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Protein

Aromatic-L-amino-acid decarboxylase

Gene

DDC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic activityi

L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

Pathwayi: dopamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dopamine from L-tyrosine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tyrosine 3-monooxygenase (TH)
  2. Aromatic-L-amino-acid decarboxylase (DDC)
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dopamine from L-tyrosine, the pathway dopamine biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821SubstrateBy similarity
Binding sitei148 – 1481Pyridoxal phosphate; via amide nitrogenBy similarity
Binding sitei149 – 1491Pyridoxal phosphateBy similarity
Binding sitei192 – 1921SubstrateBy similarity
Binding sitei246 – 2461Pyridoxal phosphate; via carbonyl oxygenBy similarity
Binding sitei300 – 3001Pyridoxal phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Catecholamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00747; UER00734.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic-L-amino-acid decarboxylase (EC:4.1.1.28)
Short name:
AADC
Alternative name(s):
DOPA decarboxylase
Short name:
DDC
Gene namesi
Name:DDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Aromatic-L-amino-acid decarboxylasePRO_0000146937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei303 – 3031N6-(pyridoxal phosphate)lysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP27718.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051814.

Structurei

3D structure databases

ProteinModelPortaliP27718.
SMRiP27718. Positions 1-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 115581Add
BLAST
Repeati118 – 178612Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 1781212 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiP27718.
KOiK01593.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASEFRRRG KEMVDYVADY LEGIEGRQVF PDVDPGYLRP LIPTTAPQEP
60 70 80 90 100
ETFEAIIEDI EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC
110 120 130 140 150
IGFSWAASPA CTELETVMMD WLGKMLQLPE AFLAGEAGEG GGVIQGTASE
160 170 180 190 200
ATLVALLAAR TKVTRHLQAA SPELMQAAIM EKLVAYASDQ AHSSVEKAGL
210 220 230 240 250
IGGVRLKAIP SDGKFAMRAS ALQEALERDK AAGLIPFFVV ATLGTTSCCS
260 270 280 290 300
FDNLLEVGPI CHEEGLWLHV DAAYAGSAFI CPEFRHLLNG VEFADSFNFN
310 320 330 340 350
PHKWLLVNFD CSAMWVKKRT DLTGAFRLDP VYLRHSHQDS GLITDYRHWQ
360 370 380 390 400
LPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVQLSHAFEA LVRQDTRFEI
410 420 430 440 450
CAEVILGLVC FRLKGSNKLN EALLESINSA KKIHLVPCSL RDRFVLRFAI
460 470 480
CSRTVELAHV QLAWEHIQEM AATVLRAQGE EKAEIKN
Length:487
Mass (Da):54,294
Last modified:February 6, 2007 - v2
Checksum:i8F104C610A332FFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1712AS → RA in AAC41615 (PubMed:2166204).Curated
Sequence conflicti175 – 1751M → T in AAC41615 (PubMed:2166204).Curated
Sequence conflicti221 – 2255ALQEA → RCRR in AAC41615 (PubMed:2166204).Curated
Sequence conflicti237 – 2371F → SC in AAC41615 (PubMed:2166204).Curated
Sequence conflicti263 – 2631E → K in AAC41615 (PubMed:2166204).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74029 mRNA. Translation: AAC41615.1.
BT026145 mRNA. Translation: ABG66984.1.
PIRiA43758.
RefSeqiNP_776332.1. NM_173907.2.
XP_010802269.1. XM_010803967.1.
UniGeneiBt.115.

Genome annotation databases

GeneIDi107131141.
280762.
KEGGibta:107131141.
bta:280762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74029 mRNA. Translation: AAC41615.1.
BT026145 mRNA. Translation: ABG66984.1.
PIRiA43758.
RefSeqiNP_776332.1. NM_173907.2.
XP_010802269.1. XM_010803967.1.
UniGeneiBt.115.

3D structure databases

ProteinModelPortaliP27718.
SMRiP27718. Positions 1-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051814.

Proteomic databases

PaxDbiP27718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107131141.
280762.
KEGGibta:107131141.
bta:280762.

Organism-specific databases

CTDi1644.

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiP27718.
KOiK01593.

Enzyme and pathway databases

UniPathwayiUPA00747; UER00734.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDC_BOVIN
AccessioniPrimary (citable) accession number: P27718
Secondary accession number(s): Q0V8S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 6, 2007
Last modified: July 6, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.