF48264. Cytochrome_P450. 1 hit. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 283012. |
| SOURCE | Search... |
Entry information
| Entry name | CP17A_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P27786 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
