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Protein

Transthyretin

Gene

TTR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Thyroid hormoneBy similarity
Binding sitei77 – 771Thyroid hormoneBy similarity

GO - Molecular functioni

  • protein domain specific binding Source: AgBase
  • small molecule binding Source: AgBase
  • thyroid hormone binding Source: GO_Central

GO - Biological processi

  • oocyte growth Source: AgBase
  • protein complex assembly Source: AgBase
  • response to virus Source: AgBase
  • retinol metabolic process Source: InterPro
  • thyroid hormone transport Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Thyroid hormone

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-GGA-2453902. The canonical retinoid cycle in rods (twilight vision).
R-GGA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
TBPA
Gene namesi
Name:TTR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  • clathrin-coated vesicle Source: AgBase
  • extracellular exosome Source: Ensembl
  • extracellular space Source: AgBase
  • macromolecular complex Source: AgBase
  • yolk Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 150130TransthyretinPRO_0000035768Add
BLAST

Proteomic databases

PaxDbiP27731.
PRIDEiP27731.

Expressioni

Tissue specificityi

Detected in serum (at protein level). Detected in liver and choroid plexus.3 Publications

Gene expression databases

BgeeiENSGALG00000015143.

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBP4P412634EBI-6622511,EBI-6622456

GO - Molecular functioni

  • protein domain specific binding Source: AgBase

Protein-protein interaction databases

IntActiP27731. 1 interaction.
STRINGi9031.ENSGALP00000024388.

Structurei

Secondary structure

1
150
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 417Combined sources
Turni42 – 454Combined sources
Beta strandi52 – 587Combined sources
Beta strandi64 – 718Combined sources
Turni84 – 863Combined sources
Beta strandi89 – 979Combined sources
Turni99 – 1068Combined sources
Beta strandi113 – 1208Combined sources
Beta strandi122 – 1243Combined sources
Beta strandi128 – 1347Combined sources
Beta strandi136 – 14510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TFPX-ray2.90A/B21-150[»]
ProteinModelPortaliP27731.
SMRiP27731. Positions 33-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27731.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1425Thyroid hormone bindingBy similarity

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
GeneTreeiENSGT00390000005321.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP27731.
OMAiKTSEFGE.
OrthoDBiEOG091G0VSV.
PhylomeDBiP27731.
TreeFamiTF300210.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PANTHERiPTHR10395:SF12. PTHR10395:SF12. 1 hit.
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFHSTLLVF LAGLVFLSEA APLVSHGSVD SKCPLMVKVL DAVRGSPAAN
60 70 80 90 100
VAVKVFKKAA DGTWQDFATG KTTEFGEIHE LTTEEQFVEG VYRVEFDTSS
110 120 130 140 150
YWKGLGLSPF HEYADVVFTA NDSGHRHYTI AALLSPFSYS TTAVVSDPQE
Length:150
Mass (Da):16,309
Last modified:August 1, 1992 - v1
Checksum:i1F82A776A9996360
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60471 mRNA. Translation: CAA43000.1.
PIRiS17827.
RefSeqiNP_990666.1. NM_205335.3.
UniGeneiGga.2620.

Genome annotation databases

EnsembliENSGALT00000024434; ENSGALP00000024388; ENSGALG00000015143.
GeneIDi396277.
KEGGigga:396277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60471 mRNA. Translation: CAA43000.1.
PIRiS17827.
RefSeqiNP_990666.1. NM_205335.3.
UniGeneiGga.2620.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TFPX-ray2.90A/B21-150[»]
ProteinModelPortaliP27731.
SMRiP27731. Positions 33-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP27731. 1 interaction.
STRINGi9031.ENSGALP00000024388.

Proteomic databases

PaxDbiP27731.
PRIDEiP27731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000024434; ENSGALP00000024388; ENSGALG00000015143.
GeneIDi396277.
KEGGigga:396277.

Organism-specific databases

CTDi7276.

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
GeneTreeiENSGT00390000005321.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP27731.
OMAiKTSEFGE.
OrthoDBiEOG091G0VSV.
PhylomeDBiP27731.
TreeFamiTF300210.

Enzyme and pathway databases

ReactomeiR-GGA-2453902. The canonical retinoid cycle in rods (twilight vision).
R-GGA-975634. Retinoid metabolism and transport.

Miscellaneous databases

EvolutionaryTraceiP27731.
PROiP27731.

Gene expression databases

BgeeiENSGALG00000015143.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR030178. Transthyretin.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PANTHERiPTHR10395:SF12. PTHR10395:SF12. 1 hit.
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTHY_CHICK
AccessioniPrimary (citable) accession number: P27731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.