Reviewed, UniProtKB/Swiss-Prot P27630 (PABB_STRLI)

Names and origin

Protein names

Recommended name:
    Para-aminobenzoate synthase component 1
    EC=2.6.1.85
Alternative name(s):
    Para-aminobenzoate synthase component I
    ADC synthase

Gene names

Name:

pabB

Organism

Streptomyces lividans

Taxonomic identifier

1916 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.
Catalytic activity	Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.
Subunit structure	Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Folate biosynthesis
Molecular function	Transferase
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-amino-4-deoxychorismate synthase activity Inferred from electronic annotation. Source: EC oxo-acid-lyase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Para-aminobenzoate synthase component 1		PRO_0000154140

Sequences

	Sequence		Length	Mass (Da)
	P27630-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 978A05EB35F2BEB3	FASTA	475	52,042
	10 20 30 40 50 60 MASCRMGARS ALEPCQVDCL DEAADERCAE TPRCHAELLE SVTGASRMSR YSIIVLDPIG 70 80 90 100 110 120 TIRAAEALTA LVDADDVIFK DEDPLKGIRS VFELGDLDPT NHEEIEFQGG ALGRFAYDIA 130 140 150 160 170 180 RRLEAIRDLG DRELAGPDAG TALYDLILYD HQDDVIWILV PNEAGEQDPS EDFRDLVNAW 190 200 210 220 230 240 SYDDEFDIGA EFGANYTDDA YADGVDRLKD YLGSGDMYQV NLAQRRVGMI SAEDYQLYIR 250 260 270 280 290 300 LRDANPAPYM AYLDIDEGLL VASPERIILD EASDLDTRPI AGTLRGRPRA GGDDEDDGRA 310 320 330 340 350 360 IDLLRVDKDR AERIMIVDLD RNDIARVGVG GSVKVREIMG LERYSGVMHL VSQVTGDLQE 370 380 390 400 410 420 AIEAVDLIRA GFPGGTLTGA PKVRTMEIID ELEPQRRAAY CGSIGYIAYK GNIDFKIAIP 430 440 450 460 470 TLYALAGQLF CQAGGGVVGD SVPDGEYRES FEKGNALIRG LEIRHGAVVA QSEDK

References

[1]	"Organization of the genes encoding p-aminobenzoic acid synthetase from Streptomyces lividans 1326." Arhin F.F., Vining L.C. Gene 126:129-133(1993) [PubMed: 8472953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 66 / 1326.
[2]	"p-aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase." Ye Q.-Z., Liu J., Walsh C.T. Proc. Natl. Acad. Sci. U.S.A. 87:9391-9395(1990) [PubMed: 2251281] [Abstract] Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M64859 Genomic DNA. Translation: AAA26798.1.
PIR	JN0578.
3D structure databases
HSSP	HSSP built from PDB template 1K0E based on UniProtKB P05041.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.6.1.85. 15238.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

PABB_STRLI

Accession

Primary (citable) accession number: P27630

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)