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Protein

C-C motif chemokine 6

Gene

Ccl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

CCL6(22-95) and CCL6(23-95) are potent chemoattractants.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 6
Alternative name(s):
Protein C10
Small-inducible cytokine A6
Cleaved into the following 2 chains:
Gene namesi
Name:Ccl6
Synonyms:C10, Scya6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98263. Ccl6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000518222 – 116C-C motif chemokine 6Add BLAST95
ChainiPRO_000004184443 – 116CCL6(22-95)Add BLAST74
ChainiPRO_000004184544 – 116CCL6(23-95)Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 73By similarity
Disulfide bondi51 ↔ 89By similarity
Disulfide bondi60 ↔ 100By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP27784.
PeptideAtlasiP27784.
PRIDEiP27784.

PTM databases

iPTMnetiP27784.
PhosphoSitePlusiP27784.

Expressioni

Tissue specificityi

Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.

Inductioni

Associated with stimuli that promote myeloid differentiation.

Gene expression databases

BgeeiENSMUSG00000018927.
CleanExiMM_CCL6.
GenevisibleiP27784. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019071.

Structurei

3D structure databases

ProteinModelPortaliP27784.
SMRiP27784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4DG. Eukaryota.
ENOG4111C2C. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP27784.
KOiK05510.
OMAiRIIQCAN.
OrthoDBiEOG091G14Y2.
PhylomeDBiP27784.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNSKTAISF FILVAVLGSQ AGLIQEMEKE DRRYNPPIIH QGFQDTSSDC
60 70 80 90 100
CFSYATQIPC KRFIYYFPTS GGCIKPGIIF ISRRGTQVCA DPSDRRVQRC
110
LSTLKQGPRS GNKVIA
Length:116
Mass (Da):12,984
Last modified:August 1, 1992 - v1
Checksum:i2B483B5DE8417082
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43F → V in AAH02073 (PubMed:15489334).Curated1
Sequence conflicti93S → R in BAB25734 (PubMed:16141072).Curated1
Sequence conflicti111G → R in AAH02073 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58004 mRNA. Translation: AAA37329.1.
AF128188 mRNA. Translation: AAF22529.1.
AF128189 mRNA. Translation: AAF22530.1.
AF128190 mRNA. Translation: AAF22531.1.
AF128191 mRNA. Translation: AAF22532.1.
AF128192 mRNA. Translation: AAF22533.1.
AB051897 Genomic DNA. Translation: BAB18729.1.
AK002697 mRNA. Translation: BAB22291.1.
AK008547 mRNA. Translation: BAB25734.1.
AK150336 mRNA. Translation: BAE29478.1.
AK154553 mRNA. Translation: BAE32672.1.
AL596122 Genomic DNA. Translation: CAI25134.1.
BC002073 mRNA. Translation: AAH02073.1.
CCDSiCCDS25171.1.
PIRiI49555.
RefSeqiNP_033165.1. NM_009139.3.
UniGeneiMm.137.

Genome annotation databases

EnsembliENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927.
GeneIDi20305.
KEGGimmu:20305.
UCSCiuc007kpm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58004 mRNA. Translation: AAA37329.1.
AF128188 mRNA. Translation: AAF22529.1.
AF128189 mRNA. Translation: AAF22530.1.
AF128190 mRNA. Translation: AAF22531.1.
AF128191 mRNA. Translation: AAF22532.1.
AF128192 mRNA. Translation: AAF22533.1.
AB051897 Genomic DNA. Translation: BAB18729.1.
AK002697 mRNA. Translation: BAB22291.1.
AK008547 mRNA. Translation: BAB25734.1.
AK150336 mRNA. Translation: BAE29478.1.
AK154553 mRNA. Translation: BAE32672.1.
AL596122 Genomic DNA. Translation: CAI25134.1.
BC002073 mRNA. Translation: AAH02073.1.
CCDSiCCDS25171.1.
PIRiI49555.
RefSeqiNP_033165.1. NM_009139.3.
UniGeneiMm.137.

3D structure databases

ProteinModelPortaliP27784.
SMRiP27784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019071.

PTM databases

iPTMnetiP27784.
PhosphoSitePlusiP27784.

Proteomic databases

PaxDbiP27784.
PeptideAtlasiP27784.
PRIDEiP27784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927.
GeneIDi20305.
KEGGimmu:20305.
UCSCiuc007kpm.1. mouse.

Organism-specific databases

CTDi20305.
MGIiMGI:98263. Ccl6.

Phylogenomic databases

eggNOGiENOG410J4DG. Eukaryota.
ENOG4111C2C. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP27784.
KOiK05510.
OMAiRIIQCAN.
OrthoDBiEOG091G14Y2.
PhylomeDBiP27784.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.

Miscellaneous databases

PROiP27784.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018927.
CleanExiMM_CCL6.
GenevisibleiP27784. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL6_MOUSE
AccessioniPrimary (citable) accession number: P27784
Secondary accession number(s): Q3U3W3
, Q5QNW1, Q99M24, Q9D830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.