##gff-version 3 P27732 UniProtKB Chain 1 2203 . . . ID=PRO_0000053936;Note=Voltage-dependent L-type calcium channel subunit alpha-1D P27732 UniProtKB Topological domain 1 126 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 127 145 . . . Note=Helical%3B Name%3DS1 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 146 163 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 164 183 . . . Note=Helical%3B Name%3DS2 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 184 195 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 196 214 . . . Note=Helical%3B Name%3DS3 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 215 235 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 236 254 . . . Note=Helical%3B Name%3DS4 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 255 273 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 274 293 . . . Note=Helical%3B Name%3DS5 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 294 381 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 382 406 . . . Note=Helical%3B Name%3DS6 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 407 582 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 583 602 . . . Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 603 617 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 618 636 . . . Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 637 644 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 645 663 . . . Note=Helical%3B Name%3DS3 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 664 673 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 674 692 . . . Note=Helical%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 693 711 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 712 732 . . . Note=Helical%3B Name%3DS5 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 733 786 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 787 811 . . . Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 812 945 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 946 964 . . . Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 965 980 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 981 1000 . . . Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1001 1012 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1013 1031 . . . Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1032 1037 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1038 1057 . . . Note=Helical%3B Name%3DS4 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1058 1076 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1077 1096 . . . Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1097 1186 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1187 1207 . . . Note=Helical%3B Name%3DS6 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1208 1264 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1265 1283 . . . Note=Helical%3B Name%3DS1 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1284 1298 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1299 1318 . . . Note=Helical%3B Name%3DS2 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1319 1325 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1326 1347 . . . Note=Helical%3B Name%3DS3 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1348 1357 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1358 1377 . . . Note=Helical%3B Name%3DS4 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1378 1396 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1397 1416 . . . Note=Helical%3B Name%3DS5 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1417 1483 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Transmembrane 1484 1508 . . . Note=Helical%3B Name%3DS6 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Topological domain 1509 2203 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Repeat 112 408 . . . Note=I P27732 UniProtKB Repeat 528 774 . . . Note=II P27732 UniProtKB Repeat 892 1174 . . . Note=III P27732 UniProtKB Repeat 1211 1486 . . . Note=IV P27732 UniProtKB Region 1 51 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Region 64 100 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Region 429 446 . . . Note=Binding to the beta subunit;Ontology_term=ECO:0000250;evidence=ECO:0000250 P27732 UniProtKB Region 449 480 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Region 822 909 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Region 1134 1224 . . . Note=Dihydropyridine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 P27732 UniProtKB Region 1464 1530 . . . Note=Dihydropyridine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 P27732 UniProtKB Region 1476 1519 . . . Note=Phenylalkylamine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 P27732 UniProtKB Region 1734 1766 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Region 1795 1816 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Region 1920 1963 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Region 2176 2195 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 35 51 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 462 480 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 822 847 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 848 862 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 863 881 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 882 897 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 1736 1755 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 1795 1809 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Compositional bias 1921 1950 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27732 UniProtKB Binding site 364 364 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07293 P27732 UniProtKB Binding site 764 764 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07293 P27732 UniProtKB Binding site 1160 1160 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07293 P27732 UniProtKB Glycosylation 155 155 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Glycosylation 225 225 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Glycosylation 329 329 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27732 UniProtKB Alternative sequence 481 492 . . . ID=VSP_000916;Note=In isoform 8. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1648940;Dbxref=PMID:1648940 P27732 UniProtKB Alternative sequence 493 512 . . . ID=VSP_000917;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1648940;Dbxref=PMID:1648940 P27732 UniProtKB Alternative sequence 1322 1392 . . . ID=VSP_000918;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9232351;Dbxref=PMID:9232351 P27732 UniProtKB Alternative sequence 1322 1349 . . . ID=VSP_000919;Note=In isoform 4 and isoform 10. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1279681,ECO:0000303|PubMed:9232351;Dbxref=PMID:1279681,PMID:9232351 P27732 UniProtKB Alternative sequence 1322 1348 . . . ID=VSP_000920;Note=In isoform 6. GYFSDAWNTFDSLIVIGSIIDVALSEA->HYFTDAWNTFDALIVVGSVVDIAITEVN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1648940;Dbxref=PMID:1648940 P27732 UniProtKB Alternative sequence 1349 1349 . . . ID=VSP_000921;Note=In isoform 6 and isoform 3. D->DPSDSENIPLPTATPG;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:1648940,ECO:0000303|PubMed:9232351;Dbxref=PMID:1648940,PMID:9232351 P27732 UniProtKB Alternative sequence 1354 1368 . . . ID=VSP_000922;Note=In isoform 10 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9232351;Dbxref=PMID:9232351 P27732 UniProtKB Alternative sequence 1642 1668 . . . ID=VSP_000923;Note=In isoform 2. DDEVTVGKFYATFLIQDYFRKFKKRKE->GNSRSGKSKAWWGNTLRRTPRSPYRRD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7760845;Dbxref=PMID:7760845 P27732 UniProtKB Alternative sequence 1669 2203 . . . ID=VSP_000924;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7760845;Dbxref=PMID:7760845 P27732 UniProtKB Alternative sequence 1686 1691 . . . ID=VSP_000925;Note=In isoform 13. AGLRTL->MLERML;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1648940;Dbxref=PMID:1648940 P27732 UniProtKB Alternative sequence 1692 2203 . . . ID=VSP_000926;Note=In isoform 13. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1648940;Dbxref=PMID:1648940 P27732 UniProtKB Mutagenesis 1656 1657 . . . Note=Loss of calcium-dependent inactivation related to the C-terminal lobe of calmodulin. IQ->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17050707;Dbxref=PMID:17050707 P27732 UniProtKB Sequence conflict 124 124 . . . Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 P27732 UniProtKB Sequence conflict 183 183 . . . Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 P27732 UniProtKB Sequence conflict 192 192 . . . Note=S->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 P27732 UniProtKB Sequence conflict 513 513 . . . Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 P27732 UniProtKB Sequence conflict 522 560 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P27732 UniProtKB Sequence conflict 1452 1452 . . . Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305