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P27732

- CAC1D_RAT

UniProt

P27732 - CAC1D_RAT

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Protein
Voltage-dependent L-type calcium channel subunit alpha-1D
Gene
Cacna1d, Cach3, Cacn4, Cacnl1a2, Cchl1a2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei364 – 3641Calcium ion selectivity and permeability By similarity
Sitei763 – 7631Calcium ion selectivity and permeability By similarity
Sitei1160 – 11601Calcium ion selectivity and permeability By similarity
Sitei1450 – 14501Calcium ion selectivity and permeability By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi1537 – 154812 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. ankyrin binding Source: BHF-UCL
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. voltage-gated calcium channel activity Source: BHF-UCL
  5. voltage-gated calcium channel activity involved in cardiac muscle cell action potential Source: BHF-UCL

GO - Biological processi

  1. calcium ion transport Source: BHF-UCL
  2. membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  3. regulation of calcium ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

TCDBi1.A.1.11.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alpha-1D
Alternative name(s):
Calcium channel, L type, alpha-1 polypeptide, isoform 2
Rat brain class D
Short name:
RBD
Voltage-gated calcium channel subunit alpha Cav1.3
Gene namesi
Name:Cacna1d
Synonyms:Cach3, Cacn4, Cacnl1a2, Cchl1a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi70973. Cacna1d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 126126Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei127 – 14519Helical; Name=S1 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini146 – 16318Extracellular Reviewed prediction
Add
BLAST
Transmembranei164 – 18320Helical; Name=S2 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini184 – 19512Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei196 – 21419Helical; Name=S3 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini215 – 23521Extracellular Reviewed prediction
Add
BLAST
Transmembranei236 – 25419Helical; Name=S4 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini255 – 27319Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei274 – 29320Helical; Name=S5 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini294 – 38188Extracellular Reviewed prediction
Add
BLAST
Transmembranei382 – 40625Helical; Name=S6 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini407 – 582176Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei583 – 60220Helical; Name=S1 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini603 – 61715Extracellular Reviewed prediction
Add
BLAST
Transmembranei618 – 63619Helical; Name=S2 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini637 – 6448Cytoplasmic Reviewed prediction
Transmembranei645 – 66319Helical; Name=S3 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini664 – 67310Extracellular Reviewed prediction
Transmembranei674 – 69219Helical; Name=S4 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini693 – 71119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei712 – 73221Helical; Name=S5 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini733 – 78654Extracellular Reviewed prediction
Add
BLAST
Transmembranei787 – 81125Helical; Name=S6 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini812 – 945134Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei946 – 96419Helical; Name=S1 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini965 – 98016Extracellular Reviewed prediction
Add
BLAST
Transmembranei981 – 100020Helical; Name=S2 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1001 – 101212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1013 – 103119Helical; Name=S3 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1032 – 10376Extracellular Reviewed prediction
Transmembranei1038 – 105720Helical; Name=S4 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1058 – 107619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1077 – 109620Helical; Name=S5 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1097 – 118690Extracellular Reviewed prediction
Add
BLAST
Transmembranei1187 – 120721Helical; Name=S6 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1208 – 126457Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1265 – 128319Helical; Name=S1 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1284 – 129815Extracellular Reviewed prediction
Add
BLAST
Transmembranei1299 – 131820Helical; Name=S2 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1319 – 13257Cytoplasmic Reviewed prediction
Transmembranei1326 – 134722Helical; Name=S3 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1348 – 135710Extracellular Reviewed prediction
Transmembranei1358 – 137720Helical; Name=S4 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1378 – 139619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1397 – 141620Helical; Name=S5 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1417 – 148367Extracellular Reviewed prediction
Add
BLAST
Transmembranei1484 – 150825Helical; Name=S6 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1509 – 2203695Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1656 – 16572IQ → AA: Loss of calcium-dependent inactivation related to the C-terminal lobe of calmodulin. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22032203Voltage-dependent L-type calcium channel subunit alpha-1D
PRO_0000053936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi329 – 3291N-linked (GlcNAc...) Reviewed prediction
Modified residuei1519 – 15191Phosphoserine; by PKA Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP27732.
PRIDEiP27732.

PTM databases

PhosphoSiteiP27732.

Expressioni

Tissue specificityi

Expressed in brain, pancreatic islets and B-lymphocytes.1 Publication

Gene expression databases

GenevestigatoriP27732.

Interactioni

Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 and CABP4, resulting in a near elimination of calcium-dependent inactivation of the channel. Interacts with RIMBP2 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gabbr2O888716EBI-8072674,EBI-7090239

Protein-protein interaction databases

DIPiDIP-60740N.
IntActiP27732. 2 interactions.
MINTiMINT-7965882.

Structurei

3D structure databases

ProteinModelPortaliP27732.
SMRiP27732. Positions 1644-1672.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati112 – 408297I
Add
BLAST
Repeati528 – 774247II
Add
BLAST
Repeati892 – 1174283III
Add
BLAST
Repeati1211 – 1486276IV
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni429 – 44618Binding to the beta subunit By similarity
Add
BLAST
Regioni1134 – 122491Dihydropyridine binding By similarity
Add
BLAST
Regioni1464 – 153067Dihydropyridine binding By similarity
Add
BLAST
Regioni1476 – 151944Phenylalkylamine binding By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 77Poly-Met
Compositional biasi712 – 7187Poly-Leu
Compositional biasi886 – 89712Poly-Glu
Add
BLAST

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOVERGENiHBG050763.
KOiK04851.
PhylomeDBiP27732.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005452. LVDCC_a1dsu.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01636. LVDCCALPHA1D.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. Align

Note: The region sequenced in isoforms ROB3 and RKC5 is identical to CACN4.

Isoform 1 (identifier: P27732-1) [UniParc]FASTAAdd to Basket

Also known as: CACN4A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV     50
LSWQAAIDAA RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS 100
RPARALFCLS LNNPIRRACI SIVDWKPFDI FILLAIFANC VALAIYIPFP 150
EDDSNSTNHN LEKVEYAFLI IFTVETFLKI IASGLLLHPN ASVRNGWNLL 200
DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR AFRVLRPLRL 250
VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 300
CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF 350
AFAMLTVFQC ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL 400
VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP 450
ENEEEGGEEG KRNTSMPTSE TESVNTENVS GEGETQGCCG SLWCWWKRRG 500
AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL VKLWTSRFSA 550
HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 600
SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD 650
CFVVCGGITE TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA 700
SLLNSMKSIA SLLLLLFLFI IIFSLLGMQL FGGKFNFDET QTKRSTFDNF 750
PQALLTVFQI LTGEDWNAVM YDGIMAYGGP SSSGMIVCIY FIILFICGNY 800
ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE SLENKKNNKP 850
EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 900
GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL 950
ILVFIMLSSA ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF 1000
GAFLHKGAFC RNYFNLLDML VVGVSLVSFG IQSSAISVVK ILRVLRVLRP 1050
LRAINRAKGL KHVVQCVFVA IRTIGNIMIV TTLLQFMFAC IGVQLFKGKF 1100
YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD FNFDNVLSAM 1150
MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1200
FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK 1250
NPYQYKFWYV VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN 1300
MVFTGVFTVE MVLKVIAFKP KGYFSDAWNT FDSLIVIGSI IDVALSEADN 1350
SEESNRISIT FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL 1400
IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV LLLFRCATGE 1450
AWQEIMLACL PGKLCDPDSD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII 1500
NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV 1550
TLLRRIQPPL GFGKLCPHRV ACKRLVAMNM PLNSDGTVMF NATLFALVRT 1600
ALKIKTEGNL EQANEELRAV IKKIWKKTSM KLLDQVVPPA GDDEVTVGKF 1650
YATFLIQDYF RKFKKRKEQG LVGKYPAKNT TIALQAGLRT LHDIGPEIRR 1700
AISCDLQDDE PEDSKPEEED VFKRNGALLG NYVNHVNSDR RESLQQTNTT 1750
HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG KQVPTSTNAN 1800
LNNANMSKAA HGKRPSIGDL EHVSENGHYS YKHDRELQRR SSIKRTRYYE 1850
TYIRSESGDE QLPTIFREDP EIHGYFRDPR CFGEQEYFSS EECCEDDSSP 1900
TWSRQNYSYY NRYPGSSMDF ERPRGYHHPQ GFLEDDDSPI GYDSRRSPRR 1950
RLLPPTPPSH RRSSFNFECL RRQNSQDDVL PSPALPHRAA LPLHLMQQQI 2000
MAVAGLDSSK AQKYSPSHST RSWATPPATP PYRDWTPCYT PLIQVDRSES 2050
MDQVNGSLPS LHRSSWYTDE PDISYRTFTP ASLTVPSSFR NKNSDKQRSA 2100
DSLVEAVLIS EGLGRYARDP KFVSATKHEI ADACDLTIDE MESAASTLLN 2150
GSVCPRANGD MGPISHRQDY ELQDFGPGYS DEEPDPGREE EDLADEMICI 2200
TTL 2203
Length:2,203
Mass (Da):250,136
Last modified:July 15, 1999 - v2
Checksum:i8E746A8D988050C6
GO
Isoform 2 (identifier: P27732-2) [UniParc]FASTAAdd to Basket

Also known as: CACN4B

The sequence of this isoform differs from the canonical sequence as follows:
     1642-1668: DDEVTVGKFYATFLIQDYFRKFKKRKE → GNSRSGKSKAWWGNTLRRTPRSPYRRD
     1669-2203: Missing.

Show »
Length:1,668
Mass (Da):189,438
Checksum:iC0B994698B1EEA77
GO
Isoform 3 (identifier: P27732-3) [UniParc]FASTAAdd to Basket

Also known as: CACH3A, RB48, RBD-55

The sequence of this isoform differs from the canonical sequence as follows:
     1349-1349: D → DPSDSENIPLPTATPG

Show »
Length:2,218
Mass (Da):251,614
Checksum:iF76CD9838B0DD9BB
GO
Isoform 4 (identifier: P27732-4) [UniParc]FASTAAdd to Basket

Also known as: Delta-IV-S3, RKC6

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1349: Missing.

Show »
Length:2,175
Mass (Da):247,135
Checksum:i3BB7746587D5E475
GO
Isoform 5 (identifier: P27732-5) [UniParc]FASTAAdd to Basket

Also known as: Delta-IV-S4

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1368: Missing.

Show »
Length:2,188
Mass (Da):248,267
Checksum:i7036D5421C98E89D
GO
Isoform 6 (identifier: P27732-6) [UniParc]FASTAAdd to Basket

Also known as: RB9

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1348: GYFSDAWNTFDSLIVIGSIIDVALSEA → HYFTDAWNTFDALIVVGSVVDIAITEVN
     1349-1349: D → DPSDSENIPLPTATPG

Show »
Length:2,219
Mass (Da):251,820
Checksum:i1720A717CCD314D0
GO
Isoform 7 (identifier: P27732-7) [UniParc]FASTAAdd to Basket

Also known as: RB11

The sequence of this isoform differs from the canonical sequence as follows:
     493-512: Missing.

Show »
Length:2,183
Mass (Da):247,705
Checksum:iACA674F99711ECC7
GO
Isoform 8 (identifier: P27732-8) [UniParc]FASTAAdd to Basket

Also known as: RB34

The sequence of this isoform differs from the canonical sequence as follows:
     481-492: Missing.

Show »
Length:2,191
Mass (Da):249,014
Checksum:iF928E1B53FAD29FF
GO
Isoform 9 (identifier: P27732-9) [UniParc]FASTAAdd to Basket

Also known as: RH1

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1392: Missing.

Show »
Length:2,132
Mass (Da):241,962
Checksum:iB0E7A0FBBB1B582A
GO
Isoform 10 (identifier: P27732-10) [UniParc]FASTAAdd to Basket

Also known as: RH2

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1349: Missing.
     1354-1368: Missing.

Show »
Length:2,160
Mass (Da):245,266
Checksum:i8CD4F488BCAB9E28
GO
Isoform 11 (identifier: P27732-13)

Also known as: RKC5

Sequence is not available
Length:
Mass (Da):
Isoform 12 (identifier: P27732-14)

Also known as: ROB3

Sequence is not available
Length:
Mass (Da):
Isoform 13 (identifier: P27732-12) [UniParc]FASTAAdd to Basket

Also known as: Truncated

The sequence of this isoform differs from the canonical sequence as follows:
     1686-1691: AGLRTL → MLERML
     1692-2203: Missing.

Show »
Length:1,691
Mass (Da):192,179
Checksum:iBF6F15F872E7F40B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei481 – 49212Missing in isoform 8.
VSP_000916Add
BLAST
Alternative sequencei493 – 51220Missing in isoform 7.
VSP_000917Add
BLAST
Alternative sequencei1322 – 139271Missing in isoform 9.
VSP_000918Add
BLAST
Alternative sequencei1322 – 134928Missing in isoform 4 and isoform 10.
VSP_000919Add
BLAST
Alternative sequencei1322 – 134827GYFSD…ALSEA → HYFTDAWNTFDALIVVGSVV DIAITEVN in isoform 6.
VSP_000920Add
BLAST
Alternative sequencei1349 – 13491D → DPSDSENIPLPTATPG in isoform 6 and isoform 3.
VSP_000921
Alternative sequencei1354 – 136815Missing in isoform 10 and isoform 5.
VSP_000922Add
BLAST
Alternative sequencei1642 – 166827DDEVT…KKRKE → GNSRSGKSKAWWGNTLRRTP RSPYRRD in isoform 2.
VSP_000923Add
BLAST
Alternative sequencei1669 – 2203535Missing in isoform 2.
VSP_000924Add
BLAST
Alternative sequencei1686 – 16916AGLRTL → MLERML in isoform 13.
VSP_000925
Alternative sequencei1692 – 2203512Missing in isoform 13.
VSP_000926Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241D → N in AAA42015. 1 Publication
Sequence conflicti183 – 1831S → Y in AAA42015. 1 Publication
Sequence conflicti192 – 1921S → Y in AAA42015. 1 Publication
Sequence conflicti513 – 5131G → C1 Publication
Sequence conflicti522 – 56039Missing1 Publication
Add
BLAST
Sequence conflicti1452 – 14521W → R in AAA89156. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38101 mRNA. Translation: BAA07282.1.
D38102 mRNA. Translation: BAA07283.1.
M57682 mRNA. Translation: AAA42015.1.
U14005 Genomic DNA. Translation: AAB60515.1.
M99221 mRNA. Translation: AAA40895.1.
U31772 mRNA. Translation: AAA89156.1.
U49126 mRNA. Translation: AAB61634.1.
U49127 mRNA. Translation: AAB61635.1.
U49128 mRNA. Translation: AAB61636.1.
PIRiJH0422.
T42742.
RefSeqiNP_058994.1. NM_017298.1. [P27732-1]
UniGeneiRn.89671.

Genome annotation databases

GeneIDi29716.
KEGGirno:29716.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38101 mRNA. Translation: BAA07282.1 .
D38102 mRNA. Translation: BAA07283.1 .
M57682 mRNA. Translation: AAA42015.1 .
U14005 Genomic DNA. Translation: AAB60515.1 .
M99221 mRNA. Translation: AAA40895.1 .
U31772 mRNA. Translation: AAA89156.1 .
U49126 mRNA. Translation: AAB61634.1 .
U49127 mRNA. Translation: AAB61635.1 .
U49128 mRNA. Translation: AAB61636.1 .
PIRi JH0422.
T42742.
RefSeqi NP_058994.1. NM_017298.1. [P27732-1 ]
UniGenei Rn.89671.

3D structure databases

ProteinModelPortali P27732.
SMRi P27732. Positions 1644-1672.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60740N.
IntActi P27732. 2 interactions.
MINTi MINT-7965882.

Chemistry

BindingDBi P27732.
ChEMBLi CHEMBL4132.
GuidetoPHARMACOLOGYi 530.

Protein family/group databases

TCDBi 1.A.1.11.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei P27732.

Proteomic databases

PaxDbi P27732.
PRIDEi P27732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29716.
KEGGi rno:29716.

Organism-specific databases

CTDi 776.
RGDi 70973. Cacna1d.

Phylogenomic databases

eggNOGi COG1226.
HOVERGENi HBG050763.
KOi K04851.
PhylomeDBi P27732.

Miscellaneous databases

NextBioi 610169.
PROi P27732.

Gene expression databases

Genevestigatori P27732.

Family and domain databases

Gene3Di 1.20.120.350. 5 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005452. LVDCC_a1dsu.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01636. LVDCCALPHA1D.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells."
    Ihara Y., Yamada Y., Fujii Y., Gonoi T., Yano H., Yasuda K., Inagaki N., Seino Y., Seino S.
    Mol. Endocrinol. 9:121-130(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Insulinoma.
  2. "Molecular cloning of multiple subtypes of a novel rat brain isoform of the alpha-1 subunit of the voltage-dependent calcium channel."
    Hui A., Ellinor P.T., Krizanova O., Wang J.-J., Diebold R.J., Schwartz A.
    Neuron 7:35-44(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8 AND 13).
    Tissue: Brain.
  3. "Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene."
    Kamp T.J., Mitas M., Fields K.L., Asoh S., Chin H., Marban E., Nirenberg M.
    Cell. Mol. Neurobiol. 15:307-326(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.
  4. "Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney."
    Yu A.S.L., Hebert S.C., Brenner B.M., Lytton J.
    Proc. Natl. Acad. Sci. U.S.A. 89:10494-10498(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1100-1410 (ISOFORMS 4 AND 11).
    Tissue: Kidney.
  5. "Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone."
    Barry E.L.R., Gesek F.A., Froehner S.C., Friedman P.A.
    Proc. Natl. Acad. Sci. U.S.A. 92:10914-10918(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1218-1498 (ISOFORM 12).
    Tissue: Osteosarcoma.
  6. "Novel variants of voltage-operated calcium channel alpha-1 subunit transcripts in a rat liver-derived cell line: deletion in the IVS4 voltage sensing region."
    Brereton H.M., Harland M.L., Froscio M., Petronijevic T., Barritt G.J.
    Cell Calcium 22:39-52(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1200-1493 (ISOFORMS 3; 4; 5; 9 AND 10).
    Tissue: Hepatoma.
  7. Cited for: NUCLEOTIDE SEQUENCE OF 1307-1479 (ISOFORM 3).
  8. "Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells."
    Yang P.S., Alseikhan B.A., Hiel H., Grant L., Mori M.X., Yang W., Fuchs P.A., Yue D.T.
    J. Neurosci. 26:10677-10689(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 1656-ILE-GLN-1657, INTERACTION WITH CABP1 AND CABP4, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCAC1D_RAT
AccessioniPrimary (citable) accession number: P27732
Secondary accession number(s): O09022
, O09023, O09024, Q01542, Q62691, Q62815, Q63491, Q63492
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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