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Protein

Pupal cuticle protein Edg-78E

Gene

Edg78E

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the cuticle of the pupa of fruit fly.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pupal cuticle protein Edg-78E
Gene namesi
Name:Edg78E
Synonyms:EDG-78E
ORF Names:CG7673
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000551. Edg78E.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 122106Pupal cuticle protein Edg-78EPRO_0000006399Add
BLAST

Proteomic databases

PaxDbiP27779.
PRIDEiP27779.

Expressioni

Tissue specificityi

Imaginal (anterior) epidermis.

Gene expression databases

BgeeiP27779.
ExpressionAtlasiP27779. differential.
GenevisibleiP27779. DM.

Interactioni

Protein-protein interaction databases

BioGridi65602. 1 interaction.
DIPiDIP-19035N.
IntActiP27779. 1 interaction.
MINTiMINT-996798.
STRINGi7227.FBpp0078062.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 9661Chitin-binding type R&RPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chitin-binding type R&R domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J25C. Eukaryota.
ENOG410YR66. LUCA.
InParanoidiP27779.
OMAiFQNDASD.
OrthoDBiEOG75J0Q6.
PhylomeDBiP27779.

Family and domain databases

InterProiIPR031311. CHIT_BIND_RR_consensus.
IPR000618. Insect_cuticle.
[Graphical view]
PfamiPF00379. Chitin_bind_4. 1 hit.
[Graphical view]
PRINTSiPR00947. CUTICLE.
PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKYLFCLAL IGCACADNIN KDAQIRSFQN DATDAEGNYQ YAYETSNGIQ
60 70 80 90 100
IQEAGNANGA RGAVAYVSPE GEHISLTYTA DEEGYHPVGD HLPTPPPVPA
110 120
YVLRALEYIR THPPAPAQKE QQ
Length:122
Mass (Da):13,347
Last modified:August 1, 1992 - v1
Checksum:iCD68BC35B62F78E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M71247 Genomic DNA. Translation: AAA28499.1.
M71248 mRNA. Translation: AAA28500.1.
AE014296 Genomic DNA. Translation: AAF51702.1.
PIRiA49773.
RefSeqiNP_001287140.1. NM_001300211.1.
NP_524198.1. NM_079474.3.
UniGeneiDm.2506.

Genome annotation databases

EnsemblMetazoaiFBtr0078408; FBpp0078062; FBgn0000551.
FBtr0344634; FBpp0310951; FBgn0000551.
GeneIDi40354.
KEGGidme:Dmel_CG7673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M71247 Genomic DNA. Translation: AAA28499.1.
M71248 mRNA. Translation: AAA28500.1.
AE014296 Genomic DNA. Translation: AAF51702.1.
PIRiA49773.
RefSeqiNP_001287140.1. NM_001300211.1.
NP_524198.1. NM_079474.3.
UniGeneiDm.2506.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65602. 1 interaction.
DIPiDIP-19035N.
IntActiP27779. 1 interaction.
MINTiMINT-996798.
STRINGi7227.FBpp0078062.

Proteomic databases

PaxDbiP27779.
PRIDEiP27779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078408; FBpp0078062; FBgn0000551.
FBtr0344634; FBpp0310951; FBgn0000551.
GeneIDi40354.
KEGGidme:Dmel_CG7673.

Organism-specific databases

CTDi40354.
FlyBaseiFBgn0000551. Edg78E.

Phylogenomic databases

eggNOGiENOG410J25C. Eukaryota.
ENOG410YR66. LUCA.
InParanoidiP27779.
OMAiFQNDASD.
OrthoDBiEOG75J0Q6.
PhylomeDBiP27779.

Miscellaneous databases

GenomeRNAii40354.
PROiP27779.

Gene expression databases

BgeeiP27779.
ExpressionAtlasiP27779. differential.
GenevisibleiP27779. DM.

Family and domain databases

InterProiIPR031311. CHIT_BIND_RR_consensus.
IPR000618. Insect_cuticle.
[Graphical view]
PfamiPF00379. Chitin_bind_4. 1 hit.
[Graphical view]
PRINTSiPR00947. CUTICLE.
PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "20-Hydroxyecdysone is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes."
    Apple R.T., Fristrom J.W.
    Dev. Biol. 146:569-582(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Oregon-R.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiCUP7_DROME
AccessioniPrimary (citable) accession number: P27779
Secondary accession number(s): Q9VP54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

The sequence shown is from genomic DNA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.