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P27659 (RL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L3
Alternative name(s):
J1 protein
Gene names
Name:Rpl3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

Subunit structure

Interacts with METTL18 By similarity.

Subcellular location

Nucleusnucleolus By similarity. Cytoplasm.

Sequence similarities

Belongs to the ribosomal protein L3P family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 40340260S ribosomal protein L3
PRO_0000077229

Amino acid modifications

Modified residue131Phosphoserine By similarity
Modified residue1361N6-acetyllysine Ref.8
Modified residue2861N6-acetyllysine Ref.8
Modified residue2941N6-acetyllysine By similarity
Modified residue3041Phosphoserine By similarity
Modified residue3661N6-acetyllysine By similarity
Modified residue3731N6-acetyllysine Ref.8

Experimental info

Sequence conflict2651S → T in CAA68370. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P27659 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 87AA82D9B2A8481E

FASTA40346,110
        10         20         30         40         50         60 
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDASKP VHLTAFLGYK AGMTHIVREV 

        70         80         90        100        110        120 
DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR TFKTVFAEHI SDECKRRFYK 

       130        140        150        160        170        180 
NWHKSKKKAF TKYCKKWQDD TGKKQLEKDF NSMKKYCQVI RIIAHTQMRL LPLRQKKAHL 

       190        200        210        220        230        240 
MEIQVNGGTV AEKLDWARER LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL 

       250        260        270        280        290        300 
PRKTHRGLRK VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK 

       310        320        330        340        350        360 
NNASTDYDLS DKSINPLGGF VHYGEVTNDF IMLKGCVVGT KKRVLTLRKS LLVQTKRRAL 

       370        380        390        400 
EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE EGA 

« Hide

References

« Hide 'large scale' references
[1]"Retrovirus activation in embryonal carcinoma cells by cellular promoters."
Peckham I., Sobel S., Comer J., Jaenisch R., Barklis E.
Genes Dev. 3:2062-2071(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cellular transcripts encoded at a locus which permits retrovirus expression in mouse embryonic cells."
Petersen R., Sobel S., Wang C.T., Jaenisch R., Barklis E.
Gene 101:177-183(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: BALB/c, C57BL/6J, DBA/2 and NOD.
Tissue: Bone marrow, Brain cortex, Heart, Kidney, Liver, Lung, Mammary gland and Thymus.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Limb and Mammary tumor.
[6]"Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis."
Chu C.C., Paul W.E.
Mol. Immunol. 35:487-502(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-299.
Strain: BALB/c.
Tissue: Spleen.
[7]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-136; LYS-286 AND LYS-373, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00225 mRNA. Translation: CAA68370.1.
U89417 mRNA. Translation: AAC36524.1.
AK088993 mRNA. Translation: BAC40691.1.
AK144518 mRNA. Translation: BAE25922.1.
AK144816 mRNA. Translation: BAE26078.1.
AK146502 mRNA. Translation: BAE27217.1.
AK149494 mRNA. Translation: BAE28917.1.
AK151596 mRNA. Translation: BAE30536.1.
AK166433 mRNA. Translation: BAE38773.1.
AK166825 mRNA. Translation: BAE39049.1.
AK167787 mRNA. Translation: BAE39818.1.
AK167947 mRNA. Translation: BAE39950.1.
AK168040 mRNA. Translation: BAE40022.1.
AK168059 mRNA. Translation: BAE40037.1.
AK168126 mRNA. Translation: BAE40095.1.
AK168128 mRNA. Translation: BAE40097.1.
AK168224 mRNA. Translation: BAE40178.1.
AK168744 mRNA. Translation: BAE40585.1.
AK169060 mRNA. Translation: BAE40848.1.
AK169235 mRNA. Translation: BAE41003.1.
AK169321 mRNA. Translation: BAE41075.1.
AK170819 mRNA. Translation: BAE42051.1.
CH466550 Genomic DNA. Translation: EDL04616.1.
BC009655 mRNA. Translation: AAH09655.1.
BC083134 mRNA. Translation: AAH83134.1.
BC094059 mRNA. Translation: AAH94059.1.
BC158039 mRNA. Translation: AAI58040.1.
RefSeqNP_038790.2. NM_013762.2.
UniGeneMm.290771.
Mm.321484.
Mm.396243.
Mm.474802.

3D structure databases

ProteinModelPortalP27659.
SMRP27659. Positions 2-398.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid205174. 9 interactions.
IntActP27659. 5 interactions.
MINTMINT-4120935.

PTM databases

PhosphoSiteP27659.

Proteomic databases

PaxDbP27659.
PRIDEP27659.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000081650; ENSMUSP00000080354; ENSMUSG00000060036.
GeneID27367.
KEGGmmu:27367.
UCSCuc007wvb.2. mouse.

Organism-specific databases

CTD6122.
MGIMGI:1351605. Rpl3.

Phylogenomic databases

eggNOGCOG0087.
GeneTreeENSGT00390000017606.
HOGENOMHOG000107319.
HOVERGENHBG001864.
InParanoidQ91VJ6.
KOK02925.
OMAEITPKGG.
OrthoDBEOG7HF1JK.
TreeFamTF300555.

Gene expression databases

BgeeP27659.
CleanExMM_RPL3.
GenevestigatorP27659.

Family and domain databases

InterProIPR000597. Ribosomal_L3.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 1 hit.
PROSITEPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio305258.
PROP27659.
SOURCESearch...

Entry information

Entry nameRL3_MOUSE
AccessionPrimary (citable) accession number: P27659
Secondary accession number(s): O89071, Q91VJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot