Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P27636

- CDC15_YEAST

UniProt

P27636 - CDC15_YEAST

Protein

Cell division control protein 15

Gene

CDC15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protein kinase of the mitotic exit network (MEN) essential for late nuclear division in the mitotic cycle. Promotes mitotic exit by phosphorylating DBF2 and directly switching on DBF2 kinase activity. Involved in the localization of DBF2 and DBF20 to the neck which is necessary to undergo cytokinesis. Plays a role in segregation of chromosomes during recovery from spindle checkpoint activation. Required for spindle pole localization of CDK1 and inactivation of CDC2 kinase activity at the end of mitosis. Required for spindle disassembly after meiosis II and plays a role in spore morphogenesis.23 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Kinase activity is inhibited by phosphorylation and activated by dephosphorylation by CDC14.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541ATPPROSITE-ProRule annotation
    Active sitei146 – 1461Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein kinase activity Source: SGD
    4. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. meiotic spindle disassembly Source: SGD
    2. mitotic cytokinesis Source: SGD
    3. mitotic nuclear division Source: UniProtKB-KW
    4. protein phosphorylation Source: SGD
    5. regulation of exit from mitosis Source: SGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28875-MONOMER.
    BRENDAi2.7.11.1. 984.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 15 (EC:2.7.11.1)
    Gene namesi
    Name:CDC15
    Synonyms:LYT1
    Ordered Locus Names:YAR019C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    SGDiS000000072. CDC15.

    Subcellular locationi

    Cytoplasmcytoskeletonspindle pole. Bud neck
    Note: Localizes to the spindle pole bodies at late anaphase and translocates to the cytoplasm upon DNA replication stress. Localization to SPBs depends on CDC5 and TEM1 and is inhibited by BUB2. Accumulates at the daughter SPB after anaphase onset when the daughter SPB begins to penetrate the bud neck. Not found in the mother SPD during early anaphase. As anaphase proceeds, continues to accumulate on the daughter SPB and also localizes to the mother SPB. At the end of telophase, a portion of CDC15 localizes at the mother-bud neck.

    GO - Cellular componenti

    1. cellular bud neck Source: SGD
    2. cytoplasm Source: UniProtKB-KW
    3. spindle pole body Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 974974Cell division control protein 15PRO_0000085717Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei561 – 5611Phosphoserine1 Publication
    Modified residuei567 – 5671Phosphoserine2 Publications
    Modified residuei870 – 8701Phosphothreonine1 Publication

    Post-translational modificationi

    Phosphorylation by CDK1 reduces the binding to the mother spindle pole body. The extent of phosphorylation gradually increases during cell-cycle progression until some point during late anaphase/telophase when it is rapidly dephosphorylated by CDC14. Phosphorylation inhibits kinase activity and dephosphorylation by CDC14 activates CDC15.6 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP27636.
    PaxDbiP27636.
    PeptideAtlasiP27636.
    PRIDEiP27636.

    Expressioni

    Inductioni

    Constitutively expressed.1 Publication

    Gene expression databases

    GenevestigatoriP27636.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with TEM1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TEM1P389872EBI-4200,EBI-19113

    Protein-protein interaction databases

    BioGridi31801. 101 interactions.
    DIPiDIP-5728N.
    IntActiP27636. 5 interactions.
    MINTiMINT-683916.
    STRINGi4932.YAR019C.

    Structurei

    3D structure databases

    ProteinModelPortaliP27636.
    SMRiP27636. Positions 31-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 272248Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni360 – 702343Self association domainAdd
    BLAST
    Regioni751 – 974224Auto-inhibitory domainAdd
    BLAST

    Domaini

    The region between residues 360 and 702 is essential for function and is required for self-association and for binding to spindle pole bodies.1 Publication
    The region between residues 751 and 974 is an auto-inhibitory domain which inhibits MEN signaling.1 Publication

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117264.
    HOGENOMiHOG000141997.
    KOiK06683.
    OMAiVKYHGFI.
    OrthoDBiEOG7T1RKJ.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P27636-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSMADTDRV NLTPIQRASE KSVQYHLKQV IGRGSYGVVY KAINKHTDQV    50
    VAIKEVVYEN DEELNDIMAE ISLLKNLNHN NIVKYHGFIR KSYELYILLE 100
    YCANGSLRRL ISRSSTGLSE NESKTYVTQT LLGLKYLHGE GVIHRDIKAA 150
    NILLSADNTV KLADFGVSTI VNSSALTLAG TLNWMAPEIL GNRGASTLSD 200
    IWSLGATVVE MLTKNPPYHN LTDANIYYAV ENDTYYPPSS FSEPLKDFLS 250
    KCFVKNMYKR PTADQLLKHV WINSTENVKV DKLNKFKEDF TDADYHWDAD 300
    FQEEKLNISP SKFSLAAAPA AWAENNQELD LMPPTESQLL SQLKSSSKPL 350
    TDLHVLFSVC SLENIADTII ECLSRTTVDK RLITAFGSIF VYDTQHNHSR 400
    LRLKFIAMGG IPLIIKFEHL AKEFVIDYPQ TLIECGIMYP PNFASLKTPK 450
    YILELVYRFY DLTSTAFWCR WCFKHLDISL LLNNIHERRA QSILLKLSSY 500
    APWSFEKILP SLIDSKLKKK ILISPQITYV VFKSINYMIT TNDDKIHKSA 550
    IPSSSSLPLS SSPTRNSPVN SVQSPSRSPV HSLMATRPSS PMRHKSISNF 600
    PHLTISSKSR LLIELPEGFF TWLTSFFVDM AQIKDLSVLK YFTKLCYLTV 650
    HINSTFLNDL LDNDAFFAFI RNIDTIIPFI DDAKTAAFIW KQITAICVEM 700
    SLDMDQMSAS LFSTAMNFIR KKNNTSISGL EIILNCLHFT LRNVNDDVAP 750
    TVGSSESHSV FLIKVNNDAA IELPIDQLVD LFYALNDDDV NLSKLISIFT 800
    KICSLPGFEN LTINIIFHPN FYEKIVSFFD TYFNSLLIQI DLLKFIKLIF 850
    SKSLLKLYDY TGQPDPIKQT EPNRRNKATV FKLRAILVQI TEFLNNNWNK 900
    DVPKRNSNQV GGDSVLICQL CEDIRSLSKK GSLQKVSSVT AAIGSSPTKD 950
    ERSNLRSSKD KSDGFSVPIT TFQT 974
    Length:974
    Mass (Da):110,242
    Last modified:July 27, 2011 - v3
    Checksum:i99383BD871A4A726
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti316 – 3161A → R in CAA43041. (PubMed:1495480)Curated
    Sequence conflicti316 – 3161A → R in CAA36906. (PubMed:1882551)Curated
    Sequence conflicti316 – 3161A → R(PubMed:7941740)Curated
    Sequence conflicti316 – 3161A → R in AAC04965. (PubMed:7731988)Curated
    Sequence conflicti321 – 3211A → P in CAA43041. (PubMed:1495480)Curated
    Sequence conflicti321 – 3211A → P in CAA36906. (PubMed:1882551)Curated
    Sequence conflicti321 – 3211A → P(PubMed:7941740)Curated
    Sequence conflicti321 – 3211A → P in AAC04965. (PubMed:7731988)Curated
    Sequence conflicti900 – 9023KDV → NGC no nucleotide entry (PubMed:7941740)Curated
    Sequence conflicti900 – 9023KDV → NGC in AAC04965. (PubMed:7731988)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60549 Genomic DNA. Translation: CAA43041.1.
    X52683 Genomic DNA. Translation: CAA36906.1.
    L22015 Genomic DNA. Translation: AAC04965.1.
    M67445 Genomic DNA. Translation: AAA34400.1.
    BK006935 Genomic DNA. Translation: DAA06996.2.
    PIRiS15038.
    RefSeqiNP_009411.2. NM_001178218.2.

    Genome annotation databases

    EnsemblFungiiYAR019C; YAR019C; YAR019C.
    GeneIDi851274.
    KEGGisce:YAR019C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60549 Genomic DNA. Translation: CAA43041.1 .
    X52683 Genomic DNA. Translation: CAA36906.1 .
    L22015 Genomic DNA. Translation: AAC04965.1 .
    M67445 Genomic DNA. Translation: AAA34400.1 .
    BK006935 Genomic DNA. Translation: DAA06996.2 .
    PIRi S15038.
    RefSeqi NP_009411.2. NM_001178218.2.

    3D structure databases

    ProteinModelPortali P27636.
    SMRi P27636. Positions 31-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31801. 101 interactions.
    DIPi DIP-5728N.
    IntActi P27636. 5 interactions.
    MINTi MINT-683916.
    STRINGi 4932.YAR019C.

    Proteomic databases

    MaxQBi P27636.
    PaxDbi P27636.
    PeptideAtlasi P27636.
    PRIDEi P27636.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAR019C ; YAR019C ; YAR019C .
    GeneIDi 851274.
    KEGGi sce:YAR019C.

    Organism-specific databases

    SGDi S000000072. CDC15.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117264.
    HOGENOMi HOG000141997.
    KOi K06683.
    OMAi VKYHGFI.
    OrthoDBi EOG7T1RKJ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28875-MONOMER.
    BRENDAi 2.7.11.1. 984.

    Miscellaneous databases

    NextBioi 968257.
    PROi P27636.

    Gene expression databases

    Genevestigatori P27636.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA."
      Schweitzer B., Philippsen P.
      Mol. Gen. Genet. 234:164-167(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain."
      Schweitzer B., Philippsen P.
      Yeast 7:265-273(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / GRF88.
    3. Schweitzer B.
      Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 900-902.
    4. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
      Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
      Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 316; 321 AND 900-902.
      Strain: ATCC 204508 / S288c.
    7. "A directed DNA sequencing strategy based upon Tn3 transposon mutagenesis: application to the ADE1 locus on Saccharomyces cerevisiae chromosome I."
      Davies C.J., Hutchison C.A. III
      Nucleic Acids Res. 19:5731-5738(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 865-974.
    8. "Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast."
      Surana U., Amon A., Dowzer C., McGrew J., Byers B., Nasmyth K.
      EMBO J. 12:1969-1978(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "A cdc-like autolytic Saccharomyces cerevisiae mutant altered in budding site selection is complemented by SPO12, a sporulation gene."
      Molero G., Yuste-Rojas M., Montesi A., Vazquez A., Nombela C., Sanchez M.
      J. Bacteriol. 175:6562-6570(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Chromosome condensation and sister chromatid pairing in budding yeast."
      Guacci V., Hogan E., Koshland D.
      J. Cell Biol. 125:517-530(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Dominant mutant alleles of yeast protein kinase gene CDC15 suppress the lte1 defect in termination of M phase and genetically interact with CDC14."
      Shirayama M., Matsui Y., Toh-e A.
      Mol. Gen. Genet. 251:176-185(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Chromosome separation and exit from mitosis in budding yeast: dependence on growth revealed by cAMP-mediated inhibition."
      Anghileri P., Branduardi P., Sternieri F., Monti P., Visintin R., Bevilacqua A., Alberghina L., Martegani E., Baroni M.D.
      Exp. Cell Res. 250:510-523(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "The budding yeast Cdc15 localizes to the spindle pole body in a cell-cycle-dependent manner."
      Cenamor R., Jimenez J., Cid V.J., Nombela C., Sanchez M.
      Mol. Cell Biol. Res. Commun. 2:178-184(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    14. "Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast."
      Xu S., Huang H.K., Kaiser P., Latterich M., Hunter T.
      Curr. Biol. 10:329-332(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, SUBCELLULAR LOCATION, FUNCTION.
    15. "Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis."
      Menssen R., Neutzner A., Seufert W.
      Curr. Biol. 11:345-350(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, SUBCELLULAR LOCATION, FUNCTION.
    16. "Cdc14 activates cdc15 to promote mitotic exit in budding yeast."
      Jaspersen S.L., Morgan D.O.
      Curr. Biol. 10:615-618(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, ENZYME REGULATION.
    17. "Order of function of the budding-yeast mitotic exit-network proteins Tem1, Cdc15, Mob1, Dbf2, and Cdc5."
      Lee S.E., Frenz L.M., Wells N.J., Johnson A.L., Johnston L.H.
      Curr. Biol. 11:784-788(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    18. "A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae."
      Asakawa K., Yoshida S., Otake F., Toh-e A.
      Genetics 157:1437-1450(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TEM1, FUNCTION.
    19. "Regulation of the mitotic exit protein kinases Cdc15 and Dbf2."
      Visintin R., Amon A.
      Mol. Biol. Cell 12:2961-2974(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    20. "Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex."
      Mah A.S., Jang J., Deshaies R.J.
      Proc. Natl. Acad. Sci. U.S.A. 98:7325-7330(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    21. "Inactivation of mitotic kinase triggers translocation of MEN components to mother-daughter neck in yeast."
      Hwa Lim H., Yeong F.M., Surana U.
      Mol. Biol. Cell 14:4734-4743(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    22. "Mitotic exit regulation through distinct domains within the protein kinase Cdc15."
      Bardin A.J., Boselli M.G., Amon A.
      Mol. Cell. Biol. 23:5018-5030(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, DOMAIN.
    23. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    24. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    25. "The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit."
      Molk J.N., Schuyler S.C., Liu J.Y., Evans J.G., Salmon E.D., Pellman D., Bloom K.
      Mol. Biol. Cell 15:1519-1532(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    26. "Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae."
      Pablo-Hernando M.E., Arnaiz-Pita Y., Nakanishi H., Dawson D., del Rey F., Neiman A.M., Vazquez de Aldana C.R.
      Genetics 177:281-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    27. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    28. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    29. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    30. "Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation."
      Schleker T., Shimada K., Sack R., Pike B.L., Gasser S.M.
      Cell Cycle 9:350-363(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    31. "Mutual regulation of cyclin-dependent kinase and the mitotic exit network."
      Konig C., Maekawa H., Schiebel E.
      J. Cell Biol. 188:351-368(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION BY CDK1, FUNCTION.
    32. "Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast."
      Meitinger F., Petrova B., Lombardi I.M., Bertazzi D.T., Hub B., Zentgraf H., Pereira G.
      J. Cell Sci. 123:1851-1861(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    33. "Unrestrained spindle elongation during recovery from spindle checkpoint activation in cdc15-2 cells results in mis-segregation of chromosomes."
      Chai C.C., Teh E.M., Yeong F.M.
      Mol. Biol. Cell 21:2384-2398(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    34. "Cell cycle phosphorylation of mitotic exit network (MEN) proteins."
      Jones M.H., Keck J.M., Wong C.C., Xu T., Yates J.R. III, Winey M.
      Cell Cycle 10:3435-3440(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-561; SER-567 AND THR-870.
    35. "Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit."
      Rock J.M., Amon A.
      Genes Dev. 25:1943-1954(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    36. "Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability."
      Ratsima H., Ladouceur A.M., Pascariu M., Sauve V., Salloum Z., Maddox P.S., D'Amours D.
      Proc. Natl. Acad. Sci. U.S.A. 108:E914-E923(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    37. "Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation."
      Hotz M., Leisner C., Chen D., Manatschal C., Wegleiter T., Ouellet J., Lindstrom D., Gottschling D.E., Vogel J., Barral Y.
      Cell 148:958-972(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    38. "Control of the mitotic exit network during meiosis."
      Attner M.A., Amon A.
      Mol. Biol. Cell 23:3122-3132(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    39. "Measurement and modeling of transcriptional noise in the cell cycle regulatory network."
      Ball D.A., Adames N.R., Reischmann N., Barik D., Franck C.T., Tyson J.J., Peccoud J.
      Cell Cycle 12:3203-3218(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    40. "The FEAR protein Slk19 restricts Cdc14 phosphatase to the nucleus until the end of anaphase, regulating its participation in mitotic exit in Saccharomyces cerevisiae."
      Faust A.M., Wong C.C., Yates Iii J.R., Drubin D.G., Barnes G.
      PLoS ONE 8:E73194-E73194(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCDC15_YEAST
    AccessioniPrimary (citable) accession number: P27636
    Secondary accession number(s): D6VPM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 142 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 238 molecules/cell in log phase SD medium.1 Publication

    Caution

    It is uncertain whether Met-1 or Met-4 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3