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Protein

Hepatic triacylglycerol lipase

Gene

Lipc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169NucleophileBy similarity1
Active sitei195Charge relay systemPROSITE-ProRule annotation1
Active sitei280Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • lipase activity Source: MGI
  • triglyceride lipase activity Source: MGI

GO - Biological processi

  • cholesterol homeostasis Source: MGI
  • cholesterol metabolic process Source: MGI
  • cholesterol transport Source: MGI
  • fatty acid biosynthetic process Source: MGI
  • high-density lipoprotein particle remodeling Source: MGI
  • low-density lipoprotein particle remodeling Source: MGI
  • triglyceride catabolic process Source: MGI
  • triglyceride homeostasis Source: MGI
  • very-low-density lipoprotein particle remodeling Source: MGI

Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-8963889. Assembly of active LPL and LIPC lipase complexes.
R-MMU-8964026. Chylomicron clearance.

Protein family/group databases

ESTHERimouse-1hlip. Hepatic_Lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
HL
Short name:
Hepatic lipase
Alternative name(s):
Lipase member C
Gene namesi
Name:Lipc
Synonyms:Hpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:96216. Lipc.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
  • high-density lipoprotein particle Source: UniProtKB-KW

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001777023 – 510Hepatic triacylglycerol lipaseAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP27656.
PaxDbiP27656.
PRIDEiP27656.

PTM databases

PhosphoSitePlusiP27656.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032207.
CleanExiMM_LIPC.
ExpressionAtlasiP27656. baseline and differential.
GenevisibleiP27656. MM.

Interactioni

Protein-protein interaction databases

BioGridi200409. 27 interactors.
STRINGi10090.ENSMUSP00000034731.

Structurei

3D structure databases

ProteinModelPortaliP27656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini353 – 487PLATPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 194Heparin-bindingSequence analysisAdd BLAST12

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIHP. Eukaryota.
ENOG4110MCZ. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038553.
HOVERGENiHBG002259.
InParanoidiP27656.
KOiK01046.
OMAiCHFLELY.
OrthoDBiEOG091G052B.
TreeFamiTF324997.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR002333. Lipase_hep.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
PANTHERiPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF139. PTHR11610:SF139. 1 hit.
PfamiView protein in Pfam
PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiView protein in SMART
SM00308. LH2. 1 hit.
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNPLQISIF LVFCIFIQSS ACGQGVGTEP FGRSLGATEA SKPLKKPETR
60 70 80 90 100
FLLFQDENDR LGCRLRPQHP ETLQECGFNS SQPLIMIIHG WSVDGLLENW
110 120 130 140 150
IWKIVSALKS RQSQPVNVGL VDWISLAYQH YTIAVQNTRI VGQDVAALLL
160 170 180 190 200
WLEESAKFSR SKVHLIGYSL GAHVSGFAGS SMDGKNKIGR ITGLDPAGPM
210 220 230 240 250
FEGTSPNERL SPDDANFVDA IHTFTREHMG LSVGIKQPIA HYDFYPNGGS
260 270 280 290 300
FQPGCHFLEL YKHIAEHGLN AITQTIKCAH ERSVHLFIDS LQHSDLQSIG
310 320 330 340 350
FQCSDMGSFS QGLCLSCKKG RCNTLGYDIR KDRSGKSKRL FLITRAQSPF
360 370 380 390 400
KVYHYQFKIQ FINQIEKPVE PTFTMSLLGT KEEIKRIPIT LGEGITSNKT
410 420 430 440 450
YSFLITLDKD IGELILLKFK WENSAVWANV WNTVQTIMLW GIEPHHSGLI
460 470 480 490 500
LKTIWVKAGE TQQRMTFCPE NLDDLQLHPS QEKVFVNCEV KSKRLTESKE
510
QMSQETHAKK
Length:510
Mass (Da):57,389
Last modified:July 27, 2011 - v2
Checksum:iE30222652D782A05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286L → P in CAA41329 (PubMed:1840530).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228765 mRNA. Translation: AAO73443.1.
X58426 mRNA. Translation: CAA41329.1.
CH466522 Genomic DNA. Translation: EDL26212.1.
BC021841 mRNA. Translation: AAH21841.1.
BC094050 mRNA. Translation: AAH94050.1.
CCDSiCCDS23324.1.
PIRiS15893.
RefSeqiNP_001311401.1. NM_001324472.1.
NP_001311402.1. NM_001324473.1.
NP_032306.2. NM_008280.2.
UniGeneiMm.390187.

Genome annotation databases

EnsembliENSMUST00000034731; ENSMUSP00000034731; ENSMUSG00000032207.
GeneIDi15450.
KEGGimmu:15450.
UCSCiuc009qos.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY228765 mRNA. Translation: AAO73443.1.
X58426 mRNA. Translation: CAA41329.1.
CH466522 Genomic DNA. Translation: EDL26212.1.
BC021841 mRNA. Translation: AAH21841.1.
BC094050 mRNA. Translation: AAH94050.1.
CCDSiCCDS23324.1.
PIRiS15893.
RefSeqiNP_001311401.1. NM_001324472.1.
NP_001311402.1. NM_001324473.1.
NP_032306.2. NM_008280.2.
UniGeneiMm.390187.

3D structure databases

ProteinModelPortaliP27656.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200409. 27 interactors.
STRINGi10090.ENSMUSP00000034731.

Protein family/group databases

ESTHERimouse-1hlip. Hepatic_Lipase.

PTM databases

PhosphoSitePlusiP27656.

Proteomic databases

MaxQBiP27656.
PaxDbiP27656.
PRIDEiP27656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034731; ENSMUSP00000034731; ENSMUSG00000032207.
GeneIDi15450.
KEGGimmu:15450.
UCSCiuc009qos.1. mouse.

Organism-specific databases

CTDi3990.
MGIiMGI:96216. Lipc.

Phylogenomic databases

eggNOGiENOG410IIHP. Eukaryota.
ENOG4110MCZ. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038553.
HOVERGENiHBG002259.
InParanoidiP27656.
KOiK01046.
OMAiCHFLELY.
OrthoDBiEOG091G052B.
TreeFamiTF324997.

Enzyme and pathway databases

ReactomeiR-MMU-8963889. Assembly of active LPL and LIPC lipase complexes.
R-MMU-8964026. Chylomicron clearance.

Miscellaneous databases

PROiPR:P27656.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032207.
CleanExiMM_LIPC.
ExpressionAtlasiP27656. baseline and differential.
GenevisibleiP27656. MM.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR002333. Lipase_hep.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
PANTHERiPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF139. PTHR11610:SF139. 1 hit.
PfamiView protein in Pfam
PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00824. HEPLIPASE.
PR00821. TAGLIPASE.
SMARTiView protein in SMART
SM00308. LH2. 1 hit.
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLIPC_MOUSE
AccessioniPrimary (citable) accession number: P27656
Secondary accession number(s): Q8VC44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: June 7, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.