P27701 (CD82_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 99.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: CD82 antigen Alternative name(s): C33 antigen IA4 Inducible membrane protein R2 Metastasis suppressor Kangai-1 Suppressor of tumorigenicity 6 protein Tetraspanin-27 Short name=Tspan-27 CD_antigen=CD82 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 267 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. |
| Subunit structure | Interacts directly with IGSF8. Ref.8 |
| Subcellular location | |
| Tissue specificity | Lymphoid specific. |
| Sequence similarities | Belongs to the tetraspanin (TM4SF) family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane Transmembrane helix |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to plasma membrane Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| VANGL1 | Q8TAA9 | 6 | EBI-682379,EBI-682393 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 267 | 267 | CD82 antigen | PRO_0000219226 | |||||
Regions | |||||||||
| Topological domain | 1 – 11 | 11 | Cytoplasmic Potential | ||||||
| Transmembrane | 12 – 32 | 21 | Helical; Potential | ||||||
| Topological domain | 33 – 53 | 21 | Extracellular Potential | ||||||
| Transmembrane | 54 – 72 | 19 | Helical; Potential | ||||||
| Topological domain | 73 – 83 | 11 | Cytoplasmic Potential | ||||||
| Transmembrane | 84 – 110 | 27 | Helical; Potential | ||||||
| Topological domain | 111 – 228 | 118 | Extracellular Potential | ||||||
| Transmembrane | 229 – 250 | 22 | Helical; Potential | ||||||
| Topological domain | 251 – 267 | 17 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 129 | 1 | N-linked (GlcNAc...) Ref.9 Ref.10 | ||||||
| Glycosylation | 157 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 198 | 1 | N-linked (GlcNAc...) Ref.10 | ||||||
Natural variations | |||||||||
| Natural variant | 241 | 1 | I → V. Ref.6 Ref.7 Corresponds to variant rs1139971 [ dbSNP | Ensembl ]. | VAR_052326 | |||||
Experimental info | |||||||||
| Sequence conflict | 240 – 241 | 2 | II → MV in AAB23825. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23." Gaugitsch H.W., Hofer E., Huber N.E., Schnabl E., Baumruker T. Eur. J. Immunol. 21:377-383(1991) [PubMed: 1842498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood lymphocyte. |
| [2] | "C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63." Imai T., Fukudome K., Takagi S., Nagira M., Furuse M., Fukuhara N., Nishimura M., Hinuma Y., Yoshie O. J. Immunol. 149:2879-2886(1992) [PubMed: 1401919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2." Dong J.T., Barrett J.C. Science 268:884-886(1995) [PubMed: 7754374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Genomic organization of the human KAI1 metastasis-suppressor gene." Dong J.T., Isaacs W.B., Barrett J.C., Isaacs J.T. Genomics 41:25-32(1997) [PubMed: 9126478] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-241. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-241. Tissue: Colon. |
| [8] | "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells." Zhang X.A., Lane W.S., Charrin S., Rubinstein E., Liu L. Cancer Res. 63:2665-2674(2003) [PubMed: 12750295] [Abstract] Cited for: INTERACTION WITH IGSF8. |
| [9] | "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-129, MASS SPECTROMETRY. Tissue: Liver. |
| [10] | "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-129 AND ASN-198, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X53795 mRNA. Translation: CAA37804.1. S48196 mRNA. Translation: AAB23825.1. U20770 mRNA. Translation: AAC50133.1. U67274 U67273 Genomic DNA. Translation: AAC51205.1.CR542255 mRNA. Translation: CAG47051.1. CH471064 Genomic DNA. Translation: EAW68063.1. CH471064 Genomic DNA. Translation: EAW68064.1. BC000726 mRNA. Translation: AAH00726.1. BC001821 mRNA. Translation: AAH01821.1. |
| IPI | IPI00020446. |
| PIR | A46493. I38942. |
| RefSeq | NP_001020015.1. NM_001024844.1. NP_002222.1. NM_002231.3. |
| UniGene | Hs.527778. |
3D structure databases | |
| ProteinModelPortal | P27701. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P27701. 1 interaction. |
| STRING | P27701. |
PTM databases | |
| PhosphoSite | P27701. |
Polymorphism databases | |
| DMDM | 131775. |
Proteomic databases | |
| PRIDE | P27701. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000227155; ENSP00000227155; ENSG00000085117. ENST00000441195; ENSP00000388758; ENSG00000085117. |
| GeneID | 3732. |
| KEGG | hsa:3732. |
| UCSC | uc001myc.1. human. |
Organism-specific databases | |
| CTD | 3732. |
| GeneCards | GC11P044544. |
| H-InvDB | HIX0017389. |
| HGNC | HGNC:6210. CD82. |
| HPA | CAB002508. HPA028900. |
| MIM | 600623. gene. |
| neXtProt | NX_P27701. |
| PharmGKB | PA142672155. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG18880. |
| HOGENOM | HBG716506. |
| HOVERGEN | HBG002324. |
| InParanoid | P27701. |
| OMA | KCCGWVS. |
| PhylomeDB | P27701. |
Gene expression databases | |
| ArrayExpress | P27701. |
| Bgee | P27701. |
| CleanEx | HS_CD82. |
| Genevestigator | P27701. |
| GermOnline | ENSG00000085117. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR018499. Tetraspanin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2. IPR000301. Tetraspanin_subgr. [Graphical view] |
| KO | K06509. |
| Pfam | PF00335. Tetraspannin. 1 hit. [Graphical view] |
| PRINTS | PR00259. TMFOUR. |
| SUPFAM | SSF48652. Tetraspanin. 1 hit. |
| PROSITE | PS00421. TM4_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 14607. |
| SOURCE | Search... |
Entry information
| Entry name | CD82_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P27701 Secondary accession number(s): D3DQN6, Q7Z2D4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with