P27784 (CCL6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 6

Alternative name(s):
Protein C10
Small-inducible cytokine A6

Cleaved into the following 2 chains:

1. CCL6(22-95)
2. CCL6(23-95)

Gene names

Name:	Ccl6
Synonyms:	C10, Scya6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	CCL6(22-95) and CCL6(23-95) are potent chemoattractants. Ref.7
Subcellular location	Secreted.
Tissue specificity	Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
Induction	Associated with stimuli that promote myeloid differentiation.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell chemotaxis Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 116	95	C-C motif chemokine 6		PRO_0000005182
	Chain	43 – 116	74	CCL6(22-95)		PRO_0000041844
	Chain	44 – 116	73	CCL6(23-95)		PRO_0000041845
Amino acid modifications
	Disulfide bond	50 ↔ 73		By similarity
	Disulfide bond	51 ↔ 89		By similarity
	Disulfide bond	60 ↔ 100		By similarity
Experimental info
	Sequence conflict	43	1	F → V in AAH02073. Ref.6
	Sequence conflict	93	1	S → R in BAB25734. Ref.4
	Sequence conflict	111	1	G → R in AAH02073. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P27784 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 2B483B5DE8417082	FASTA	116	12,984
	10 20 30 40 50 60 MRNSKTAISF FILVAVLGSQ AGLIQEMEKE DRRYNPPIIH QGFQDTSSDC CFSYATQIPC 70 80 90 100 110 KRFIYYFPTS GGCIKPGIIF ISRRGTQVCA DPSDRRVQRC LSTLKQGPRS GNKVIA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes." Orlofsky A., Berger M.S., Prystowsky M.B. Cell Regul. 2:403-412(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CBA/J. Tissue: Bone marrow.
[2]	"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis." Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P. J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J. Tissue: Spleen.
[3]	"Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES." Nomiyama H. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/Sv.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Bone marrow and Pancreas.
[5]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[7]	"Proteolytic activation of alternative CCR1 ligands in inflammation." Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J. J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF CCL6(22-95) AND CCL6(23-95), PROTEOLYTIC PROCESSING OF N-TERMINAL, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M58004 mRNA. Translation: AAA37329.1. AF128188 mRNA. Translation: AAF22529.1. AF128189 mRNA. Translation: AAF22530.1. AF128190 mRNA. Translation: AAF22531.1. AF128191 mRNA. Translation: AAF22532.1. AF128192 mRNA. Translation: AAF22533.1. AB051897 Genomic DNA. Translation: BAB18729.1. AK002697 mRNA. Translation: BAB22291.1. AK008547 mRNA. Translation: BAB25734.1. AK150336 mRNA. Translation: BAE29478.1. AK154553 mRNA. Translation: BAE32672.1. AL596122 Genomic DNA. Translation: CAI25134.1. BC002073 mRNA. Translation: AAH02073.1.
IPI	IPI00119938.
PIR	I49555.
RefSeq	NP_033165.1. NM_009139.3.
UniGene	Mm.137.
3D structure databases
ProteinModelPortal	P27784.
SMR	P27784. Positions 45-105.
ModBase	Search...
PTM databases
PhosphoSite	P27784.
Proteomic databases
PaxDb	P27784.
PRIDE	P27784.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927.
GeneID	20305.
KEGG	mmu:20305.
UCSC	uc007kpm.1. mouse.
Organism-specific databases
CTD	20305.
MGI	MGI:98263. Ccl6.
Phylogenomic databases
eggNOG	NOG26004.
GeneTree	ENSGT00560000076972.
HOGENOM	HOG000036685.
HOVERGEN	HBG017871.
InParanoid	P27784.
KO	K05510.
OMA	KEDRRYN.
OrthoDB	EOG49PB11.
Gene expression databases
Bgee	P27784.
CleanEx	MM_CCL6.
Genevestigator	P27784.
GermOnline	ENSMUSG00000018927. Mus musculus.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	C12orf57. mouse.
NextBio	298059.
SOURCE	Search...

Entry information

Entry name

CCL6_MOUSE

Accession

Primary (citable) accession number: P27784
Secondary accession number(s): Q3U3W3 , Q5QNW1, Q99M24, Q9D830

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program