Reviewed,
UniProtKB/Swiss-Prot P27656 (LIPC_MOUSE)
Last modified
October 13, 2009.
Version 91.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hepatic triacylglycerol lipase Short name=Hepatic lipase Short name=HL EC=3.1.1.3 Alternative name(s): Lipase member C | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 510 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. |
| Catalytic activity | Triacylglycerol + H2O = diacylglycerol + a carboxylate. |
| Subcellular location | |
| Sequence similarities | Belongs to the AB hydrolase superfamily. Lipase family. Contains 1 PLAT domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid degradation |
| Cellular component | HDL Secreted |
| Domain | Signal |
| Ligand | Heparin-binding |
| Molecular function | Hydrolase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | cholesterol homeostasis Inferred from genetic interaction. Source: MGI cholesterol metabolic processInferred from genetic interaction. Source: MGI cholesterol transportInferred from mutant phenotype. Source: MGI |
| Cellular component | high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | heparin binding Inferred from electronic annotation. Source: UniProtKB-KW triglyceride lipase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | By similarity | ||||||
| Chain | 23 – 510 | 488 | Hepatic triacylglycerol lipase | PRO_0000017770 | |||||
Regions | |||||||||
| Domain | 353 – 487 | 135 | PLAT | ||||||
| Region | 183 – 194 | 12 | Heparin-binding Potential | ||||||
Sites | |||||||||
| Active site | 169 | 1 | Nucleophile By similarity | ||||||
| Active site | 195 | 1 | Charge relay system By similarity | ||||||
| Active site | 280 | 1 | Charge relay system By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 79 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 398 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "Characterization of cDNA encoding the mouse hepatic triglyceride lipase and expression by in vitro translation." Chang S.F., Netter H.J., Will H. FEBS Lett. 289:69-72(1991) [PubMed: 1840530] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X58426 mRNA. Translation: CAA41329.1. | |
| IPI | IPI00331108. |
| UniGene | Mm.390187 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1RP1 based on UniProtKB P06857. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P27656. |
PTM databases | |
| PhosphoSite | P27656. |
Proteomic databases | |
| PRIDE | P27656. |
Genome annotation databases | |
| Ensembl | ENSMUST00000034731; ENSMUSP00000034731; ENSMUSG00000032207; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:96216. Lipc. |
Phylogenomic databases | |
| HOVERGEN | P27656. |
Enzyme and pathway databases | |
| BRENDA | 3.1.1.3. 244. |
Gene expression databases | |
| ArrayExpress | P27656. |
| Bgee | P27656. |
| CleanEx | MM_LIPC. |
| Genevestigator | P27656. |
| GermOnline | ENSMUSG00000032207. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000734. Lipase. IPR002333. Lipase_hep. IPR013818. Lipase_N. IPR008262. Lipase_Ser_AS. IPR001024. LipOase_LH2. IPR016272. Lipoprotein_lipase_LIPH. [Graphical view] |
| PANTHER | PTHR11610. Lipase. 1 hit. PTHR11610:SF2. Lipase_hep. 1 hit. |
| Pfam | PF00151. Lipase. 1 hit. PF01477. PLAT. 1 hit. [Graphical view] |
| PIRSF | PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit. |
| PRINTS | PR00824. HEPLIPASE. PR00821. TAGLIPASE. |
| SMART | SM00308. LH2. 1 hit. [Graphical view] |
| PROSITE | PS00120. LIPASE_SER. 1 hit. PS50095. PLAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | LIPC_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P27656 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


