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P27786

- CP17A_MOUSE

UniProt

P27786 - CP17A_MOUSE

Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

Cyp17a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

    Catalytic activityi

    A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
    17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

    Cofactori

    Heme group.By similarity

    Enzyme regulationi

    Regulated predominantly by intracellular cAMP levels.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi441 – 4411Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. steroid 17-alpha-monooxygenase activity Source: MGI

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. biphenyl metabolic process Source: Ensembl
    3. cellular response to antibiotic Source: Ensembl
    4. cellular response to gonadotropin stimulus Source: Ensembl
    5. cellular response to lipopolysaccharide Source: Ensembl
    6. dibenzo-p-dioxin metabolic process Source: Ensembl
    7. glucocorticoid biosynthetic process Source: MGI
    8. hippocampus development Source: Ensembl
    9. hormone biosynthetic process Source: UniProtKB
    10. Leydig cell differentiation Source: Ensembl
    11. ovulation Source: Ensembl
    12. phenol-containing compound metabolic process Source: Ensembl
    13. phthalate metabolic process Source: Ensembl
    14. positive regulation of steroid hormone biosynthetic process Source: Ensembl
    15. progesterone metabolic process Source: UniProtKB
    16. response to acetate Source: Ensembl
    17. response to cAMP Source: Ensembl
    18. response to cytokine Source: Ensembl
    19. response to drug Source: Ensembl
    20. response to fungicide Source: Ensembl
    21. response to herbicide Source: Ensembl
    22. response to insecticide Source: Ensembl
    23. response to ionizing radiation Source: Ensembl
    24. response to methylmercury Source: Ensembl
    25. response to nutrient levels Source: Ensembl
    26. response to retinoic acid Source: Ensembl
    27. response to steroid hormone Source: Ensembl
    28. steroid metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_207160. Glucocorticoid biosynthesis.
    REACT_220332. Androgen biosynthesis.
    REACT_227038. Endogenous sterols.
    UniPathwayiUPA00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
    Alternative name(s):
    17-alpha-hydroxyprogesterone aldolase
    CYPXVII
    Cytochrome P450 17A1
    Cytochrome P450-C17
    Short name:
    Cytochrome P450c17
    Gene namesi
    Name:Cyp17a1
    Synonyms:Cyp17
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:88586. Cyp17a1.

    Subcellular locationi

    Membrane Curated

    GO - Cellular componenti

    1. axon Source: MGI
    2. endoplasmic reticulum Source: Ensembl
    3. membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: MGI
    5. neuronal cell body Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051935Add
    BLAST

    Proteomic databases

    PaxDbiP27786.
    PRIDEiP27786.

    PTM databases

    PhosphoSiteiP27786.

    Expressioni

    Gene expression databases

    BgeeiP27786.
    GenevestigatoriP27786.

    Structurei

    3D structure databases

    ProteinModelPortaliP27786.
    SMRiP27786. Positions 34-502.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    InParanoidiP27786.
    KOiK00512.
    OMAiILAYFFW.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP27786.
    TreeFamiTF105095.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27786-1 [UniParc]FASTAAdd to Basket

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    MWELVGLLLL ILAYFFWPKS KTPNAKFPRS LPFLPLVGSL PFLPRRGHMH    50
    ANFFKLQEKY GPIYSLRLGT TTAVIVGHYQ LAREVLVKKG KEFSGRPQMV 100
    TLGLLSDQGK GVAFADSSSS WQLHRKLVFS TFSLFRDDQK LEKMICQEAN 150
    SLCDLILTYD GESRDLSTLI FKSVINIICT ICFNISFENK DPILTTIQTF 200
    TEGIVDVLGH SDLVDIFPWL KIFPNKNLEM IKEHTKIREK TLVEMFEKCK 250
    EKFNSESLSS LTDILIQAKM NAENNNTGEG QDPSVFSDKH ILVTVGDIFG 300
    AGIETTSSVL NWILAFLVHN PEVKRKIQKE IDQYVGFSRT PSFNDRTHLL 350
    MLEATIREVL RIRPVAPLLI PHKANIDSSI GEFAIPKDTH VIINLWALHH 400
    DKNEWDQPDR FMPERFLDPT GSHLITPTPS YLPFGAGPRS CIGEALARQE 450
    LFIFMALLLQ RFDFDVSDDK QLPCLVGDPK VVFLIDPFKV KITVRQAWKD 500
    AQVEVST 507
    Length:507
    Mass (Da):57,638
    Last modified:August 1, 1992 - v1
    Checksum:iC0916193356EFEBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64863 mRNA. Translation: AAA39877.1.
    CCDSiCCDS29882.1.
    PIRiA39072.
    RefSeqiNP_031835.3. NM_007809.3.
    UniGeneiMm.1262.

    Genome annotation databases

    EnsembliENSMUST00000026012; ENSMUSP00000026012; ENSMUSG00000003555.
    GeneIDi13074.
    KEGGimmu:13074.
    UCSCiuc008hua.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64863 mRNA. Translation: AAA39877.1 .
    CCDSi CCDS29882.1.
    PIRi A39072.
    RefSeqi NP_031835.3. NM_007809.3.
    UniGenei Mm.1262.

    3D structure databases

    ProteinModelPortali P27786.
    SMRi P27786. Positions 34-502.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P27786.

    Proteomic databases

    PaxDbi P27786.
    PRIDEi P27786.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026012 ; ENSMUSP00000026012 ; ENSMUSG00000003555 .
    GeneIDi 13074.
    KEGGi mmu:13074.
    UCSCi uc008hua.2. mouse.

    Organism-specific databases

    CTDi 1586.
    MGIi MGI:88586. Cyp17a1.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    InParanoidi P27786.
    KOi K00512.
    OMAi ILAYFFW.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P27786.
    TreeFami TF105095.

    Enzyme and pathway databases

    UniPathwayi UPA00062 .
    Reactomei REACT_207160. Glucocorticoid biosynthesis.
    REACT_220332. Androgen biosynthesis.
    REACT_227038. Endogenous sterols.

    Miscellaneous databases

    NextBioi 283012.
    PROi P27786.
    SOURCEi Search...

    Gene expression databases

    Bgeei P27786.
    Genevestigatori P27786.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterization, and chromosomal mapping of mouse P450 17 alpha-hydroxylase/C17-20 lyase."
      Youngblood G.L., Sartorius C., Taylor B.A., Payne A.H.
      Genomics 10:270-275(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP17A_MOUSE
    AccessioniPrimary (citable) accession number: P27786
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3