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P27784

- CCL6_MOUSE

UniProt

P27784 - CCL6_MOUSE

Protein

C-C motif chemokine 6

Gene

Ccl6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    CCL6(22-95) and CCL6(23-95) are potent chemoattractants.1 Publication

    GO - Biological processi

    1. cell chemotaxis Source: Ensembl
    2. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 6
    Alternative name(s):
    Protein C10
    Small-inducible cytokine A6
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Ccl6
    Synonyms:C10, Scya6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98263. Ccl6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 11695C-C motif chemokine 6PRO_0000005182Add
    BLAST
    Chaini43 – 11674CCL6(22-95)PRO_0000041844Add
    BLAST
    Chaini44 – 11673CCL6(23-95)PRO_0000041845Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 73By similarity
    Disulfide bondi51 ↔ 89By similarity
    Disulfide bondi60 ↔ 100By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP27784.
    PRIDEiP27784.

    PTM databases

    PhosphoSiteiP27784.

    Expressioni

    Tissue specificityi

    Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.

    Inductioni

    Associated with stimuli that promote myeloid differentiation.

    Gene expression databases

    BgeeiP27784.
    CleanExiMM_CCL6.
    GenevestigatoriP27784.

    Structurei

    3D structure databases

    ProteinModelPortaliP27784.
    SMRiP27784. Positions 45-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26004.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP27784.
    KOiK05510.
    OMAiIFITKSK.
    OrthoDBiEOG79KPHQ.
    PhylomeDBiP27784.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27784-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNSKTAISF FILVAVLGSQ AGLIQEMEKE DRRYNPPIIH QGFQDTSSDC    50
    CFSYATQIPC KRFIYYFPTS GGCIKPGIIF ISRRGTQVCA DPSDRRVQRC 100
    LSTLKQGPRS GNKVIA 116
    Length:116
    Mass (Da):12,984
    Last modified:August 1, 1992 - v1
    Checksum:i2B483B5DE8417082
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431F → V in AAH02073. (PubMed:15489334)Curated
    Sequence conflicti93 – 931S → R in BAB25734. (PubMed:16141072)Curated
    Sequence conflicti111 – 1111G → R in AAH02073. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58004 mRNA. Translation: AAA37329.1.
    AF128188 mRNA. Translation: AAF22529.1.
    AF128189 mRNA. Translation: AAF22530.1.
    AF128190 mRNA. Translation: AAF22531.1.
    AF128191 mRNA. Translation: AAF22532.1.
    AF128192 mRNA. Translation: AAF22533.1.
    AB051897 Genomic DNA. Translation: BAB18729.1.
    AK002697 mRNA. Translation: BAB22291.1.
    AK008547 mRNA. Translation: BAB25734.1.
    AK150336 mRNA. Translation: BAE29478.1.
    AK154553 mRNA. Translation: BAE32672.1.
    AL596122 Genomic DNA. Translation: CAI25134.1.
    BC002073 mRNA. Translation: AAH02073.1.
    CCDSiCCDS25171.1.
    PIRiI49555.
    RefSeqiNP_033165.1. NM_009139.3.
    UniGeneiMm.137.

    Genome annotation databases

    EnsembliENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927.
    GeneIDi20305.
    KEGGimmu:20305.
    UCSCiuc007kpm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58004 mRNA. Translation: AAA37329.1 .
    AF128188 mRNA. Translation: AAF22529.1 .
    AF128189 mRNA. Translation: AAF22530.1 .
    AF128190 mRNA. Translation: AAF22531.1 .
    AF128191 mRNA. Translation: AAF22532.1 .
    AF128192 mRNA. Translation: AAF22533.1 .
    AB051897 Genomic DNA. Translation: BAB18729.1 .
    AK002697 mRNA. Translation: BAB22291.1 .
    AK008547 mRNA. Translation: BAB25734.1 .
    AK150336 mRNA. Translation: BAE29478.1 .
    AK154553 mRNA. Translation: BAE32672.1 .
    AL596122 Genomic DNA. Translation: CAI25134.1 .
    BC002073 mRNA. Translation: AAH02073.1 .
    CCDSi CCDS25171.1.
    PIRi I49555.
    RefSeqi NP_033165.1. NM_009139.3.
    UniGenei Mm.137.

    3D structure databases

    ProteinModelPortali P27784.
    SMRi P27784. Positions 45-105.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P27784.

    Proteomic databases

    PaxDbi P27784.
    PRIDEi P27784.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019071 ; ENSMUSP00000019071 ; ENSMUSG00000018927 .
    GeneIDi 20305.
    KEGGi mmu:20305.
    UCSCi uc007kpm.1. mouse.

    Organism-specific databases

    CTDi 20305.
    MGIi MGI:98263. Ccl6.

    Phylogenomic databases

    eggNOGi NOG26004.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P27784.
    KOi K05510.
    OMAi IFITKSK.
    OrthoDBi EOG79KPHQ.
    PhylomeDBi P27784.
    TreeFami TF334888.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi C12orf57. mouse.
    NextBioi 298059.
    PROi P27784.
    SOURCEi Search...

    Gene expression databases

    Bgeei P27784.
    CleanExi MM_CCL6.
    Genevestigatori P27784.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes."
      Orlofsky A., Berger M.S., Prystowsky M.B.
      Cell Regul. 2:403-412(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CBA/J.
      Tissue: Bone marrow.
    2. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
      Tissue: Spleen.
    3. "Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES."
      Nomiyama H.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow and Pancreas.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    7. "Proteolytic activation of alternative CCR1 ligands in inflammation."
      Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
      J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF CCL6(22-95) AND CCL6(23-95), PROTEOLYTIC PROCESSING OF N-TERMINAL, FUNCTION.

    Entry informationi

    Entry nameiCCL6_MOUSE
    AccessioniPrimary (citable) accession number: P27784
    Secondary accession number(s): Q3U3W3
    , Q5QNW1, Q99M24, Q9D830
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3