Reviewed,
UniProtKB/Swiss-Prot P27747 (ACOC_RALEH)
Last modified
June 16, 2009.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system EC=2.3.1.12 Alternative name(s): Acetoin dehydrogenase E2 component Dihydrolipoamide acetyltransferase component of acetoin cleaving system Fast-migrating protein Short name=FMP | ||||
| Gene names |
| ||||
| Organism | Ralstonia eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 381666 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus |
Protein attributes
| Sequence length | 374 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Dihydrolipoamide acetyltransferase involved in acetoin catabolism. |
| Catalytic activity | Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. |
| Cofactor | Binds 1 lipoyl cofactor covalently By similarity. |
| Pathway | |
| Induction | By growth on acetoin. |
| Sequence similarities | Contains 1 lipoyl-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Acetoin catabolism |
| Domain | Lipoyl |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | acetoin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | dihydrolipoyllysine-residue acetyltransferase activity Inferred from electronic annotation. Source: EC lipoic acid bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.1 | ||||||
| Chain | 2 – 374 | 373 | Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system | PRO_0000162304 | |||||
Regions | |||||||||
| Domain | 10 – 83 | 74 | Lipoyl-binding | ||||||
Amino acid modifications | |||||||||
| Modified residue | 50 | 1 | N6-lipoyllysine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 95 | 1 | D → G in AAA21950. Ref.1 | ||||||
| Sequence conflict | 121 | 1 | V → G in AAA21950. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism." Priefert H., Hein S., Krueger N., Zeh K., Schmidt B., Steinbuechel A. J. Bacteriol. 173:4056-4071(1991) [PubMed: 2061286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-28. |
| [2] | "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16." Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B. Nat. Biotechnol. 24:1257-1262(2006) [PubMed: 16964242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| M66060 Genomic DNA. Translation: AAA21950.1. AM260480 Genomic DNA. Translation: CAJ94952.1. | |
| RefSeq | YP_728317.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EHY based on UniProtKB O31243. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S33.010. |
Genome annotation databases | |
| GeneID | 4454951. |
| GenomeReviews | Gene locus H16_B0146 in contig AM260480_GR. |
| KEGG | reh:H16_B0146. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P27747. |
| OMA | P27747. CEVAPNR. |
Family and domain databases | |
| InterPro | IPR003016. 2-oxoA_DH_lipoyl-BS. IPR000073. AB_hydrolase_1. IPR000089. Biotin_lipoyl. [Graphical view] |
| Pfam | PF00561. Abhydrolase_1. 1 hit. PF00364. Biotin_lipoyl. 1 hit. [Graphical view] |
| PROSITE | PS50968. BIOTINYL_LIPOYL. 1 hit. PS00189. LIPOYL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ACOC_RALEH | ||||||||
| Accession | Primary (citable) accession number: P27747 Secondary accession number(s): Q0K4X2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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