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P27699

- CREM_MOUSE

UniProt

P27699 - CREM_MOUSE

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Protein

cAMP-responsive element modulator

Gene

Crem

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (PubMed:16595651).1 Publication
Isoform 11: Plays a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.2 Publications

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: UniProtKB
  2. DNA binding Source: MGI
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. circadian regulation of gene expression Source: UniProtKB
  2. circadian rhythm Source: UniProtKB
  3. glycosphingolipid metabolic process Source: MGI
  4. negative regulation of transcription, DNA-templated Source: UniProtKB
  5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  6. response to cAMP Source: UniProtKB
  7. rhythmic process Source: UniProtKB-KW
  8. spermatogenesis Source: MGI
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element modulator
Alternative name(s):
Inducible cAMP early repressor
Short name:
ICER
Gene namesi
Name:Crem
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:88495. Crem.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: MGI
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357cAMP-responsive element modulatorPRO_0000076608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841PhosphoserinePROSITE-ProRule annotation
Modified residuei287 – 2871PhosphoserinePROSITE-ProRule annotation
Modified residuei290 – 2901PhosphoserinePROSITE-ProRule annotation

Post-translational modificationi

Stimulated by phosphorylation.By similarity
Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP27699.
PRIDEiP27699.

Expressioni

Developmental stagei

In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts.

Inductioni

Isoform 11 is expressed in a circadian manner in the adrenal gland with an expression peak at ZT20 (at protein level). It is induced by cAMP in an immediate-early fashion and can repress its own production via a negative autoregulatory mechanism.2 Publications

Gene expression databases

BgeeiP27699.
CleanExiMM_CREM.
ExpressionAtlasiP27699. baseline and differential.
GenevestigatoriP27699.

Interactioni

Subunit structurei

Binds DNA as a dimer By similarity. Interacts with CDC34 By similarity. Interacts with FHL5. Isoform 1 forms a heterodimer with CREB3L4.By similarity2 Publications

Protein-protein interaction databases

BioGridi198877. 5 interactions.
IntActiP27699. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP27699.
SMRiP27699. Positions 120-146, 301-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 16060KIDPROSITE-ProRule annotationAdd
BLAST
Domaini299 – 35759bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni300 – 32526Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni327 – 34822Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
Contains 1 KID (kinase-inducible) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG300199.
GeneTreeiENSGT00390000008655.
HOGENOMiHOG000007365.
HOVERGENiHBG011077.
InParanoidiP27699.
KOiK09052.
OMAiPAWQMAL.
PhylomeDBiP27699.
TreeFamiTF106464.

Family and domain databases

InterProiIPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: P27699-1) [UniParc]FASTAAdd to Basket

Also known as: CREM-BCEFGgammaHIbeta, Tau

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP
60 70 80 90 100
TLAQVSVAGS GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ
110 120 130 140 150
TVQVATIAET DDSADSEVID SHKRREILSR RPSYRKILNE LSSDVPGIPK
160 170 180 190 200
IEEEKSEEEG TPPNIATMAV PTSIYQTSTG QYIAIAQGGT IQISNPGSDG
210 220 230 240 250
VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS QVVVQDEETD
260 270 280 290 300
LAPSHMAAAT GDMPTYQIRA PTTALPQGVV MAASPGSLHS PQQLAEEATR
310 320 330 340 350
KRELRLMKNR EAAKECRRRK KEYVKCLESR VAVLEVQNKK LIEELETLKD

ICSPKTD
Length:357
Mass (Da):38,516
Last modified:September 22, 2009 - v2
Checksum:i0B387B7247113088
GO
Isoform 2 (identifier: P27699-2) [UniParc]FASTAAdd to Basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:245
Mass (Da):27,473
Checksum:iA508BB074EAEA8A6
GO
Isoform 3 (identifier: P27699-3) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N

Show »
Length:245
Mass (Da):27,389
Checksum:iF85FB7D3B0451514
GO
Isoform 4 (identifier: P27699-4) [UniParc]FASTAAdd to Basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T

Show »
Length:233
Mass (Da):26,123
Checksum:i9645439A10824456
GO
Isoform 5 (identifier: P27699-5) [UniParc]FASTAAdd to Basket

Also known as: Tau Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     246-257: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:345
Mass (Da):37,303
Checksum:i508E5448D03B5F8D
GO
Isoform 6 (identifier: P27699-6) [UniParc]FASTAAdd to Basket

Also known as: Tau 2 Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:308
Mass (Da):33,698
Checksum:i438CD86068BA7DAF
GO
Isoform 7 (identifier: P27699-7) [UniParc]FASTAAdd to Basket

Also known as: Tau 1 Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:294
Mass (Da):32,376
Checksum:iC637D53AC9A9BCF8
GO
Isoform 8 (identifier: P27699-8) [UniParc]FASTAAdd to Basket

Also known as: Tau 1 Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:282
Mass (Da):31,109
Checksum:i46A1DA7CDA89F4B5
GO
Isoform 9 (identifier: P27699-9) [UniParc]FASTAAdd to Basket

Also known as: Tau 1 Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T

Show »
Length:282
Mass (Da):31,025
Checksum:i1BF6D6A824624907
GO
Isoform 10 (identifier: P27699-10) [UniParc]FASTAAdd to Basket

Also known as: Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:233
Mass (Da):26,207
Checksum:iCB124F4EEE69F9E4
GO
Isoform 11 (identifier: P27699-11) [UniParc]FASTAAdd to Basket

Also known as: Icer Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: MSKCGRKKYM...FVPGSQVVVQ → MAVTGDET
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Note: Produced by alternative promoter usage.

Show »
Length:120
Mass (Da):13,437
Checksum:i6A84CA55E6C049F1
GO

Sequence cautioni

The sequence AAA17495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAA17496.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAA17497.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAV28551.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAV28552.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAV28553.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAV28554.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAV28555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAV28556.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 245245MSKCG…QVVVQ → MAVTGDET in isoform 11. 1 PublicationVSP_055987Add
BLAST
Alternative sequencei55 – 10349Missing in isoform 2, isoform 3, isoform 4, isoform 6 and isoform 10. 2 PublicationsVSP_000602Add
BLAST
Alternative sequencei183 – 25775Missing in isoform 4, isoform 8, isoform 9 and isoform 10. 2 PublicationsVSP_000605Add
BLAST
Alternative sequencei183 – 24563Missing in isoform 2, isoform 3 and isoform 7. 2 PublicationsVSP_000603Add
BLAST
Alternative sequencei246 – 25712Missing in isoform 5. 1 PublicationVSP_038016Add
BLAST
Alternative sequencei246 – 2461D → N in isoform 2, isoform 3 and isoform 7. 2 PublicationsVSP_000604
Alternative sequencei258 – 2581A → T in isoform 4, isoform 8, isoform 9 and isoform 10. 2 PublicationsVSP_000606
Alternative sequencei314 – 35744KECRR…SPKTD → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKAE in isoform 2, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 11. 3 PublicationsVSP_000607Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ311667 mRNA. Translation: CAC34846.1.
AC117589 Genomic DNA. No translation available.
M60285 mRNA. Translation: AAA17495.1. Different initiation.
M60285 mRNA. Translation: AAA17496.1. Different initiation.
M60285 mRNA. Translation: AAA17497.1. Different initiation.
AY738715 mRNA. Translation: AAV28551.1. Different initiation.
AY738716 mRNA. Translation: AAV28552.1. Different initiation.
AY738717 mRNA. Translation: AAV28553.1. Different initiation.
AY738718 mRNA. Translation: AAV28554.1. Different initiation.
AY738719 mRNA. Translation: AAV28555.1. Different initiation.
AY738721 mRNA. Translation: AAV28556.1. Different initiation.
CCDSiCCDS29031.2. [P27699-2]
CCDS50214.1. [P27699-7]
CCDS50215.1. [P27699-1]
CCDS70862.1. [P27699-6]
CCDS70863.1. [P27699-8]
CCDS70864.1. [P27699-5]
PIRiA37944.
B37944.
C37944.
S20827.
RefSeqiNP_001104320.1. NM_001110850.2. [P27699-10]
NP_001104324.2. NM_001110854.1.
NP_001104325.2. NM_001110855.1.
NP_001104326.1. NM_001110856.2. [P27699-7]
NP_001104327.1. NM_001110857.2. [P27699-3]
NP_001104328.1. NM_001110858.2. [P27699-4]
NP_001104329.1. NM_001110859.2. [P27699-1]
NP_001258432.1. NM_001271503.1. [P27699-9]
NP_001258433.1. NM_001271504.1. [P27699-8]
NP_001258434.1. NM_001271505.1. [P27699-6]
NP_001258435.1. NM_001271506.1. [P27699-5]
NP_038526.2. NM_013498.3. [P27699-2]
XP_006525618.1. XM_006525555.1. [P27699-1]
XP_006525619.1. XM_006525556.1. [P27699-5]
XP_006525624.1. XM_006525561.1. [P27699-6]
XP_006525628.1. XM_006525565.1. [P27699-7]
XP_006525630.1. XM_006525567.1. [P27699-8]
XP_006525631.1. XM_006525568.1. [P27699-9]
XP_006525636.1. XM_006525573.1. [P27699-2]
XP_006525637.1. XM_006525574.1. [P27699-3]
XP_006525638.1. XM_006525575.1. [P27699-10]
XP_006525639.1. XM_006525576.1. [P27699-4]
UniGeneiMm.5244.

Genome annotation databases

EnsembliENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889. [P27699-5]
ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889. [P27699-6]
ENSMUST00000123672; ENSMUSP00000120557; ENSMUSG00000063889.
ENSMUST00000130599; ENSMUSP00000115471; ENSMUSG00000063889.
ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889. [P27699-1]
ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889. [P27699-2]
ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889. [P27699-8]
ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889. [P27699-7]
GeneIDi12916.
KEGGimmu:12916.
UCSCiuc008dxn.2. mouse. [P27699-2]
uc008dxo.2. mouse. [P27699-7]
uc008dxp.2. mouse. [P27699-8]
uc008dxq.2. mouse. [P27699-9]
uc008dxr.2. mouse. [P27699-5]
uc008dxs.2. mouse. [P27699-6]
uc008dxt.2. mouse. [P27699-10]
uc012ayt.1. mouse. [P27699-1]
uc012ayu.1. mouse. [P27699-3]
uc012ayv.1. mouse. [P27699-4]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ311667 mRNA. Translation: CAC34846.1 .
AC117589 Genomic DNA. No translation available.
M60285 mRNA. Translation: AAA17495.1 . Different initiation.
M60285 mRNA. Translation: AAA17496.1 . Different initiation.
M60285 mRNA. Translation: AAA17497.1 . Different initiation.
AY738715 mRNA. Translation: AAV28551.1 . Different initiation.
AY738716 mRNA. Translation: AAV28552.1 . Different initiation.
AY738717 mRNA. Translation: AAV28553.1 . Different initiation.
AY738718 mRNA. Translation: AAV28554.1 . Different initiation.
AY738719 mRNA. Translation: AAV28555.1 . Different initiation.
AY738721 mRNA. Translation: AAV28556.1 . Different initiation.
CCDSi CCDS29031.2. [P27699-2 ]
CCDS50214.1. [P27699-7 ]
CCDS50215.1. [P27699-1 ]
CCDS70862.1. [P27699-6 ]
CCDS70863.1. [P27699-8 ]
CCDS70864.1. [P27699-5 ]
PIRi A37944.
B37944.
C37944.
S20827.
RefSeqi NP_001104320.1. NM_001110850.2. [P27699-10 ]
NP_001104324.2. NM_001110854.1.
NP_001104325.2. NM_001110855.1.
NP_001104326.1. NM_001110856.2. [P27699-7 ]
NP_001104327.1. NM_001110857.2. [P27699-3 ]
NP_001104328.1. NM_001110858.2. [P27699-4 ]
NP_001104329.1. NM_001110859.2. [P27699-1 ]
NP_001258432.1. NM_001271503.1. [P27699-9 ]
NP_001258433.1. NM_001271504.1. [P27699-8 ]
NP_001258434.1. NM_001271505.1. [P27699-6 ]
NP_001258435.1. NM_001271506.1. [P27699-5 ]
NP_038526.2. NM_013498.3. [P27699-2 ]
XP_006525618.1. XM_006525555.1. [P27699-1 ]
XP_006525619.1. XM_006525556.1. [P27699-5 ]
XP_006525624.1. XM_006525561.1. [P27699-6 ]
XP_006525628.1. XM_006525565.1. [P27699-7 ]
XP_006525630.1. XM_006525567.1. [P27699-8 ]
XP_006525631.1. XM_006525568.1. [P27699-9 ]
XP_006525636.1. XM_006525573.1. [P27699-2 ]
XP_006525637.1. XM_006525574.1. [P27699-3 ]
XP_006525638.1. XM_006525575.1. [P27699-10 ]
XP_006525639.1. XM_006525576.1. [P27699-4 ]
UniGenei Mm.5244.

3D structure databases

ProteinModelPortali P27699.
SMRi P27699. Positions 120-146, 301-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198877. 5 interactions.
IntActi P27699. 1 interaction.

Proteomic databases

MaxQBi P27699.
PRIDEi P27699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025069 ; ENSMUSP00000025069 ; ENSMUSG00000063889 . [P27699-5 ]
ENSMUST00000082141 ; ENSMUSP00000080780 ; ENSMUSG00000063889 . [P27699-6 ]
ENSMUST00000123672 ; ENSMUSP00000120557 ; ENSMUSG00000063889 .
ENSMUST00000130599 ; ENSMUSP00000115471 ; ENSMUSG00000063889 .
ENSMUST00000150235 ; ENSMUSP00000121233 ; ENSMUSG00000063889 . [P27699-1 ]
ENSMUST00000154135 ; ENSMUSP00000122051 ; ENSMUSG00000063889 . [P27699-2 ]
ENSMUST00000154470 ; ENSMUSP00000118128 ; ENSMUSG00000063889 . [P27699-8 ]
ENSMUST00000165086 ; ENSMUSP00000127353 ; ENSMUSG00000063889 . [P27699-7 ]
GeneIDi 12916.
KEGGi mmu:12916.
UCSCi uc008dxn.2. mouse. [P27699-2 ]
uc008dxo.2. mouse. [P27699-7 ]
uc008dxp.2. mouse. [P27699-8 ]
uc008dxq.2. mouse. [P27699-9 ]
uc008dxr.2. mouse. [P27699-5 ]
uc008dxs.2. mouse. [P27699-6 ]
uc008dxt.2. mouse. [P27699-10 ]
uc012ayt.1. mouse. [P27699-1 ]
uc012ayu.1. mouse. [P27699-3 ]
uc012ayv.1. mouse. [P27699-4 ]

Organism-specific databases

CTDi 1390.
MGIi MGI:88495. Crem.

Phylogenomic databases

eggNOGi NOG300199.
GeneTreei ENSGT00390000008655.
HOGENOMi HOG000007365.
HOVERGENi HBG011077.
InParanoidi P27699.
KOi K09052.
OMAi PAWQMAL.
PhylomeDBi P27699.
TreeFami TF106464.

Miscellaneous databases

NextBioi 282558.
PROi P27699.
SOURCEi Search...

Gene expression databases

Bgeei P27699.
CleanExi MM_CREM.
ExpressionAtlasi P27699. baseline and differential.
Genevestigatori P27699.

Family and domain databases

InterProi IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view ]
PRINTSi PR00041. LEUZIPPRCREB.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor."
    Molina C.A., Foulkes N.S., Lalli E., Sassone-Corsi P.
    Cell 75:875-886(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION, INDUCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription."
    Foulkes N.S., Borrelli E., Sassone-Corsi P.
    Cell 64:739-749(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-357 (ISOFORMS 2; 3 AND 4).
  4. "Identification of novel cAMP responsive element modulator (CREM) isoforms expressed by osteoblasts."
    Liu F., Huang Y.-F., Kream B.E.
    Calcif. Tissue Int. 77:91-95(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-357 (ISOFORMS 5; 6; 7; 8; 9 AND 10).
    Tissue: Osteoblast.
  5. "Developmental switch of CREM function during spermatogenesis: from antagonist to activator."
    Foulkes N.S., Mellstroem B., Benusiglio E., Sassone-Corsi P.
    Nature 355:80-84(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-357 (ISOFORM 1).
  6. "CBP-independent activation of CREM and CREB by the LIM-only protein ACT."
    Fimia G.M., De Cesare D., Sassone-Corsi P.
    Nature 398:165-169(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FHL5.
  7. "Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation."
    Nagamori I., Yomogida K., Adams P.D., Sassone-Corsi P., Nojima H.
    J. Biol. Chem. 281:15073-15081(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CREB3L4.
  8. "Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks."
    Zmrzljak U.P., Korencic A., Kosir R., Golicnik M., Sassone-Corsi P., Rozman D.
    J. Biol. Chem. 288:10318-10327(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 11), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION, INDUCTION.

Entry informationi

Entry nameiCREM_MOUSE
AccessioniPrimary (citable) accession number: P27699
Secondary accession number(s): P27698
, Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3, Q99JF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

CREM-null deficient mice display male infertility: while spermatogonia differentiate normally into round spermatids, all the elongating spermatids are eliminated by apoptosis during spermiogenesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3