P27629 (PABB_LACLL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Para-aminobenzoate synthase component 1
EC=2.6.1.85

Alternative name(s):
ADC synthase
Para-aminobenzoate synthase component I

Gene names

Name:

pabB

Organism

Lactococcus lactis subsp. lactis (Streptococcus lactis)

Taxonomic identifier

1360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.
Catalytic activity	Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.
Subunit structure	Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Folate biosynthesis
Molecular function	Transferase
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-amino-4-deoxychorismate synthase activity Inferred from electronic annotation. Source: EC oxo-acid-lyase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Para-aminobenzoate synthase component 1		PRO_0000154138

Sequences

	Sequence		Length	Mass (Da)
	P27629 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: D2B50CD11A467817	FASTA	470	50,970
	10 20 30 40 50 60 MFTISGVVLI TRPVYDEGSL NYCQSGAMNN GILLESVEGN KPRYSIGGAE PIGTINANAV 70 80 90 100 110 120 LTAATYAEDV KFTDADPLNG TRVAICNGED TQQEEMGFQG GALGYFAYDV GRRLEGYNDL 130 140 150 160 170 180 GIEDWAIPDL AGSSYEIGVS ADHQNDVIVL IAHASADGND VFITSSRQLS MVAGPTCCAS 190 200 210 220 230 240 GDVEILRNKL HYYGVIPFSQ DDCGFNRLKD YLGSGDMYQV NLGNRNVGAI VMTLFQGYNQ 250 260 270 280 290 300 LRLMNPGPYM VFLDEANIIM ASPEIVLADE ANDLNTRPIA GTLMRLNEQD EDGVNAACLG 310 320 330 340 350 360 QHHKDRAEHM MIVDLVRNDL GRVGRFGSVN VQEIVGAENY SVVMHIVSRV TGSLNEAFEA 370 380 390 400 410 420 MEIIRAGFPG GSITGAPKVR AMEIIEELEP QRRDGWGGSI GYIAYRGNIG YRIAIRTLFA 430 440 450 460 470 CNGQLFASSG AGLVGDSMED GEYNETFEKM RALRSFFCAA VHMGKTPYLS

References

[1]	"Cloning, nucleotide sequence and expression in Streptomyces lividans and Escherichia coli of pabB from Lactococcus lactis subsp. lactis NCDO 496." Arhin F.F., Vining L.C. J. Gen. Microbiol. 139:1785-1793(1993) [PubMed: 8409921] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11454 / DSM 20729 / NCDO 496 / NCIB 8586.
[2]	"p-aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase." Ye Q.-Z., Liu J., Walsh C.T. Proc. Natl. Acad. Sci. U.S.A. 87:9391-9395(1990) [PubMed: 2251281] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64860 Unassigned DNA. Translation: AAA17025.1.
3D structure databases
ProteinModelPortal	P27629.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR015890. Chorismate-bd_C. IPR010118. Para-NH2Bz/anthranilate_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR01824. PabB-clade2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PABB_LACLL

Accession

Primary (citable) accession number: P27629

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	October 19, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program