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Protein

Transthyretin

Gene

TTR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38Thyroid hormoneBy similarity1
Binding sitei77Thyroid hormoneBy similarity1

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • hormone binding Source: AgBase
  • protein domain specific binding Source: AgBase
  • protein heterodimerization activity Source: AgBase
  • small molecule binding Source: AgBase
  • thyroid hormone binding Source: AgBase

GO - Biological processi

  • oocyte growth Source: AgBase
  • protein-containing complex assembly Source: AgBase
  • protein tetramerization Source: AgBase
  • response to virus Source: AgBase
  • retinol metabolic process Source: AgBase
  • thyroid hormone transport Source: AgBase

Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processTransport

Enzyme and pathway databases

ReactomeiR-GGA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-GGA-3000171 Non-integrin membrane-ECM interactions
R-GGA-6798695 Neutrophil degranulation
R-GGA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
TBPA
Gene namesi
Name:TTR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003576821 – 150TransthyretinAdd BLAST130

Proteomic databases

PaxDbiP27731
PRIDEiP27731

Expressioni

Tissue specificityi

Detected in serum (at protein level). Detected in liver and choroid plexus.3 Publications

Gene expression databases

BgeeiENSGALG00000015143

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBP4P412634EBI-6622511,EBI-6622456

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • protein domain specific binding Source: AgBase
  • protein heterodimerization activity Source: AgBase

Protein-protein interaction databases

IntActiP27731, 1 interactor
STRINGi9031.ENSGALP00000024388

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 41Combined sources7
Turni42 – 45Combined sources4
Beta strandi52 – 58Combined sources7
Beta strandi64 – 71Combined sources8
Turni84 – 86Combined sources3
Beta strandi89 – 97Combined sources9
Turni99 – 106Combined sources8
Beta strandi113 – 120Combined sources8
Beta strandi122 – 124Combined sources3
Beta strandi128 – 134Combined sources7
Beta strandi136 – 145Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TFPX-ray2.90A/B21-150[»]
ProteinModelPortaliP27731
SMRiP27731
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27731

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 142Thyroid hormone bindingBy similarity5

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3006 Eukaryota
COG2351 LUCA
GeneTreeiENSGT00390000005321
HOGENOMiHOG000251776
HOVERGENiHBG000285
InParanoidiP27731
KOiK20731
OMAiHRHYTIA
OrthoDBiEOG091G0VSV
PhylomeDBiP27731
TreeFamiTF300210

Family and domain databases

Gene3Di2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR023418 Thyroxine_BS
IPR030178 Transthyretin
IPR000895 Transthyretin/HIU_hydrolase
IPR023416 Transthyretin/HIU_hydrolase_d
IPR036817 Transthyretin/HIU_hydrolase_sf
IPR023419 Transthyretin_CS
PANTHERiPTHR10395 PTHR10395, 1 hit
PTHR10395:SF12 PTHR10395:SF12, 1 hit
PfamiView protein in Pfam
PF00576 Transthyretin, 1 hit
PRINTSiPR00189 TRNSTHYRETIN
SMARTiView protein in SMART
SM00095 TR_THY, 1 hit
SUPFAMiSSF49472 SSF49472, 1 hit
PROSITEiView protein in PROSITE
PS00768 TRANSTHYRETIN_1, 1 hit
PS00769 TRANSTHYRETIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFHSTLLVF LAGLVFLSEA APLVSHGSVD SKCPLMVKVL DAVRGSPAAN
60 70 80 90 100
VAVKVFKKAA DGTWQDFATG KTTEFGEIHE LTTEEQFVEG VYRVEFDTSS
110 120 130 140 150
YWKGLGLSPF HEYADVVFTA NDSGHRHYTI AALLSPFSYS TTAVVSDPQE
Length:150
Mass (Da):16,309
Last modified:August 1, 1992 - v1
Checksum:i1F82A776A9996360
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60471 mRNA Translation: CAA43000.1
PIRiS17827
RefSeqiNP_990666.1, NM_205335.3
UniGeneiGga.2620

Genome annotation databases

EnsembliENSGALT00000086031; ENSGALP00000064113; ENSGALG00000015143
GeneIDi396277
KEGGigga:396277

Similar proteinsi

Entry informationi

Entry nameiTTHY_CHICK
AccessioniPrimary (citable) accession number: P27731
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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