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P27630

- PABB_STRLI

UniProt

P27630 - PABB_STRLI

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Protein
Aminodeoxychorismate synthase component 1
Gene
pabB
Organism
Streptomyces lividans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC By similarity.

Catalytic activityi

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. 4-amino-4-deoxychorismate synthase activity Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. oxo-acid-lyase activity Source: InterPro

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

UniPathwayiUPA00077; UER00149.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminodeoxychorismate synthase component 1 (EC:2.6.1.85)
Short name:
ADC synthase
Short name:
ADCS
Alternative name(s):
4-amino-4-deoxychorismate synthase component 1
Gene namesi
Name:pabB
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Aminodeoxychorismate synthase component 1
PRO_0000154140Add
BLAST

Interactioni

Subunit structurei

Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB) By similarity.

Structurei

3D structure databases

ProteinModelPortaliP27630.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.60.120.10. 1 hit.
InterProiIPR005801. ADC_synthase.
IPR019999. Anth_synth_I_like.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate-bd_C.
[Graphical view]
PfamiPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSiPR00095. ANTSNTHASEI.
SUPFAMiSSF56322. SSF56322. 1 hit.

Sequencei

Sequence statusi: Complete.

P27630-1 [UniParc]FASTAAdd to Basket

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MASCRMGARS ALEPCQVDCL DEAADERCAE TPRCHAELLE SVTGASRMSR    50
YSIIVLDPIG TIRAAEALTA LVDADDVIFK DEDPLKGIRS VFELGDLDPT 100
NHEEIEFQGG ALGRFAYDIA RRLEAIRDLG DRELAGPDAG TALYDLILYD 150
HQDDVIWILV PNEAGEQDPS EDFRDLVNAW SYDDEFDIGA EFGANYTDDA 200
YADGVDRLKD YLGSGDMYQV NLAQRRVGMI SAEDYQLYIR LRDANPAPYM 250
AYLDIDEGLL VASPERIILD EASDLDTRPI AGTLRGRPRA GGDDEDDGRA 300
IDLLRVDKDR AERIMIVDLD RNDIARVGVG GSVKVREIMG LERYSGVMHL 350
VSQVTGDLQE AIEAVDLIRA GFPGGTLTGA PKVRTMEIID ELEPQRRAAY 400
CGSIGYIAYK GNIDFKIAIP TLYALAGQLF CQAGGGVVGD SVPDGEYRES 450
FEKGNALIRG LEIRHGAVVA QSEDK 475
Length:475
Mass (Da):52,042
Last modified:August 1, 1992 - v1
Checksum:i978A05EB35F2BEB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64859 Genomic DNA. Translation: AAA26798.1.
PIRiJN0578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64859 Genomic DNA. Translation: AAA26798.1 .
PIRi JN0578.

3D structure databases

ProteinModelPortali P27630.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00149 .

Family and domain databases

Gene3Di 3.60.120.10. 1 hit.
InterProi IPR005801. ADC_synthase.
IPR019999. Anth_synth_I_like.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate-bd_C.
[Graphical view ]
Pfami PF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view ]
PRINTSi PR00095. ANTSNTHASEI.
SUPFAMi SSF56322. SSF56322. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Organization of the genes encoding p-aminobenzoic acid synthetase from Streptomyces lividans 1326."
    Arhin F.F., Vining L.C.
    Gene 126:129-133(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 66 / 1326.

Entry informationi

Entry nameiPABB_STRLI
AccessioniPrimary (citable) accession number: P27630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: December 11, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The catalytically active amino acid residue K274 of the E.coli enzyme is missing.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3