Reviewed, UniProtKB/Swiss-Prot P27771 (P5CR_TREPA)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	TP_0797

Organism

Treponema pallidum [Complete proteome] [HAMAP]

Taxonomic identifier

160 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Pyrroline-5-carboxylate reductase		PRO_0000187310
Experimental info
	Sequence conflict	1 – 65	65	MNVGF…KSEWI → MTWDFWVLEQWDGRWQKGWC TQERCKRSSVRLCVKSGKVA CAVYIFGHRCLRVSSGTGTE KVNGF Ref.1
	Sequence conflict	77 – 93	17	VLRDR…LISLA → GTARSPIFQESAISC in AAA27478. Ref.1
	Sequence conflict	256 – 260	5	VRAAL → CRWLS Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P27771-1 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: ED4AD7C54BAF9D61	FASTA	263	27,645
	10 20 30 40 50 60 MNVGFLGFGA MGRALAEGLV HAGALQAAQV YACALNQEKL RAQCTSLGIG ACASVQELVQ 70 80 90 100 110 120 KSEWIFLAVK PSQISTVLRD RQSFQGKVLI SLAAGMSCAA YEALFAADPH QGIRHLSLLP 130 140 150 160 170 180 NLPCQVARGV IIAEARHTLH HDEHAALLAV LRTVAQVEVV DTAYFAIAGV IAGCAPAFAA 190 200 210 220 230 240 QFIEALADAG VRYGLARDQA YRLAAHMLEG TAALIQHSGV HPAQLKDRVC SPAGSTIRGV 250 260 LALEEQGLRR AVIHAVRAAL SSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complementation of an Escherichia coli proC mutation by a gene cloned from Treponema pallidum." Gherardini F.C., Hobbs M.M., Stamm L.V., Bassford P.J. Jr. J. Bacteriol. 172:2996-3002(1990) [PubMed: 2188947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Nichols.
[2]	"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M73825 Genomic DNA. Translation: AAA27478.1. AE000520 Genomic DNA. Translation: AAC65760.1.
PIR	D71281.
RefSeq	NP_219234.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P27771. 5 interactions.
Genome annotation databases
GeneID	2610812.
GenomeReviews	Gene locus TP_0797 in contig AE000520_GR.
KEGG	tpa:TP0797.
NMPDR	fig|243276.1.peg.793.
TIGR	TP_0797.
Phylogenomic databases
HOGENOM	P27771.
OMA	P27771. PGAMKDA.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0797-MON.
BRENDA	1.5.1.2. 142600.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_TREPA

Accession

Primary (citable) accession number: P27771
Secondary accession number(s): O83775

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	December 15, 1998
Last modified:	June 16, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)