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Protein

Troponin I, fast skeletal muscle

Gene

Tnni2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi105 – 11612By similarityAdd
BLAST

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-RNO-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:Tnni2
Synonyms:Trp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi62050. Tnni2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: Ensembl
  • troponin complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 182181Troponin I, fast skeletal musclePRO_0000186146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Modified residuei12 – 121PhosphothreonineBy similarity
Modified residuei118 – 1181PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP27768.
PRIDEiP27768.

PTM databases

iPTMnetiP27768.
PhosphoSiteiP27768.

Expressioni

Gene expression databases

ExpressionAtlasiP27768. baseline and differential.
GenevisibleiP27768. RN.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Protein-protein interaction databases

MINTiMINT-1534490.
STRINGi10116.ENSRNOP00000027487.

Structurei

3D structure databases

ProteinModelPortaliP27768.
SMRiP27768. Positions 4-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 4847Involved in binding TNCAdd
BLAST
Regioni97 – 11721Involved in binding TNC and actinAdd
BLAST

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP27768.
KOiK12043.
OMAiLKSAMLQ.
PhylomeDBiP27768.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KQNYLSEHCP
60 70 80 90 100
PLHIPGSMSE VQELCKQLHA KIDAAEEEKY DMEVKVQKSS KELEDMNQKL
110 120 130 140 150
FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE
160 170 180
KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
Length:182
Mass (Da):21,328
Last modified:January 23, 2007 - v2
Checksum:i6640081F44AA0EDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73701 mRNA. Translation: AAA42149.1.
RefSeqiNP_058881.1. NM_017185.1.
UniGeneiRn.9924.

Genome annotation databases

EnsembliENSRNOT00000076140; ENSRNOP00000068152; ENSRNOG00000020276.
ENSRNOT00000076187; ENSRNOP00000068190; ENSRNOG00000020276.
GeneIDi29389.
KEGGirno:29389.
UCSCiRGD:62050. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73701 mRNA. Translation: AAA42149.1.
RefSeqiNP_058881.1. NM_017185.1.
UniGeneiRn.9924.

3D structure databases

ProteinModelPortaliP27768.
SMRiP27768. Positions 4-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1534490.
STRINGi10116.ENSRNOP00000027487.

PTM databases

iPTMnetiP27768.
PhosphoSiteiP27768.

Proteomic databases

PaxDbiP27768.
PRIDEiP27768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000076140; ENSRNOP00000068152; ENSRNOG00000020276.
ENSRNOT00000076187; ENSRNOP00000068190; ENSRNOG00000020276.
GeneIDi29389.
KEGGirno:29389.
UCSCiRGD:62050. rat.

Organism-specific databases

CTDi7136.
RGDi62050. Tnni2.

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP27768.
KOiK12043.
OMAiLKSAMLQ.
PhylomeDBiP27768.

Enzyme and pathway databases

ReactomeiR-RNO-390522. Striated Muscle Contraction.

Miscellaneous databases

PROiP27768.

Gene expression databases

ExpressionAtlasiP27768. baseline and differential.
GenevisibleiP27768. RN.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI2_RAT
AccessioniPrimary (citable) accession number: P27768
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.