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Protein

60S ribosomal protein L3

Gene

Rpl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to interleukin-4 Source: MGI
  • ribosomal large subunit assembly Source: GO_Central
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L3
Alternative name(s):
J1 protein
Gene namesi
Name:Rpl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1351605 Rpl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000772291 – 40360S ribosomal protein L3Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei136N6-acetyllysineCombined sources1
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei286N6-acetyllysine; alternateCombined sources1
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei294N6-acetyllysine; alternateBy similarity1
Cross-linki294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residuei304PhosphoserineBy similarity1
Modified residuei366N6-acetyllysine; alternateBy similarity1
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei373N6-acetyllysineCombined sources1
Cross-linki386Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki393Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP27659
MaxQBiP27659
PaxDbiP27659
PeptideAtlasiP27659
PRIDEiP27659

PTM databases

iPTMnetiP27659
PhosphoSitePlusiP27659
SwissPalmiP27659

Expressioni

Gene expression databases

BgeeiENSMUSG00000060036
CleanExiMM_RPL3
ExpressionAtlasiP27659 baseline and differential
GenevisibleiP27659 MM

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Interacts with METTL18. Interacts with DHX33 (PubMed:26100019).By similarity1 Publication

Protein-protein interaction databases

BioGridi205174, 7 interactors
CORUMiP27659
IntActiP27659, 5 interactors
MINTiP27659
STRINGi10090.ENSMUSP00000080354

Structurei

3D structure databases

ProteinModelPortaliP27659
SMRiP27659
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0746 Eukaryota
COG0087 LUCA
GeneTreeiENSGT00390000017606
HOGENOMiHOG000107319
HOVERGENiHBG001864
InParanoidiP27659
KOiK02925
OMAiHQRTEYN
OrthoDBiEOG091G086T
TreeFamiTF300555

Family and domain databases

InterProiView protein in InterPro
IPR000597 Ribosomal_L3
IPR019926 Ribosomal_L3_CS
IPR009000 Transl_B-barrel_sf
PfamiView protein in Pfam
PF00297 Ribosomal_L3, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
PROSITEiView protein in PROSITE
PS00474 RIBOSOMAL_L3, 1 hit

Sequencei

Sequence statusi: Complete.

P27659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDASKP VHLTAFLGYK
60 70 80 90 100
AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR
110 120 130 140 150
TFKTVFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDD TGKKQLEKDF
160 170 180 190 200
NSMKKYCQVI RIIAHTQMRL LPLRQKKAHL MEIQVNGGTV AEKLDWARER
210 220 230 240 250
LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL PRKTHRGLRK
260 270 280 290 300
VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK
310 320 330 340 350
NNASTDYDLS DKSINPLGGF VHYGEVTNDF IMLKGCVVGT KKRVLTLRKS
360 370 380 390 400
LLVQTKRRAL EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE

EGA
Length:403
Mass (Da):46,110
Last modified:July 27, 2011 - v3
Checksum:i87AA82D9B2A8481E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265S → T in CAA68370 (PubMed:2628163).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00225 mRNA Translation: CAA68370.1
U89417 mRNA Translation: AAC36524.1
AK088993 mRNA Translation: BAC40691.1
AK144518 mRNA Translation: BAE25922.1
AK144816 mRNA Translation: BAE26078.1
AK146502 mRNA Translation: BAE27217.1
AK149494 mRNA Translation: BAE28917.1
AK151596 mRNA Translation: BAE30536.1
AK166433 mRNA Translation: BAE38773.1
AK166825 mRNA Translation: BAE39049.1
AK167787 mRNA Translation: BAE39818.1
AK167947 mRNA Translation: BAE39950.1
AK168040 mRNA Translation: BAE40022.1
AK168059 mRNA Translation: BAE40037.1
AK168126 mRNA Translation: BAE40095.1
AK168128 mRNA Translation: BAE40097.1
AK168224 mRNA Translation: BAE40178.1
AK168744 mRNA Translation: BAE40585.1
AK169060 mRNA Translation: BAE40848.1
AK169235 mRNA Translation: BAE41003.1
AK169321 mRNA Translation: BAE41075.1
AK170819 mRNA Translation: BAE42051.1
CH466550 Genomic DNA Translation: EDL04616.1
BC009655 mRNA Translation: AAH09655.1
BC083134 mRNA Translation: AAH83134.1
BC094059 mRNA Translation: AAH94059.1
BC158039 mRNA Translation: AAI58040.1
CCDSiCCDS37144.1
RefSeqiNP_038790.2, NM_013762.2
UniGeneiMm.290771
Mm.321484
Mm.396243
Mm.474802

Genome annotation databases

EnsembliENSMUST00000081650; ENSMUSP00000080354; ENSMUSG00000060036
GeneIDi27367
KEGGimmu:27367
UCSCiuc007wvb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRL3_MOUSE
AccessioniPrimary (citable) accession number: P27659
Secondary accession number(s): O89071, Q91VJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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