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Protein

Neuroendocrine protein 7B2

Gene

Scg5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Neuropeptide

Keywords - Biological processi

Transport

Protein family/group databases

MEROPSiI21.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroendocrine protein 7B2
Alternative name(s):
Secretogranin V
Secretogranin-5
Secretory granule endocrine protein I
Cleaved into the following 2 chains:
Gene namesi
Name:Scg5
Synonyms:Sgne1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3669. Scg5.

Subcellular locationi

  • Secreted

  • Note: Neuroendocrine and endocrine secretory granules.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 210186Neuroendocrine protein 7B2PRO_0000000050Add
BLAST
Chaini25 – 176152N-terminal peptideBy similarityPRO_0000000051Add
BLAST
Peptidei198 – 21013C-terminal peptideBy similarityPRO_0000000052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi118 ↔ 128By similarity
Modified residuei139 – 1391PhosphoserineBy similarity
Modified residuei203 – 2031PhosphoserineCombined sources

Post-translational modificationi

Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.By similarity
Sulfated on tyrosine residues.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP27682.
PRIDEiP27682.

PTM databases

iPTMnetiP27682.
PhosphoSiteiP27682.

Interactioni

Subunit structurei

Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Pcsk2P288414EBI-988232,EBI-988244

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247748. 1 interaction.
IntActiP27682. 1 interaction.
STRINGi10116.ENSRNOP00000010679.

Family & Domainsi

Sequence similaritiesi

Belongs to the 7B2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4187. Eukaryota.
ENOG410ZRXV. LUCA.
HOGENOMiHOG000259690.
HOVERGENiHBG000031.
InParanoidiP27682.
PhylomeDBiP27682.

Family and domain databases

InterProiIPR007945. Secretogranin_V.
[Graphical view]
PANTHERiPTHR12738. PTHR12738. 1 hit.
PfamiPF05281. Secretogranin_V. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRMAILSG LLFWLLLEWN PAFAYSPRTP DRVSETDIQR LLHGVMEQLG
60 70 80 90 100
IARPRVEYPA HQAMNLVGPQ SIEGGAHEGL QHLGPFGNIP NIVAELTGDN
110 120 130 140 150
IPKDFSEDQG YPDPPNPCPL GKTADDGCLE NAPDTAEFSR EFQLDQHLFD
160 170 180 190 200
PEHDYPGLGK WNKKLLYEKM KGGQRRKRRS VNPYLQGKRL DNVVAKKSVP
210
HFSEEEKEPE
Length:210
Mass (Da):23,684
Last modified:August 1, 1992 - v1
Checksum:i14FBA7D070E79992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63901 mRNA. Translation: AAA40626.1.
BC061560 mRNA. Translation: AAH61560.1.
PIRiA49745.
RefSeqiNP_037307.1. NM_013175.3.
UniGeneiRn.6173.

Genome annotation databases

GeneIDi25719.
KEGGirno:25719.
UCSCiRGD:3669. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63901 mRNA. Translation: AAA40626.1.
BC061560 mRNA. Translation: AAH61560.1.
PIRiA49745.
RefSeqiNP_037307.1. NM_013175.3.
UniGeneiRn.6173.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247748. 1 interaction.
IntActiP27682. 1 interaction.
STRINGi10116.ENSRNOP00000010679.

Protein family/group databases

MEROPSiI21.001.

PTM databases

iPTMnetiP27682.
PhosphoSiteiP27682.

Proteomic databases

PaxDbiP27682.
PRIDEiP27682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25719.
KEGGirno:25719.
UCSCiRGD:3669. rat.

Organism-specific databases

CTDi6447.
RGDi3669. Scg5.

Phylogenomic databases

eggNOGiKOG4187. Eukaryota.
ENOG410ZRXV. LUCA.
HOGENOMiHOG000259690.
HOVERGENiHBG000031.
InParanoidiP27682.
PhylomeDBiP27682.

Miscellaneous databases

PROiP27682.

Family and domain databases

InterProiIPR007945. Secretogranin_V.
[Graphical view]
PANTHERiPTHR12738. PTHR12738. 1 hit.
PfamiPF05281. Secretogranin_V. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the rat complementary deoxyribonucleic acid and gene encoding the neuroendocrine peptide 7B2."
    Waldbieser G.C., Aimi J., Dixon J.E.
    Endocrinology 128:3228-3236(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary anterior lobe.
  3. "Neuroendocrine secretory protein 7B2: structure, expression and functions."
    Mbikay M., Seidah N.G., Chretien M.
    Biochem. J. 357:329-342(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei7B2_RAT
AccessioniPrimary (citable) accession number: P27682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.