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P27660

- CISY_BACCO

UniProt

P27660 - CISY_BACCO

Protein

Citrate synthase

Gene

ctsA

Organism
Bacillus coagulans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei262 – 2621PROSITE-ProRule annotation
    Active sitei314 – 3141PROSITE-ProRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:ctsA
    OrganismiBacillus coagulans
    Taxonomic identifieri1398 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Citrate synthasePRO_0000169927Add
    BLAST

    Proteomic databases

    PRIDEiP27660.

    Interactioni

    Subunit structurei

    Homohexamer.

    Structurei

    3D structure databases

    ProteinModelPortaliP27660.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27660-1 [UniParc]FASTAAdd to Basket

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    MVNTNQFIPG LEGVIASETK ISFLDTVNSE IVIKGYDLLA LSKTKGYLDI    50
    VHLLLEGTIP NEAEKQHLEE TLKQEYDVPD EIIQVLSLLP KTAHPMDALR 100
    TGVSVLASFD TELLNREHST NLKRAYQLLG KIPNIVANSY HILHSEEPVQ 150
    PLQDLSYSAN FLYMITGKKP TELEEKIFDR SLVLYSEHEL PNSTFTARVI 200
    ASTLSDLYGA LTGAVASLKG HLHGGANEAV MEMLQDAQTV EGFKHLLHDK 250
    LSKKEKIMGF GHRVYMKKMD PRAAMMKEAL KELSAVNGDD LLLQMCEAGE 300
    QIMREEKGLF PNLDYYAAPV YWKLGIPIPL YTPIFFSSRT VGLCAHVMEQ 350
    HENNRIFRPR VLYTGARNLR VED 373
    Length:373
    Mass (Da):41,970
    Last modified:August 1, 1992 - v1
    Checksum:iB4B6FC7170077523
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74818 Genomic DNA. Translation: AAA52231.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74818 Genomic DNA. Translation: AAA52231.1 .

    3D structure databases

    ProteinModelPortali P27660.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P27660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and nucleotide sequence of the gene coding for citrate synthase from a thermotolerant Bacillus sp."
      Schendel F.J., August P.R., Anderson C.R., Hanson R.S., Flickinger M.C.
      Appl. Environ. Microbiol. 58:335-345(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 55182.

    Entry informationi

    Entry nameiCISY_BACCO
    AccessioniPrimary (citable) accession number: P27660
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Allosteric enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3