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Protein

CD82 antigen

Gene

CD82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

GO - Biological processi

Enzyme and pathway databases

SIGNORiP27701

Names & Taxonomyi

Protein namesi
Recommended name:
CD82 antigen
Alternative name(s):
C33 antigen
IA4
Inducible membrane protein R2
Metastasis suppressor Kangai-1
Suppressor of tumorigenicity 6 protein
Tetraspanin-27
Short name:
Tspan-27
CD_antigen: CD82
Gene namesi
Name:CD82
Synonyms:KAI1, SAR2, ST6, TSPAN27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000085117.11
HGNCiHGNC:6210 CD82
MIMi600623 gene
neXtProtiNX_P27701

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 53ExtracellularSequence analysisAdd BLAST21
Transmembranei54 – 72HelicalSequence analysisAdd BLAST19
Topological domaini73 – 83CytoplasmicSequence analysisAdd BLAST11
Transmembranei84 – 110HelicalSequence analysisAdd BLAST27
Topological domaini111 – 228ExtracellularSequence analysisAdd BLAST118
Transmembranei229 – 250HelicalSequence analysisAdd BLAST22
Topological domaini251 – 267CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3732
MalaCardsiCD82
OpenTargetsiENSG00000085117
PharmGKBiPA142672155

Polymorphism and mutation databases

BioMutaiCD82
DMDMi131775

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192261 – 267CD82 antigenAdd BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP27701
MaxQBiP27701
PaxDbiP27701
PeptideAtlasiP27701
PRIDEiP27701

PTM databases

iPTMnetiP27701
PhosphoSitePlusiP27701
SwissPalmiP27701

Expressioni

Tissue specificityi

Lymphoid specific.

Gene expression databases

BgeeiENSG00000085117
CleanExiHS_CD82
ExpressionAtlasiP27701 baseline and differential
GenevisibleiP27701 HS

Organism-specific databases

HPAiCAB002508
HPA028900
HPA061418

Interactioni

Subunit structurei

Interacts directly with IGSF8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VANGL1Q8TAA96EBI-682379,EBI-682393

Protein-protein interaction databases

BioGridi109935, 24 interactors
IntActiP27701, 7 interactors
STRINGi9606.ENSP00000227155

Structurei

3D structure databases

ProteinModelPortaliP27701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP27701
KOiK06509
OMAiQVKCCGW
OrthoDBiEOG091G0G4W
PhylomeDBiP27701
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P27701-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS
60 70 80 90 100
SLRMGAYVFI GVGAVTMLMG FLGCIGAVNE VRCLLGLYFA FLLLILIAQV
110 120 130 140 150
TAGALFYFNM GKLKQEMGGI VTELIRDYNS SREDSLQDAW DYVQAQVKCC
160 170 180 190 200
GWVSFYNWTD NAELMNRPEV TYPCSCEVKG EEDNSLSVRK GFCEAPGNRT
210 220 230 240 250
QSGNHPEDWP VYQEGCMEKV QAWLQENLGI ILGVGVGVAI IELLGMVLSI
260
CLCRHVHSED YSKVPKY
Length:267
Mass (Da):29,626
Last modified:August 1, 1992 - v1
Checksum:iFC379855BD1CABDE
GO
Isoform 2 (identifier: P27701-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-112: Missing.

Show »
Length:242
Mass (Da):26,818
Checksum:iE80ECE34CFFF383D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124L → P in AAP76181 (Ref. 4) Curated1
Sequence conflicti240 – 241II → MV in AAB23825 (PubMed:1401919).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052326241I → V3 PublicationsCorresponds to variant dbSNP:rs1139971Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04565688 – 112Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53795 mRNA Translation: CAA37804.1
S48196 mRNA Translation: AAB23825.1
U20770 mRNA Translation: AAC50133.1
AY303776 mRNA Translation: AAP76181.1
U67274
, U67268, U67269, U67270, U67271, U67272, U67273 Genomic DNA Translation: AAC51205.1
CR542255 mRNA Translation: CAG47051.1
AC010768 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68063.1
CH471064 Genomic DNA Translation: EAW68064.1
BC000726 mRNA Translation: AAH00726.1
BC001821 mRNA Translation: AAH01821.1
CCDSiCCDS31469.1 [P27701-2]
CCDS7909.1 [P27701-1]
PIRiI38942 A46493
RefSeqiNP_001020015.1, NM_001024844.1 [P27701-2]
NP_002222.1, NM_002231.3 [P27701-1]
XP_006718286.1, XM_006718223.2 [P27701-1]
UniGeneiHs.527778

Genome annotation databases

EnsembliENST00000227155; ENSP00000227155; ENSG00000085117 [P27701-1]
ENST00000342935; ENSP00000339686; ENSG00000085117 [P27701-2]
GeneIDi3732
KEGGihsa:3732
UCSCiuc001myc.4 human [P27701-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD82_HUMAN
AccessioniPrimary (citable) accession number: P27701
Secondary accession number(s): D3DQN6
, E9PC70, Q7Z2D4, Q7Z5N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 28, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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