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P27630

- PABB_STRLI

UniProt

P27630 - PABB_STRLI

Protein

Aminodeoxychorismate synthase component 1

Gene

pabB

Organism
Streptomyces lividans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC By similarity.By similarity

    Catalytic activityi

    Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. 4-amino-4-deoxychorismate synthase activity Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. oxo-acid-lyase activity Source: InterPro

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. tetrahydrofolate biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Folate biosynthesis

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    UniPathwayiUPA00077; UER00149.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminodeoxychorismate synthase component 1 (EC:2.6.1.85)
    Short name:
    ADC synthase
    Short name:
    ADCS
    Alternative name(s):
    4-amino-4-deoxychorismate synthase component 1
    Gene namesi
    Name:pabB
    OrganismiStreptomyces lividans
    Taxonomic identifieri1916 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475Aminodeoxychorismate synthase component 1PRO_0000154140Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB) By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP27630.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.60.120.10. 1 hit.
    InterProiIPR005801. ADC_synthase.
    IPR019999. Anth_synth_I_like.
    IPR006805. Anth_synth_I_N.
    IPR015890. Chorismate-bd_C.
    [Graphical view]
    PfamiPF04715. Anth_synt_I_N. 1 hit.
    PF00425. Chorismate_bind. 1 hit.
    [Graphical view]
    PRINTSiPR00095. ANTSNTHASEI.
    SUPFAMiSSF56322. SSF56322. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P27630-1 [UniParc]FASTAAdd to Basket

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    MASCRMGARS ALEPCQVDCL DEAADERCAE TPRCHAELLE SVTGASRMSR    50
    YSIIVLDPIG TIRAAEALTA LVDADDVIFK DEDPLKGIRS VFELGDLDPT 100
    NHEEIEFQGG ALGRFAYDIA RRLEAIRDLG DRELAGPDAG TALYDLILYD 150
    HQDDVIWILV PNEAGEQDPS EDFRDLVNAW SYDDEFDIGA EFGANYTDDA 200
    YADGVDRLKD YLGSGDMYQV NLAQRRVGMI SAEDYQLYIR LRDANPAPYM 250
    AYLDIDEGLL VASPERIILD EASDLDTRPI AGTLRGRPRA GGDDEDDGRA 300
    IDLLRVDKDR AERIMIVDLD RNDIARVGVG GSVKVREIMG LERYSGVMHL 350
    VSQVTGDLQE AIEAVDLIRA GFPGGTLTGA PKVRTMEIID ELEPQRRAAY 400
    CGSIGYIAYK GNIDFKIAIP TLYALAGQLF CQAGGGVVGD SVPDGEYRES 450
    FEKGNALIRG LEIRHGAVVA QSEDK 475
    Length:475
    Mass (Da):52,042
    Last modified:August 1, 1992 - v1
    Checksum:i978A05EB35F2BEB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64859 Genomic DNA. Translation: AAA26798.1.
    PIRiJN0578.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64859 Genomic DNA. Translation: AAA26798.1 .
    PIRi JN0578.

    3D structure databases

    ProteinModelPortali P27630.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00149 .

    Family and domain databases

    Gene3Di 3.60.120.10. 1 hit.
    InterProi IPR005801. ADC_synthase.
    IPR019999. Anth_synth_I_like.
    IPR006805. Anth_synth_I_N.
    IPR015890. Chorismate-bd_C.
    [Graphical view ]
    Pfami PF04715. Anth_synt_I_N. 1 hit.
    PF00425. Chorismate_bind. 1 hit.
    [Graphical view ]
    PRINTSi PR00095. ANTSNTHASEI.
    SUPFAMi SSF56322. SSF56322. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Organization of the genes encoding p-aminobenzoic acid synthetase from Streptomyces lividans 1326."
      Arhin F.F., Vining L.C.
      Gene 126:129-133(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 66 / 1326.

    Entry informationi

    Entry nameiPABB_STRLI
    AccessioniPrimary (citable) accession number: P27630
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The catalytically active amino acid residue K274 of the E.coli enzyme is missing.

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3