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P27735

- THRC_SERMA

UniProt

P27735 - THRC_SERMA

Protein

Threonine synthase

Gene

thrC

Organism
Serratia marcescens
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrC
    OrganismiSerratia marcescens
    Taxonomic identifieri615 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Threonine synthasePRO_0000185640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei107 – 1071N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP27735.

    Structurei

    3D structure databases

    ProteinModelPortaliP27735.
    SMRiP27735. Positions 1-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Family and domain databases

    Gene3Di3.90.1380.10. 1 hit.
    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27735-1 [UniParc]FASTAAdd to Basket

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    MKLYNLKDHN EQVSFAQAIK QGLGKQQGLF FPLDLPEFEL TEIDHLLEQD    50
    FVTRSSRILS AFIGEEVPET ALKKRVQAAF EFPAPVAKVT DDVSCLELFH 100
    GPTLAFKDFG GRFMAQMLAE VAGEQPVTIL TATSGDTGAA VAHAFYGLKN 150
    VRVVILYPQG KISPLQEKLF CTLGGNIHTV AIDGDFDACQ ALVKQAFDDQ 200
    ELKDALHLNS ANSINISRLL AQICYYFEAV AQLPQEARNQ LVISVPSGNF 250
    GDLTAGLLAK SLGLPVKRFI AATNANDTVP RFLTSGQWQP HATVATLSNA 300
    MDVSQPNNWP RVEELFRRKV WQLKELGHAA VSDETTKDTM RELAELGYIS 350
    EPHAAIAYRA LRDQLQEGEF GLFLGTAHPA KFKESVEAIL GQELPLPKAL 400
    ALRAELPLLS HTLPASFGEL RKFLMGLPA 429
    Length:429
    Mass (Da):47,094
    Last modified:August 1, 1992 - v1
    Checksum:iB47262DE94848015
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10387 Genomic DNA. Translation: BAA01222.1.
    X60821 Genomic DNA. Translation: CAA43214.1.
    PIRiD47057. S16043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10387 Genomic DNA. Translation: BAA01222.1 .
    X60821 Genomic DNA. Translation: CAA43214.1 .
    PIRi D47057. S16043.

    3D structure databases

    ProteinModelPortali P27735.
    SMRi P27735. Positions 1-425.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P27735.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .

    Family and domain databases

    Gene3Di 3.90.1380.10. 1 hit.
    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR029144. Thr_synth_N.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    PF14821. Thr_synth_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the Serratia marcescens threonine operon and analysis of the threonine operon mutations which alter feedback inhibition of both aspartokinase I and homoserine dehydrogenase I."
      Omori K., Suzuki S., Komatsubara S.
      J. Bacteriol. 175:785-794(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sr41.

    Entry informationi

    Entry nameiTHRC_SERMA
    AccessioniPrimary (citable) accession number: P27735
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3