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P27732

- CAC1D_RAT

UniProt

P27732 - CAC1D_RAT

Protein

Voltage-dependent L-type calcium channel subunit alpha-1D

Gene

Cacna1d

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei364 – 3641Calcium ion selectivity and permeabilityBy similarity
    Sitei763 – 7631Calcium ion selectivity and permeabilityBy similarity
    Sitei1160 – 11601Calcium ion selectivity and permeabilityBy similarity
    Sitei1450 – 14501Calcium ion selectivity and permeabilityBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi1537 – 154812Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. ankyrin binding Source: BHF-UCL
    2. high voltage-gated calcium channel activity Source: RGD
    3. metal ion binding Source: UniProtKB-KW
    4. PDZ domain binding Source: RGD
    5. protein binding Source: IntAct
    6. voltage-gated calcium channel activity Source: BHF-UCL
    7. voltage-gated calcium channel activity involved in cardiac muscle cell action potential Source: BHF-UCL

    GO - Biological processi

    1. aging Source: RGD
    2. calcium ion import Source: RGD
    3. calcium ion transport Source: BHF-UCL
    4. calcium-mediated signaling Source: RGD
    5. divalent metal ion transport Source: RGD
    6. heart development Source: RGD
    7. membrane depolarization during action potential Source: RefGenome
    8. membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
    9. memory Source: RGD
    10. positive regulation of CREB transcription factor activity Source: RGD
    11. regulation of calcium ion transport Source: BHF-UCL

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Metal-binding

    Protein family/group databases

    TCDBi1.A.1.11.1. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent L-type calcium channel subunit alpha-1D
    Alternative name(s):
    Calcium channel, L type, alpha-1 polypeptide, isoform 2
    Rat brain class D
    Short name:
    RBD
    Voltage-gated calcium channel subunit alpha Cav1.3
    Gene namesi
    Name:Cacna1d
    Synonyms:Cach3, Cacn4, Cacnl1a2, Cchl1a2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi70973. Cacna1d.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. dendrite Source: RGD
    3. dendrite membrane Source: RGD
    4. neuronal cell body Source: RGD
    5. nucleus Source: RGD
    6. plasma membrane Source: RGD
    7. sarcolemma Source: RGD
    8. voltage-gated calcium channel complex Source: RGD

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1656 – 16572IQ → AA: Loss of calcium-dependent inactivation related to the C-terminal lobe of calmodulin. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22032203Voltage-dependent L-type calcium channel subunit alpha-1DPRO_0000053936Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1519 – 15191Phosphoserine; by PKASequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP27732.
    PRIDEiP27732.

    PTM databases

    PhosphoSiteiP27732.

    Expressioni

    Tissue specificityi

    Expressed in brain, pancreatic islets and B-lymphocytes.1 Publication

    Gene expression databases

    GenevestigatoriP27732.

    Interactioni

    Subunit structurei

    Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 and CABP4, resulting in a near elimination of calcium-dependent inactivation of the channel. Interacts with RIMBP2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Gabbr2O888716EBI-8072674,EBI-7090239

    Protein-protein interaction databases

    DIPiDIP-60740N.
    IntActiP27732. 2 interactions.
    MINTiMINT-7965882.

    Structurei

    3D structure databases

    ProteinModelPortaliP27732.
    SMRiP27732. Positions 1644-1672.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 126126CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini146 – 16318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 19512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini215 – 23521ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini255 – 27319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini294 – 38188ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini407 – 582176CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini603 – 61715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini637 – 6448CytoplasmicSequence Analysis
    Topological domaini664 – 67310ExtracellularSequence Analysis
    Topological domaini693 – 71119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini733 – 78654ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini812 – 945134CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini965 – 98016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1001 – 101212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1032 – 10376ExtracellularSequence Analysis
    Topological domaini1058 – 107619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1097 – 118690ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1208 – 126457CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1284 – 129815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1319 – 13257CytoplasmicSequence Analysis
    Topological domaini1348 – 135710ExtracellularSequence Analysis
    Topological domaini1378 – 139619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1417 – 148367ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1509 – 2203695CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei127 – 14519Helical; Name=S1 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei164 – 18320Helical; Name=S2 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei196 – 21419Helical; Name=S3 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei236 – 25419Helical; Name=S4 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei274 – 29320Helical; Name=S5 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei382 – 40625Helical; Name=S6 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei583 – 60220Helical; Name=S1 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei618 – 63619Helical; Name=S2 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei645 – 66319Helical; Name=S3 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei674 – 69219Helical; Name=S4 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei712 – 73221Helical; Name=S5 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei787 – 81125Helical; Name=S6 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei946 – 96419Helical; Name=S1 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei981 – 100020Helical; Name=S2 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1013 – 103119Helical; Name=S3 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1038 – 105720Helical; Name=S4 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1077 – 109620Helical; Name=S5 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1187 – 120721Helical; Name=S6 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1265 – 128319Helical; Name=S1 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1299 – 131820Helical; Name=S2 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1326 – 134722Helical; Name=S3 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1358 – 137720Helical; Name=S4 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1397 – 141620Helical; Name=S5 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1484 – 150825Helical; Name=S6 of repeat IVSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati112 – 408297IAdd
    BLAST
    Repeati528 – 774247IIAdd
    BLAST
    Repeati892 – 1174283IIIAdd
    BLAST
    Repeati1211 – 1486276IVAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni429 – 44618Binding to the beta subunitBy similarityAdd
    BLAST
    Regioni1134 – 122491Dihydropyridine bindingBy similarityAdd
    BLAST
    Regioni1464 – 153067Dihydropyridine bindingBy similarityAdd
    BLAST
    Regioni1476 – 151944Phenylalkylamine bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 77Poly-Met
    Compositional biasi712 – 7187Poly-Leu
    Compositional biasi886 – 89712Poly-GluAdd
    BLAST

    Domaini

    Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOVERGENiHBG050763.
    KOiK04851.
    PhylomeDBiP27732.

    Family and domain databases

    Gene3Di1.20.120.350. 5 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR005452. LVDCC_a1dsu.
    IPR014873. VDCC_a1su_IQ.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    PR01636. LVDCCALPHA1D.
    SMARTiSM01062. Ca_chan_IQ. 1 hit.
    [Graphical view]

    Sequences (13)i

    Sequence statusi: Complete.

    This entry describes 13 isoformsi produced by alternative splicing. Align

    Note: The region sequenced in isoforms ROB3 and RKC5 is identical to CACN4.

    Isoform 1 (identifier: P27732-1) [UniParc]FASTAAdd to Basket

    Also known as: CACN4A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV     50
    LSWQAAIDAA RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS 100
    RPARALFCLS LNNPIRRACI SIVDWKPFDI FILLAIFANC VALAIYIPFP 150
    EDDSNSTNHN LEKVEYAFLI IFTVETFLKI IASGLLLHPN ASVRNGWNLL 200
    DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR AFRVLRPLRL 250
    VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 300
    CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF 350
    AFAMLTVFQC ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL 400
    VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP 450
    ENEEEGGEEG KRNTSMPTSE TESVNTENVS GEGETQGCCG SLWCWWKRRG 500
    AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL VKLWTSRFSA 550
    HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 600
    SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD 650
    CFVVCGGITE TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA 700
    SLLNSMKSIA SLLLLLFLFI IIFSLLGMQL FGGKFNFDET QTKRSTFDNF 750
    PQALLTVFQI LTGEDWNAVM YDGIMAYGGP SSSGMIVCIY FIILFICGNY 800
    ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE SLENKKNNKP 850
    EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 900
    GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL 950
    ILVFIMLSSA ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF 1000
    GAFLHKGAFC RNYFNLLDML VVGVSLVSFG IQSSAISVVK ILRVLRVLRP 1050
    LRAINRAKGL KHVVQCVFVA IRTIGNIMIV TTLLQFMFAC IGVQLFKGKF 1100
    YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD FNFDNVLSAM 1150
    MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1200
    FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK 1250
    NPYQYKFWYV VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN 1300
    MVFTGVFTVE MVLKVIAFKP KGYFSDAWNT FDSLIVIGSI IDVALSEADN 1350
    SEESNRISIT FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL 1400
    IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV LLLFRCATGE 1450
    AWQEIMLACL PGKLCDPDSD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII 1500
    NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV 1550
    TLLRRIQPPL GFGKLCPHRV ACKRLVAMNM PLNSDGTVMF NATLFALVRT 1600
    ALKIKTEGNL EQANEELRAV IKKIWKKTSM KLLDQVVPPA GDDEVTVGKF 1650
    YATFLIQDYF RKFKKRKEQG LVGKYPAKNT TIALQAGLRT LHDIGPEIRR 1700
    AISCDLQDDE PEDSKPEEED VFKRNGALLG NYVNHVNSDR RESLQQTNTT 1750
    HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG KQVPTSTNAN 1800
    LNNANMSKAA HGKRPSIGDL EHVSENGHYS YKHDRELQRR SSIKRTRYYE 1850
    TYIRSESGDE QLPTIFREDP EIHGYFRDPR CFGEQEYFSS EECCEDDSSP 1900
    TWSRQNYSYY NRYPGSSMDF ERPRGYHHPQ GFLEDDDSPI GYDSRRSPRR 1950
    RLLPPTPPSH RRSSFNFECL RRQNSQDDVL PSPALPHRAA LPLHLMQQQI 2000
    MAVAGLDSSK AQKYSPSHST RSWATPPATP PYRDWTPCYT PLIQVDRSES 2050
    MDQVNGSLPS LHRSSWYTDE PDISYRTFTP ASLTVPSSFR NKNSDKQRSA 2100
    DSLVEAVLIS EGLGRYARDP KFVSATKHEI ADACDLTIDE MESAASTLLN 2150
    GSVCPRANGD MGPISHRQDY ELQDFGPGYS DEEPDPGREE EDLADEMICI 2200
    TTL 2203
    Length:2,203
    Mass (Da):250,136
    Last modified:July 15, 1999 - v2
    Checksum:i8E746A8D988050C6
    GO
    Isoform 2 (identifier: P27732-2) [UniParc]FASTAAdd to Basket

    Also known as: CACN4B

    The sequence of this isoform differs from the canonical sequence as follows:
         1642-1668: DDEVTVGKFYATFLIQDYFRKFKKRKE → GNSRSGKSKAWWGNTLRRTPRSPYRRD
         1669-2203: Missing.

    Show »
    Length:1,668
    Mass (Da):189,438
    Checksum:iC0B994698B1EEA77
    GO
    Isoform 3 (identifier: P27732-3) [UniParc]FASTAAdd to Basket

    Also known as: CACH3A, RB48, RBD-55

    The sequence of this isoform differs from the canonical sequence as follows:
         1349-1349: D → DPSDSENIPLPTATPG

    Show »
    Length:2,218
    Mass (Da):251,614
    Checksum:iF76CD9838B0DD9BB
    GO
    Isoform 4 (identifier: P27732-4) [UniParc]FASTAAdd to Basket

    Also known as: Delta-IV-S3, RKC6

    The sequence of this isoform differs from the canonical sequence as follows:
         1322-1349: Missing.

    Show »
    Length:2,175
    Mass (Da):247,135
    Checksum:i3BB7746587D5E475
    GO
    Isoform 5 (identifier: P27732-5) [UniParc]FASTAAdd to Basket

    Also known as: Delta-IV-S4

    The sequence of this isoform differs from the canonical sequence as follows:
         1354-1368: Missing.

    Show »
    Length:2,188
    Mass (Da):248,267
    Checksum:i7036D5421C98E89D
    GO
    Isoform 6 (identifier: P27732-6) [UniParc]FASTAAdd to Basket

    Also known as: RB9

    The sequence of this isoform differs from the canonical sequence as follows:
         1322-1348: GYFSDAWNTFDSLIVIGSIIDVALSEA → HYFTDAWNTFDALIVVGSVVDIAITEVN
         1349-1349: D → DPSDSENIPLPTATPG

    Show »
    Length:2,219
    Mass (Da):251,820
    Checksum:i1720A717CCD314D0
    GO
    Isoform 7 (identifier: P27732-7) [UniParc]FASTAAdd to Basket

    Also known as: RB11

    The sequence of this isoform differs from the canonical sequence as follows:
         493-512: Missing.

    Show »
    Length:2,183
    Mass (Da):247,705
    Checksum:iACA674F99711ECC7
    GO
    Isoform 8 (identifier: P27732-8) [UniParc]FASTAAdd to Basket

    Also known as: RB34

    The sequence of this isoform differs from the canonical sequence as follows:
         481-492: Missing.

    Show »
    Length:2,191
    Mass (Da):249,014
    Checksum:iF928E1B53FAD29FF
    GO
    Isoform 9 (identifier: P27732-9) [UniParc]FASTAAdd to Basket

    Also known as: RH1

    The sequence of this isoform differs from the canonical sequence as follows:
         1322-1392: Missing.

    Show »
    Length:2,132
    Mass (Da):241,962
    Checksum:iB0E7A0FBBB1B582A
    GO
    Isoform 10 (identifier: P27732-10) [UniParc]FASTAAdd to Basket

    Also known as: RH2

    The sequence of this isoform differs from the canonical sequence as follows:
         1322-1349: Missing.
         1354-1368: Missing.

    Show »
    Length:2,160
    Mass (Da):245,266
    Checksum:i8CD4F488BCAB9E28
    GO
    Isoform 11 (identifier: P27732-13)

    Also known as: RKC5

    Sequence is not available
    Length:
    Mass (Da):
    Isoform 12 (identifier: P27732-14)

    Also known as: ROB3

    Sequence is not available
    Length:
    Mass (Da):
    Isoform 13 (identifier: P27732-12) [UniParc]FASTAAdd to Basket

    Also known as: Truncated

    The sequence of this isoform differs from the canonical sequence as follows:
         1686-1691: AGLRTL → MLERML
         1692-2203: Missing.

    Show »
    Length:1,691
    Mass (Da):192,179
    Checksum:iBF6F15F872E7F40B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241D → N in AAA42015. (PubMed:1648940)Curated
    Sequence conflicti183 – 1831S → Y in AAA42015. (PubMed:1648940)Curated
    Sequence conflicti192 – 1921S → Y in AAA42015. (PubMed:1648940)Curated
    Sequence conflicti513 – 5131G → C(PubMed:1648940)Curated
    Sequence conflicti522 – 56039Missing(PubMed:1648940)CuratedAdd
    BLAST
    Sequence conflicti1452 – 14521W → R in AAA89156. (PubMed:7479909)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei481 – 49212Missing in isoform 8. 1 PublicationVSP_000916Add
    BLAST
    Alternative sequencei493 – 51220Missing in isoform 7. 1 PublicationVSP_000917Add
    BLAST
    Alternative sequencei1322 – 139271Missing in isoform 9. 1 PublicationVSP_000918Add
    BLAST
    Alternative sequencei1322 – 134928Missing in isoform 4 and isoform 10. 2 PublicationsVSP_000919Add
    BLAST
    Alternative sequencei1322 – 134827GYFSD…ALSEA → HYFTDAWNTFDALIVVGSVV DIAITEVN in isoform 6. 1 PublicationVSP_000920Add
    BLAST
    Alternative sequencei1349 – 13491D → DPSDSENIPLPTATPG in isoform 6 and isoform 3. 2 PublicationsVSP_000921
    Alternative sequencei1354 – 136815Missing in isoform 10 and isoform 5. 1 PublicationVSP_000922Add
    BLAST
    Alternative sequencei1642 – 166827DDEVT…KKRKE → GNSRSGKSKAWWGNTLRRTP RSPYRRD in isoform 2. 1 PublicationVSP_000923Add
    BLAST
    Alternative sequencei1669 – 2203535Missing in isoform 2. 1 PublicationVSP_000924Add
    BLAST
    Alternative sequencei1686 – 16916AGLRTL → MLERML in isoform 13. 1 PublicationVSP_000925
    Alternative sequencei1692 – 2203512Missing in isoform 13. 1 PublicationVSP_000926Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38101 mRNA. Translation: BAA07282.1.
    D38102 mRNA. Translation: BAA07283.1.
    M57682 mRNA. Translation: AAA42015.1.
    U14005 Genomic DNA. Translation: AAB60515.1.
    M99221 mRNA. Translation: AAA40895.1.
    U31772 mRNA. Translation: AAA89156.1.
    U49126 mRNA. Translation: AAB61634.1.
    U49127 mRNA. Translation: AAB61635.1.
    U49128 mRNA. Translation: AAB61636.1.
    PIRiJH0422.
    T42742.
    RefSeqiNP_058994.1. NM_017298.1. [P27732-1]
    UniGeneiRn.89671.

    Genome annotation databases

    GeneIDi29716.
    KEGGirno:29716.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38101 mRNA. Translation: BAA07282.1 .
    D38102 mRNA. Translation: BAA07283.1 .
    M57682 mRNA. Translation: AAA42015.1 .
    U14005 Genomic DNA. Translation: AAB60515.1 .
    M99221 mRNA. Translation: AAA40895.1 .
    U31772 mRNA. Translation: AAA89156.1 .
    U49126 mRNA. Translation: AAB61634.1 .
    U49127 mRNA. Translation: AAB61635.1 .
    U49128 mRNA. Translation: AAB61636.1 .
    PIRi JH0422.
    T42742.
    RefSeqi NP_058994.1. NM_017298.1. [P27732-1 ]
    UniGenei Rn.89671.

    3D structure databases

    ProteinModelPortali P27732.
    SMRi P27732. Positions 1644-1672.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60740N.
    IntActi P27732. 2 interactions.
    MINTi MINT-7965882.

    Chemistry

    BindingDBi P27732.
    ChEMBLi CHEMBL4132.
    GuidetoPHARMACOLOGYi 530.

    Protein family/group databases

    TCDBi 1.A.1.11.1. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei P27732.

    Proteomic databases

    PaxDbi P27732.
    PRIDEi P27732.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29716.
    KEGGi rno:29716.

    Organism-specific databases

    CTDi 776.
    RGDi 70973. Cacna1d.

    Phylogenomic databases

    eggNOGi COG1226.
    HOVERGENi HBG050763.
    KOi K04851.
    PhylomeDBi P27732.

    Miscellaneous databases

    NextBioi 610169.
    PROi P27732.

    Gene expression databases

    Genevestigatori P27732.

    Family and domain databases

    Gene3Di 1.20.120.350. 5 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR005452. LVDCC_a1dsu.
    IPR014873. VDCC_a1su_IQ.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    PR01636. LVDCCALPHA1D.
    SMARTi SM01062. Ca_chan_IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells."
      Ihara Y., Yamada Y., Fujii Y., Gonoi T., Yano H., Yasuda K., Inagaki N., Seino Y., Seino S.
      Mol. Endocrinol. 9:121-130(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Insulinoma.
    2. "Molecular cloning of multiple subtypes of a novel rat brain isoform of the alpha-1 subunit of the voltage-dependent calcium channel."
      Hui A., Ellinor P.T., Krizanova O., Wang J.-J., Diebold R.J., Schwartz A.
      Neuron 7:35-44(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8 AND 13).
      Tissue: Brain.
    3. "Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene."
      Kamp T.J., Mitas M., Fields K.L., Asoh S., Chin H., Marban E., Nirenberg M.
      Cell. Mol. Neurobiol. 15:307-326(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.
    4. "Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney."
      Yu A.S.L., Hebert S.C., Brenner B.M., Lytton J.
      Proc. Natl. Acad. Sci. U.S.A. 89:10494-10498(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1100-1410 (ISOFORMS 4 AND 11).
      Tissue: Kidney.
    5. "Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone."
      Barry E.L.R., Gesek F.A., Froehner S.C., Friedman P.A.
      Proc. Natl. Acad. Sci. U.S.A. 92:10914-10918(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1218-1498 (ISOFORM 12).
      Tissue: Osteosarcoma.
    6. "Novel variants of voltage-operated calcium channel alpha-1 subunit transcripts in a rat liver-derived cell line: deletion in the IVS4 voltage sensing region."
      Brereton H.M., Harland M.L., Froscio M., Petronijevic T., Barritt G.J.
      Cell Calcium 22:39-52(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1200-1493 (ISOFORMS 3; 4; 5; 9 AND 10).
      Tissue: Hepatoma.
    7. Cited for: NUCLEOTIDE SEQUENCE OF 1307-1479 (ISOFORM 3).
    8. "Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells."
      Yang P.S., Alseikhan B.A., Hiel H., Grant L., Mori M.X., Yang W., Fuchs P.A., Yue D.T.
      J. Neurosci. 26:10677-10689(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 1656-ILE-GLN-1657, INTERACTION WITH CABP1 AND CABP4, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCAC1D_RAT
    AccessioniPrimary (citable) accession number: P27732
    Secondary accession number(s): O09022
    , O09023, O09024, Q01542, Q62691, Q62815, Q63491, Q63492
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3