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Protein

Low affinity immunoglobulin gamma Fc region receptor III

Gene

Fcgr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the Fc region of complexed immunoglobulins gamma (PubMed:1692135). Low affinity receptor which binds to IgG1, IgG2a and IgG2b (By similarity). Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • nerve development Source: RGD

Keywordsi

Molecular functionIgG-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-RNO-2029481. FCGR activation.
R-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-2029485. Role of phospholipids in phagocytosis.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor III
Short name:
IgG Fc receptor III
Alternative name(s):
Fc-gamma RIII
Short name:
FcRIII
CD_antigen: CD16
Gene namesi
Name:Fcgr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi71069. Fcgr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini37 – 221ExtracellularSequence analysisAdd BLAST185
Transmembranei222 – 241HelicalSequence analysisAdd BLAST20
Topological domaini242 – 267CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000001515637 – 267Low affinity immunoglobulin gamma Fc region receptor IIIAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 104PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 187PROSITE-ProRule annotation
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP27645.
PRIDEiP27645.

PTM databases

PhosphoSitePlusiP27645.

Expressioni

Tissue specificityi

Expressed on natural killer cells and macrophages.

Gene expression databases

BgeeiENSRNOG00000049422.
GenevisibleiP27645. RN.

Interactioni

Subunit structurei

May form multisubunit complex with other heteroproteins. This association is required for efficient cell-surface expression. Does not associate with CD3 zeta.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039989.

Structurei

3D structure databases

ProteinModelPortaliP27645.
SMRiP27645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 121Ig-like C2-type 1Add BLAST83
Domaini122 – 204Ig-like C2-type 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AP. Eukaryota.
ENOG410YXNK. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP27645.
KOiK06463.
K06472.
K16824.
OMAiXAENTIT.
OrthoDBiEOG091G0JSA.
PhylomeDBiP27645.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
PfamiView protein in Pfam
PF13895. Ig_2. 2 hits.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform C (identifier: P27645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLETQMFQN AHSGSQWLLP PLTMLLLFAF ADRQTANLPK AVVKRDPPWI
60 70 80 90 100
QVLKEDTVTL TCEGTHNPGN SSTQWFHNQS STWGQVQASY TFKATVNDSG
110 120 130 140 150
EYRCRMAHTS LSDPVHLEVI SDWLLLQTPQ LVFEEGETIT LRCHSWKNKQ
160 170 180 190 200
LTKVLLFQNG KPVRYYYQSS NFSIPKANHS HSGNYYCKAY LGRTMHVSKP
210 220 230 240 250
VTITVQGSAT ASTSSLVWFH AAFCLVMCLL FAVDTGLYFC VRRNLQTSGE
260
DWRKSLSVGK YKAPQDK
Length:267
Mass (Da):30,282
Last modified:August 1, 1992 - v1
Checksum:iDD4D6A7A3F70ED92
GO
Isoform A (identifier: P27645-3)
Sequence is not available
Length:
Mass (Da):
Isoform B (identifier: P27645-4)
Sequence is not available
Length:
Mass (Da):
Isoform D (identifier: P27645-5)
Sequence is not available
Length:
Mass (Da):
Isoform E (identifier: P27645-6)
Sequence is not available
Length:
Mass (Da):
Isoform F (identifier: P27645-7)
Sequence is not available
Length:
Mass (Da):
Isoform G (identifier: P27645-8)
Sequence is not available
Length:
Mass (Da):
Isoform H (identifier: P27645-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-176: SWKNKQLTKVLLFQNGKPVRYYYQSSNFSIPK → GWKSIQLARISFLQNGEFVSFHPYNVSYSISN

Show »
Length:267
Mass (Da):30,108
Checksum:i340BF4A6538D3E4D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti36 – 39ANLP → GDLL in isoform A and isoform H. 4
Natural varianti55E → D in isoform A and isoform H. 1
Natural varianti56D → G in isoform D. 1
Natural varianti115V → I in isoform A and isoform B. 1
Natural varianti134E → L in isoform H. 1
Natural varianti138T → R in isoform H. 1
Natural varianti184N → D in isoform H. 1
Natural varianti195M → E in isoform H. 1
Natural varianti254K → R in isoform H. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002647145 – 176SWKNK…FSIPK → GWKSIQLARISFLQNGEFVS FHPYNVSYSISN in isoform H. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64368 mRNA. Translation: AAA42049.1.
M64369 mRNA. Translation: AAA42048.1.
M64370 mRNA. Translation: AAA42050.1.
M32062 mRNA. Translation: AAA41148.1.
L08446 mRNA. Translation: AAA41151.1.
PIRiA35902.
I56110.
I72882.
RefSeqiNP_001129464.1. NM_001135992.1.
NP_446295.2. NM_053843.2.
XP_006250365.1. XM_006250303.3.
XP_006250367.1. XM_006250305.3.
XP_008767970.1. XM_008769748.2.
XP_008767989.1. XM_008769767.1. [P27645-1]
XP_008767990.1. XM_008769768.2. [P27645-1]
XP_008767991.1. XM_008769769.2. [P27645-1]
XP_008767993.1. XM_008769771.2. [P27645-1]
XP_008767994.1. XM_008769772.2. [P27645-1]
XP_008767996.1. XM_008769774.2.
XP_008767997.1. XM_008769775.2.
XP_008767998.1. XM_008769776.2.
XP_017454126.1. XM_017598637.1.
UniGeneiRn.154415.
Rn.6050.

Genome annotation databases

EnsembliENSRNOT00000004204; ENSRNOP00000004204; ENSRNOG00000049422. [P27645-1]
ENSRNOT00000047349; ENSRNOP00000039989; ENSRNOG00000049422. [P27645-1]
GeneIDi100911825.
108348047.
116591.
498276.
KEGGirno:100911825.
rno:108348047.
rno:116591.
rno:498276.
UCSCiRGD:71069. rat. [P27645-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFCGR3_RAT
AccessioniPrimary (citable) accession number: P27645
Secondary accession number(s): Q04798, Q63204
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 5, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome