P27732 (CAC1D_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent L-type calcium channel subunit alpha-1D

Alternative name(s):
Calcium channel, L type, alpha-1 polypeptide, isoform 2
Rat brain class D
Short name=RBD
Voltage-gated calcium channel subunit alpha Cav1.3

Gene names

Name:	Cacna1d
Synonyms:	Cach3, Cacn4, Cacnl1a2, Cchl1a2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	2203 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Ref.8
Subunit structure	Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 and CABP4, resulting in a near elimination of calcium-dependent inactivation of the channel. Interacts with RIMBP2 By similarity. Ref.8
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain, pancreatic islets and B-lymphocytes. Ref.8
Domain	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of calcium ion transport Inferred from direct assay PubMed 21859974. Source: BHF-UCL
Cellular_component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity involved in regulation of cardiac muscle cell action potential Inferred by curator PubMed 21859974. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Note: The region sequenced in isoforms ROB3 and RKC5 is identical to CACN4.

Isoform 1 (identifier: P27732-1)

Also known as: CACN4A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P27732-2)

Also known as: CACN4B;

The sequence of this isoform differs from the canonical sequence as follows:
     1642-1668: DDEVTVGKFYATFLIQDYFRKFKKRKE → GNSRSGKSKAWWGNTLRRTPRSPYRRD
     1669-2203: Missing.

Isoform 3 (identifier: P27732-3)

Also known as: CACH3A; RB48; RBD-55;

The sequence of this isoform differs from the canonical sequence as follows:
     1349-1349: D → DPSDSENIPLPTATPG

Isoform 4 (identifier: P27732-4)

Also known as: Delta-IV-S3; RKC6;

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1349: Missing.

Isoform 5 (identifier: P27732-5)

Also known as: Delta-IV-S4;

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1368: Missing.

Isoform 6 (identifier: P27732-6)

Also known as: RB9;

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1348: GYFSDAWNTFDSLIVIGSIIDVALSEA → HYFTDAWNTFDALIVVGSVVDIAITEVN
     1349-1349: D → DPSDSENIPLPTATPG

Isoform 7 (identifier: P27732-7)

Also known as: RB11;

The sequence of this isoform differs from the canonical sequence as follows:
     493-512: Missing.

Isoform 8 (identifier: P27732-8)

Also known as: RB34;

The sequence of this isoform differs from the canonical sequence as follows:
     481-492: Missing.

Isoform 9 (identifier: P27732-9)

Also known as: RH1;

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1392: Missing.

Isoform 10 (identifier: P27732-10)

Also known as: RH2;

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1349: Missing.
     1354-1368: Missing.

Isoform 11 (identifier: P27732-13)

Also known as: RKC5;

The sequence of this isoform is not available.

Isoform 12 (identifier: P27732-14)

Also known as: ROB3;

The sequence of this isoform is not available.

Isoform 13 (identifier: P27732-12)

Also known as: Truncated;

The sequence of this isoform differs from the canonical sequence as follows:
     1686-1691: AGLRTL → MLERML
     1692-2203: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2203	2203	Voltage-dependent L-type calcium channel subunit alpha-1D		PRO_0000053936
Regions
	Topological domain	1 – 126	126	Cytoplasmic Potential
	Transmembrane	127 – 145	19	Helical; Name=S1 of repeat I; Potential
	Topological domain	146 – 163	18	Extracellular Potential
	Transmembrane	164 – 183	20	Helical; Name=S2 of repeat I; Potential
	Topological domain	184 – 195	12	Cytoplasmic Potential
	Transmembrane	196 – 214	19	Helical; Name=S3 of repeat I; Potential
	Topological domain	215 – 235	21	Extracellular Potential
	Transmembrane	236 – 254	19	Helical; Name=S4 of repeat I; Potential
	Topological domain	255 – 273	19	Cytoplasmic Potential
	Transmembrane	274 – 293	20	Helical; Name=S5 of repeat I; Potential
	Topological domain	294 – 381	88	Extracellular Potential
	Transmembrane	382 – 406	25	Helical; Name=S6 of repeat I; Potential
	Topological domain	407 – 582	176	Cytoplasmic Potential
	Transmembrane	583 – 602	20	Helical; Name=S1 of repeat II; Potential
	Topological domain	603 – 617	15	Extracellular Potential
	Transmembrane	618 – 636	19	Helical; Name=S2 of repeat II; Potential
	Topological domain	637 – 644	8	Cytoplasmic Potential
	Transmembrane	645 – 663	19	Helical; Name=S3 of repeat II; Potential
	Topological domain	664 – 673	10	Extracellular Potential
	Transmembrane	674 – 692	19	Helical; Name=S4 of repeat II; Potential
	Topological domain	693 – 711	19	Cytoplasmic Potential
	Transmembrane	712 – 732	21	Helical; Name=S5 of repeat II; Potential
	Topological domain	733 – 786	54	Extracellular Potential
	Transmembrane	787 – 811	25	Helical; Name=S6 of repeat II; Potential
	Topological domain	812 – 945	134	Cytoplasmic Potential
	Transmembrane	946 – 964	19	Helical; Name=S1 of repeat III; Potential
	Topological domain	965 – 980	16	Extracellular Potential
	Transmembrane	981 – 1000	20	Helical; Name=S2 of repeat III; Potential
	Topological domain	1001 – 1012	12	Cytoplasmic Potential
	Transmembrane	1013 – 1031	19	Helical; Name=S3 of repeat III; Potential
	Topological domain	1032 – 1037	6	Extracellular Potential
	Transmembrane	1038 – 1057	20	Helical; Name=S4 of repeat III; Potential
	Topological domain	1058 – 1076	19	Cytoplasmic Potential
	Transmembrane	1077 – 1096	20	Helical; Name=S5 of repeat III; Potential
	Topological domain	1097 – 1186	90	Extracellular Potential
	Transmembrane	1187 – 1207	21	Helical; Name=S6 of repeat III; Potential
	Topological domain	1208 – 1264	57	Cytoplasmic Potential
	Transmembrane	1265 – 1283	19	Helical; Name=S1 of repeat IV; Potential
	Topological domain	1284 – 1298	15	Extracellular Potential
	Transmembrane	1299 – 1318	20	Helical; Name=S2 of repeat IV; Potential
	Topological domain	1319 – 1325	7	Cytoplasmic Potential
	Transmembrane	1326 – 1347	22	Helical; Name=S3 of repeat IV; Potential
	Topological domain	1348 – 1357	10	Extracellular Potential
	Transmembrane	1358 – 1377	20	Helical; Name=S4 of repeat IV; Potential
	Topological domain	1378 – 1396	19	Cytoplasmic Potential
	Transmembrane	1397 – 1416	20	Helical; Name=S5 of repeat IV; Potential
	Topological domain	1417 – 1483	67	Extracellular Potential
	Transmembrane	1484 – 1508	25	Helical; Name=S6 of repeat IV; Potential
	Topological domain	1509 – 2203	695	Cytoplasmic Potential
	Repeat	112 – 408	297	I
	Repeat	528 – 774	247	II
	Repeat	892 – 1174	283	III
	Repeat	1211 – 1486	276	IV
	Calcium binding	1537 – 1548	12	Potential
	Region	429 – 446	18	Binding to the beta subunit By similarity
	Region	1134 – 1224	91	Dihydropyridine binding By similarity
	Region	1464 – 1530	67	Dihydropyridine binding By similarity
	Region	1476 – 1519	44	Phenylalkylamine binding By similarity
	Compositional bias	1 – 7	7	Poly-Met
	Compositional bias	712 – 718	7	Poly-Leu
	Compositional bias	886 – 897	12	Poly-Glu
Sites
	Site	364	1	Calcium ion selectivity and permeability By similarity
	Site	763	1	Calcium ion selectivity and permeability By similarity
	Site	1160	1	Calcium ion selectivity and permeability By similarity
	Site	1450	1	Calcium ion selectivity and permeability By similarity
Amino acid modifications
	Modified residue	1519	1	Phosphoserine; by PKA Potential
	Glycosylation	155	1	N-linked (GlcNAc...) Potential
	Glycosylation	225	1	N-linked (GlcNAc...) Potential
	Glycosylation	329	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	481 – 492	12	Missing in isoform 8.		VSP_000916
	Alternative sequence	493 – 512	20	Missing in isoform 7.		VSP_000917
	Alternative sequence	1322 – 1392	71	Missing in isoform 9.		VSP_000918
	Alternative sequence	1322 – 1349	28	Missing in isoform 4 and isoform 10.		VSP_000919
	Alternative sequence	1322 – 1348	27	GYFSD…ALSEA → HYFTDAWNTFDALIVVGSVV DIAITEVN in isoform 6.		VSP_000920
	Alternative sequence	1349	1	D → DPSDSENIPLPTATPG in isoform 6 and isoform 3.		VSP_000921
	Alternative sequence	1354 – 1368	15	Missing in isoform 10 and isoform 5.		VSP_000922
	Alternative sequence	1642 – 1668	27	DDEVT…KKRKE → GNSRSGKSKAWWGNTLRRTP RSPYRRD in isoform 2.		VSP_000923
	Alternative sequence	1669 – 2203	535	Missing in isoform 2.		VSP_000924
	Alternative sequence	1686 – 1691	6	AGLRTL → MLERML in isoform 13.		VSP_000925
	Alternative sequence	1692 – 2203	512	Missing in isoform 13.		VSP_000926
Experimental info
	Mutagenesis	1656 – 1657	2	IQ → AA: Loss of calcium-dependent inactivation related to the C-terminal lobe of calmodulin. Ref.8
	Sequence conflict	124	1	D → N in AAA42015. Ref.2
	Sequence conflict	183	1	S → Y in AAA42015. Ref.2
	Sequence conflict	192	1	S → Y in AAA42015. Ref.2
	Sequence conflict	513	1	G → C Ref.2
	Sequence conflict	522 – 560	39	Missing Ref.2
	Sequence conflict	1452	1	W → R in AAA89156. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (CACN4A) [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 8E746A8D988050C6	FASTA	2,203	250,136
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KGYFSDAWNT FDSLIVIGSI IDVALSEADN SEESNRISIT FFRLFRVMRL VKLLSRGEGI 1390 1400 1410 1420 1430 1440 RTLLWTFIKS FQALPYVALL IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV 1450 1460 1470 1480 1490 1500 LLLFRCATGE AWQEIMLACL PGKLCDPDSD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII 1510 1520 1530 1540 1550 1560 NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL 1570 1580 1590 1600 1610 1620 GFGKLCPHRV ACKRLVAMNM PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV 1630 1640 1650 1660 1670 1680 IKKIWKKTSM KLLDQVVPPA GDDEVTVGKF YATFLIQDYF RKFKKRKEQG LVGKYPAKNT 1690 1700 1710 1720 1730 1740 TIALQAGLRT LHDIGPEIRR AISCDLQDDE PEDSKPEEED VFKRNGALLG NYVNHVNSDR 1750 1760 1770 1780 1790 1800 RESLQQTNTT HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG KQVPTSTNAN 1810 1820 1830 1840 1850 1860 LNNANMSKAA HGKRPSIGDL EHVSENGHYS YKHDRELQRR SSIKRTRYYE TYIRSESGDE 1870 1880 1890 1900 1910 1920 QLPTIFREDP EIHGYFRDPR CFGEQEYFSS EECCEDDSSP TWSRQNYSYY NRYPGSSMDF 1930 1940 1950 1960 1970 1980 ERPRGYHHPQ GFLEDDDSPI GYDSRRSPRR RLLPPTPPSH RRSSFNFECL RRQNSQDDVL 1990 2000 2010 2020 2030 2040 PSPALPHRAA LPLHLMQQQI MAVAGLDSSK AQKYSPSHST RSWATPPATP PYRDWTPCYT 2050 2060 2070 2080 2090 2100 PLIQVDRSES MDQVNGSLPS LHRSSWYTDE PDISYRTFTP ASLTVPSSFR NKNSDKQRSA 2110 2120 2130 2140 2150 2160 DSLVEAVLIS EGLGRYARDP KFVSATKHEI ADACDLTIDE MESAASTLLN GSVCPRANGD 2170 2180 2190 2200 MGPISHRQDY ELQDFGPGYS DEEPDPGREE EDLADEMICI TTL
	Isoform 2 (CACN4B) [UniParc]. Checksum: C0B994698B1EEA77	FASTA	1,668	189,438
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KGYFSDAWNT FDSLIVIGSI IDVALSEADN SEESNRISIT FFRLFRVMRL VKLLSRGEGI 1390 1400 1410 1420 1430 1440 RTLLWTFIKS FQALPYVALL IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV 1450 1460 1470 1480 1490 1500 LLLFRCATGE AWQEIMLACL PGKLCDPDSD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII 1510 1520 1530 1540 1550 1560 NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL 1570 1580 1590 1600 1610 1620 GFGKLCPHRV ACKRLVAMNM PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV 1630 1640 1650 1660 IKKIWKKTSM KLLDQVVPPA GGNSRSGKSK AWWGNTLRRT PRSPYRRD
	Isoform 3 (CACH3A) (RB48) (RBD-55) [UniParc]. Checksum: F76CD9838B0DD9BB	FASTA	2,218	251,614
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KGYFSDAWNT FDSLIVIGSI IDVALSEADP SDSENIPLPT ATPGNSEESN RISITFFRLF 1390 1400 1410 1420 1430 1440 RVMRLVKLLS RGEGIRTLLW TFIKSFQALP YVALLIAMLF FIYAVIGMQM FGKVAMRDNN 1450 1460 1470 1480 1490 1500 QINRNNNFQT FPQAVLLLFR CATGEAWQEI MLACLPGKLC DPDSDYNPGE EYTCGSNFAI 1510 1520 1530 1540 1550 1560 VYFISFYMLC AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWSE YDPEAKGRIK 1570 1580 1590 1600 1610 1620 HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VAMNMPLNSD GTVMFNATLF ALVRTALKIK 1630 1640 1650 1660 1670 1680 TEGNLEQANE ELRAVIKKIW KKTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQDYFRKFKK 1690 1700 1710 1720 1730 1740 RKEQGLVGKY PAKNTTIALQ AGLRTLHDIG PEIRRAISCD LQDDEPEDSK PEEEDVFKRN 1750 1760 1770 1780 1790 1800 GALLGNYVNH VNSDRRESLQ QTNTTHRPLH VQRPSIPPAS DTEKPLFPPA GNSVCHNHHN 1810 1820 1830 1840 1850 1860 HNSIGKQVPT STNANLNNAN MSKAAHGKRP SIGDLEHVSE NGHYSYKHDR ELQRRSSIKR 1870 1880 1890 1900 1910 1920 TRYYETYIRS ESGDEQLPTI FREDPEIHGY FRDPRCFGEQ EYFSSEECCE DDSSPTWSRQ 1930 1940 1950 1960 1970 1980 NYSYYNRYPG SSMDFERPRG YHHPQGFLED DDSPIGYDSR RSPRRRLLPP TPPSHRRSSF 1990 2000 2010 2020 2030 2040 NFECLRRQNS QDDVLPSPAL PHRAALPLHL MQQQIMAVAG LDSSKAQKYS PSHSTRSWAT 2050 2060 2070 2080 2090 2100 PPATPPYRDW TPCYTPLIQV DRSESMDQVN GSLPSLHRSS WYTDEPDISY RTFTPASLTV 2110 2120 2130 2140 2150 2160 PSSFRNKNSD KQRSADSLVE AVLISEGLGR YARDPKFVSA TKHEIADACD LTIDEMESAA 2170 2180 2190 2200 2210 STLLNGSVCP RANGDMGPIS HRQDYELQDF GPGYSDEEPD PGREEEDLAD EMICITTL
	Isoform 4 (Delta-IV-S3) (RKC6) [UniParc]. Checksum: 3BB7746587D5E475	FASTA	2,175	247,135
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KNSEESNRIS ITFFRLFRVM RLVKLLSRGE GIRTLLWTFI KSFQALPYVA LLIAMLFFIY 1390 1400 1410 1420 1430 1440 AVIGMQMFGK VAMRDNNQIN RNNNFQTFPQ AVLLLFRCAT GEAWQEIMLA CLPGKLCDPD 1450 1460 1470 1480 1490 1500 SDYNPGEEYT CGSNFAIVYF ISFYMLCAFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE 1510 1520 1530 1540 1550 1560 FKRIWSEYDP EAKGRIKHLD VVTLLRRIQP PLGFGKLCPH RVACKRLVAM NMPLNSDGTV 1570 1580 1590 1600 1610 1620 MFNATLFALV RTALKIKTEG NLEQANEELR AVIKKIWKKT SMKLLDQVVP PAGDDEVTVG 1630 1640 1650 1660 1670 1680 KFYATFLIQD YFRKFKKRKE QGLVGKYPAK NTTIALQAGL RTLHDIGPEI RRAISCDLQD 1690 1700 1710 1720 1730 1740 DEPEDSKPEE EDVFKRNGAL LGNYVNHVNS DRRESLQQTN TTHRPLHVQR PSIPPASDTE 1750 1760 1770 1780 1790 1800 KPLFPPAGNS VCHNHHNHNS IGKQVPTSTN ANLNNANMSK AAHGKRPSIG DLEHVSENGH 1810 1820 1830 1840 1850 1860 YSYKHDRELQ RRSSIKRTRY YETYIRSESG DEQLPTIFRE DPEIHGYFRD PRCFGEQEYF 1870 1880 1890 1900 1910 1920 SSEECCEDDS SPTWSRQNYS YYNRYPGSSM DFERPRGYHH PQGFLEDDDS PIGYDSRRSP 1930 1940 1950 1960 1970 1980 RRRLLPPTPP SHRRSSFNFE CLRRQNSQDD VLPSPALPHR AALPLHLMQQ QIMAVAGLDS 1990 2000 2010 2020 2030 2040 SKAQKYSPSH STRSWATPPA TPPYRDWTPC YTPLIQVDRS ESMDQVNGSL PSLHRSSWYT 2050 2060 2070 2080 2090 2100 DEPDISYRTF TPASLTVPSS FRNKNSDKQR SADSLVEAVL ISEGLGRYAR DPKFVSATKH 2110 2120 2130 2140 2150 2160 EIADACDLTI DEMESAASTL LNGSVCPRAN GDMGPISHRQ DYELQDFGPG YSDEEPDPGR 2170 EEEDLADEMI CITTL
	Isoform 5 (Delta-IV-S4) [UniParc]. Checksum: 7036D5421C98E89D	FASTA	2,188	248,267
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KGYFSDAWNT FDSLIVIGSI IDVALSEADN SEERLVKLLS RGEGIRTLLW TFIKSFQALP 1390 1400 1410 1420 1430 1440 YVALLIAMLF FIYAVIGMQM FGKVAMRDNN QINRNNNFQT FPQAVLLLFR CATGEAWQEI 1450 1460 1470 1480 1490 1500 MLACLPGKLC DPDSDYNPGE EYTCGSNFAI VYFISFYMLC AFLIINLFVA VIMDNFDYLT 1510 1520 1530 1540 1550 1560 RDWSILGPHH LDEFKRIWSE YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL CPHRVACKRL 1570 1580 1590 1600 1610 1620 VAMNMPLNSD GTVMFNATLF ALVRTALKIK TEGNLEQANE ELRAVIKKIW KKTSMKLLDQ 1630 1640 1650 1660 1670 1680 VVPPAGDDEV TVGKFYATFL IQDYFRKFKK RKEQGLVGKY PAKNTTIALQ AGLRTLHDIG 1690 1700 1710 1720 1730 1740 PEIRRAISCD LQDDEPEDSK PEEEDVFKRN GALLGNYVNH VNSDRRESLQ QTNTTHRPLH 1750 1760 1770 1780 1790 1800 VQRPSIPPAS DTEKPLFPPA GNSVCHNHHN HNSIGKQVPT STNANLNNAN MSKAAHGKRP 1810 1820 1830 1840 1850 1860 SIGDLEHVSE NGHYSYKHDR ELQRRSSIKR TRYYETYIRS ESGDEQLPTI FREDPEIHGY 1870 1880 1890 1900 1910 1920 FRDPRCFGEQ EYFSSEECCE DDSSPTWSRQ NYSYYNRYPG SSMDFERPRG YHHPQGFLED 1930 1940 1950 1960 1970 1980 DDSPIGYDSR RSPRRRLLPP TPPSHRRSSF NFECLRRQNS QDDVLPSPAL PHRAALPLHL 1990 2000 2010 2020 2030 2040 MQQQIMAVAG LDSSKAQKYS PSHSTRSWAT PPATPPYRDW TPCYTPLIQV DRSESMDQVN 2050 2060 2070 2080 2090 2100 GSLPSLHRSS WYTDEPDISY RTFTPASLTV PSSFRNKNSD KQRSADSLVE AVLISEGLGR 2110 2120 2130 2140 2150 2160 YARDPKFVSA TKHEIADACD LTIDEMESAA STLLNGSVCP RANGDMGPIS HRQDYELQDF 2170 2180 GPGYSDEEPD PGREEEDLAD EMICITTL
	Isoform 6 (RB9) [UniParc]. Checksum: 1720A717CCD314D0	FASTA	2,219	251,820
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KHYFTDAWNT FDALIVVGSV VDIAITEVND PSDSENIPLP TATPGNSEES NRISITFFRL 1390 1400 1410 1420 1430 1440 FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIAML FFIYAVIGMQ MFGKVAMRDN 1450 1460 1470 1480 1490 1500 NQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLACLPGKL CDPDSDYNPG EEYTCGSNFA 1510 1520 1530 1540 1550 1560 IVYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWS EYDPEAKGRI 1570 1580 1590 1600 1610 1620 KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVAMNMPLNS DGTVMFNATL FALVRTALKI 1630 1640 1650 1660 1670 1680 KTEGNLEQAN EELRAVIKKI WKKTSMKLLD QVVPPAGDDE VTVGKFYATF LIQDYFRKFK 1690 1700 1710 1720 1730 1740 KRKEQGLVGK YPAKNTTIAL QAGLRTLHDI GPEIRRAISC DLQDDEPEDS KPEEEDVFKR 1750 1760 1770 1780 1790 1800 NGALLGNYVN HVNSDRRESL QQTNTTHRPL HVQRPSIPPA SDTEKPLFPP AGNSVCHNHH 1810 1820 1830 1840 1850 1860 NHNSIGKQVP TSTNANLNNA NMSKAAHGKR PSIGDLEHVS ENGHYSYKHD RELQRRSSIK 1870 1880 1890 1900 1910 1920 RTRYYETYIR SESGDEQLPT IFREDPEIHG YFRDPRCFGE QEYFSSEECC EDDSSPTWSR 1930 1940 1950 1960 1970 1980 QNYSYYNRYP GSSMDFERPR GYHHPQGFLE DDDSPIGYDS RRSPRRRLLP PTPPSHRRSS 1990 2000 2010 2020 2030 2040 FNFECLRRQN SQDDVLPSPA LPHRAALPLH LMQQQIMAVA GLDSSKAQKY SPSHSTRSWA 2050 2060 2070 2080 2090 2100 TPPATPPYRD WTPCYTPLIQ VDRSESMDQV NGSLPSLHRS SWYTDEPDIS YRTFTPASLT 2110 2120 2130 2140 2150 2160 VPSSFRNKNS DKQRSADSLV EAVLISEGLG RYARDPKFVS ATKHEIADAC DLTIDEMESA 2170 2180 2190 2200 2210 ASTLLNGSVC PRANGDMGPI SHRQDYELQD FGPGYSDEEP DPGREEEDLA DEMICITTL
	Isoform 7 (RB11) [UniParc]. Checksum: ACA674F99711ECC7	FASTA	2,183	247,705
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLGQAISKSK LRSHGAREAL CVCRCSLESL VKLWTSRFSA HLQAAYVRPY 550 560 570 580 590 600 SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS SEHYNQPDWL TQIQDIANKV 610 620 630 640 650 660 LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE TILVELELMS PLGVSVFRCV 670 680 690 700 710 720 RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI IIFSLLGMQL FGGKFNFDET 730 740 750 760 770 780 QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP SSSGMIVCIY FIILFICGNY 790 800 810 820 830 840 ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE SLENKKNNKP EVNQIANSDN 850 860 870 880 890 900 KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA GPRPRRISEL NMKEKIAPIP 910 920 930 940 950 960 EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA ALAAEDPIRS HSFRNTILGY 970 980 990 1000 1010 1020 FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML VVGVSLVSFG IQSSAISVVK 1030 1040 1050 1060 1070 1080 ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV TTLLQFMFAC IGVQLFKGKF 1090 1100 1110 1120 1130 1140 YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD FNFDNVLSAM MALFTVSTFE 1150 1160 1170 1180 1190 1200 GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF FMMNIFVGFV IVTFQEQGEK 1210 1220 1230 1240 1250 1260 EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV VNSSPFEYMM FVLIMLNTLC 1270 1280 1290 1300 1310 1320 LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP KGYFSDAWNT FDSLIVIGSI 1330 1340 1350 1360 1370 1380 IDVALSEADN SEESNRISIT FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL 1390 1400 1410 1420 1430 1440 IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV LLLFRCATGE AWQEIMLACL 1450 1460 1470 1480 1490 1500 PGKLCDPDSD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII NLFVAVIMDN FDYLTRDWSI 1510 1520 1530 1540 1550 1560 LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL GFGKLCPHRV ACKRLVAMNM 1570 1580 1590 1600 1610 1620 PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV IKKIWKKTSM KLLDQVVPPA 1630 1640 1650 1660 1670 1680 GDDEVTVGKF YATFLIQDYF RKFKKRKEQG LVGKYPAKNT TIALQAGLRT LHDIGPEIRR 1690 1700 1710 1720 1730 1740 AISCDLQDDE PEDSKPEEED VFKRNGALLG NYVNHVNSDR RESLQQTNTT HRPLHVQRPS 1750 1760 1770 1780 1790 1800 IPPASDTEKP LFPPAGNSVC HNHHNHNSIG KQVPTSTNAN LNNANMSKAA HGKRPSIGDL 1810 1820 1830 1840 1850 1860 EHVSENGHYS YKHDRELQRR SSIKRTRYYE TYIRSESGDE QLPTIFREDP EIHGYFRDPR 1870 1880 1890 1900 1910 1920 CFGEQEYFSS EECCEDDSSP TWSRQNYSYY NRYPGSSMDF ERPRGYHHPQ GFLEDDDSPI 1930 1940 1950 1960 1970 1980 GYDSRRSPRR RLLPPTPPSH RRSSFNFECL RRQNSQDDVL PSPALPHRAA LPLHLMQQQI 1990 2000 2010 2020 2030 2040 MAVAGLDSSK AQKYSPSHST RSWATPPATP PYRDWTPCYT PLIQVDRSES MDQVNGSLPS 2050 2060 2070 2080 2090 2100 LHRSSWYTDE PDISYRTFTP ASLTVPSSFR NKNSDKQRSA DSLVEAVLIS EGLGRYARDP 2110 2120 2130 2140 2150 2160 KFVSATKHEI ADACDLTIDE MESAASTLLN GSVCPRANGD MGPISHRQDY ELQDFGPGYS 2170 2180 DEEPDPGREE EDLADEMICI TTL
	Isoform 8 (RB34) [UniParc]. Checksum: F928E1B53FAD29FF	FASTA	2,191	249,014
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 WCWWKRRGAA KTGPSGCRRW GQAISKSKLR SHGAREALCV CRCSLESLVK LWTSRFSAHL 550 560 570 580 590 600 QAAYVRPYSR RWRRWNRFNR RRCRAAVKSV TFYWLVIVLV FLNTLTISSE HYNQPDWLTQ 610 620 630 640 650 660 IQDIANKVLL ALFTCEMLVK MYSLGLQAYF VSLFNRFDCF VVCGGITETI LVELELMSPL 670 680 690 700 710 720 GVSVFRCVRL LRIFKVTRHW TSLSNLVASL LNSMKSIASL LLLLFLFIII FSLLGMQLFG 730 740 750 760 770 780 GKFNFDETQT KRSTFDNFPQ ALLTVFQILT GEDWNAVMYD GIMAYGGPSS SGMIVCIYFI 790 800 810 820 830 840 ILFICGNYIL LKLFLAIAVD NLADAESLNT AQKEEAEEKE RKKIARKESL ENKKNNKPEV 850 860 870 880 890 900 NQIANSDNKV TIDDYQEEAE DKDPYPPCDV PVGEEEEEEE EDEPEVPAGP RPRRISELNM 910 920 930 940 950 960 KEKIAPIPEG SAFFILSKTN PIRVGCHKLI NHHIFTNLIL VFIMLSSAAL AAEDPIRSHS 970 980 990 1000 1010 1020 FRNTILGYFD YAFTAIFTVE ILLKMTTFGA FLHKGAFCRN YFNLLDMLVV GVSLVSFGIQ 1030 1040 1050 1060 1070 1080 SSAISVVKIL RVLRVLRPLR AINRAKGLKH VVQCVFVAIR TIGNIMIVTT LLQFMFACIG 1090 1100 1110 1120 1130 1140 VQLFKGKFYR CTDEAKSNPE ECRGLFILYK DGDVDSPVVR ERIWQNSDFN FDNVLSAMMA 1150 1160 1170 1180 1190 1200 LFTVSTFEGW PALLYKAIDS NGENVGPVYN YRVEISIFFI IYIIIVAFFM MNIFVGFVIV 1210 1220 1230 1240 1250 1260 TFQEQGEKEY KNCELDKNQR QCVEYALKAR PLRRYIPKNP YQYKFWYVVN SSPFEYMMFV 1270 1280 1290 1300 1310 1320 LIMLNTLCLA MQHYEQSKMF NDAMDILNMV FTGVFTVEMV LKVIAFKPKG YFSDAWNTFD 1330 1340 1350 1360 1370 1380 SLIVIGSIID VALSEADNSE ESNRISITFF RLFRVMRLVK LLSRGEGIRT LLWTFIKSFQ 1390 1400 1410 1420 1430 1440 ALPYVALLIA MLFFIYAVIG MQMFGKVAMR DNNQINRNNN FQTFPQAVLL LFRCATGEAW 1450 1460 1470 1480 1490 1500 QEIMLACLPG KLCDPDSDYN PGEEYTCGSN FAIVYFISFY MLCAFLIINL FVAVIMDNFD 1510 1520 1530 1540 1550 1560 YLTRDWSILG PHHLDEFKRI WSEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC 1570 1580 1590 1600 1610 1620 KRLVAMNMPL NSDGTVMFNA TLFALVRTAL KIKTEGNLEQ ANEELRAVIK KIWKKTSMKL 1630 1640 1650 1660 1670 1680 LDQVVPPAGD DEVTVGKFYA TFLIQDYFRK FKKRKEQGLV GKYPAKNTTI ALQAGLRTLH 1690 1700 1710 1720 1730 1740 DIGPEIRRAI SCDLQDDEPE DSKPEEEDVF KRNGALLGNY VNHVNSDRRE SLQQTNTTHR 1750 1760 1770 1780 1790 1800 PLHVQRPSIP PASDTEKPLF PPAGNSVCHN HHNHNSIGKQ VPTSTNANLN NANMSKAAHG 1810 1820 1830 1840 1850 1860 KRPSIGDLEH VSENGHYSYK HDRELQRRSS IKRTRYYETY IRSESGDEQL PTIFREDPEI 1870 1880 1890 1900 1910 1920 HGYFRDPRCF GEQEYFSSEE CCEDDSSPTW SRQNYSYYNR YPGSSMDFER PRGYHHPQGF 1930 1940 1950 1960 1970 1980 LEDDDSPIGY DSRRSPRRRL LPPTPPSHRR SSFNFECLRR QNSQDDVLPS PALPHRAALP 1990 2000 2010 2020 2030 2040 LHLMQQQIMA VAGLDSSKAQ KYSPSHSTRS WATPPATPPY RDWTPCYTPL IQVDRSESMD 2050 2060 2070 2080 2090 2100 QVNGSLPSLH RSSWYTDEPD ISYRTFTPAS LTVPSSFRNK NSDKQRSADS LVEAVLISEG 2110 2120 2130 2140 2150 2160 LGRYARDPKF VSATKHEIAD ACDLTIDEME SAASTLLNGS VCPRANGDMG PISHRQDYEL 2170 2180 2190 QDFGPGYSDE EPDPGREEED LADEMICITT L
	Isoform 9 (RH1) [UniParc]. Checksum: B0E7A0FBBB1B582A	FASTA	2,132	241,962
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KALPYVALLI AMLFFIYAVI GMQMFGKVAM RDNNQINRNN NFQTFPQAVL LLFRCATGEA 1390 1400 1410 1420 1430 1440 WQEIMLACLP GKLCDPDSDY NPGEEYTCGS NFAIVYFISF YMLCAFLIIN LFVAVIMDNF 1450 1460 1470 1480 1490 1500 DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT LLRRIQPPLG FGKLCPHRVA 1510 1520 1530 1540 1550 1560 CKRLVAMNMP LNSDGTVMFN ATLFALVRTA LKIKTEGNLE QANEELRAVI KKIWKKTSMK 1570 1580 1590 1600 1610 1620 LLDQVVPPAG DDEVTVGKFY ATFLIQDYFR KFKKRKEQGL VGKYPAKNTT IALQAGLRTL 1630 1640 1650 1660 1670 1680 HDIGPEIRRA ISCDLQDDEP EDSKPEEEDV FKRNGALLGN YVNHVNSDRR ESLQQTNTTH 1690 1700 1710 1720 1730 1740 RPLHVQRPSI PPASDTEKPL FPPAGNSVCH NHHNHNSIGK QVPTSTNANL NNANMSKAAH 1750 1760 1770 1780 1790 1800 GKRPSIGDLE HVSENGHYSY KHDRELQRRS SIKRTRYYET YIRSESGDEQ LPTIFREDPE 1810 1820 1830 1840 1850 1860 IHGYFRDPRC FGEQEYFSSE ECCEDDSSPT WSRQNYSYYN RYPGSSMDFE RPRGYHHPQG 1870 1880 1890 1900 1910 1920 FLEDDDSPIG YDSRRSPRRR LLPPTPPSHR RSSFNFECLR RQNSQDDVLP SPALPHRAAL 1930 1940 1950 1960 1970 1980 PLHLMQQQIM AVAGLDSSKA QKYSPSHSTR SWATPPATPP YRDWTPCYTP LIQVDRSESM 1990 2000 2010 2020 2030 2040 DQVNGSLPSL HRSSWYTDEP DISYRTFTPA SLTVPSSFRN KNSDKQRSAD SLVEAVLISE 2050 2060 2070 2080 2090 2100 GLGRYARDPK FVSATKHEIA DACDLTIDEM ESAASTLLNG SVCPRANGDM GPISHRQDYE 2110 2120 2130 LQDFGPGYSD EEPDPGREEE DLADEMICIT TL
	Isoform 10 (RH2) [UniParc]. Checksum: 8CD4F488BCAB9E28	FASTA	2,160	245,266
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KNSEERLVKL LSRGEGIRTL LWTFIKSFQA LPYVALLIAM LFFIYAVIGM QMFGKVAMRD 1390 1400 1410 1420 1430 1440 NNQINRNNNF QTFPQAVLLL FRCATGEAWQ EIMLACLPGK LCDPDSDYNP GEEYTCGSNF 1450 1460 1470 1480 1490 1500 AIVYFISFYM LCAFLIINLF VAVIMDNFDY LTRDWSILGP HHLDEFKRIW SEYDPEAKGR 1510 1520 1530 1540 1550 1560 IKHLDVVTLL RRIQPPLGFG KLCPHRVACK RLVAMNMPLN SDGTVMFNAT LFALVRTALK 1570 1580 1590 1600 1610 1620 IKTEGNLEQA NEELRAVIKK IWKKTSMKLL DQVVPPAGDD EVTVGKFYAT FLIQDYFRKF 1630 1640 1650 1660 1670 1680 KKRKEQGLVG KYPAKNTTIA LQAGLRTLHD IGPEIRRAIS CDLQDDEPED SKPEEEDVFK 1690 1700 1710 1720 1730 1740 RNGALLGNYV NHVNSDRRES LQQTNTTHRP LHVQRPSIPP ASDTEKPLFP PAGNSVCHNH 1750 1760 1770 1780 1790 1800 HNHNSIGKQV PTSTNANLNN ANMSKAAHGK RPSIGDLEHV SENGHYSYKH DRELQRRSSI 1810 1820 1830 1840 1850 1860 KRTRYYETYI RSESGDEQLP TIFREDPEIH GYFRDPRCFG EQEYFSSEEC CEDDSSPTWS 1870 1880 1890 1900 1910 1920 RQNYSYYNRY PGSSMDFERP RGYHHPQGFL EDDDSPIGYD SRRSPRRRLL PPTPPSHRRS 1930 1940 1950 1960 1970 1980 SFNFECLRRQ NSQDDVLPSP ALPHRAALPL HLMQQQIMAV AGLDSSKAQK YSPSHSTRSW 1990 2000 2010 2020 2030 2040 ATPPATPPYR DWTPCYTPLI QVDRSESMDQ VNGSLPSLHR SSWYTDEPDI SYRTFTPASL 2050 2060 2070 2080 2090 2100 TVPSSFRNKN SDKQRSADSL VEAVLISEGL GRYARDPKFV SATKHEIADA CDLTIDEMES 2110 2120 2130 2140 2150 2160 AASTLLNGSV CPRANGDMGP ISHRQDYELQ DFGPGYSDEE PDPGREEEDL ADEMICITTL
	Isoform 11 (RKC5) (Sequence not available).		–	–
	Isoform 12 (ROB3) (Sequence not available).		–	–
	Isoform 13 (Truncated) [UniParc]. Checksum: BF6F15F872E7F40B	FASTA	1,691	192,179
	10 20 30 40 50 60 MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 70 80 90 100 110 120 RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 130 140 150 160 170 180 SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 190 200 210 220 230 240 IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 250 260 270 280 290 300 AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 310 320 330 340 350 360 CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 370 380 390 400 410 420 ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 430 440 450 460 470 480 DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 490 500 510 520 530 540 GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 550 560 570 580 590 600 VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 610 620 630 640 650 660 SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 670 680 690 700 710 720 TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 730 740 750 760 770 780 IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 790 800 810 820 830 840 SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 850 860 870 880 890 900 SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 910 920 930 940 950 960 GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 970 980 990 1000 1010 1020 ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1030 1040 1050 1060 1070 1080 VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1090 1100 1110 1120 1130 1140 TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1150 1160 1170 1180 1190 1200 FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1210 1220 1230 1240 1250 1260 FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1270 1280 1290 1300 1310 1320 VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1330 1340 1350 1360 1370 1380 KGYFSDAWNT FDSLIVIGSI IDVALSEADN SEESNRISIT FFRLFRVMRL VKLLSRGEGI 1390 1400 1410 1420 1430 1440 RTLLWTFIKS FQALPYVALL IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV 1450 1460 1470 1480 1490 1500 LLLFRCATGE AWQEIMLACL PGKLCDPDSD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII 1510 1520 1530 1540 1550 1560 NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL 1570 1580 1590 1600 1610 1620 GFGKLCPHRV ACKRLVAMNM PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV 1630 1640 1650 1660 1670 1680 IKKIWKKTSM KLLDQVVPPA GDDEVTVGKF YATFLIQDYF RKFKKRKEQG LVGKYPAKNT 1690 TIALQMLERM L

References

[1]	"Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells." Ihara Y., Yamada Y., Fujii Y., Gonoi T., Yano H., Yasuda K., Inagaki N., Seino Y., Seino S. Mol. Endocrinol. 9:121-130(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Insulinoma.
[2]	"Molecular cloning of multiple subtypes of a novel rat brain isoform of the alpha-1 subunit of the voltage-dependent calcium channel." Hui A., Ellinor P.T., Krizanova O., Wang J.-J., Diebold R.J., Schwartz A. Neuron 7:35-44(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8 AND 13). Tissue: Brain.
[3]	"Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene." Kamp T.J., Mitas M., Fields K.L., Asoh S., Chin H., Marban E., Nirenberg M. Cell. Mol. Neurobiol. 15:307-326(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.
[4]	"Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney." Yu A.S.L., Hebert S.C., Brenner B.M., Lytton J. Proc. Natl. Acad. Sci. U.S.A. 89:10494-10498(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1100-1410 (ISOFORMS 4 AND 11). Tissue: Kidney.
[5]	"Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone." Barry E.L.R., Gesek F.A., Froehner S.C., Friedman P.A. Proc. Natl. Acad. Sci. U.S.A. 92:10914-10918(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1218-1498 (ISOFORM 12). Tissue: Osteosarcoma.
[6]	"Novel variants of voltage-operated calcium channel alpha-1 subunit transcripts in a rat liver-derived cell line: deletion in the IVS4 voltage sensing region." Brereton H.M., Harland M.L., Froscio M., Petronijevic T., Barritt G.J. Cell Calcium 22:39-52(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1200-1493 (ISOFORMS 3; 4; 5; 9 AND 10). Tissue: Hepatoma.
[7]	"Rat brain expresses a heterogeneous family of calcium channels." Snutch T.P., Leonard J.P., Gilbert M.M., Lester H.A., Davidson N. Proc. Natl. Acad. Sci. U.S.A. 87:3391-3395(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1307-1479 (ISOFORM 3).
[8]	"Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells." Yang P.S., Alseikhan B.A., Hiel H., Grant L., Mori M.X., Yang W., Fuchs P.A., Yue D.T. J. Neurosci. 26:10677-10689(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF 1656-ILE-GLN-1657, INTERACTION WITH CABP1 AND CABP4, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D38101 mRNA. Translation: BAA07282.1. D38102 mRNA. Translation: BAA07283.1. M57682 mRNA. Translation: AAA42015.1. U14005 Genomic DNA. Translation: AAB60515.1. M99221 mRNA. Translation: AAA40895.1. U31772 mRNA. Translation: AAA89156.1. U49126 mRNA. Translation: AAB61634.1. U49127 mRNA. Translation: AAB61635.1. U49128 mRNA. Translation: AAB61636.1.
IPI	IPI00199764. IPI00231109. IPI00231110. IPI00231111. IPI00231112. IPI00231113. IPI00231114. IPI00231116. IPI00231117. IPI00231808. IPI00231809.
PIR	JH0422. T42742.
RefSeq	NP_058994.1. NM_017298.1.
UniGene	Rn.89671.
3D structure databases
ProteinModelPortal	P27732.
SMR	P27732. Positions 1644-1672.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7965882.
Protein family/group databases
TCDB	1.A.1.11.1. voltage-gated ion channel (VIC) superfamily.
PTM databases
PhosphoSite	P27732.
Proteomic databases
PaxDb	P27732.
PRIDE	P27732.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	29716.
KEGG	rno:29716.
Organism-specific databases
CTD	776.
RGD	70973. Cacna1d.
Phylogenomic databases
eggNOG	COG1226.
HOVERGEN	HBG050763.
KO	K04851.
Enzyme and pathway databases
Reactome	REACT_113568. Metabolism.
Gene expression databases
ArrayExpress	P27732.
Genevestigator	P27732.
GermOnline	ENSRNOG00000013147. Rattus norvegicus.
Family and domain databases
Gene3D	1.20.120.350. 5 hits.
InterPro	IPR005821. Ion_trans_dom. IPR027359. K_channel_four-helix_dom. IPR005452. LVDCC_a1dsu. IPR014873. VDCC_a1su_IQ. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01636. LVDCCALPHA1D.
SMART	SM01062. Ca_chan_IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P27732.
ChEMBL	CHEMBL4132.
NextBio	610169.

Entry information

Entry name

CAC1D_RAT

Accession

Primary (citable) accession number: P27732
Secondary accession number(s): O09022 , O09023, O09024, Q01542, Q62691, Q62815, Q63491, Q63492

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 15, 1999
Last modified:	May 29, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program