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Protein

Hepatic triacylglycerol lipase

Gene

Lipc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169NucleophileBy similarity1
Active sitei195Charge relay systemPROSITE-ProRule annotation1
Active sitei280Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • lipase activity Source: MGI
  • triglyceride lipase activity Source: MGI

GO - Biological processi

  • cholesterol homeostasis Source: MGI
  • cholesterol metabolic process Source: MGI
  • cholesterol transport Source: MGI
  • fatty acid biosynthetic process Source: MGI
  • high-density lipoprotein particle remodeling Source: MGI
  • low-density lipoprotein particle remodeling Source: MGI
  • triglyceride catabolic process Source: MGI
  • triglyceride homeostasis Source: MGI
  • very-low-density lipoprotein particle remodeling Source: MGI

Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-8963889 Assembly of active LPL and LIPC lipase complexes
R-MMU-8964026 Chylomicron clearance

Protein family/group databases

ESTHERimouse-1hlip Hepatic_Lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
HL
Short name:
Hepatic lipase
Alternative name(s):
Lipase member C
Gene namesi
Name:Lipc
Synonyms:Hpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:96216 Lipc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001777023 – 510Hepatic triacylglycerol lipaseAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP27656
PaxDbiP27656
PRIDEiP27656

PTM databases

PhosphoSitePlusiP27656

Expressioni

Gene expression databases

BgeeiENSMUSG00000032207
CleanExiMM_LIPC
ExpressionAtlasiP27656 baseline and differential
GenevisibleiP27656 MM

Interactioni

Protein-protein interaction databases

BioGridi200409, 27 interactors
STRINGi10090.ENSMUSP00000034731

Structurei

3D structure databases

ProteinModelPortaliP27656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini353 – 487PLATPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 194Heparin-bindingSequence analysisAdd BLAST12

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIHP Eukaryota
ENOG4110MCZ LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038553
HOVERGENiHBG002259
InParanoidiP27656
KOiK22283
OMAiCHFLELY
OrthoDBiEOG091G052B
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR002333 Lipase_hep
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PTHR11610:SF2 PTHR11610:SF2, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00824 HEPLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNPLQISIF LVFCIFIQSS ACGQGVGTEP FGRSLGATEA SKPLKKPETR
60 70 80 90 100
FLLFQDENDR LGCRLRPQHP ETLQECGFNS SQPLIMIIHG WSVDGLLENW
110 120 130 140 150
IWKIVSALKS RQSQPVNVGL VDWISLAYQH YTIAVQNTRI VGQDVAALLL
160 170 180 190 200
WLEESAKFSR SKVHLIGYSL GAHVSGFAGS SMDGKNKIGR ITGLDPAGPM
210 220 230 240 250
FEGTSPNERL SPDDANFVDA IHTFTREHMG LSVGIKQPIA HYDFYPNGGS
260 270 280 290 300
FQPGCHFLEL YKHIAEHGLN AITQTIKCAH ERSVHLFIDS LQHSDLQSIG
310 320 330 340 350
FQCSDMGSFS QGLCLSCKKG RCNTLGYDIR KDRSGKSKRL FLITRAQSPF
360 370 380 390 400
KVYHYQFKIQ FINQIEKPVE PTFTMSLLGT KEEIKRIPIT LGEGITSNKT
410 420 430 440 450
YSFLITLDKD IGELILLKFK WENSAVWANV WNTVQTIMLW GIEPHHSGLI
460 470 480 490 500
LKTIWVKAGE TQQRMTFCPE NLDDLQLHPS QEKVFVNCEV KSKRLTESKE
510
QMSQETHAKK
Length:510
Mass (Da):57,389
Last modified:July 27, 2011 - v2
Checksum:iE30222652D782A05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286L → P in CAA41329 (PubMed:1840530).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228765 mRNA Translation: AAO73443.1
X58426 mRNA Translation: CAA41329.1
CH466522 Genomic DNA Translation: EDL26212.1
BC021841 mRNA Translation: AAH21841.1
BC094050 mRNA Translation: AAH94050.1
CCDSiCCDS23324.1
PIRiS15893
RefSeqiNP_001311401.1, NM_001324472.1
NP_001311402.1, NM_001324473.1
NP_032306.2, NM_008280.2
UniGeneiMm.390187

Genome annotation databases

EnsembliENSMUST00000034731; ENSMUSP00000034731; ENSMUSG00000032207
GeneIDi15450
KEGGimmu:15450
UCSCiuc009qos.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLIPC_MOUSE
AccessioniPrimary (citable) accession number: P27656
Secondary accession number(s): Q8VC44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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