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P27732 (CAC1D_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent L-type calcium channel subunit alpha-1D
Alternative name(s):
Calcium channel, L type, alpha-1 polypeptide, isoform 2
Rat brain class D
Short name=RBD
Voltage-gated calcium channel subunit alpha Cav1.3
Gene names
Name:Cacna1d
Synonyms:Cach3, Cacn4, Cacnl1a2, Cchl1a2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length2203 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1Dgives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Ref.8

Subunit structure

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 and CABP4, resulting in a near elimination of calcium-dependent inactivation of the channel. Interacts with RIMBP2 By similarity. Ref.8

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in brain, pancreatic islets and B-lymphocytes. Ref.8

Domain

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. [View classification]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Gabbr2O888716EBI-8072674,EBI-7090239

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Note: The region sequenced in isoforms ROB3 and RKC5 is identical to CACN4.
Isoform 1 (identifier: P27732-1)

Also known as: CACN4A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P27732-2)

Also known as: CACN4B;

The sequence of this isoform differs from the canonical sequence as follows:
     1642-1668: DDEVTVGKFYATFLIQDYFRKFKKRKE → GNSRSGKSKAWWGNTLRRTPRSPYRRD
     1669-2203: Missing.
Isoform 3 (identifier: P27732-3)

Also known as: CACH3A; RB48; RBD-55;

The sequence of this isoform differs from the canonical sequence as follows:
     1349-1349: D → DPSDSENIPLPTATPG
Isoform 4 (identifier: P27732-4)

Also known as: Delta-IV-S3; RKC6;

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1349: Missing.
Isoform 5 (identifier: P27732-5)

Also known as: Delta-IV-S4;

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1368: Missing.
Isoform 6 (identifier: P27732-6)

Also known as: RB9;

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1348: GYFSDAWNTFDSLIVIGSIIDVALSEA → HYFTDAWNTFDALIVVGSVVDIAITEVN
     1349-1349: D → DPSDSENIPLPTATPG
Isoform 7 (identifier: P27732-7)

Also known as: RB11;

The sequence of this isoform differs from the canonical sequence as follows:
     493-512: Missing.
Isoform 8 (identifier: P27732-8)

Also known as: RB34;

The sequence of this isoform differs from the canonical sequence as follows:
     481-492: Missing.
Isoform 9 (identifier: P27732-9)

Also known as: RH1;

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1392: Missing.
Isoform 10 (identifier: P27732-10)

Also known as: RH2;

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1349: Missing.
     1354-1368: Missing.
Isoform 11 (identifier: P27732-13)

Also known as: RKC5;

The sequence of this isoform is not available.
Isoform 12 (identifier: P27732-14)

Also known as: ROB3;

The sequence of this isoform is not available.
Isoform 13 (identifier: P27732-12)

Also known as: Truncated;

The sequence of this isoform differs from the canonical sequence as follows:
     1686-1691: AGLRTL → MLERML
     1692-2203: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22032203Voltage-dependent L-type calcium channel subunit alpha-1D
PRO_0000053936

Regions

Topological domain1 – 126126Cytoplasmic Potential
Transmembrane127 – 14519Helical; Name=S1 of repeat I; Potential
Topological domain146 – 16318Extracellular Potential
Transmembrane164 – 18320Helical; Name=S2 of repeat I; Potential
Topological domain184 – 19512Cytoplasmic Potential
Transmembrane196 – 21419Helical; Name=S3 of repeat I; Potential
Topological domain215 – 23521Extracellular Potential
Transmembrane236 – 25419Helical; Name=S4 of repeat I; Potential
Topological domain255 – 27319Cytoplasmic Potential
Transmembrane274 – 29320Helical; Name=S5 of repeat I; Potential
Topological domain294 – 38188Extracellular Potential
Transmembrane382 – 40625Helical; Name=S6 of repeat I; Potential
Topological domain407 – 582176Cytoplasmic Potential
Transmembrane583 – 60220Helical; Name=S1 of repeat II; Potential
Topological domain603 – 61715Extracellular Potential
Transmembrane618 – 63619Helical; Name=S2 of repeat II; Potential
Topological domain637 – 6448Cytoplasmic Potential
Transmembrane645 – 66319Helical; Name=S3 of repeat II; Potential
Topological domain664 – 67310Extracellular Potential
Transmembrane674 – 69219Helical; Name=S4 of repeat II; Potential
Topological domain693 – 71119Cytoplasmic Potential
Transmembrane712 – 73221Helical; Name=S5 of repeat II; Potential
Topological domain733 – 78654Extracellular Potential
Transmembrane787 – 81125Helical; Name=S6 of repeat II; Potential
Topological domain812 – 945134Cytoplasmic Potential
Transmembrane946 – 96419Helical; Name=S1 of repeat III; Potential
Topological domain965 – 98016Extracellular Potential
Transmembrane981 – 100020Helical; Name=S2 of repeat III; Potential
Topological domain1001 – 101212Cytoplasmic Potential
Transmembrane1013 – 103119Helical; Name=S3 of repeat III; Potential
Topological domain1032 – 10376Extracellular Potential
Transmembrane1038 – 105720Helical; Name=S4 of repeat III; Potential
Topological domain1058 – 107619Cytoplasmic Potential
Transmembrane1077 – 109620Helical; Name=S5 of repeat III; Potential
Topological domain1097 – 118690Extracellular Potential
Transmembrane1187 – 120721Helical; Name=S6 of repeat III; Potential
Topological domain1208 – 126457Cytoplasmic Potential
Transmembrane1265 – 128319Helical; Name=S1 of repeat IV; Potential
Topological domain1284 – 129815Extracellular Potential
Transmembrane1299 – 131820Helical; Name=S2 of repeat IV; Potential
Topological domain1319 – 13257Cytoplasmic Potential
Transmembrane1326 – 134722Helical; Name=S3 of repeat IV; Potential
Topological domain1348 – 135710Extracellular Potential
Transmembrane1358 – 137720Helical; Name=S4 of repeat IV; Potential
Topological domain1378 – 139619Cytoplasmic Potential
Transmembrane1397 – 141620Helical; Name=S5 of repeat IV; Potential
Topological domain1417 – 148367Extracellular Potential
Transmembrane1484 – 150825Helical; Name=S6 of repeat IV; Potential
Topological domain1509 – 2203695Cytoplasmic Potential
Repeat112 – 408297I
Repeat528 – 774247II
Repeat892 – 1174283III
Repeat1211 – 1486276IV
Calcium binding1537 – 154812 Potential
Region429 – 44618Binding to the beta subunit By similarity
Region1134 – 122491Dihydropyridine binding By similarity
Region1464 – 153067Dihydropyridine binding By similarity
Region1476 – 151944Phenylalkylamine binding By similarity
Compositional bias1 – 77Poly-Met
Compositional bias712 – 7187Poly-Leu
Compositional bias886 – 89712Poly-Glu

Sites

Site3641Calcium ion selectivity and permeability By similarity
Site7631Calcium ion selectivity and permeability By similarity
Site11601Calcium ion selectivity and permeability By similarity
Site14501Calcium ion selectivity and permeability By similarity

Amino acid modifications

Modified residue15191Phosphoserine; by PKA Potential
Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation3291N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence481 – 49212Missing in isoform 8.
VSP_000916
Alternative sequence493 – 51220Missing in isoform 7.
VSP_000917
Alternative sequence1322 – 139271Missing in isoform 9.
VSP_000918
Alternative sequence1322 – 134928Missing in isoform 4 and isoform 10.
VSP_000919
Alternative sequence1322 – 134827GYFSD…ALSEA → HYFTDAWNTFDALIVVGSVV DIAITEVN in isoform 6.
VSP_000920
Alternative sequence13491D → DPSDSENIPLPTATPG in isoform 6 and isoform 3.
VSP_000921
Alternative sequence1354 – 136815Missing in isoform 10 and isoform 5.
VSP_000922
Alternative sequence1642 – 166827DDEVT…KKRKE → GNSRSGKSKAWWGNTLRRTP RSPYRRD in isoform 2.
VSP_000923
Alternative sequence1669 – 2203535Missing in isoform 2.
VSP_000924
Alternative sequence1686 – 16916AGLRTL → MLERML in isoform 13.
VSP_000925
Alternative sequence1692 – 2203512Missing in isoform 13.
VSP_000926

Experimental info

Mutagenesis1656 – 16572IQ → AA: Loss of calcium-dependent inactivation related to the C-terminal lobe of calmodulin. Ref.8
Sequence conflict1241D → N in AAA42015. Ref.2
Sequence conflict1831S → Y in AAA42015. Ref.2
Sequence conflict1921S → Y in AAA42015. Ref.2
Sequence conflict5131G → C Ref.2
Sequence conflict522 – 56039Missing Ref.2
Sequence conflict14521W → R in AAA89156. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (CACN4A) [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 8E746A8D988050C6

FASTA2,203250,136
        10         20         30         40         50         60 
MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 

        70         80         90        100        110        120 
RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 

       130        140        150        160        170        180 
SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 

       190        200        210        220        230        240 
IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 

       250        260        270        280        290        300 
AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 

       310        320        330        340        350        360 
CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 

       370        380        390        400        410        420 
ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 

       430        440        450        460        470        480 
DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 

       490        500        510        520        530        540 
GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 

       550        560        570        580        590        600 
VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 

       610        620        630        640        650        660 
SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 

       670        680        690        700        710        720 
TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 

       730        740        750        760        770        780 
IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 

       790        800        810        820        830        840 
SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 

       850        860        870        880        890        900 
SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 

       910        920        930        940        950        960 
GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 

       970        980        990       1000       1010       1020 
ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 

      1030       1040       1050       1060       1070       1080 
VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 

      1090       1100       1110       1120       1130       1140 
TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 

      1150       1160       1170       1180       1190       1200 
FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 

      1210       1220       1230       1240       1250       1260 
FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 

      1270       1280       1290       1300       1310       1320 
VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 

      1330       1340       1350       1360       1370       1380 
KGYFSDAWNT FDSLIVIGSI IDVALSEADN SEESNRISIT FFRLFRVMRL VKLLSRGEGI 

      1390       1400       1410       1420       1430       1440 
RTLLWTFIKS FQALPYVALL IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV 

      1450       1460       1470       1480       1490       1500 
LLLFRCATGE AWQEIMLACL PGKLCDPDSD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII 

      1510       1520       1530       1540       1550       1560 
NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL 

      1570       1580       1590       1600       1610       1620 
GFGKLCPHRV ACKRLVAMNM PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV 

      1630       1640       1650       1660       1670       1680 
IKKIWKKTSM KLLDQVVPPA GDDEVTVGKF YATFLIQDYF RKFKKRKEQG LVGKYPAKNT 

      1690       1700       1710       1720       1730       1740 
TIALQAGLRT LHDIGPEIRR AISCDLQDDE PEDSKPEEED VFKRNGALLG NYVNHVNSDR 

      1750       1760       1770       1780       1790       1800 
RESLQQTNTT HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG KQVPTSTNAN 

      1810       1820       1830       1840       1850       1860 
LNNANMSKAA HGKRPSIGDL EHVSENGHYS YKHDRELQRR SSIKRTRYYE TYIRSESGDE 

      1870       1880       1890       1900       1910       1920 
QLPTIFREDP EIHGYFRDPR CFGEQEYFSS EECCEDDSSP TWSRQNYSYY NRYPGSSMDF 

      1930       1940       1950       1960       1970       1980 
ERPRGYHHPQ GFLEDDDSPI GYDSRRSPRR RLLPPTPPSH RRSSFNFECL RRQNSQDDVL 

      1990       2000       2010       2020       2030       2040 
PSPALPHRAA LPLHLMQQQI MAVAGLDSSK AQKYSPSHST RSWATPPATP PYRDWTPCYT 

      2050       2060       2070       2080       2090       2100 
PLIQVDRSES MDQVNGSLPS LHRSSWYTDE PDISYRTFTP ASLTVPSSFR NKNSDKQRSA 

      2110       2120       2130       2140       2150       2160 
DSLVEAVLIS EGLGRYARDP KFVSATKHEI ADACDLTIDE MESAASTLLN GSVCPRANGD 

      2170       2180       2190       2200 
MGPISHRQDY ELQDFGPGYS DEEPDPGREE EDLADEMICI TTL 

« Hide

Isoform 2 (CACN4B) [UniParc].

Checksum: C0B994698B1EEA77
Show »

FASTA1,668189,438
Isoform 3 (CACH3A) (RB48) (RBD-55) [UniParc].

Checksum: F76CD9838B0DD9BB
Show »

FASTA2,218251,614
Isoform 4 (Delta-IV-S3) (RKC6) [UniParc].

Checksum: 3BB7746587D5E475
Show »

FASTA2,175247,135
Isoform 5 (Delta-IV-S4) [UniParc].

Checksum: 7036D5421C98E89D
Show »

FASTA2,188248,267
Isoform 6 (RB9) [UniParc].

Checksum: 1720A717CCD314D0
Show »

FASTA2,219251,820
Isoform 7 (RB11) [UniParc].

Checksum: ACA674F99711ECC7
Show »

FASTA2,183247,705
Isoform 8 (RB34) [UniParc].

Checksum: F928E1B53FAD29FF
Show »

FASTA2,191249,014
Isoform 9 (RH1) [UniParc].

Checksum: B0E7A0FBBB1B582A
Show »

FASTA2,132241,962
Isoform 10 (RH2) [UniParc].

Checksum: 8CD4F488BCAB9E28
Show »

FASTA2,160245,266
Isoform 11 (RKC5) (Sequence not available).
Isoform 12 (ROB3) (Sequence not available).
Isoform 13 (Truncated) [UniParc].

Checksum: BF6F15F872E7F40B
Show »

FASTA1,691192,179

References

[1]"Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells."
Ihara Y., Yamada Y., Fujii Y., Gonoi T., Yano H., Yasuda K., Inagaki N., Seino Y., Seino S.
Mol. Endocrinol. 9:121-130(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Insulinoma.
[2]"Molecular cloning of multiple subtypes of a novel rat brain isoform of the alpha-1 subunit of the voltage-dependent calcium channel."
Hui A., Ellinor P.T., Krizanova O., Wang J.-J., Diebold R.J., Schwartz A.
Neuron 7:35-44(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8 AND 13).
Tissue: Brain.
[3]"Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene."
Kamp T.J., Mitas M., Fields K.L., Asoh S., Chin H., Marban E., Nirenberg M.
Cell. Mol. Neurobiol. 15:307-326(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.
[4]"Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney."
Yu A.S.L., Hebert S.C., Brenner B.M., Lytton J.
Proc. Natl. Acad. Sci. U.S.A. 89:10494-10498(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1100-1410 (ISOFORMS 4 AND 11).
Tissue: Kidney.
[5]"Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone."
Barry E.L.R., Gesek F.A., Froehner S.C., Friedman P.A.
Proc. Natl. Acad. Sci. U.S.A. 92:10914-10918(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1218-1498 (ISOFORM 12).
Tissue: Osteosarcoma.
[6]"Novel variants of voltage-operated calcium channel alpha-1 subunit transcripts in a rat liver-derived cell line: deletion in the IVS4 voltage sensing region."
Brereton H.M., Harland M.L., Froscio M., Petronijevic T., Barritt G.J.
Cell Calcium 22:39-52(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1200-1493 (ISOFORMS 3; 4; 5; 9 AND 10).
Tissue: Hepatoma.
[7]"Rat brain expresses a heterogeneous family of calcium channels."
Snutch T.P., Leonard J.P., Gilbert M.M., Lester H.A., Davidson N.
Proc. Natl. Acad. Sci. U.S.A. 87:3391-3395(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1307-1479 (ISOFORM 3).
[8]"Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells."
Yang P.S., Alseikhan B.A., Hiel H., Grant L., Mori M.X., Yang W., Fuchs P.A., Yue D.T.
J. Neurosci. 26:10677-10689(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF 1656-ILE-GLN-1657, INTERACTION WITH CABP1 AND CABP4, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38101 mRNA. Translation: BAA07282.1.
D38102 mRNA. Translation: BAA07283.1.
M57682 mRNA. Translation: AAA42015.1.
U14005 Genomic DNA. Translation: AAB60515.1.
M99221 mRNA. Translation: AAA40895.1.
U31772 mRNA. Translation: AAA89156.1.
U49126 mRNA. Translation: AAB61634.1.
U49127 mRNA. Translation: AAB61635.1.
U49128 mRNA. Translation: AAB61636.1.
PIRJH0422.
T42742.
RefSeqNP_058994.1. NM_017298.1. [P27732-1]
UniGeneRn.89671.

3D structure databases

ProteinModelPortalP27732.
SMRP27732. Positions 1644-1672.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60740N.
IntActP27732. 2 interactions.
MINTMINT-7965882.

Chemistry

BindingDBP27732.
ChEMBLCHEMBL4132.
GuidetoPHARMACOLOGY530.

Protein family/group databases

TCDB1.A.1.11.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteP27732.

Proteomic databases

PaxDbP27732.
PRIDEP27732.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29716.
KEGGrno:29716.

Organism-specific databases

CTD776.
RGD70973. Cacna1d.

Phylogenomic databases

eggNOGCOG1226.
HOVERGENHBG050763.
KOK04851.
PhylomeDBP27732.

Enzyme and pathway databases

ReactomeREACT_205051. Metabolism.

Gene expression databases

GenevestigatorP27732.

Family and domain databases

Gene3D1.20.120.350. 5 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005452. LVDCC_a1dsu.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01636. LVDCCALPHA1D.
SMARTSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610169.
PROP27732.

Entry information

Entry nameCAC1D_RAT
AccessionPrimary (citable) accession number: P27732
Secondary accession number(s): O09022 expand/collapse secondary AC list , O09023, O09024, Q01542, Q62691, Q62815, Q63491, Q63492
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families