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P27699

- CREM_MOUSE

UniProt

P27699 - CREM_MOUSE

Protein

cAMP-responsive element modulator

Gene

Crem

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (PubMed:16595651).1 Publication
    Isoform 11: Plays a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.2 Publications

    GO - Molecular functioni

    1. core promoter sequence-specific DNA binding Source: UniProtKB
    2. DNA binding Source: MGI
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. circadian regulation of gene expression Source: UniProtKB
    2. circadian rhythm Source: UniProtKB
    3. glycosphingolipid metabolic process Source: MGI
    4. negative regulation of transcription, DNA-templated Source: UniProtKB
    5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    6. response to cAMP Source: UniProtKB
    7. spermatogenesis Source: MGI
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-responsive element modulator
    Alternative name(s):
    Inducible cAMP early repressor
    Short name:
    ICER
    Gene namesi
    Name:Crem
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:88495. Crem.

    Subcellular locationi

    Nucleus 2 Publications

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: MGI
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357cAMP-responsive element modulatorPRO_0000076608Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei284 – 2841PhosphoserinePROSITE-ProRule annotation
    Modified residuei287 – 2871PhosphoserinePROSITE-ProRule annotation
    Modified residuei290 – 2901PhosphoserinePROSITE-ProRule annotation

    Post-translational modificationi

    Stimulated by phosphorylation.By similarity
    Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP27699.

    Expressioni

    Developmental stagei

    In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts.

    Inductioni

    Isoform 11 is expressed in a circadian manner in the adrenal gland with an expression peak at ZT20 (at protein level). It is induced by cAMP in an immediate-early fashion and can repress its own production via a negative autoregulatory mechanism.2 Publications

    Gene expression databases

    ArrayExpressiP27699.
    BgeeiP27699.
    CleanExiMM_CREM.
    GenevestigatoriP27699.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer By similarity. Interacts with CDC34 By similarity. Interacts with FHL5. Isoform 1 forms a heterodimer with CREB3L4.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi198877. 5 interactions.
    IntActiP27699. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP27699.
    SMRiP27699. Positions 120-146, 301-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 16060KIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini299 – 35759bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni300 – 32526Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni327 – 34822Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
    Contains 1 KID (kinase-inducible) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG300199.
    GeneTreeiENSGT00390000008655.
    HOGENOMiHOG000007365.
    HOVERGENiHBG011077.
    InParanoidiQ5XTP8.
    KOiK09052.
    OMAiPAWQMAL.
    PhylomeDBiP27699.
    TreeFamiTF106464.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF02173. pKID. 1 hit.
    [Graphical view]
    PRINTSiPR00041. LEUZIPPRCREB.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS50953. KID. 1 hit.
    [Graphical view]

    Sequences (11)i

    Sequence statusi: Complete.

    This entry describes 11 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: P27699-1) [UniParc]FASTAAdd to Basket

    Also known as: CREM-BCEFGgammaHIbeta, Tau

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP    50
    TLAQVSVAGS GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ 100
    TVQVATIAET DDSADSEVID SHKRREILSR RPSYRKILNE LSSDVPGIPK 150
    IEEEKSEEEG TPPNIATMAV PTSIYQTSTG QYIAIAQGGT IQISNPGSDG 200
    VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS QVVVQDEETD 250
    LAPSHMAAAT GDMPTYQIRA PTTALPQGVV MAASPGSLHS PQQLAEEATR 300
    KRELRLMKNR EAAKECRRRK KEYVKCLESR VAVLEVQNKK LIEELETLKD 350
    ICSPKTD 357
    Length:357
    Mass (Da):38,516
    Last modified:September 22, 2009 - v2
    Checksum:i0B387B7247113088
    GO
    Isoform 2 (identifier: P27699-2) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         55-103: Missing.
         183-245: Missing.
         246-246: D → N
         314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

    Show »
    Length:245
    Mass (Da):27,473
    Checksum:iA508BB074EAEA8A6
    GO
    Isoform 3 (identifier: P27699-3) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         55-103: Missing.
         183-245: Missing.
         246-246: D → N

    Show »
    Length:245
    Mass (Da):27,389
    Checksum:iF85FB7D3B0451514
    GO
    Isoform 4 (identifier: P27699-4) [UniParc]FASTAAdd to Basket

    Also known as: Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         55-103: Missing.
         183-257: Missing.
         258-258: A → T

    Show »
    Length:233
    Mass (Da):26,123
    Checksum:i9645439A10824456
    GO
    Isoform 5 (identifier: P27699-5) [UniParc]FASTAAdd to Basket

    Also known as: Tau Alpha Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         246-257: Missing.
         314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

    Show »
    Length:345
    Mass (Da):37,303
    Checksum:i508E5448D03B5F8D
    GO
    Isoform 6 (identifier: P27699-6) [UniParc]FASTAAdd to Basket

    Also known as: Tau 2 Alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         55-103: Missing.
         314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

    Show »
    Length:308
    Mass (Da):33,698
    Checksum:i438CD86068BA7DAF
    GO
    Isoform 7 (identifier: P27699-7) [UniParc]FASTAAdd to Basket

    Also known as: Tau 1 Alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         183-245: Missing.
         246-246: D → N
         314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

    Show »
    Length:294
    Mass (Da):32,376
    Checksum:iC637D53AC9A9BCF8
    GO
    Isoform 8 (identifier: P27699-8) [UniParc]FASTAAdd to Basket

    Also known as: Tau 1 Alpha Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         183-257: Missing.
         258-258: A → T
         314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

    Show »
    Length:282
    Mass (Da):31,109
    Checksum:i46A1DA7CDA89F4B5
    GO
    Isoform 9 (identifier: P27699-9) [UniParc]FASTAAdd to Basket

    Also known as: Tau 1 Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         183-257: Missing.
         258-258: A → T

    Show »
    Length:282
    Mass (Da):31,025
    Checksum:i1BF6D6A824624907
    GO
    Isoform 10 (identifier: P27699-10) [UniParc]FASTAAdd to Basket

    Also known as: Alpha Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         55-103: Missing.
         183-257: Missing.
         258-258: A → T
         314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

    Show »
    Length:233
    Mass (Da):26,207
    Checksum:iCB124F4EEE69F9E4
    GO
    Isoform 11 (identifier: P27699-11) [UniParc]FASTAAdd to Basket

    Also known as: Icer Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         1-245: MSKCGRKKYM...FVPGSQVVVQ → MAVTGDET
         314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

    Note: Produced by alternative promoter usage.

    Show »
    Length:120
    Mass (Da):13,437
    Checksum:i6A84CA55E6C049F1
    GO

    Sequence cautioni

    The sequence AAA17495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAA17496.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAA17497.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAV28551.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAV28552.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAV28553.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAV28554.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAV28555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAV28556.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 245245MSKCG…QVVVQ → MAVTGDET in isoform 11. 1 PublicationVSP_055987Add
    BLAST
    Alternative sequencei55 – 10349Missing in isoform 2, isoform 3, isoform 4, isoform 6 and isoform 10. 2 PublicationsVSP_000602Add
    BLAST
    Alternative sequencei183 – 25775Missing in isoform 4, isoform 8, isoform 9 and isoform 10. 2 PublicationsVSP_000605Add
    BLAST
    Alternative sequencei183 – 24563Missing in isoform 2, isoform 3 and isoform 7. 2 PublicationsVSP_000603Add
    BLAST
    Alternative sequencei246 – 25712Missing in isoform 5. 1 PublicationVSP_038016Add
    BLAST
    Alternative sequencei246 – 2461D → N in isoform 2, isoform 3 and isoform 7. 2 PublicationsVSP_000604
    Alternative sequencei258 – 2581A → T in isoform 4, isoform 8, isoform 9 and isoform 10. 2 PublicationsVSP_000606
    Alternative sequencei314 – 35744KECRR…SPKTD → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKAE in isoform 2, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 11. 3 PublicationsVSP_000607Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311667 mRNA. Translation: CAC34846.1.
    AC117589 Genomic DNA. No translation available.
    M60285 mRNA. Translation: AAA17495.1. Different initiation.
    M60285 mRNA. Translation: AAA17496.1. Different initiation.
    M60285 mRNA. Translation: AAA17497.1. Different initiation.
    AY738715 mRNA. Translation: AAV28551.1. Different initiation.
    AY738716 mRNA. Translation: AAV28552.1. Different initiation.
    AY738717 mRNA. Translation: AAV28553.1. Different initiation.
    AY738718 mRNA. Translation: AAV28554.1. Different initiation.
    AY738719 mRNA. Translation: AAV28555.1. Different initiation.
    AY738721 mRNA. Translation: AAV28556.1. Different initiation.
    CCDSiCCDS29031.2. [P27699-2]
    CCDS50214.1. [P27699-7]
    CCDS50215.1. [P27699-1]
    CCDS70862.1. [P27699-6]
    CCDS70863.1. [P27699-8]
    CCDS70864.1. [P27699-5]
    PIRiA37944.
    B37944.
    C37944.
    S20827.
    RefSeqiNP_001104320.1. NM_001110850.2. [P27699-10]
    NP_001104324.2. NM_001110854.1.
    NP_001104325.2. NM_001110855.1.
    NP_001104326.1. NM_001110856.2. [P27699-7]
    NP_001104327.1. NM_001110857.2. [P27699-3]
    NP_001104328.1. NM_001110858.2. [P27699-4]
    NP_001104329.1. NM_001110859.2. [P27699-1]
    NP_001258432.1. NM_001271503.1. [P27699-9]
    NP_001258433.1. NM_001271504.1. [P27699-8]
    NP_001258434.1. NM_001271505.1. [P27699-6]
    NP_001258435.1. NM_001271506.1. [P27699-5]
    NP_038526.2. NM_013498.3. [P27699-2]
    XP_006525618.1. XM_006525555.1. [P27699-1]
    XP_006525619.1. XM_006525556.1. [P27699-5]
    XP_006525624.1. XM_006525561.1. [P27699-6]
    XP_006525628.1. XM_006525565.1. [P27699-7]
    XP_006525630.1. XM_006525567.1. [P27699-8]
    XP_006525631.1. XM_006525568.1. [P27699-9]
    XP_006525636.1. XM_006525573.1. [P27699-2]
    XP_006525637.1. XM_006525574.1. [P27699-3]
    XP_006525638.1. XM_006525575.1. [P27699-10]
    XP_006525639.1. XM_006525576.1. [P27699-4]
    UniGeneiMm.5244.

    Genome annotation databases

    EnsembliENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889. [P27699-5]
    ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889. [P27699-6]
    ENSMUST00000123672; ENSMUSP00000120557; ENSMUSG00000063889.
    ENSMUST00000130599; ENSMUSP00000115471; ENSMUSG00000063889.
    ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889. [P27699-1]
    ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889. [P27699-2]
    ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889. [P27699-8]
    ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889. [P27699-7]
    GeneIDi12916.
    KEGGimmu:12916.
    UCSCiuc008dxk.2. mouse.
    uc008dxn.2. mouse. [P27699-2]
    uc008dxo.2. mouse. [P27699-7]
    uc008dxp.2. mouse. [P27699-8]
    uc008dxq.2. mouse. [P27699-9]
    uc008dxr.2. mouse. [P27699-5]
    uc008dxs.2. mouse. [P27699-6]
    uc008dxt.2. mouse. [P27699-10]
    uc012ayt.1. mouse. [P27699-1]
    uc012ayu.1. mouse. [P27699-3]
    uc012ayv.1. mouse. [P27699-4]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311667 mRNA. Translation: CAC34846.1 .
    AC117589 Genomic DNA. No translation available.
    M60285 mRNA. Translation: AAA17495.1 . Different initiation.
    M60285 mRNA. Translation: AAA17496.1 . Different initiation.
    M60285 mRNA. Translation: AAA17497.1 . Different initiation.
    AY738715 mRNA. Translation: AAV28551.1 . Different initiation.
    AY738716 mRNA. Translation: AAV28552.1 . Different initiation.
    AY738717 mRNA. Translation: AAV28553.1 . Different initiation.
    AY738718 mRNA. Translation: AAV28554.1 . Different initiation.
    AY738719 mRNA. Translation: AAV28555.1 . Different initiation.
    AY738721 mRNA. Translation: AAV28556.1 . Different initiation.
    CCDSi CCDS29031.2. [P27699-2 ]
    CCDS50214.1. [P27699-7 ]
    CCDS50215.1. [P27699-1 ]
    CCDS70862.1. [P27699-6 ]
    CCDS70863.1. [P27699-8 ]
    CCDS70864.1. [P27699-5 ]
    PIRi A37944.
    B37944.
    C37944.
    S20827.
    RefSeqi NP_001104320.1. NM_001110850.2. [P27699-10 ]
    NP_001104324.2. NM_001110854.1.
    NP_001104325.2. NM_001110855.1.
    NP_001104326.1. NM_001110856.2. [P27699-7 ]
    NP_001104327.1. NM_001110857.2. [P27699-3 ]
    NP_001104328.1. NM_001110858.2. [P27699-4 ]
    NP_001104329.1. NM_001110859.2. [P27699-1 ]
    NP_001258432.1. NM_001271503.1. [P27699-9 ]
    NP_001258433.1. NM_001271504.1. [P27699-8 ]
    NP_001258434.1. NM_001271505.1. [P27699-6 ]
    NP_001258435.1. NM_001271506.1. [P27699-5 ]
    NP_038526.2. NM_013498.3. [P27699-2 ]
    XP_006525618.1. XM_006525555.1. [P27699-1 ]
    XP_006525619.1. XM_006525556.1. [P27699-5 ]
    XP_006525624.1. XM_006525561.1. [P27699-6 ]
    XP_006525628.1. XM_006525565.1. [P27699-7 ]
    XP_006525630.1. XM_006525567.1. [P27699-8 ]
    XP_006525631.1. XM_006525568.1. [P27699-9 ]
    XP_006525636.1. XM_006525573.1. [P27699-2 ]
    XP_006525637.1. XM_006525574.1. [P27699-3 ]
    XP_006525638.1. XM_006525575.1. [P27699-10 ]
    XP_006525639.1. XM_006525576.1. [P27699-4 ]
    UniGenei Mm.5244.

    3D structure databases

    ProteinModelPortali P27699.
    SMRi P27699. Positions 120-146, 301-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198877. 5 interactions.
    IntActi P27699. 1 interaction.

    Proteomic databases

    PRIDEi P27699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025069 ; ENSMUSP00000025069 ; ENSMUSG00000063889 . [P27699-5 ]
    ENSMUST00000082141 ; ENSMUSP00000080780 ; ENSMUSG00000063889 . [P27699-6 ]
    ENSMUST00000123672 ; ENSMUSP00000120557 ; ENSMUSG00000063889 .
    ENSMUST00000130599 ; ENSMUSP00000115471 ; ENSMUSG00000063889 .
    ENSMUST00000150235 ; ENSMUSP00000121233 ; ENSMUSG00000063889 . [P27699-1 ]
    ENSMUST00000154135 ; ENSMUSP00000122051 ; ENSMUSG00000063889 . [P27699-2 ]
    ENSMUST00000154470 ; ENSMUSP00000118128 ; ENSMUSG00000063889 . [P27699-8 ]
    ENSMUST00000165086 ; ENSMUSP00000127353 ; ENSMUSG00000063889 . [P27699-7 ]
    GeneIDi 12916.
    KEGGi mmu:12916.
    UCSCi uc008dxk.2. mouse.
    uc008dxn.2. mouse. [P27699-2 ]
    uc008dxo.2. mouse. [P27699-7 ]
    uc008dxp.2. mouse. [P27699-8 ]
    uc008dxq.2. mouse. [P27699-9 ]
    uc008dxr.2. mouse. [P27699-5 ]
    uc008dxs.2. mouse. [P27699-6 ]
    uc008dxt.2. mouse. [P27699-10 ]
    uc012ayt.1. mouse. [P27699-1 ]
    uc012ayu.1. mouse. [P27699-3 ]
    uc012ayv.1. mouse. [P27699-4 ]

    Organism-specific databases

    CTDi 1390.
    MGIi MGI:88495. Crem.

    Phylogenomic databases

    eggNOGi NOG300199.
    GeneTreei ENSGT00390000008655.
    HOGENOMi HOG000007365.
    HOVERGENi HBG011077.
    InParanoidi Q5XTP8.
    KOi K09052.
    OMAi PAWQMAL.
    PhylomeDBi P27699.
    TreeFami TF106464.

    Miscellaneous databases

    NextBioi 282558.
    PROi P27699.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P27699.
    Bgeei P27699.
    CleanExi MM_CREM.
    Genevestigatori P27699.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR003102. Coactivator_CBP_pKID.
    IPR001630. Leuzip_CREB.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF02173. pKID. 1 hit.
    [Graphical view ]
    PRINTSi PR00041. LEUZIPPRCREB.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    PS50953. KID. 1 hit.
    [Graphical view ]
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    Publicationsi

    1. "Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor."
      Molina C.A., Foulkes N.S., Lalli E., Sassone-Corsi P.
      Cell 75:875-886(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION, INDUCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription."
      Foulkes N.S., Borrelli E., Sassone-Corsi P.
      Cell 64:739-749(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-357 (ISOFORMS 2; 3 AND 4).
    4. "Identification of novel cAMP responsive element modulator (CREM) isoforms expressed by osteoblasts."
      Liu F., Huang Y.-F., Kream B.E.
      Calcif. Tissue Int. 77:91-95(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-357 (ISOFORMS 5; 6; 7; 8; 9 AND 10).
      Tissue: Osteoblast.
    5. "Developmental switch of CREM function during spermatogenesis: from antagonist to activator."
      Foulkes N.S., Mellstroem B., Benusiglio E., Sassone-Corsi P.
      Nature 355:80-84(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-357 (ISOFORM 1).
    6. "CBP-independent activation of CREM and CREB by the LIM-only protein ACT."
      Fimia G.M., De Cesare D., Sassone-Corsi P.
      Nature 398:165-169(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FHL5.
    7. "Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation."
      Nagamori I., Yomogida K., Adams P.D., Sassone-Corsi P., Nojima H.
      J. Biol. Chem. 281:15073-15081(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CREB3L4.
    8. "Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks."
      Zmrzljak U.P., Korencic A., Kosir R., Golicnik M., Sassone-Corsi P., Rozman D.
      J. Biol. Chem. 288:10318-10327(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM 11), ALTERNATIVE PROMOTER USAGE, SUBCELLULAR LOCATION, INDUCTION.

    Entry informationi

    Entry nameiCREM_MOUSE
    AccessioniPrimary (citable) accession number: P27699
    Secondary accession number(s): P27698
    , Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3, Q99JF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    CREM-null deficient mice display male infertility: while spermatogonia differentiate normally into round spermatids, all the elongating spermatids are eliminated by apoptosis during spermiogenesis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3