P27699 (CREM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cAMP-responsive element modulator

Gene names

Name:

Crem

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange. Ref.6
Subunit structure	Binds DNA as a dimer By similarity. Interacts with CDC34 By similarity. Interacts with FHL5. Isoform 1 forms a heterodimer with CREB3L4. Ref.5 Ref.6
Subcellular location	Nucleus.
Developmental stage	In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts.
Post-translational modification	Stimulated by phosphorylation By similarity. Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome By similarity.
Miscellaneous	CREM-null deficient mice display male infertility: while spermatogonia differentiate normally into round spermatids, all the elongating spermatids are eliminated by apoptosis during spermiogenesis.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain. Contains 1 KID (kinase-inducible) domain.
Sequence caution	The sequence AAA17495.1 differs from that shown. Reason: Erroneous initiation. The sequence AAA17496.1 differs from that shown. Reason: Erroneous initiation. The sequence AAA17497.1 differs from that shown. Reason: Erroneous initiation. The sequence AAV28551.1 differs from that shown. Reason: Erroneous initiation. The sequence AAV28552.1 differs from that shown. Reason: Erroneous initiation. The sequence AAV28553.1 differs from that shown. Reason: Erroneous initiation. The sequence AAV28554.1 differs from that shown. Reason: Erroneous initiation. The sequence AAV28555.1 differs from that shown. Reason: Erroneous initiation. The sequence AAV28556.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Molecular function	Activator Repressor
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycosphingolipid metabolic process Inferred from mutant phenotype PubMed 18308723. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 20488182. Source: MGI spermatogenesis Inferred from mutant phenotype PubMed 14757819. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor complex Inferred from direct assay PubMed 11354513. Source: MGI
Molecular_function	DNA binding Inferred from direct assay PubMed 11354513. Source: MGI sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P27699-1)

Also known as: CREM-BCEFGgammaHIbeta; Tau;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P27699-2)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Isoform 3 (identifier: P27699-3)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N

Isoform 4 (identifier: P27699-4)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T

Isoform 5 (identifier: P27699-5)

Also known as: Tau Alpha Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     246-257: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Isoform 6 (identifier: P27699-6)

Also known as: Tau 2 Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Isoform 7 (identifier: P27699-7)

Also known as: Tau 1 Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Isoform 8 (identifier: P27699-8)

Also known as: Tau 1 Alpha Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Isoform 9 (identifier: P27699-9)

Also known as: Tau 1 Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T

Isoform 10 (identifier: P27699-10)

Also known as: Alpha Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	cAMP-responsive element modulator		PRO_0000076608
Regions
	Domain	101 – 160	60	KID
	Domain	299 – 357	59	bZIP
	Region	300 – 325	26	Basic motif By similarity
	Region	327 – 348	22	Leucine-zipper By similarity
Amino acid modifications
	Modified residue	284	1	Phosphoserine By similarity
	Modified residue	287	1	Phosphoserine By similarity
	Modified residue	290	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	55 – 103	49	Missing in isoform 2, isoform 3, isoform 4, isoform 6 and isoform 10.		VSP_000602
	Alternative sequence	183 – 257	75	Missing in isoform 4, isoform 8, isoform 9 and isoform 10.		VSP_000605
	Alternative sequence	183 – 245	63	Missing in isoform 2, isoform 3 and isoform 7.		VSP_000603
	Alternative sequence	246 – 257	12	Missing in isoform 5.		VSP_038016
	Alternative sequence	246	1	D → N in isoform 2, isoform 3 and isoform 7.		VSP_000604
	Alternative sequence	258	1	A → T in isoform 4, isoform 8, isoform 9 and isoform 10.		VSP_000606
	Alternative sequence	314 – 357	44	KECRR…SPKTD → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKAE in isoform 2, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 10.		VSP_000607

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (CREM-BCEFGgammaHIbeta) (Tau) [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 0B387B7247113088	FASTA	357	38,516
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVSVAGS 70 80 90 100 110 120 GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ TVQVATIAET DDSADSEVID 130 140 150 160 170 180 SHKRREILSR RPSYRKILNE LSSDVPGIPK IEEEKSEEEG TPPNIATMAV PTSIYQTSTG 190 200 210 220 230 240 QYIAIAQGGT IQISNPGSDG VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS 250 260 270 280 290 300 QVVVQDEETD LAPSHMAAAT GDMPTYQIRA PTTALPQGVV MAASPGSLHS PQQLAEEATR 310 320 330 340 350 KRELRLMKNR EAAKECRRRK KEYVKCLESR VAVLEVQNKK LIEELETLKD ICSPKTD
	Isoform 2 (Alpha) [UniParc]. Checksum: A508BB074EAEA8A6	FASTA	245	27,473
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVATIAE 70 80 90 100 110 120 TDDSADSEVI DSHKRREILS RRPSYRKILN ELSSDVPGIP KIEEEKSEEE GTPPNIATMA 130 140 150 160 170 180 VPTSIYQTST GQYNEETDLA PSHMAAATGD MPTYQIRAPT TALPQGVVMA ASPGSLHSPQ 190 200 210 220 230 240 QLAEEATRKR ELRLMKNREA ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY CHKAE
	Isoform 3 (Beta) [UniParc]. Checksum: F85FB7D3B0451514	FASTA	245	27,389
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVATIAE 70 80 90 100 110 120 TDDSADSEVI DSHKRREILS RRPSYRKILN ELSSDVPGIP KIEEEKSEEE GTPPNIATMA 130 140 150 160 170 180 VPTSIYQTST GQYNEETDLA PSHMAAATGD MPTYQIRAPT TALPQGVVMA ASPGSLHSPQ 190 200 210 220 230 240 QLAEEATRKR ELRLMKNREA AKECRRRKKE YVKCLESRVA VLEVQNKKLI EELETLKDIC SPKTD
	Isoform 4 (Gamma) [UniParc]. Checksum: 9645439A10824456	FASTA	233	26,123
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVATIAE 70 80 90 100 110 120 TDDSADSEVI DSHKRREILS RRPSYRKILN ELSSDVPGIP KIEEEKSEEE GTPPNIATMA 130 140 150 160 170 180 VPTSIYQTST GQYTATGDMP TYQIRAPTTA LPQGVVMAAS PGSLHSPQQL AEEATRKREL 190 200 210 220 230 RLMKNREAAK ECRRRKKEYV KCLESRVAVL EVQNKKLIEE LETLKDICSP KTD
	Isoform 5 (Tau Alpha Gamma) [UniParc]. Checksum: 508E5448D03B5F8D	FASTA	345	37,303
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVSVAGS 70 80 90 100 110 120 GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ TVQVATIAET DDSADSEVID 130 140 150 160 170 180 SHKRREILSR RPSYRKILNE LSSDVPGIPK IEEEKSEEEG TPPNIATMAV PTSIYQTSTG 190 200 210 220 230 240 QYIAIAQGGT IQISNPGSDG VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS 250 260 270 280 290 300 QVVVQAATGD MPTYQIRAPT TALPQGVVMA ASPGSLHSPQ QLAEEATRKR ELRLMKNREA 310 320 330 340 ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY CHKAE
	Isoform 6 (Tau 2 Alpha) [UniParc]. Checksum: 438CD86068BA7DAF	FASTA	308	33,698
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVATIAE 70 80 90 100 110 120 TDDSADSEVI DSHKRREILS RRPSYRKILN ELSSDVPGIP KIEEEKSEEE GTPPNIATMA 130 140 150 160 170 180 VPTSIYQTST GQYIAIAQGG TIQISNPGSD GVQGLQALTM TNSGAPPPGA TIVQYAAQSA 190 200 210 220 230 240 DGTQQFFVPG SQVVVQDEET DLAPSHMAAA TGDMPTYQIR APTTALPQGV VMAASPGSLH 250 260 270 280 290 300 SPQQLAEEAT RKRELRLMKN REAARECRRK KKEYVKCLEN RVAVLENQNK TLIEELKALK DLYCHKAE
	Isoform 7 (Tau 1 Alpha) [UniParc]. Checksum: C637D53AC9A9BCF8	FASTA	294	32,376
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVSVAGS 70 80 90 100 110 120 GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ TVQVATIAET DDSADSEVID 130 140 150 160 170 180 SHKRREILSR RPSYRKILNE LSSDVPGIPK IEEEKSEEEG TPPNIATMAV PTSIYQTSTG 190 200 210 220 230 240 QYNEETDLAP SHMAAATGDM PTYQIRAPTT ALPQGVVMAA SPGSLHSPQQ LAEEATRKRE 250 260 270 280 290 LRLMKNREAA RECRRKKKEY VKCLENRVAV LENQNKTLIE ELKALKDLYC HKAE
	Isoform 8 (Tau 1 Alpha Gamma) [UniParc]. Checksum: 46A1DA7CDA89F4B5	FASTA	282	31,109
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVSVAGS 70 80 90 100 110 120 GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ TVQVATIAET DDSADSEVID 130 140 150 160 170 180 SHKRREILSR RPSYRKILNE LSSDVPGIPK IEEEKSEEEG TPPNIATMAV PTSIYQTSTG 190 200 210 220 230 240 QYTATGDMPT YQIRAPTTAL PQGVVMAASP GSLHSPQQLA EEATRKRELR LMKNREAARE 250 260 270 280 CRRKKKEYVK CLENRVAVLE NQNKTLIEEL KALKDLYCHK AE
	Isoform 9 (Tau 1 Gamma) [UniParc]. Checksum: 1BF6D6A824624907	FASTA	282	31,025
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVSVAGS 70 80 90 100 110 120 GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ TVQVATIAET DDSADSEVID 130 140 150 160 170 180 SHKRREILSR RPSYRKILNE LSSDVPGIPK IEEEKSEEEG TPPNIATMAV PTSIYQTSTG 190 200 210 220 230 240 QYTATGDMPT YQIRAPTTAL PQGVVMAASP GSLHSPQQLA EEATRKRELR LMKNREAAKE 250 260 270 280 CRRRKKEYVK CLESRVAVLE VQNKKLIEEL ETLKDICSPK TD
	Isoform 10 (Alpha Gamma) [UniParc]. Checksum: CB124F4EEE69F9E4	FASTA	233	26,207
	10 20 30 40 50 60 MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP TLAQVATIAE 70 80 90 100 110 120 TDDSADSEVI DSHKRREILS RRPSYRKILN ELSSDVPGIP KIEEEKSEEE GTPPNIATMA 130 140 150 160 170 180 VPTSIYQTST GQYTATGDMP TYQIRAPTTA LPQGVVMAAS PGSLHSPQQL AEEATRKREL 190 200 210 220 230 RLMKNREAAR ECRRKKKEYV KCLENRVAVL ENQNKTLIEE LKALKDLYCH KAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription." Foulkes N.S., Borrelli E., Sassone-Corsi P. Cell 64:739-749(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-357 (ISOFORMS 2; 3 AND 4).
[3]	"Identification of novel cAMP responsive element modulator (CREM) isoforms expressed by osteoblasts." Liu F., Huang Y.-F., Kream B.E. Calcif. Tissue Int. 77:91-95(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-357 (ISOFORMS 5; 6; 7; 8; 9 AND 10). Tissue: Osteoblast.
[4]	"Developmental switch of CREM function during spermatogenesis: from antagonist to activator." Foulkes N.S., Mellstroem B., Benusiglio E., Sassone-Corsi P. Nature 355:80-84(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-357 (ISOFORM 1).
[5]	"CBP-independent activation of CREM and CREB by the LIM-only protein ACT." Fimia G.M., De Cesare D., Sassone-Corsi P. Nature 398:165-169(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FHL5.
[6]	"Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation." Nagamori I., Yomogida K., Adams P.D., Sassone-Corsi P., Nojima H. J. Biol. Chem. 281:15073-15081(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CREB3L4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC117589 Genomic DNA. No translation available. M60285 mRNA. Translation: AAA17495.1. Different initiation. M60285 mRNA. Translation: AAA17496.1. Different initiation. M60285 mRNA. Translation: AAA17497.1. Different initiation. AY738715 mRNA. Translation: AAV28551.1. Different initiation. AY738716 mRNA. Translation: AAV28552.1. Different initiation. AY738717 mRNA. Translation: AAV28553.1. Different initiation. AY738718 mRNA. Translation: AAV28554.1. Different initiation. AY738719 mRNA. Translation: AAV28555.1. Different initiation. AY738721 mRNA. Translation: AAV28556.1. Different initiation.
IPI	IPI00118888. IPI00221395. IPI00221396. IPI00230770. IPI00480218. IPI00877312. IPI00877317. IPI00918128. IPI00918700. IPI00919039.
PIR	A37944. B37944. C37944. S20827.
RefSeq	NP_001104320.1. NM_001110850.2. NP_001104324.2. NM_001110854.1. NP_001104325.2. NM_001110855.1. NP_001104326.1. NM_001110856.2. NP_001104327.1. NM_001110857.2. NP_001104328.1. NM_001110858.2. NP_001104329.1. NM_001110859.2. NP_001258432.1. NM_001271503.1. NP_001258433.1. NM_001271504.1. NP_001258434.1. NM_001271505.1. NP_001258435.1. NM_001271506.1. NP_038526.2. NM_013498.3.
UniGene	Mm.5244.
3D structure databases
ProteinModelPortal	P27699.
SMR	P27699. Positions 120-146, 301-355.
ModBase	Search...
Proteomic databases
PRIDE	P27699.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889. ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889. ENSMUST00000123672; ENSMUSP00000120557; ENSMUSG00000063889. ENSMUST00000130599; ENSMUSP00000115471; ENSMUSG00000063889. ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889. ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889. ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889. ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889.
GeneID	12916.
KEGG	mmu:12916.
UCSC	uc008dxm.2. mouse. uc008dxq.2. mouse. uc008dxr.2. mouse. uc008dxs.2. mouse. uc008dxt.2. mouse. uc012ayv.1. mouse.
Organism-specific databases
CTD	1390.
MGI	MGI:88495. Crem.
Phylogenomic databases
eggNOG	NOG300199.
GeneTree	ENSGT00390000008655.
HOVERGEN	HBG011077.
InParanoid	Q5XTP8.
KO	K09052.
OMA	ESESAHM.
Gene expression databases
ArrayExpress	P27699.
Bgee	P27699.
CleanEx	MM_CREM.
Genevestigator	P27699.
GermOnline	ENSMUSG00000063889. Mus musculus.
Family and domain databases
InterPro	IPR004827. bZIP. IPR003102. Coactivator_CBP_pKID. IPR001630. Leuzip_CREB. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. PF02173. pKID. 1 hit. [Graphical view]
PRINTS	PR00041. LEUZIPPRCREB.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. PS50953. KID. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	282558.
SOURCE	Search...

Entry information

Entry name

CREM_MOUSE

Accession

Primary (citable) accession number: P27699
Secondary accession number(s): P27698 , Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	September 22, 2009
Last modified:	April 3, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program