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P27656

- LIPC_MOUSE

UniProt

P27656 - LIPC_MOUSE

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Protein

Hepatic triacylglycerol lipase

Gene
Lipc, Hpl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691Nucleophile By similarity
Active sitei195 – 1951Charge relay system By similarity
Active sitei280 – 2801Charge relay system By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. lipase activity Source: MGI
  3. protein binding Source: MGI
  4. triglyceride lipase activity Source: UniProtKB-EC

GO - Biological processi

  1. cholesterol homeostasis Source: MGI
  2. cholesterol metabolic process Source: MGI
  3. cholesterol transport Source: MGI
  4. fatty acid biosynthetic process Source: Ensembl
  5. high-density lipoprotein particle remodeling Source: Ensembl
  6. low-density lipoprotein particle remodeling Source: Ensembl
  7. triglyceride catabolic process Source: Ensembl
  8. triglyceride homeostasis Source: Ensembl
  9. very-low-density lipoprotein particle remodeling Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
HL
Short name:
Hepatic lipase
Alternative name(s):
Lipase member C
Gene namesi
Name:Lipc
Synonyms:Hpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:96216. Lipc.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. high-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarityAdd
BLAST
Chaini23 – 510488Hepatic triacylglycerol lipasePRO_0000017770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi398 – 3981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP27656.
PRIDEiP27656.

PTM databases

PhosphoSiteiP27656.

Expressioni

Gene expression databases

ArrayExpressiP27656.
BgeeiP27656.
CleanExiMM_LIPC.
GenevestigatoriP27656.

Interactioni

Protein-protein interaction databases

BioGridi200409. 27 interactions.
STRINGi10090.ENSMUSP00000034731.

Structurei

3D structure databases

ProteinModelPortaliP27656.
SMRiP27656. Positions 37-471.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini353 – 487135PLATAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni183 – 19412Heparin-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 PLAT domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG81747.
GeneTreeiENSGT00750000117234.
HOGENOMiHOG000038553.
HOVERGENiHBG002259.
InParanoidiQ8VC44.
KOiK01046.
OMAiCHFLELY.
OrthoDBiEOG757CX5.
TreeFamiTF324997.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27656-1 [UniParc]FASTAAdd to Basket

« Hide

MGNPLQISIF LVFCIFIQSS ACGQGVGTEP FGRSLGATEA SKPLKKPETR    50
FLLFQDENDR LGCRLRPQHP ETLQECGFNS SQPLIMIIHG WSVDGLLENW 100
IWKIVSALKS RQSQPVNVGL VDWISLAYQH YTIAVQNTRI VGQDVAALLL 150
WLEESAKFSR SKVHLIGYSL GAHVSGFAGS SMDGKNKIGR ITGLDPAGPM 200
FEGTSPNERL SPDDANFVDA IHTFTREHMG LSVGIKQPIA HYDFYPNGGS 250
FQPGCHFLEL YKHIAEHGLN AITQTIKCAH ERSVHLFIDS LQHSDLQSIG 300
FQCSDMGSFS QGLCLSCKKG RCNTLGYDIR KDRSGKSKRL FLITRAQSPF 350
KVYHYQFKIQ FINQIEKPVE PTFTMSLLGT KEEIKRIPIT LGEGITSNKT 400
YSFLITLDKD IGELILLKFK WENSAVWANV WNTVQTIMLW GIEPHHSGLI 450
LKTIWVKAGE TQQRMTFCPE NLDDLQLHPS QEKVFVNCEV KSKRLTESKE 500
QMSQETHAKK 510
Length:510
Mass (Da):57,389
Last modified:July 27, 2011 - v2
Checksum:iE30222652D782A05
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861L → P in CAA41329. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY228765 mRNA. Translation: AAO73443.1.
X58426 mRNA. Translation: CAA41329.1.
CH466522 Genomic DNA. Translation: EDL26212.1.
BC021841 mRNA. Translation: AAH21841.1.
BC094050 mRNA. Translation: AAH94050.1.
CCDSiCCDS23324.1.
PIRiS15893.
RefSeqiNP_032306.2. NM_008280.2.
UniGeneiMm.390187.

Genome annotation databases

EnsembliENSMUST00000034731; ENSMUSP00000034731; ENSMUSG00000032207.
GeneIDi15450.
KEGGimmu:15450.
UCSCiuc009qos.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY228765 mRNA. Translation: AAO73443.1 .
X58426 mRNA. Translation: CAA41329.1 .
CH466522 Genomic DNA. Translation: EDL26212.1 .
BC021841 mRNA. Translation: AAH21841.1 .
BC094050 mRNA. Translation: AAH94050.1 .
CCDSi CCDS23324.1.
PIRi S15893.
RefSeqi NP_032306.2. NM_008280.2.
UniGenei Mm.390187.

3D structure databases

ProteinModelPortali P27656.
SMRi P27656. Positions 37-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200409. 27 interactions.
STRINGi 10090.ENSMUSP00000034731.

PTM databases

PhosphoSitei P27656.

Proteomic databases

PaxDbi P27656.
PRIDEi P27656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034731 ; ENSMUSP00000034731 ; ENSMUSG00000032207 .
GeneIDi 15450.
KEGGi mmu:15450.
UCSCi uc009qos.1. mouse.

Organism-specific databases

CTDi 3990.
MGIi MGI:96216. Lipc.

Phylogenomic databases

eggNOGi NOG81747.
GeneTreei ENSGT00750000117234.
HOGENOMi HOG000038553.
HOVERGENi HBG002259.
InParanoidi Q8VC44.
KOi K01046.
OMAi CHFLELY.
OrthoDBi EOG757CX5.
TreeFami TF324997.

Miscellaneous databases

NextBioi 288252.
PROi P27656.
SOURCEi Search...

Gene expression databases

ArrayExpressi P27656.
Bgeei P27656.
CleanExi MM_LIPC.
Genevestigatori P27656.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR002333. Lipase_hep.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
PTHR11610:SF2. PTHR11610:SF2. 1 hit.
Pfami PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSi PR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mouse hepatic triacylglycerol lipase: gene expression in combined lipase-deficient (cld/cld) mice."
    Oka K., Nakano T., Tkalcevic G.T., Scow R.O., Brown W.V.
    Biochim. Biophys. Acta 1089:13-20(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of cDNA encoding the mouse hepatic triglyceride lipase and expression by in vitro translation."
    Chang S.F., Netter H.J., Will H.
    FEBS Lett. 289:69-72(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiLIPC_MOUSE
AccessioniPrimary (citable) accession number: P27656
Secondary accession number(s): Q8VC44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi