Reviewed, UniProtKB/Swiss-Prot P27735 (THRC_SERMA)

Names and origin

Protein names

Recommended name:
    Threonine synthase
    EC=4.2.3.1

Gene names

Name:

thrC

Organism

Serratia marcescens

Taxonomic identifier

615 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Threonine synthase		PRO_0000185640
Amino acid modifications
	Modified residue	107	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27735-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: B47262DE94848015	FASTA	429	47,094
	10 20 30 40 50 60 MKLYNLKDHN EQVSFAQAIK QGLGKQQGLF FPLDLPEFEL TEIDHLLEQD FVTRSSRILS 70 80 90 100 110 120 AFIGEEVPET ALKKRVQAAF EFPAPVAKVT DDVSCLELFH GPTLAFKDFG GRFMAQMLAE 130 140 150 160 170 180 VAGEQPVTIL TATSGDTGAA VAHAFYGLKN VRVVILYPQG KISPLQEKLF CTLGGNIHTV 190 200 210 220 230 240 AIDGDFDACQ ALVKQAFDDQ ELKDALHLNS ANSINISRLL AQICYYFEAV AQLPQEARNQ 250 260 270 280 290 300 LVISVPSGNF GDLTAGLLAK SLGLPVKRFI AATNANDTVP RFLTSGQWQP HATVATLSNA 310 320 330 340 350 360 MDVSQPNNWP RVEELFRRKV WQLKELGHAA VSDETTKDTM RELAELGYIS EPHAAIAYRA 370 380 390 400 410 420 LRDQLQEGEF GLFLGTAHPA KFKESVEAIL GQELPLPKAL ALRAELPLLS HTLPASFGEL RKFLMGLPA

References

[1]

"Nucleotide sequence of the Serratia marcescens threonine operon and analysis of the threonine operon mutations which alter feedback inhibition of both aspartokinase I and homoserine dehydrogenase I." Omori K., Suzuki S., Komatsubara S. J. Bacteriol. 175:785-794(1993) [PubMed: 8423151] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sr41.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10387 Genomic DNA. Translation: BAA01222.1. X60821 Genomic DNA. Translation: CAA43214.1.
PIR	S16043. D47057.
3D structure databases
SMR	P27735. Positions 1-425.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.2.3.1. 457.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_SERMA

Accession

Primary (citable) accession number: P27735

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)