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P27699

- CREM_MOUSE

UniProt

P27699 - CREM_MOUSE

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Protein

cAMP-responsive element modulator

Gene
Crem
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange.1 Publication

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. glycosphingolipid metabolic process Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. spermatogenesis Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element modulator
Gene namesi
Name:Crem
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:88495. Crem.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357cAMP-responsive element modulatorPRO_0000076608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841Phosphoserine By similarity
Modified residuei287 – 2871Phosphoserine By similarity
Modified residuei290 – 2901Phosphoserine By similarity

Post-translational modificationi

Stimulated by phosphorylation By similarity.
Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP27699.

Expressioni

Developmental stagei

In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts.

Gene expression databases

ArrayExpressiP27699.
BgeeiP27699.
CleanExiMM_CREM.
GenevestigatoriP27699.

Interactioni

Subunit structurei

Binds DNA as a dimer By similarity. Interacts with CDC34 By similarity. Interacts with FHL5. Isoform 1 forms a heterodimer with CREB3L4.2 Publications

Protein-protein interaction databases

BioGridi198877. 5 interactions.
IntActiP27699. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP27699.
SMRiP27699. Positions 120-146, 301-355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 16060KIDAdd
BLAST
Domaini299 – 35759bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni300 – 32526Basic motif By similarityAdd
BLAST
Regioni327 – 34822Leucine-zipper By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.

Phylogenomic databases

eggNOGiNOG300199.
GeneTreeiENSGT00390000008655.
HOVERGENiHBG011077.
InParanoidiQ5XTP8.
KOiK09052.
OMAiPAWQMAL.
PhylomeDBiP27699.
TreeFamiTF106464.

Family and domain databases

InterProiIPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view]
PRINTSiPR00041. LEUZIPPRCREB.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P27699-1) [UniParc]FASTAAdd to Basket

Also known as: CREM-BCEFGgammaHIbeta, Tau

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP    50
TLAQVSVAGS GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ 100
TVQVATIAET DDSADSEVID SHKRREILSR RPSYRKILNE LSSDVPGIPK 150
IEEEKSEEEG TPPNIATMAV PTSIYQTSTG QYIAIAQGGT IQISNPGSDG 200
VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS QVVVQDEETD 250
LAPSHMAAAT GDMPTYQIRA PTTALPQGVV MAASPGSLHS PQQLAEEATR 300
KRELRLMKNR EAAKECRRRK KEYVKCLESR VAVLEVQNKK LIEELETLKD 350
ICSPKTD 357
Length:357
Mass (Da):38,516
Last modified:September 22, 2009 - v2
Checksum:i0B387B7247113088
GO
Isoform 2 (identifier: P27699-2) [UniParc]FASTAAdd to Basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:245
Mass (Da):27,473
Checksum:iA508BB074EAEA8A6
GO
Isoform 3 (identifier: P27699-3) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N

Show »
Length:245
Mass (Da):27,389
Checksum:iF85FB7D3B0451514
GO
Isoform 4 (identifier: P27699-4) [UniParc]FASTAAdd to Basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T

Show »
Length:233
Mass (Da):26,123
Checksum:i9645439A10824456
GO
Isoform 5 (identifier: P27699-5) [UniParc]FASTAAdd to Basket

Also known as: Tau Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     246-257: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:345
Mass (Da):37,303
Checksum:i508E5448D03B5F8D
GO
Isoform 6 (identifier: P27699-6) [UniParc]FASTAAdd to Basket

Also known as: Tau 2 Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:308
Mass (Da):33,698
Checksum:i438CD86068BA7DAF
GO
Isoform 7 (identifier: P27699-7) [UniParc]FASTAAdd to Basket

Also known as: Tau 1 Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:294
Mass (Da):32,376
Checksum:iC637D53AC9A9BCF8
GO
Isoform 8 (identifier: P27699-8) [UniParc]FASTAAdd to Basket

Also known as: Tau 1 Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:282
Mass (Da):31,109
Checksum:i46A1DA7CDA89F4B5
GO
Isoform 9 (identifier: P27699-9) [UniParc]FASTAAdd to Basket

Also known as: Tau 1 Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T

Show »
Length:282
Mass (Da):31,025
Checksum:i1BF6D6A824624907
GO
Isoform 10 (identifier: P27699-10) [UniParc]FASTAAdd to Basket

Also known as: Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:233
Mass (Da):26,207
Checksum:iCB124F4EEE69F9E4
GO

Sequence cautioni

The sequence AAA17495.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAA17496.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAA17497.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAV28551.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAV28552.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAV28553.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAV28554.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAV28555.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAV28556.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 10349Missing in isoform 2, isoform 3, isoform 4, isoform 6 and isoform 10. VSP_000602Add
BLAST
Alternative sequencei183 – 25775Missing in isoform 4, isoform 8, isoform 9 and isoform 10. VSP_000605Add
BLAST
Alternative sequencei183 – 24563Missing in isoform 2, isoform 3 and isoform 7. VSP_000603Add
BLAST
Alternative sequencei246 – 25712Missing in isoform 5. VSP_038016Add
BLAST
Alternative sequencei246 – 2461D → N in isoform 2, isoform 3 and isoform 7. VSP_000604
Alternative sequencei258 – 2581A → T in isoform 4, isoform 8, isoform 9 and isoform 10. VSP_000606
Alternative sequencei314 – 35744KECRR…SPKTD → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKAE in isoform 2, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 10. VSP_000607Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC117589 Genomic DNA. No translation available.
M60285 mRNA. Translation: AAA17495.1. Different initiation.
M60285 mRNA. Translation: AAA17496.1. Different initiation.
M60285 mRNA. Translation: AAA17497.1. Different initiation.
AY738715 mRNA. Translation: AAV28551.1. Different initiation.
AY738716 mRNA. Translation: AAV28552.1. Different initiation.
AY738717 mRNA. Translation: AAV28553.1. Different initiation.
AY738718 mRNA. Translation: AAV28554.1. Different initiation.
AY738719 mRNA. Translation: AAV28555.1. Different initiation.
AY738721 mRNA. Translation: AAV28556.1. Different initiation.
CCDSiCCDS29031.2. [P27699-2]
CCDS50214.1. [P27699-7]
CCDS50215.1. [P27699-1]
CCDS70862.1. [P27699-6]
CCDS70863.1. [P27699-8]
CCDS70864.1. [P27699-5]
PIRiA37944.
B37944.
C37944.
S20827.
RefSeqiNP_001104320.1. NM_001110850.2. [P27699-10]
NP_001104324.2. NM_001110854.1.
NP_001104325.2. NM_001110855.1.
NP_001104326.1. NM_001110856.2. [P27699-7]
NP_001104327.1. NM_001110857.2. [P27699-3]
NP_001104328.1. NM_001110858.2. [P27699-4]
NP_001104329.1. NM_001110859.2. [P27699-1]
NP_001258432.1. NM_001271503.1. [P27699-9]
NP_001258433.1. NM_001271504.1. [P27699-8]
NP_001258434.1. NM_001271505.1. [P27699-6]
NP_001258435.1. NM_001271506.1. [P27699-5]
NP_038526.2. NM_013498.3. [P27699-2]
XP_006525618.1. XM_006525555.1. [P27699-1]
XP_006525619.1. XM_006525556.1. [P27699-5]
XP_006525624.1. XM_006525561.1. [P27699-6]
XP_006525628.1. XM_006525565.1. [P27699-7]
XP_006525630.1. XM_006525567.1. [P27699-8]
XP_006525631.1. XM_006525568.1. [P27699-9]
XP_006525636.1. XM_006525573.1. [P27699-2]
XP_006525637.1. XM_006525574.1. [P27699-3]
XP_006525638.1. XM_006525575.1. [P27699-10]
XP_006525639.1. XM_006525576.1. [P27699-4]
UniGeneiMm.5244.

Genome annotation databases

EnsembliENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889. [P27699-5]
ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889. [P27699-6]
ENSMUST00000123672; ENSMUSP00000120557; ENSMUSG00000063889.
ENSMUST00000130599; ENSMUSP00000115471; ENSMUSG00000063889.
ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889. [P27699-1]
ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889. [P27699-2]
ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889. [P27699-8]
ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889. [P27699-7]
GeneIDi12916.
KEGGimmu:12916.
UCSCiuc008dxn.2. mouse. [P27699-2]
uc008dxo.2. mouse. [P27699-7]
uc008dxp.2. mouse. [P27699-8]
uc008dxq.2. mouse. [P27699-9]
uc008dxr.2. mouse. [P27699-5]
uc008dxs.2. mouse. [P27699-6]
uc008dxt.2. mouse. [P27699-10]
uc012ayt.1. mouse. [P27699-1]
uc012ayu.1. mouse. [P27699-3]
uc012ayv.1. mouse. [P27699-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC117589 Genomic DNA. No translation available.
M60285 mRNA. Translation: AAA17495.1 . Different initiation.
M60285 mRNA. Translation: AAA17496.1 . Different initiation.
M60285 mRNA. Translation: AAA17497.1 . Different initiation.
AY738715 mRNA. Translation: AAV28551.1 . Different initiation.
AY738716 mRNA. Translation: AAV28552.1 . Different initiation.
AY738717 mRNA. Translation: AAV28553.1 . Different initiation.
AY738718 mRNA. Translation: AAV28554.1 . Different initiation.
AY738719 mRNA. Translation: AAV28555.1 . Different initiation.
AY738721 mRNA. Translation: AAV28556.1 . Different initiation.
CCDSi CCDS29031.2. [P27699-2 ]
CCDS50214.1. [P27699-7 ]
CCDS50215.1. [P27699-1 ]
CCDS70862.1. [P27699-6 ]
CCDS70863.1. [P27699-8 ]
CCDS70864.1. [P27699-5 ]
PIRi A37944.
B37944.
C37944.
S20827.
RefSeqi NP_001104320.1. NM_001110850.2. [P27699-10 ]
NP_001104324.2. NM_001110854.1.
NP_001104325.2. NM_001110855.1.
NP_001104326.1. NM_001110856.2. [P27699-7 ]
NP_001104327.1. NM_001110857.2. [P27699-3 ]
NP_001104328.1. NM_001110858.2. [P27699-4 ]
NP_001104329.1. NM_001110859.2. [P27699-1 ]
NP_001258432.1. NM_001271503.1. [P27699-9 ]
NP_001258433.1. NM_001271504.1. [P27699-8 ]
NP_001258434.1. NM_001271505.1. [P27699-6 ]
NP_001258435.1. NM_001271506.1. [P27699-5 ]
NP_038526.2. NM_013498.3. [P27699-2 ]
XP_006525618.1. XM_006525555.1. [P27699-1 ]
XP_006525619.1. XM_006525556.1. [P27699-5 ]
XP_006525624.1. XM_006525561.1. [P27699-6 ]
XP_006525628.1. XM_006525565.1. [P27699-7 ]
XP_006525630.1. XM_006525567.1. [P27699-8 ]
XP_006525631.1. XM_006525568.1. [P27699-9 ]
XP_006525636.1. XM_006525573.1. [P27699-2 ]
XP_006525637.1. XM_006525574.1. [P27699-3 ]
XP_006525638.1. XM_006525575.1. [P27699-10 ]
XP_006525639.1. XM_006525576.1. [P27699-4 ]
UniGenei Mm.5244.

3D structure databases

ProteinModelPortali P27699.
SMRi P27699. Positions 120-146, 301-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198877. 5 interactions.
IntActi P27699. 1 interaction.

Proteomic databases

PRIDEi P27699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025069 ; ENSMUSP00000025069 ; ENSMUSG00000063889 . [P27699-5 ]
ENSMUST00000082141 ; ENSMUSP00000080780 ; ENSMUSG00000063889 . [P27699-6 ]
ENSMUST00000123672 ; ENSMUSP00000120557 ; ENSMUSG00000063889 .
ENSMUST00000130599 ; ENSMUSP00000115471 ; ENSMUSG00000063889 .
ENSMUST00000150235 ; ENSMUSP00000121233 ; ENSMUSG00000063889 . [P27699-1 ]
ENSMUST00000154135 ; ENSMUSP00000122051 ; ENSMUSG00000063889 . [P27699-2 ]
ENSMUST00000154470 ; ENSMUSP00000118128 ; ENSMUSG00000063889 . [P27699-8 ]
ENSMUST00000165086 ; ENSMUSP00000127353 ; ENSMUSG00000063889 . [P27699-7 ]
GeneIDi 12916.
KEGGi mmu:12916.
UCSCi uc008dxn.2. mouse. [P27699-2 ]
uc008dxo.2. mouse. [P27699-7 ]
uc008dxp.2. mouse. [P27699-8 ]
uc008dxq.2. mouse. [P27699-9 ]
uc008dxr.2. mouse. [P27699-5 ]
uc008dxs.2. mouse. [P27699-6 ]
uc008dxt.2. mouse. [P27699-10 ]
uc012ayt.1. mouse. [P27699-1 ]
uc012ayu.1. mouse. [P27699-3 ]
uc012ayv.1. mouse. [P27699-4 ]

Organism-specific databases

CTDi 1390.
MGIi MGI:88495. Crem.

Phylogenomic databases

eggNOGi NOG300199.
GeneTreei ENSGT00390000008655.
HOVERGENi HBG011077.
InParanoidi Q5XTP8.
KOi K09052.
OMAi PAWQMAL.
PhylomeDBi P27699.
TreeFami TF106464.

Miscellaneous databases

NextBioi 282558.
PROi P27699.
SOURCEi Search...

Gene expression databases

ArrayExpressi P27699.
Bgeei P27699.
CleanExi MM_CREM.
Genevestigatori P27699.

Family and domain databases

InterProi IPR004827. bZIP.
IPR003102. Coactivator_CBP_pKID.
IPR001630. Leuzip_CREB.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF02173. pKID. 1 hit.
[Graphical view ]
PRINTSi PR00041. LEUZIPPRCREB.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS50953. KID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription."
    Foulkes N.S., Borrelli E., Sassone-Corsi P.
    Cell 64:739-749(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-357 (ISOFORMS 2; 3 AND 4).
  3. "Identification of novel cAMP responsive element modulator (CREM) isoforms expressed by osteoblasts."
    Liu F., Huang Y.-F., Kream B.E.
    Calcif. Tissue Int. 77:91-95(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-357 (ISOFORMS 5; 6; 7; 8; 9 AND 10).
    Tissue: Osteoblast.
  4. "Developmental switch of CREM function during spermatogenesis: from antagonist to activator."
    Foulkes N.S., Mellstroem B., Benusiglio E., Sassone-Corsi P.
    Nature 355:80-84(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-357 (ISOFORM 1).
  5. "CBP-independent activation of CREM and CREB by the LIM-only protein ACT."
    Fimia G.M., De Cesare D., Sassone-Corsi P.
    Nature 398:165-169(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FHL5.
  6. "Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation."
    Nagamori I., Yomogida K., Adams P.D., Sassone-Corsi P., Nojima H.
    J. Biol. Chem. 281:15073-15081(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CREB3L4.

Entry informationi

Entry nameiCREM_MOUSE
AccessioniPrimary (citable) accession number: P27699
Secondary accession number(s): P27698
, Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

CREM-null deficient mice display male infertility: while spermatogonia differentiate normally into round spermatids, all the elongating spermatids are eliminated by apoptosis during spermiogenesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi