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Protein

Troponin I, fast skeletal muscle

Gene

Tnni2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi105 – 116By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

ReactomeiR-RNO-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:Tnni2
Synonyms:Trp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi62050. Tnni2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861462 – 182Troponin I, fast skeletal muscleAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei118PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP27768.
PRIDEiP27768.

PTM databases

iPTMnetiP27768.
PhosphoSitePlusiP27768.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020276.
ExpressionAtlasiP27768. baseline and differential.
GenevisibleiP27768. RN.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1534490.
STRINGi10116.ENSRNOP00000027487.

Structurei

3D structure databases

ProteinModelPortaliP27768.
SMRiP27768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Involved in binding TNCAdd BLAST47
Regioni97 – 117Involved in binding TNC and actinAdd BLAST21

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP27768.
KOiK12043.
OMAiYLSEHCP.
PhylomeDBiP27768.

Family and domain databases

InterProiView protein in InterPro
IPR001978. Troponin.
PfamiView protein in Pfam
PF00992. Troponin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KQNYLSEHCP
60 70 80 90 100
PLHIPGSMSE VQELCKQLHA KIDAAEEEKY DMEVKVQKSS KELEDMNQKL
110 120 130 140 150
FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE
160 170 180
KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
Length:182
Mass (Da):21,328
Last modified:January 23, 2007 - v2
Checksum:i6640081F44AA0EDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73701 mRNA. Translation: AAA42149.1.
RefSeqiNP_058881.1. NM_017185.1.
UniGeneiRn.9924.

Genome annotation databases

EnsembliENSRNOT00000076140; ENSRNOP00000068152; ENSRNOG00000020276.
ENSRNOT00000076187; ENSRNOP00000068190; ENSRNOG00000020276.
GeneIDi29389.
KEGGirno:29389.
UCSCiRGD:62050. rat.

Similar proteinsi

Entry informationi

Entry nameiTNNI2_RAT
AccessioniPrimary (citable) accession number: P27768
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families