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P27784 (CCL6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 6
Alternative name(s):
Protein C10
Small-inducible cytokine A6

Cleaved into the following 2 chains:

  1. CCL6(22-95)
  2. CCL6(23-95)
Gene names
Name:Ccl6
Synonyms:C10, Scya6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

CCL6(22-95) and CCL6(23-95) are potent chemoattractants. Ref.7

Subcellular location

Secreted.

Tissue specificity

Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.

Induction

Associated with stimuli that promote myeloid differentiation.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 11695C-C motif chemokine 6
PRO_0000005182
Chain43 – 11674CCL6(22-95)
PRO_0000041844
Chain44 – 11673CCL6(23-95)
PRO_0000041845

Amino acid modifications

Disulfide bond50 ↔ 73 By similarity
Disulfide bond51 ↔ 89 By similarity
Disulfide bond60 ↔ 100 By similarity

Experimental info

Sequence conflict431F → V in AAH02073. Ref.6
Sequence conflict931S → R in BAB25734. Ref.4
Sequence conflict1111G → R in AAH02073. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P27784 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 2B483B5DE8417082

FASTA11612,984
        10         20         30         40         50         60 
MRNSKTAISF FILVAVLGSQ AGLIQEMEKE DRRYNPPIIH QGFQDTSSDC CFSYATQIPC 

        70         80         90        100        110 
KRFIYYFPTS GGCIKPGIIF ISRRGTQVCA DPSDRRVQRC LSTLKQGPRS GNKVIA 

« Hide

References

« Hide 'large scale' references
[1]"Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes."
Orlofsky A., Berger M.S., Prystowsky M.B.
Cell Regul. 2:403-412(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CBA/J.
Tissue: Bone marrow.
[2]"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
Tissue: Spleen.
[3]"Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES."
Nomiyama H.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Bone marrow and Pancreas.
[5]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[7]"Proteolytic activation of alternative CCR1 ligands in inflammation."
Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.
J. Immunol. 174:7341-7351(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF CCL6(22-95) AND CCL6(23-95), PROTEOLYTIC PROCESSING OF N-TERMINAL, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M58004 mRNA. Translation: AAA37329.1.
AF128188 mRNA. Translation: AAF22529.1.
AF128189 mRNA. Translation: AAF22530.1.
AF128190 mRNA. Translation: AAF22531.1.
AF128191 mRNA. Translation: AAF22532.1.
AF128192 mRNA. Translation: AAF22533.1.
AB051897 Genomic DNA. Translation: BAB18729.1.
AK002697 mRNA. Translation: BAB22291.1.
AK008547 mRNA. Translation: BAB25734.1.
AK150336 mRNA. Translation: BAE29478.1.
AK154553 mRNA. Translation: BAE32672.1.
AL596122 Genomic DNA. Translation: CAI25134.1.
BC002073 mRNA. Translation: AAH02073.1.
PIRI49555.
RefSeqNP_033165.1. NM_009139.3.
UniGeneMm.137.

3D structure databases

ProteinModelPortalP27784.
SMRP27784. Positions 45-105.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP27784.

Proteomic databases

PaxDbP27784.
PRIDEP27784.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927.
GeneID20305.
KEGGmmu:20305.
UCSCuc007kpm.1. mouse.

Organism-specific databases

CTD20305.
MGIMGI:98263. Ccl6.

Phylogenomic databases

eggNOGNOG26004.
GeneTreeENSGT00730000110278.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidP27784.
KOK05510.
OMARIIQCAN.
OrthoDBEOG79KPHQ.
PhylomeDBP27784.
TreeFamTF334888.

Gene expression databases

BgeeP27784.
CleanExMM_CCL6.
GenevestigatorP27784.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC12orf57. mouse.
NextBio298059.
PROP27784.
SOURCESearch...

Entry information

Entry nameCCL6_MOUSE
AccessionPrimary (citable) accession number: P27784
Secondary accession number(s): Q3U3W3 expand/collapse secondary AC list , Q5QNW1, Q99M24, Q9D830
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot