##gff-version 3 P27694 UniProtKB Chain 1 616 . . . ID=PRO_0000423231;Note=Replication protein A 70 kDa DNA-binding subunit P27694 UniProtKB Initiator methionine 1 1 . . . Note=Removed%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.8 P27694 UniProtKB Chain 2 616 . . . ID=PRO_0000097260;Note=Replication protein A 70 kDa DNA-binding subunit%2C N-terminally processed P27694 UniProtKB DNA binding 197 281 . . . Note=OB P27694 UniProtKB Zinc finger 481 503 . . . Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255 P27694 UniProtKB Region 121 154 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27694 UniProtKB Compositional bias 138 154 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P27694 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22223895;Dbxref=PMID:19413330,PMID:22223895 P27694 UniProtKB Modified residue 163 163 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P27694 UniProtKB Modified residue 167 167 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P27694 UniProtKB Modified residue 180 180 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17525332,ECO:0007744|PubMed:20068231;Dbxref=PMID:17525332,PMID:20068231 P27694 UniProtKB Modified residue 191 191 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 P27694 UniProtKB Modified residue 259 259 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P27694 UniProtKB Modified residue 384 384 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 P27694 UniProtKB Cross-link 22 22 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 88 88 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 163 163 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 167 167 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 183 183 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 220 220 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 244 244 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 259 259 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 267 267 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 331 331 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 410 410 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 431 431 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 449 449 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20705237;Dbxref=PMID:20705237 P27694 UniProtKB Cross-link 458 458 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 553 553 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26474068;Dbxref=PMID:26474068 P27694 UniProtKB Cross-link 577 577 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20705237;Dbxref=PMID:20705237 P27694 UniProtKB Natural variant 227 227 . . . ID=VAR_086965;Note=In PFBMFT6%3B uncertain significance%3B increased single-stranded DNA binding%3B increased telomeric DNA binding%3B has no effect on the formation of canonical replication protein A complex. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34767620;Dbxref=PMID:34767620 P27694 UniProtKB Natural variant 240 240 . . . ID=VAR_086966;Note=In PFBMFT6%3B results in shortened telomeres and impaired hematopoiesis when expressed in iPSC-derived hematopoietic cells%3B increased single-stranded DNA binding%3B increased telomeric DNA binding%3B has no effect on the formation of canonical replication protein A complex. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34767620;Dbxref=PMID:34767620 P27694 UniProtKB Natural variant 270 270 . . . ID=VAR_086967;Note=In PFBMFT6%3B uncertain significance%3B has DNA-binding properties similar to the wild-type%3B has no effect on the formation of canonical replication protein A complex. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34767620;Dbxref=PMID:34767620 P27694 UniProtKB Natural variant 351 351 . . . ID=VAR_019236;Note=T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|Ref.4,ECO:0000269|Ref.5;Dbxref=dbSNP:rs5030755 P27694 UniProtKB Mutagenesis 41 41 . . . Note=Loss of HELB-binding%3B when associated with E-43. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22194613;Dbxref=PMID:22194613 P27694 UniProtKB Mutagenesis 43 43 . . . Note=Loss of HELB-binding%3B when associated with E-41. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22194613;Dbxref=PMID:22194613 P27694 UniProtKB Mutagenesis 449 449 . . . Note=Significant reduction of sumoylation. Loss of sumoylation%3B when associated with R-577. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20705237;Dbxref=PMID:20705237 P27694 UniProtKB Mutagenesis 500 500 . . . Note=Loss of function in DNA replication and mismatch repair without effect on DNA-binding activity%3B when associated with S-503. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9430682;Dbxref=PMID:9430682 P27694 UniProtKB Mutagenesis 503 503 . . . Note=Loss of function in DNA replication and mismatch repair without effect on DNA-binding activity%3B when associated with S-500. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9430682;Dbxref=PMID:9430682 P27694 UniProtKB Mutagenesis 577 577 . . . Note=Slight sumoylation decrease. Loss of sumoylation%3B when associated with R-449. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20705237;Dbxref=PMID:20705237 P27694 UniProtKB Helix 2 4 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Helix 9 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Turn 15 17 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EWI P27694 UniProtKB Beta strand 18 20 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EWI P27694 UniProtKB Beta strand 24 32 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Beta strand 36 38 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Beta strand 42 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Beta strand 49 58 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Helix 60 62 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Helix 63 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Beta strand 70 74 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1EWI P27694 UniProtKB Beta strand 76 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Beta strand 88 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2B29 P27694 UniProtKB Beta strand 92 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Helix 105 108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4O0A P27694 UniProtKB Beta strand 116 119 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7XUT P27694 UniProtKB Helix 187 189 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 198 206 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 210 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 218 227 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 232 238 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Helix 239 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Helix 246 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 254 258 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 261 264 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Helix 267 269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 275 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 285 288 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Helix 305 310 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 316 326 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 330 334 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Turn 335 338 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 339 349 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 355 361 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Helix 362 367 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 375 384 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 388 392 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Beta strand 398 402 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Helix 406 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Turn 417 419 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JMC P27694 UniProtKB Helix 445 451 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Turn 452 454 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 455 458 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 460 471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 477 480 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 491 493 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Turn 494 496 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 497 500 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Turn 501 504 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 505 509 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 512 521 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 526 532 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Helix 533 540 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Helix 544 550 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Helix 555 564 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Turn 565 567 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 569 577 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Beta strand 588 596 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O P27694 UniProtKB Helix 599 615 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1L1O