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P27636

- CDC15_YEAST

UniProt

P27636 - CDC15_YEAST

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Protein

Cell division control protein 15

Gene

CDC15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Protein kinase of the mitotic exit network (MEN) essential for late nuclear division in the mitotic cycle. Promotes mitotic exit by phosphorylating DBF2 and directly switching on DBF2 kinase activity. Involved in the localization of DBF2 and DBF20 to the neck which is necessary to undergo cytokinesis. Plays a role in segregation of chromosomes during recovery from spindle checkpoint activation. Required for spindle pole localization of CDK1 and inactivation of CDC2 kinase activity at the end of mitosis. Required for spindle disassembly after meiosis II and plays a role in spore morphogenesis.23 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Kinase activity is inhibited by phosphorylation and activated by dephosphorylation by CDC14.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATPPROSITE-ProRule annotation
Active sitei146 – 1461Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: SGD
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. meiotic spindle disassembly Source: SGD
  2. mitotic cytokinesis Source: SGD
  3. mitotic nuclear division Source: UniProtKB-KW
  4. protein phosphorylation Source: SGD
  5. regulation of exit from mitosis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28875-MONOMER.
BRENDAi2.7.11.1. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 15 (EC:2.7.11.1)
Gene namesi
Name:CDC15
Synonyms:LYT1
Ordered Locus Names:YAR019C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

SGDiS000000072. CDC15.

Subcellular locationi

Cytoplasmcytoskeletonspindle pole. Bud neck
Note: Localizes to the spindle pole bodies at late anaphase and translocates to the cytoplasm upon DNA replication stress. Localization to SPBs depends on CDC5 and TEM1 and is inhibited by BUB2. Accumulates at the daughter SPB after anaphase onset when the daughter SPB begins to penetrate the bud neck. Not found in the mother SPD during early anaphase. As anaphase proceeds, continues to accumulate on the daughter SPB and also localizes to the mother SPB. At the end of telophase, a portion of CDC15 localizes at the mother-bud neck.

GO - Cellular componenti

  1. cellular bud neck Source: SGD
  2. cytoplasm Source: UniProtKB-KW
  3. spindle pole body Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974Cell division control protein 15PRO_0000085717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei561 – 5611Phosphoserine1 Publication
Modified residuei567 – 5671Phosphoserine2 Publications
Modified residuei870 – 8701Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylation by CDK1 reduces the binding to the mother spindle pole body. The extent of phosphorylation gradually increases during cell-cycle progression until some point during late anaphase/telophase when it is rapidly dephosphorylated by CDC14. Phosphorylation inhibits kinase activity and dephosphorylation by CDC14 activates CDC15.6 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP27636.
PaxDbiP27636.
PeptideAtlasiP27636.
PRIDEiP27636.

Expressioni

Inductioni

Constitutively expressed.1 Publication

Gene expression databases

GenevestigatoriP27636.

Interactioni

Subunit structurei

Homodimer. Interacts with TEM1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TEM1P389872EBI-4200,EBI-19113

Protein-protein interaction databases

BioGridi31801. 102 interactions.
DIPiDIP-5728N.
IntActiP27636. 5 interactions.
MINTiMINT-683916.
STRINGi4932.YAR019C.

Structurei

3D structure databases

ProteinModelPortaliP27636.
SMRiP27636. Positions 31-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 272248Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni360 – 702343Self association domainAdd
BLAST
Regioni751 – 974224Auto-inhibitory domainAdd
BLAST

Domaini

The region between residues 360 and 702 is essential for function and is required for self-association and for binding to spindle pole bodies.1 Publication
The region between residues 751 and 974 is an auto-inhibitory domain which inhibits MEN signaling.1 Publication

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00720000108839.
HOGENOMiHOG000141997.
InParanoidiP27636.
KOiK06683.
OMAiVKYHGFI.
OrthoDBiEOG7T1RKJ.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P27636-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSMADTDRV NLTPIQRASE KSVQYHLKQV IGRGSYGVVY KAINKHTDQV
60 70 80 90 100
VAIKEVVYEN DEELNDIMAE ISLLKNLNHN NIVKYHGFIR KSYELYILLE
110 120 130 140 150
YCANGSLRRL ISRSSTGLSE NESKTYVTQT LLGLKYLHGE GVIHRDIKAA
160 170 180 190 200
NILLSADNTV KLADFGVSTI VNSSALTLAG TLNWMAPEIL GNRGASTLSD
210 220 230 240 250
IWSLGATVVE MLTKNPPYHN LTDANIYYAV ENDTYYPPSS FSEPLKDFLS
260 270 280 290 300
KCFVKNMYKR PTADQLLKHV WINSTENVKV DKLNKFKEDF TDADYHWDAD
310 320 330 340 350
FQEEKLNISP SKFSLAAAPA AWAENNQELD LMPPTESQLL SQLKSSSKPL
360 370 380 390 400
TDLHVLFSVC SLENIADTII ECLSRTTVDK RLITAFGSIF VYDTQHNHSR
410 420 430 440 450
LRLKFIAMGG IPLIIKFEHL AKEFVIDYPQ TLIECGIMYP PNFASLKTPK
460 470 480 490 500
YILELVYRFY DLTSTAFWCR WCFKHLDISL LLNNIHERRA QSILLKLSSY
510 520 530 540 550
APWSFEKILP SLIDSKLKKK ILISPQITYV VFKSINYMIT TNDDKIHKSA
560 570 580 590 600
IPSSSSLPLS SSPTRNSPVN SVQSPSRSPV HSLMATRPSS PMRHKSISNF
610 620 630 640 650
PHLTISSKSR LLIELPEGFF TWLTSFFVDM AQIKDLSVLK YFTKLCYLTV
660 670 680 690 700
HINSTFLNDL LDNDAFFAFI RNIDTIIPFI DDAKTAAFIW KQITAICVEM
710 720 730 740 750
SLDMDQMSAS LFSTAMNFIR KKNNTSISGL EIILNCLHFT LRNVNDDVAP
760 770 780 790 800
TVGSSESHSV FLIKVNNDAA IELPIDQLVD LFYALNDDDV NLSKLISIFT
810 820 830 840 850
KICSLPGFEN LTINIIFHPN FYEKIVSFFD TYFNSLLIQI DLLKFIKLIF
860 870 880 890 900
SKSLLKLYDY TGQPDPIKQT EPNRRNKATV FKLRAILVQI TEFLNNNWNK
910 920 930 940 950
DVPKRNSNQV GGDSVLICQL CEDIRSLSKK GSLQKVSSVT AAIGSSPTKD
960 970
ERSNLRSSKD KSDGFSVPIT TFQT
Length:974
Mass (Da):110,242
Last modified:July 27, 2011 - v3
Checksum:i99383BD871A4A726
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti316 – 3161A → R in CAA43041. (PubMed:1495480)Curated
Sequence conflicti316 – 3161A → R in CAA36906. (PubMed:1882551)Curated
Sequence conflicti316 – 3161A → R(PubMed:7941740)Curated
Sequence conflicti316 – 3161A → R in AAC04965. (PubMed:7731988)Curated
Sequence conflicti321 – 3211A → P in CAA43041. (PubMed:1495480)Curated
Sequence conflicti321 – 3211A → P in CAA36906. (PubMed:1882551)Curated
Sequence conflicti321 – 3211A → P(PubMed:7941740)Curated
Sequence conflicti321 – 3211A → P in AAC04965. (PubMed:7731988)Curated
Sequence conflicti900 – 9023KDV → NGC no nucleotide entry (PubMed:7941740)Curated
Sequence conflicti900 – 9023KDV → NGC in AAC04965. (PubMed:7731988)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60549 Genomic DNA. Translation: CAA43041.1.
X52683 Genomic DNA. Translation: CAA36906.1.
L22015 Genomic DNA. Translation: AAC04965.1.
M67445 Genomic DNA. Translation: AAA34400.1.
BK006935 Genomic DNA. Translation: DAA06996.2.
PIRiS15038.
RefSeqiNP_009411.2. NM_001178218.2.

Genome annotation databases

EnsemblFungiiYAR019C; YAR019C; YAR019C.
GeneIDi851274.
KEGGisce:YAR019C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60549 Genomic DNA. Translation: CAA43041.1 .
X52683 Genomic DNA. Translation: CAA36906.1 .
L22015 Genomic DNA. Translation: AAC04965.1 .
M67445 Genomic DNA. Translation: AAA34400.1 .
BK006935 Genomic DNA. Translation: DAA06996.2 .
PIRi S15038.
RefSeqi NP_009411.2. NM_001178218.2.

3D structure databases

ProteinModelPortali P27636.
SMRi P27636. Positions 31-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31801. 102 interactions.
DIPi DIP-5728N.
IntActi P27636. 5 interactions.
MINTi MINT-683916.
STRINGi 4932.YAR019C.

Proteomic databases

MaxQBi P27636.
PaxDbi P27636.
PeptideAtlasi P27636.
PRIDEi P27636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAR019C ; YAR019C ; YAR019C .
GeneIDi 851274.
KEGGi sce:YAR019C.

Organism-specific databases

SGDi S000000072. CDC15.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00720000108839.
HOGENOMi HOG000141997.
InParanoidi P27636.
KOi K06683.
OMAi VKYHGFI.
OrthoDBi EOG7T1RKJ.

Enzyme and pathway databases

BioCyci YEAST:G3O-28875-MONOMER.
BRENDAi 2.7.11.1. 984.

Miscellaneous databases

NextBioi 968257.
PROi P27636.

Gene expression databases

Genevestigatori P27636.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA."
    Schweitzer B., Philippsen P.
    Mol. Gen. Genet. 234:164-167(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain."
    Schweitzer B., Philippsen P.
    Yeast 7:265-273(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  3. Schweitzer B.
    Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 900-902.
  4. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
    Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
    Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 316; 321 AND 900-902.
    Strain: ATCC 204508 / S288c.
  7. "A directed DNA sequencing strategy based upon Tn3 transposon mutagenesis: application to the ADE1 locus on Saccharomyces cerevisiae chromosome I."
    Davies C.J., Hutchison C.A. III
    Nucleic Acids Res. 19:5731-5738(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 865-974.
  8. "Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast."
    Surana U., Amon A., Dowzer C., McGrew J., Byers B., Nasmyth K.
    EMBO J. 12:1969-1978(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A cdc-like autolytic Saccharomyces cerevisiae mutant altered in budding site selection is complemented by SPO12, a sporulation gene."
    Molero G., Yuste-Rojas M., Montesi A., Vazquez A., Nombela C., Sanchez M.
    J. Bacteriol. 175:6562-6570(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Chromosome condensation and sister chromatid pairing in budding yeast."
    Guacci V., Hogan E., Koshland D.
    J. Cell Biol. 125:517-530(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Dominant mutant alleles of yeast protein kinase gene CDC15 suppress the lte1 defect in termination of M phase and genetically interact with CDC14."
    Shirayama M., Matsui Y., Toh-e A.
    Mol. Gen. Genet. 251:176-185(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Chromosome separation and exit from mitosis in budding yeast: dependence on growth revealed by cAMP-mediated inhibition."
    Anghileri P., Branduardi P., Sternieri F., Monti P., Visintin R., Bevilacqua A., Alberghina L., Martegani E., Baroni M.D.
    Exp. Cell Res. 250:510-523(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "The budding yeast Cdc15 localizes to the spindle pole body in a cell-cycle-dependent manner."
    Cenamor R., Jimenez J., Cid V.J., Nombela C., Sanchez M.
    Mol. Cell Biol. Res. Commun. 2:178-184(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  14. "Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast."
    Xu S., Huang H.K., Kaiser P., Latterich M., Hunter T.
    Curr. Biol. 10:329-332(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, SUBCELLULAR LOCATION, FUNCTION.
  15. "Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis."
    Menssen R., Neutzner A., Seufert W.
    Curr. Biol. 11:345-350(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, SUBCELLULAR LOCATION, FUNCTION.
  16. "Cdc14 activates cdc15 to promote mitotic exit in budding yeast."
    Jaspersen S.L., Morgan D.O.
    Curr. Biol. 10:615-618(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, DEPHOSPHORYLATION BY CDC14, ENZYME REGULATION.
  17. "Order of function of the budding-yeast mitotic exit-network proteins Tem1, Cdc15, Mob1, Dbf2, and Cdc5."
    Lee S.E., Frenz L.M., Wells N.J., Johnson A.L., Johnston L.H.
    Curr. Biol. 11:784-788(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  18. "A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae."
    Asakawa K., Yoshida S., Otake F., Toh-e A.
    Genetics 157:1437-1450(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TEM1, FUNCTION.
  19. "Regulation of the mitotic exit protein kinases Cdc15 and Dbf2."
    Visintin R., Amon A.
    Mol. Biol. Cell 12:2961-2974(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  20. "Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex."
    Mah A.S., Jang J., Deshaies R.J.
    Proc. Natl. Acad. Sci. U.S.A. 98:7325-7330(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  21. "Inactivation of mitotic kinase triggers translocation of MEN components to mother-daughter neck in yeast."
    Hwa Lim H., Yeong F.M., Surana U.
    Mol. Biol. Cell 14:4734-4743(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  22. "Mitotic exit regulation through distinct domains within the protein kinase Cdc15."
    Bardin A.J., Boselli M.G., Amon A.
    Mol. Cell. Biol. 23:5018-5030(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, DOMAIN.
  23. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  24. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  25. "The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit."
    Molk J.N., Schuyler S.C., Liu J.Y., Evans J.G., Salmon E.D., Pellman D., Bloom K.
    Mol. Biol. Cell 15:1519-1532(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  26. "Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae."
    Pablo-Hernando M.E., Arnaiz-Pita Y., Nakanishi H., Dawson D., del Rey F., Neiman A.M., Vazquez de Aldana C.R.
    Genetics 177:281-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  27. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  28. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  29. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  30. "Cell cycle-dependent phosphorylation of Rad53 kinase by Cdc5 and Cdc28 modulates checkpoint adaptation."
    Schleker T., Shimada K., Sack R., Pike B.L., Gasser S.M.
    Cell Cycle 9:350-363(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  31. "Mutual regulation of cyclin-dependent kinase and the mitotic exit network."
    Konig C., Maekawa H., Schiebel E.
    J. Cell Biol. 188:351-368(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION BY CDK1, FUNCTION.
  32. "Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast."
    Meitinger F., Petrova B., Lombardi I.M., Bertazzi D.T., Hub B., Zentgraf H., Pereira G.
    J. Cell Sci. 123:1851-1861(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  33. "Unrestrained spindle elongation during recovery from spindle checkpoint activation in cdc15-2 cells results in mis-segregation of chromosomes."
    Chai C.C., Teh E.M., Yeong F.M.
    Mol. Biol. Cell 21:2384-2398(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  34. "Cell cycle phosphorylation of mitotic exit network (MEN) proteins."
    Jones M.H., Keck J.M., Wong C.C., Xu T., Yates J.R. III, Winey M.
    Cell Cycle 10:3435-3440(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-561; SER-567 AND THR-870.
  35. "Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit."
    Rock J.M., Amon A.
    Genes Dev. 25:1943-1954(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  36. "Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability."
    Ratsima H., Ladouceur A.M., Pascariu M., Sauve V., Salloum Z., Maddox P.S., D'Amours D.
    Proc. Natl. Acad. Sci. U.S.A. 108:E914-E923(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  37. "Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation."
    Hotz M., Leisner C., Chen D., Manatschal C., Wegleiter T., Ouellet J., Lindstrom D., Gottschling D.E., Vogel J., Barral Y.
    Cell 148:958-972(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  38. "Control of the mitotic exit network during meiosis."
    Attner M.A., Amon A.
    Mol. Biol. Cell 23:3122-3132(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  39. "Measurement and modeling of transcriptional noise in the cell cycle regulatory network."
    Ball D.A., Adames N.R., Reischmann N., Barik D., Franck C.T., Tyson J.J., Peccoud J.
    Cell Cycle 12:3203-3218(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  40. "The FEAR protein Slk19 restricts Cdc14 phosphatase to the nucleus until the end of anaphase, regulating its participation in mitotic exit in Saccharomyces cerevisiae."
    Faust A.M., Wong C.C., Yates Iii J.R., Drubin D.G., Barnes G.
    PLoS ONE 8:E73194-E73194(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCDC15_YEAST
AccessioniPrimary (citable) accession number: P27636
Secondary accession number(s): D6VPM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3