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Protein

Lysosome membrane protein 2

Gene

Scarb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome membrane protein 2
Alternative name(s):
85 kDa lysosomal membrane sialoglycoprotein
Short name:
LGP85
CD36 antigen-like 2
Lysosome membrane protein II
Short name:
LIMP II
Scavenger receptor class B member 2
CD_antigen: CD36
Gene namesi
Name:Scarb2
Synonyms:Cd36l2, Limpii
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi621882. Scarb2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 43CytoplasmicSequence analysis
Transmembranei5 – 2723HelicalSequence analysisAdd
BLAST
Topological domaini28 – 433406LumenalSequence analysisAdd
BLAST
Transmembranei434 – 45926HelicalSequence analysisAdd
BLAST
Topological domaini460 – 47819CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 478477Lysosome membrane protein 2PRO_0000144157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence analysis
Disulfide bondi274 ↔ 329By similarity
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi312 ↔ 318By similarity
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence analysis
Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Acylated by palmitic acid group(s).

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP27615.
PRIDEiP27615.

PTM databases

SwissPalmiP27615.
UniCarbKBiP27615.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002225.
GenevisibleiP27615. RN.

Interactioni

Subunit structurei

Interacts with GBA.By similarity

Protein-protein interaction databases

IntActiP27615. 1 interaction.
STRINGi10116.ENSRNOP00000003052.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 19137Important for interaction with GBABy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106707.
InParanoidiP27615.
KOiK12384.
OMAiNTICWVA.
OrthoDBiEOG091G0CH9.
PhylomeDBiP27615.
TreeFamiTF317925.

Family and domain databases

InterProiIPR002159. CD36_fam.
IPR005429. LimpII.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01609. CD36FAMILY.
PR01611. LIMPII.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQTIEKN MVLQNGTKVF
60 70 80 90 100
DSWEKPPLPV YIQFYFFNVT NPEEILQGEI PLLEEVGPYT YRELRNKANV
110 120 130 140 150
QFGENGTTIS AVTNKAYIFE RNQSVGDPTV DLIRTINIPL LTVVEMAQQP
160 170 180 190 200
FLREIIEAML KAYQQTLFVT HTVHELLWGY KDEVLSLVHI FRPDVSPNFG
210 220 230 240 250
LFYERNGTND GEYVFLTGED NYLNFTKIVE WNGKTSLDWW TTDTCNMING
260 270 280 290 300
TDGDSFHPLI SKDETLYIFP SDFCRSVYIT FSSFENVEGL PAFRYKVPAE
310 320 330 340 350
ILANSSENAG FCIPEGNCMD AGVLNVSICK NGAPIIMSFP HFYQADEKFV
360 370 380 390 400
SAIKGMRPNK EEHESFVDIN PLTGIILRGA KRFQINTYVK KLDDFVETGN
410 420 430 440 450
IRTMVFPVMY LNESVLIDKE TASQLKSVIN TTLIVTNIPY IIMALGVFFG
460 470
LIFTWLACRG QGSTDEGTAD ERAPLIRT
Length:478
Mass (Da):54,091
Last modified:January 23, 2007 - v2
Checksum:i3EA6E653C38E3002
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68965 mRNA. Translation: AAA41531.1.
D10587 mRNA. Translation: BAA01444.1.
BC061853 mRNA. Translation: AAH61853.1.
PIRiJH0241.
RefSeqiNP_446453.1. NM_054001.2.
UniGeneiRn.3957.

Genome annotation databases

EnsembliENSRNOT00000003052; ENSRNOP00000003052; ENSRNOG00000002225.
GeneIDi117106.
KEGGirno:117106.
UCSCiRGD:621882. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68965 mRNA. Translation: AAA41531.1.
D10587 mRNA. Translation: BAA01444.1.
BC061853 mRNA. Translation: AAH61853.1.
PIRiJH0241.
RefSeqiNP_446453.1. NM_054001.2.
UniGeneiRn.3957.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP27615. 1 interaction.
STRINGi10116.ENSRNOP00000003052.

PTM databases

SwissPalmiP27615.
UniCarbKBiP27615.

Proteomic databases

PaxDbiP27615.
PRIDEiP27615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003052; ENSRNOP00000003052; ENSRNOG00000002225.
GeneIDi117106.
KEGGirno:117106.
UCSCiRGD:621882. rat.

Organism-specific databases

CTDi950.
RGDi621882. Scarb2.

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106707.
InParanoidiP27615.
KOiK12384.
OMAiNTICWVA.
OrthoDBiEOG091G0CH9.
PhylomeDBiP27615.
TreeFamiTF317925.

Miscellaneous databases

PROiP27615.

Gene expression databases

BgeeiENSRNOG00000002225.
GenevisibleiP27615. RN.

Family and domain databases

InterProiIPR002159. CD36_fam.
IPR005429. LimpII.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01609. CD36FAMILY.
PR01611. LIMPII.
ProtoNetiSearch...

Entry informationi

Entry nameiSCRB2_RAT
AccessioniPrimary (citable) accession number: P27615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.