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P27660 (CISY_BACCO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:ctsA
OrganismBacillus coagulans
Taxonomic identifier1398 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homohexamer.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Citrate synthase
PRO_0000169927

Sites

Active site2621 By similarity
Active site3141 By similarity

Sequences

Sequence LengthMass (Da)Tools
P27660 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: B4B6FC7170077523

FASTA37341,970
        10         20         30         40         50         60 
MVNTNQFIPG LEGVIASETK ISFLDTVNSE IVIKGYDLLA LSKTKGYLDI VHLLLEGTIP 

        70         80         90        100        110        120 
NEAEKQHLEE TLKQEYDVPD EIIQVLSLLP KTAHPMDALR TGVSVLASFD TELLNREHST 

       130        140        150        160        170        180 
NLKRAYQLLG KIPNIVANSY HILHSEEPVQ PLQDLSYSAN FLYMITGKKP TELEEKIFDR 

       190        200        210        220        230        240 
SLVLYSEHEL PNSTFTARVI ASTLSDLYGA LTGAVASLKG HLHGGANEAV MEMLQDAQTV 

       250        260        270        280        290        300 
EGFKHLLHDK LSKKEKIMGF GHRVYMKKMD PRAAMMKEAL KELSAVNGDD LLLQMCEAGE 

       310        320        330        340        350        360 
QIMREEKGLF PNLDYYAAPV YWKLGIPIPL YTPIFFSSRT VGLCAHVMEQ HENNRIFRPR 

       370 
VLYTGARNLR VED 

« Hide

References

[1]"Cloning and nucleotide sequence of the gene coding for citrate synthase from a thermotolerant Bacillus sp."
Schendel F.J., August P.R., Anderson C.R., Hanson R.S., Flickinger M.C.
Appl. Environ. Microbiol. 58:335-345(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 55182.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M74818 Genomic DNA. Translation: AAA52231.1.

3D structure databases

ProteinModelPortalP27660.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP27660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_BACCO
AccessionPrimary (citable) accession number: P27660
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways