Reviewed,
UniProtKB/Swiss-Prot P27620 (TAGA_BACSU)
Last modified
June 16, 2009.
Version 64.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative N-acetylmannosaminyltransferase EC=2.4.1.187 Alternative name(s): UDP-N-acetylmannosamine transferase N-acetylglucosaminyldiphospho-undecaprenol N-acetyl-beta-D-mannosaminyltransferase Major teichoic acid biosynthesis protein A | ||||
| Gene names |
| ||||
| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 256 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, a key lipid intermediate in the de novo synthesis of teichoic acid Potential. |
| Catalytic activity | UDP-N-acetyl-D-mannosamine + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol. |
| Pathway | Cell wall biogenesis; poly(glycerol phosphate) teichoic acid biosynthesis. |
| Subcellular location | |
| Induction | Positively regulated by yycF. Mainly expressed during exponential growth and rapidly shut off as cells enter the stationary phase. |
| Sequence similarities | Belongs to the glycosyltransferase 26 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell wall biogenesis/degradation Teichoic acid biosynthesis |
| Cellular component | Secreted |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular regionInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 256 | 256 | Putative N-acetylmannosaminyltransferase | PRO_0000208438 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genes concerned with synthesis of poly(glycerol phosphate), the essential teichoic acid in Bacillus subtilis strain 168, are organized in two divergent transcription units." Maueel C., Young M., Karamata D. J. Gen. Microbiol. 137:929-941(1991) [PubMed: 1906926] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Comparison of ribitol and glycerol teichoic acid genes in Bacillus subtilis W23 and 168: identical function, similar divergent organization, but different regulation." Lazarevic V., Abellan F.-X., Beggah Moeller S., Karamata D., Maueel C. Microbiology 148:815-824(2002) [PubMed: 11882717] [Abstract] Cited for: PUTATIVE FUNCTION. |
| [4] | "Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach." Howell A., Dubrac S., Andersen K.K., Noone D., Fert J., Msadek T., Devine K. Mol. Microbiol. 49:1639-1655(2003) [PubMed: 12950927] [Abstract] Cited for: REGULATION BY YYCF/YYCG. |
Cross-references
Sequence databases | |
|---|---|
| M57497 Genomic DNA. Translation: AAA22844.1. AL009126 Genomic DNA. Translation: CAB15592.1. | |
| PIR | B49757. |
| RefSeq | NP_391456.1. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT26. Glycosyltransferase Family 26. |
Genome annotation databases | |
| GeneID | 936810. |
| GenomeReviews | Gene locus BSU35750 in contig AL009126_GR. |
| KEGG | bsu:BSU35750. |
| NMPDR | fig|224308.1.peg.3582. |
Organism-specific databases | |
| SubtiList | BG10450. tagA. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P27620. |
| OMA | P27620. NPEIVDY. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU3573-MON. MetaCyc:MON-8807. |
| BRENDA | 2.4.1.187. 150. |
Family and domain databases | |
| InterPro | IPR004629. WecB_TagA_CpsF. [Graphical view] |
| Pfam | PF03808. Glyco_tran_WecB. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00696. wecB_tagA_cpsF. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | TAGA_BACSU | ||||||||
| Accession | Primary (citable) accession number: P27620 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
