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P27636 (CDC15_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 15

EC=2.7.11.1
Gene names
Name:CDC15
Synonyms:LYT1
Ordered Locus Names:YAR019C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length974 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein kinase of the mitotic exit network (MEN) essential for late nuclear division in the mitotic cycle. Promotes mitotic exit by phosphorylating DBF2 and directly switching on DBF2 kinase activity. Involved in the localization of DBF2 and DBF20 to the neck which is necessary to undergo cytokinesis. Plays a role in segregation of chromosomes during recovery from spindle checkpoint activation. Required for spindle pole localization of CDK1 and inactivation of CDC2 kinase activity at the end of mitosis. Required for spindle disassembly after meiosis II and plays a role in spore morphogenesis. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14 Ref.15 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.26 Ref.30 Ref.31 Ref.32 Ref.33 Ref.35 Ref.36 Ref.37 Ref.38 Ref.40

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Kinase activity is inhibited by phosphorylation and activated by dephosphorylation by CDC14. Ref.16

Subunit structure

Homodimer. Interacts with TEM1. Ref.18 Ref.22

Subcellular location

Cytoplasmcytoskeletonspindle pole. Bud neck. Note: Localizes to the spindle pole bodies at late anaphase and translocates to the cytoplasm upon DNA replication stress. Localization to SPBs depends on CDC5 and TEM1 and is inhibited by BUB2. Accumulates at the daughter SPB after anaphase onset when the daughter SPB begins to penetrate the bud neck. Not found in the mother SPD during early anaphase. As anaphase proceeds, continues to accumulate on the daughter SPB and also localizes to the mother SPB. At the end of telophase, a portion of CDC15 localizes at the mother-bud neck. Ref.13 Ref.14 Ref.15 Ref.17 Ref.19 Ref.23 Ref.25 Ref.31 Ref.35

Induction

Constitutively expressed. Ref.16 Ref.39

Domain

The region between residues 360 and 702 is essential for function and is required for self-association and for binding to spindle pole bodies. Ref.22

The region between residues 751 and 974 is an auto-inhibitory domain which inhibits MEN signaling. Ref.22

Post-translational modification

Phosphorylation by CDK1 reduces the binding to the mother spindle pole body. The extent of phosphorylation gradually increases during cell-cycle progression until some point during late anaphase/telophase when it is rapidly dephosphorylated by CDC14. Phosphorylation inhibits kinase activity and dephosphorylation by CDC14 activates CDC15. Ref.14 Ref.15 Ref.16 Ref.31 Ref.34

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TEM1P389872EBI-4200,EBI-19113

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 974974Cell division control protein 15
PRO_0000085717

Regions

Domain25 – 272248Protein kinase
Nucleotide binding31 – 399ATP By similarity
Region360 – 702343Self association domain
Region751 – 974224Auto-inhibitory domain

Sites

Active site1461Proton acceptor By similarity
Binding site541ATP By similarity

Amino acid modifications

Modified residue5611Phosphoserine Ref.34
Modified residue5671Phosphoserine Ref.29 Ref.34
Modified residue8701Phosphothreonine Ref.34

Experimental info

Sequence conflict3161A → R in CAA43041. Ref.1
Sequence conflict3161A → R in CAA36906. Ref.2
Sequence conflict3161A → R Ref.4
Sequence conflict3161A → R in AAC04965. Ref.5
Sequence conflict3211A → P in CAA43041. Ref.1
Sequence conflict3211A → P in CAA36906. Ref.2
Sequence conflict3211A → P Ref.4
Sequence conflict3211A → P in AAC04965. Ref.5
Sequence conflict900 – 9023KDV → NGC no nucleotide entry Ref.4
Sequence conflict900 – 9023KDV → NGC in AAC04965. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P27636 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 99383BD871A4A726

FASTA974110,242
        10         20         30         40         50         60 
MNSMADTDRV NLTPIQRASE KSVQYHLKQV IGRGSYGVVY KAINKHTDQV VAIKEVVYEN 

        70         80         90        100        110        120 
DEELNDIMAE ISLLKNLNHN NIVKYHGFIR KSYELYILLE YCANGSLRRL ISRSSTGLSE 

       130        140        150        160        170        180 
NESKTYVTQT LLGLKYLHGE GVIHRDIKAA NILLSADNTV KLADFGVSTI VNSSALTLAG 

       190        200        210        220        230        240 
TLNWMAPEIL GNRGASTLSD IWSLGATVVE MLTKNPPYHN LTDANIYYAV ENDTYYPPSS 

       250        260        270        280        290        300 
FSEPLKDFLS KCFVKNMYKR PTADQLLKHV WINSTENVKV DKLNKFKEDF TDADYHWDAD 

       310        320        330        340        350        360 
FQEEKLNISP SKFSLAAAPA AWAENNQELD LMPPTESQLL SQLKSSSKPL TDLHVLFSVC 

       370        380        390        400        410        420 
SLENIADTII ECLSRTTVDK RLITAFGSIF VYDTQHNHSR LRLKFIAMGG IPLIIKFEHL 

       430        440        450        460        470        480 
AKEFVIDYPQ TLIECGIMYP PNFASLKTPK YILELVYRFY DLTSTAFWCR WCFKHLDISL 

       490        500        510        520        530        540 
LLNNIHERRA QSILLKLSSY APWSFEKILP SLIDSKLKKK ILISPQITYV VFKSINYMIT 

       550        560        570        580        590        600 
TNDDKIHKSA IPSSSSLPLS SSPTRNSPVN SVQSPSRSPV HSLMATRPSS PMRHKSISNF 

       610        620        630        640        650        660 
PHLTISSKSR LLIELPEGFF TWLTSFFVDM AQIKDLSVLK YFTKLCYLTV HINSTFLNDL 

       670        680        690        700        710        720 
LDNDAFFAFI RNIDTIIPFI DDAKTAAFIW KQITAICVEM SLDMDQMSAS LFSTAMNFIR 

       730        740        750        760        770        780 
KKNNTSISGL EIILNCLHFT LRNVNDDVAP TVGSSESHSV FLIKVNNDAA IELPIDQLVD 

       790        800        810        820        830        840 
LFYALNDDDV NLSKLISIFT KICSLPGFEN LTINIIFHPN FYEKIVSFFD TYFNSLLIQI 

       850        860        870        880        890        900 
DLLKFIKLIF SKSLLKLYDY TGQPDPIKQT EPNRRNKATV FKLRAILVQI TEFLNNNWNK 

       910        920        930        940        950        960 
DVPKRNSNQV GGDSVLICQL CEDIRSLSKK GSLQKVSSVT AAIGSSPTKD ERSNLRSSKD 

       970 
KSDGFSVPIT TFQT 

« Hide

References

« Hide 'large scale' references
[1]"NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA."
Schweitzer B., Philippsen P.
Mol. Gen. Genet. 234:164-167(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain."
Schweitzer B., Philippsen P.
Yeast 7:265-273(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / GRF88.
[3]Schweitzer B.
Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 900-902.
[4]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[5]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]Saccharomyces Genome Database
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 316; 321 AND 900-902.
Strain: ATCC 204508 / S288c.
[7]"A directed DNA sequencing strategy based upon Tn3 transposon mutagenesis: application to the ADE1 locus on Saccharomyces cerevisiae chromosome I."
Davies C.J., Hutchison C.A. III
Nucleic Acids Res. 19:5731-5738(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 865-974.
[8]"Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast."
Surana U., Amon A., Dowzer C., McGrew J., Byers B., Nasmyth K.
EMBO J. 12:1969-1978(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"A cdc-like autolytic Saccharomyces cerevisiae mutant altered in budding site selection is complemented by SPO12, a sporulation gene."
Molero G., Yuste-Rojas M., Montesi A., Vazquez A., Nombela C., Sanchez M.
J. Bacteriol. 175:6562-6570(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"Chromosome condensation and sister chromatid pairing in budding yeast."
Guacci V., Hogan E., Koshland D.
J. Cell Biol. 125:517-530(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"Dominant mutant alleles of yeast protein kinase gene CDC15 suppress the lte1 defect in termination of M phase and genetically interact with CDC14."
Shirayama M., Matsui Y., Toh-e A.
Mol. Gen. Genet. 251:176-185(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"Chromosome separation and exit from mitosis in budding yeast: dependence on growth revealed by cAMP-mediated inhibition."
Anghileri P., Branduardi P., Sternieri F., Monti P., Visintin R., Bevilacqua A., Alberghina L., Martegani E., Baroni M.D.
Exp. Cell Res. 250:510-523(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[13]"The budding yeast Cdc15 localizes to the spindle pole body in a cell-cycle-dependent manner."
Cenamor R., Jimenez J., Cid V.J., Nombela C., Sanchez M.
Mol. Cell Biol. Res. Commun. 2:178-184(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[14]"Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast."
Xu S., Huang H.K., Kaiser P., Latterich M., Hunter T.
Curr. Biol. 10:329-332(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, SUBCELLULAR LOCATION, FUNCTION.
[15]"Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis."
Menssen R., Neutzner A., Seufert W.
Curr. Biol. 11:345-350(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, SUBCELLULAR LOCATION, FUNCTION.
[16]"Cdc14 activates cdc15 to promote mitotic exit in budding yeast."
Jaspersen S.L., Morgan D.O.
Curr. Biol. 10:615-618(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, ENZYME REGULATION.
[17]"Order of function of the budding-yeast mitotic exit-network proteins Tem1, Cdc15, Mob1, Dbf2, and Cdc5."
Lee S.E., Frenz L.M., Wells N.J., Johnson A.L., Johnston L.H.
Curr. Biol. 11:784-788(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[18]"A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae."
Asakawa K., Yoshida S., Otake F., Toh-e A.
Genetics 157:1437-1450(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TEM1, FUNCTION.
[19]"Regulation of the mitotic exit protein kinases Cdc15 and Dbf2."
Visintin R., Amon A.
Mol. Biol. Cell 12:2961-2974(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION.
[20]"Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex."
Mah A.S., Jang J., Deshaies R.J.
Proc. Natl. Acad. Sci. U.S.A. 98:7325-7330(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[21]"Inactivation of mitotic kinase triggers translocation of MEN components to mother-daughter neck in yeast."
Hwa Lim H., Yeong F.M., Surana U.
Mol. Biol. Cell 14:4734-4743(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[22]"Mitotic exit regulation through distinct domains within the protein kinase Cdc15."
Bardin A.J., Boselli M.G., Amon A.
Mol. Cell. Biol. 23:5018-5030(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, DOMAIN.
[23]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[24]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[25]"The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit."
Molk J.N., Schuyler S.C., Liu J.Y., Evans J.G., Salmon E.D., Pellman D., Bloom K.
Mol. Biol. Cell 15:1519-1532(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[26]"Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae."
Pablo-Hernando M.E., Arnaiz-Pita Y., Nakanishi H., Dawson D., del Rey F., Neiman A.M., Vazquez de Aldana C.R.
Genetics 177:281-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[27]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[28]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[29]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[30]"Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation."
Schleker T., Shimada K., Sack R., Pike B.L., Gasser S.M.
Cell Cycle 9:350-363(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[31]"Mutual regulation of cyclin-dependent kinase and the mitotic exit network."
Konig C., Maekawa H., Schiebel E.
J. Cell Biol. 188:351-368(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION BY CDK1, FUNCTION.
[32]"Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast."
Meitinger F., Petrova B., Lombardi I.M., Bertazzi D.T., Hub B., Zentgraf H., Pereira G.
J. Cell Sci. 123:1851-1861(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[33]"Unrestrained spindle elongation during recovery from spindle checkpoint activation in cdc15-2 cells results in mis-segregation of chromosomes."
Chai C.C., Teh E.M., Yeong F.M.
Mol. Biol. Cell 21:2384-2398(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[34]"Cell cycle phosphorylation of mitotic exit network (MEN) proteins."
Jones M.H., Keck J.M., Wong C.C., Xu T., Yates J.R. III, Winey M.
Cell Cycle 10:3435-3440(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-561; SER-567 AND THR-870.
[35]"Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit."
Rock J.M., Amon A.
Genes Dev. 25:1943-1954(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[36]"Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability."
Ratsima H., Ladouceur A.M., Pascariu M., Sauve V., Salloum Z., Maddox P.S., D'Amours D.
Proc. Natl. Acad. Sci. U.S.A. 108:E914-E923(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[37]"Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation."
Hotz M., Leisner C., Chen D., Manatschal C., Wegleiter T., Ouellet J., Lindstrom D., Gottschling D.E., Vogel J., Barral Y.
Cell 148:958-972(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[38]"Control of the mitotic exit network during meiosis."
Attner M.A., Amon A.
Mol. Biol. Cell 23:3122-3132(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[39]"Measurement and modeling of transcriptional noise in the cell cycle regulatory network."
Ball D.A., Adames N.R., Reischmann N., Barik D., Franck C.T., Tyson J.J., Peccoud J.
Cell Cycle 12:3203-3218(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[40]"The FEAR protein Slk19 restricts Cdc14 phosphatase to the nucleus until the end of anaphase, regulating its participation in mitotic exit in Saccharomyces cerevisiae."
Faust A.M., Wong C.C., Yates Iii J.R., Drubin D.G., Barnes G.
PLoS ONE 8:E73194-E73194(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60549 Genomic DNA. Translation: CAA43041.1.
X52683 Genomic DNA. Translation: CAA36906.1.
L22015 Genomic DNA. Translation: AAC04965.1.
M67445 Genomic DNA. Translation: AAA34400.1.
BK006935 Genomic DNA. Translation: DAA06996.2.
PIRS15038.
RefSeqNP_009411.2. NM_001178218.2.

3D structure databases

ProteinModelPortalP27636.
SMRP27636. Positions 29-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31801. 101 interactions.
DIPDIP-5728N.
IntActP27636. 5 interactions.
MINTMINT-683916.
STRING4932.YAR019C.

Proteomic databases

PaxDbP27636.
PeptideAtlasP27636.
PRIDEP27636.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAR019C; YAR019C; YAR019C.
GeneID851274.
KEGGsce:YAR019C.

Organism-specific databases

SGDS000000072. CDC15.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117264.
HOGENOMHOG000141997.
KOK06683.
OMAVKYHGFI.
OrthoDBEOG7T1RKJ.

Enzyme and pathway databases

BioCycYEAST:G3O-28875-MONOMER.
BRENDA2.7.11.1. 984.

Gene expression databases

GenevestigatorP27636.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968257.
PROP27636.

Entry information

Entry nameCDC15_YEAST
AccessionPrimary (citable) accession number: P27636
Secondary accession number(s): D6VPM6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families