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Protein

Aminodeoxychorismate synthase component 1

Gene

pabB

Organism
Streptomyces lividans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC (By similarity).By similarity

Catalytic activityi

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. 4-amino-4-deoxychorismate synthase activity Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. oxo-acid-lyase activity Source: InterPro

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

UniPathwayiUPA00077; UER00149.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate synthase component 1 (EC:2.6.1.85)
Short name:
ADC synthase
Short name:
ADCS
Alternative name(s):
4-amino-4-deoxychorismate synthase component 1
Gene namesi
Name:pabB
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Aminodeoxychorismate synthase component 1PRO_0000154140Add
BLAST

Interactioni

Subunit structurei

Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB) (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP27630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.60.120.10. 1 hit.
InterProiIPR005801. ADC_synthase.
IPR019999. Anth_synth_I_like.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate_C.
[Graphical view]
PfamiPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSiPR00095. ANTSNTHASEI.
SUPFAMiSSF56322. SSF56322. 1 hit.

Sequencei

Sequence statusi: Complete.

P27630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASCRMGARS ALEPCQVDCL DEAADERCAE TPRCHAELLE SVTGASRMSR
60 70 80 90 100
YSIIVLDPIG TIRAAEALTA LVDADDVIFK DEDPLKGIRS VFELGDLDPT
110 120 130 140 150
NHEEIEFQGG ALGRFAYDIA RRLEAIRDLG DRELAGPDAG TALYDLILYD
160 170 180 190 200
HQDDVIWILV PNEAGEQDPS EDFRDLVNAW SYDDEFDIGA EFGANYTDDA
210 220 230 240 250
YADGVDRLKD YLGSGDMYQV NLAQRRVGMI SAEDYQLYIR LRDANPAPYM
260 270 280 290 300
AYLDIDEGLL VASPERIILD EASDLDTRPI AGTLRGRPRA GGDDEDDGRA
310 320 330 340 350
IDLLRVDKDR AERIMIVDLD RNDIARVGVG GSVKVREIMG LERYSGVMHL
360 370 380 390 400
VSQVTGDLQE AIEAVDLIRA GFPGGTLTGA PKVRTMEIID ELEPQRRAAY
410 420 430 440 450
CGSIGYIAYK GNIDFKIAIP TLYALAGQLF CQAGGGVVGD SVPDGEYRES
460 470
FEKGNALIRG LEIRHGAVVA QSEDK
Length:475
Mass (Da):52,042
Last modified:August 1, 1992 - v1
Checksum:i978A05EB35F2BEB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64859 Genomic DNA. Translation: AAA26798.1.
PIRiJN0578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64859 Genomic DNA. Translation: AAA26798.1.
PIRiJN0578.

3D structure databases

ProteinModelPortaliP27630.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00077; UER00149.

Family and domain databases

Gene3Di3.60.120.10. 1 hit.
InterProiIPR005801. ADC_synthase.
IPR019999. Anth_synth_I_like.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate_C.
[Graphical view]
PfamiPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSiPR00095. ANTSNTHASEI.
SUPFAMiSSF56322. SSF56322. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Organization of the genes encoding p-aminobenzoic acid synthetase from Streptomyces lividans 1326."
    Arhin F.F., Vining L.C.
    Gene 126:129-133(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 66 / 1326.

Entry informationi

Entry nameiPABB_STRLI
AccessioniPrimary (citable) accession number: P27630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The catalytically active amino acid residue K274 of the E.coli enzyme is missing.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.