Reviewed, UniProtKB/Swiss-Prot P27627 (PABA_STRLI)

Names and origin

Protein names	Recommended name:     Para-aminobenzoate synthase glutamine amidotransferase component II     EC=2.6.1.85 Alternative name(s):     ADC synthase
Organism	Streptomyces lividans
Taxonomic identifier	1916 [NCBI]
Taxonomic lineage	Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Function	Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.
Catalytic activity	Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.
Pathway	Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.
Subunit structure	Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Folate biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Transferase
Gene Ontology (GO)
Biological process	folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-amino-4-deoxychorismate synthase activity Inferred from electronic annotation. Source: EC anthranilate synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Para-aminobenzoate synthase glutamine amidotransferase component II		PRO_0000056853
Regions
	Domain	3 – 192	190	Glutamine amidotransferase type-1
Sites
	Active site	83	1	By similarity
	Active site	170	1	By similarity
	Active site	172	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P27627-1 [UniParc]. Last modified August 1, 1992. Version 1. Checksum: 6BBA054AEC6E679E	FASTA	192	20,759
	10 20 30 40 50 60 MTSVLMIDNC DSFTYNLVDQ FSPHGTIVIV KRNHPFYDGE IEAIMALTSI CITPGPCYPA 70 80 90 100 110 120 EAALNSCSII GHLAGRIPIL GICLGQQALG QARGGLVIFA HGKLSNIEHN GIFAPLFNPP 130 140 150 160 170 180 RALPAGRYHS LVVEPARIEV TGQCNQLEVV PQEIMAIRHR DLPVEGVQFH PESILSSNGA 190 AILANLIHRP CH

References

[1]	"Organization of the genes encoding p-aminobenzoic acid synthetase from Streptomyces lividans 1326." Arhin F.F., Vining L.C. Gene 126:129-133(1993) [PubMed: 8472953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 66 / 1326.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M64859 Genomic DNA. Translation: AAA26799.1.
PIR	JN0577.
3D structure databases
HSSP	HSSP built from PDB template 1I1Q based on UniProtKB P00905.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.6.1.85. 15238.
Family and domain databases
InterPro	IPR006220. Anth_synthII. IPR011702. GATASE. IPR017926. GATASE_1. IPR000991. GATase_class1_C. IPR006221. TrpG_papA. [Graphical view]
Pfam	PF00117. GATase. 1 hit. [Graphical view]
PRINTS	PR00097. ANTSNTHASEII. PR00096. GATASE.
TIGRFAMs	TIGR00566. trpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PABA_STRLI

Accession

Primary (citable) accession number: P27627

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	August 1, 1992
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)