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Protein

Gamma-aminobutyric acid receptor subunit gamma-3

Gene

Gabrg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-MMU-975298. Ligand-gated ion channel transport.
R-MMU-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-3
Alternative name(s):
GABA(A) receptor subunit gamma-3
Gene namesi
Name:Gabrg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95624. Gabrg3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 254ExtracellularCuratedAdd BLAST237
Transmembranei255 – 277HelicalCuratedAdd BLAST23
Transmembranei281 – 303HelicalCuratedAdd BLAST23
Transmembranei315 – 337HelicalCuratedAdd BLAST23
Topological domaini338 – 443CytoplasmicCuratedAdd BLAST106
Transmembranei444 – 467HelicalCuratedAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2094133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000048218 – 467Gamma-aminobutyric acid receptor subunit gamma-3Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi171 ↔ 185By similarity
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

May be palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP27681.
PRIDEiP27681.

PTM databases

PhosphoSitePlusiP27681.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055026.
ExpressionAtlasiP27681. baseline and differential.
GenevisibleiP27681. MM.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067632.

Structurei

3D structure databases

ProteinModelPortaliP27681.
SMRiP27681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP27681.
KOiK05186.
OMAiMYWQDFE.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005440. GABBAg3_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01623. GABAARGAMMA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKLLLLLC LFSGLHARSR RVEEDENEDS PSNQKWVLAP KSQDTDVTLI
60 70 80 90 100
LNKLLREYDK KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ
110 120 130 140 150
TWTDSRLRFN STMKILTLNS NMVGLIWIPD TIFRNSKTAE AHWITTPNQL
160 170 180 190 200
LRIWNDGKIL YTLRLTINAE CQLQLHNFPM DAHACPLTFS SYGYPKEEMI
210 220 230 240 250
YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY VVMTIYFELS
260 270 280 290 300
RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTTLGI TTVLTMTTLS
310 320 330 340 350
TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTIRK
360 370 380 390 400
KKTSLLHPDS TRWIPDRISL QAPSNYSLLD MRPPPPVMIT LNNSMYWQEF
410 420 430 440 450
EDTCVYECLD GKDCQSFFCC YEECKSGSWR RGRIHIDVSE LDSYSRVFFP
460
TSFLLFNLVY WVGYLYL
Length:467
Mass (Da):54,334
Last modified:October 3, 2012 - v2
Checksum:iE13529EABFB623DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42S → P in CAA41988 (PubMed:1647983).Curated1
Sequence conflicti47V → A in CAA41988 (PubMed:1647983).Curated1
Sequence conflicti115I → T in CAA41988 (PubMed:1647983).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59300 mRNA. Translation: CAA41988.1.
AC102098 Genomic DNA. No translation available.
AC102129 Genomic DNA. No translation available.
AC116146 Genomic DNA. No translation available.
AC134844 Genomic DNA. No translation available.
AC156610 Genomic DNA. No translation available.
AC158550 Genomic DNA. No translation available.
CH466599 Genomic DNA. Translation: EDL21863.1.
CCDSiCCDS21320.1.
PIRiS16915.
RefSeqiNP_032100.2. NM_008074.2.
UniGeneiMm.434343.

Genome annotation databases

EnsembliENSMUST00000068911; ENSMUSP00000067632; ENSMUSG00000055026.
GeneIDi14407.
KEGGimmu:14407.
UCSCiuc009hdz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59300 mRNA. Translation: CAA41988.1.
AC102098 Genomic DNA. No translation available.
AC102129 Genomic DNA. No translation available.
AC116146 Genomic DNA. No translation available.
AC134844 Genomic DNA. No translation available.
AC156610 Genomic DNA. No translation available.
AC158550 Genomic DNA. No translation available.
CH466599 Genomic DNA. Translation: EDL21863.1.
CCDSiCCDS21320.1.
PIRiS16915.
RefSeqiNP_032100.2. NM_008074.2.
UniGeneiMm.434343.

3D structure databases

ProteinModelPortaliP27681.
SMRiP27681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067632.

Chemistry databases

ChEMBLiCHEMBL2094133.

PTM databases

PhosphoSitePlusiP27681.

Proteomic databases

PaxDbiP27681.
PRIDEiP27681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068911; ENSMUSP00000067632; ENSMUSG00000055026.
GeneIDi14407.
KEGGimmu:14407.
UCSCiuc009hdz.1. mouse.

Organism-specific databases

CTDi2567.
MGIiMGI:95624. Gabrg3.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP27681.
KOiK05186.
OMAiMYWQDFE.
OrthoDBiEOG091G0805.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiR-MMU-975298. Ligand-gated ion channel transport.
R-MMU-977441. GABA A receptor activation.

Miscellaneous databases

ChiTaRSiGabrg3. mouse.
PROiP27681.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055026.
ExpressionAtlasiP27681. baseline and differential.
GenevisibleiP27681. MM.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005440. GABBAg3_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01623. GABAARGAMMA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRG3_MOUSE
AccessioniPrimary (citable) accession number: P27681
Secondary accession number(s): G5E8E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This subunit carries the benzodiazepine binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.