true1992-08-012024-01-24184LIPC_MOUSEMolecular cloning of mouse hepatic triacylglycerol lipase: gene expression in combined lipase-deficient (cld/cld) mice.Oka K.Nakano T.Tkalcevic G.T.Scow R.O.Brown W.V.doi:10.1016/0167-4781(91)90078-z1991Biochim. Biophys. Acta108913-20NUCLEOTIDE SEQUENCE [MRNA]Characterization of cDNA encoding the mouse hepatic triglyceride lipase and expression by in vitro translation.Chang S.F.Netter H.J.Will H.doi:10.1016/0014-5793(91)80910-u1991FEBS Lett.28969-72NUCLEOTIDE SEQUENCE [MRNA]C57BL/6 X CBALiverMural R.J.Adams M.D.Myers E.W.Smith H.O.Venter J.C.2003-02EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]FVB/N28Hepatic_Lipase2 sites, No reported glycans2 sites408 antibodies from 30 providersmouseLipcEukaryotaAssembly of active LPL and LIPC lipase complexesChylomicron clearance6 hits in 80 CRISPR screensProteinExpressed in left lobe of liver and 45 other cell types or tissuesbaseline and differentialPancreat_lipase_likePLAT_LPLalpha/beta hydrolasePLAT/LH2 domainAB_hydrolaseLipaseLipase_hepLipase_LIPHLipase_NPLAT/LH2_domPLAT/LH2_dom_sfTAG_lipaseHEPATIC TRIACYLGLYCEROL LIPASELIPASELipasePLATLipoprotein_lipase_LIPHHEPLIPASETAGLIPASELH2alpha/beta-HydrolasesLipase/lipooxygenase domain (PLAT/LH2 domain)LIPASE_SERPLATMMHepatic triacylglycerol lipaseHLHepatic lipase3.1.1.3Lipase member CLysophospholipase3.1.1.5Phospholipase A13.1.1.32LipcHplCatalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (By similarity). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity).Homodimer.Belongs to the AB hydrolase superfamily. Lipase family.121Hepatic triacylglycerol lipase5507822510PLAT353487Essential for determining substrate specificity255278Nucleophile169Charge relay system195Charge relay system280N-linked (GlcNAc...) asparagine79N-linked (GlcNAc...) asparagine398P2862011-07-272true5738978f59df78a4b44ed26f375b4d53098bbMGNPLQISIFLVFCIFIQSSACGQGVGTEPFGRSLGATEASKPLKKPETRFLLFQDENDRLGCRLRPQHPETLQECGFNSSQPLIMIIHGWSVDGLLENWIWKIVSALKSRQSQPVNVGLVDWISLAYQHYTIAVQNTRIVGQDVAALLLWLEESAKFSRSKVHLIGYSLGAHVSGFAGSSMDGKNKIGRITGLDPAGPMFEGTSPNERLSPDDANFVDAIHTFTREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAITQTIKCAHERSVHLFIDSLQHSDLQSIGFQCSDMGSFSQGLCLSCKKGRCNTLGYDIRKDRSGKSKRLFLITRAQSPFKVYHYQFKIQFINQIEKPVEPTFTMSLLGTKEEIKRIPITLGEGITSNKTYSFLITLDKDIGELILLKFKWENSAVWANVWNTVQTIMLWGIEPHHSGLILKTIWVKAGETQQRMTFCPENLDDLQLHPSQEKVFVNCEVKSKRLTESKEQMSQETHAKKtruetruetruetruetruetruetruetruetruetruetruetruetrue