Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P27630 (PABB_STRLI) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminodeoxychorismate synthase component 1

Short name=ADC synthase
Short name=ADCS
EC=2.6.1.85
Alternative name(s):
4-amino-4-deoxychorismate synthase component 1
Gene names
Name:pabB
OrganismStreptomyces lividans
Taxonomic identifier1916 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC By similarity.

Catalytic activity

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Cofactor

Magnesium By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.

Subunit structure

Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB) By similarity.

Miscellaneous

The catalytically active amino acid residue K274 of the E.coli enzyme is missing.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475Aminodeoxychorismate synthase component 1
PRO_0000154140

Sequences

Sequence LengthMass (Da)Tools
P27630 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 978A05EB35F2BEB3

FASTA47552,042
        10         20         30         40         50         60 
MASCRMGARS ALEPCQVDCL DEAADERCAE TPRCHAELLE SVTGASRMSR YSIIVLDPIG 

        70         80         90        100        110        120 
TIRAAEALTA LVDADDVIFK DEDPLKGIRS VFELGDLDPT NHEEIEFQGG ALGRFAYDIA 

       130        140        150        160        170        180 
RRLEAIRDLG DRELAGPDAG TALYDLILYD HQDDVIWILV PNEAGEQDPS EDFRDLVNAW 

       190        200        210        220        230        240 
SYDDEFDIGA EFGANYTDDA YADGVDRLKD YLGSGDMYQV NLAQRRVGMI SAEDYQLYIR 

       250        260        270        280        290        300 
LRDANPAPYM AYLDIDEGLL VASPERIILD EASDLDTRPI AGTLRGRPRA GGDDEDDGRA 

       310        320        330        340        350        360 
IDLLRVDKDR AERIMIVDLD RNDIARVGVG GSVKVREIMG LERYSGVMHL VSQVTGDLQE 

       370        380        390        400        410        420 
AIEAVDLIRA GFPGGTLTGA PKVRTMEIID ELEPQRRAAY CGSIGYIAYK GNIDFKIAIP 

       430        440        450        460        470 
TLYALAGQLF CQAGGGVVGD SVPDGEYRES FEKGNALIRG LEIRHGAVVA QSEDK 

« Hide

References

[1]"Organization of the genes encoding p-aminobenzoic acid synthetase from Streptomyces lividans 1326."
Arhin F.F., Vining L.C.
Gene 126:129-133(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 66 / 1326.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64859 Genomic DNA. Translation: AAA26798.1.
PIRJN0578.

3D structure databases

ProteinModelPortalP27630.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00077; UER00149.

Family and domain databases

Gene3D3.60.120.10. 1 hit.
InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I_like.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate-bd_C.
[Graphical view]
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. SSF56322. 1 hit.
ProtoNetSearch...

Entry information

Entry namePABB_STRLI
AccessionPrimary (citable) accession number: P27630
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: December 11, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways