ID   PLAP_MOUSE              Reviewed;         794 AA.
AC   P27612; A4QPD6; Q8C6C4;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 4.
DT   25-JAN-2012, entry version 104.
DE   RecName: Full=Phospholipase A-2-activating protein;
DE            Short=PLA2P;
DE            Short=PLAP;
GN   Name=Plaa; Synonyms=Plap;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-312.
RX   MEDLINE=91271400; PubMed=2052621; DOI=10.1073/pnas.88.12.5418;
RA   Clark M.A., Oezguer L.E., Conway T.M., Dispoto J., Crooke S.T.,
RA   Bomalaski J.S.;
RT   "Cloning of a phospholipase A2-activating protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5418-5422(1991).
RN   [6]
RP   SEQUENCE REVISION.
RX   MEDLINE=95394363; PubMed=7665086; DOI=10.1016/0378-1119(95)00253-3;
RA   Wang H., Lemasters J.J., Herman B.;
RT   "Cloning of a rat cDNA encoding a protein with high homology to mouse
RT   phospholipase A2-activating protein.";
RL   Gene 161:237-241(1995).
CC   -!- FUNCTION: Involved in the maintenance of ubiquitin levels (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with ubiquitin. Interacts with VCP (By
CC       similarity).
CC   -!- INDUCTION: In smooth muscle and endothelial cells by leukotriene
CC       D4, by tumor necrosis factor in endothelial cells and by uric acid
CC       crystals in macrophages.
CC   -!- DOMAIN: The PUL domain is composed of 6 armadillo-like repeats and
CC       mediates the interaction with VCP C-terminus (By similarity).
CC   -!- DOMAIN: The PFU domain mediates interaction with ubiquitin (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the WD repeat PLAP family.
CC   -!- SIMILARITY: Contains 6 ARM repeats.
CC   -!- SIMILARITY: Contains 1 PFU domain.
CC   -!- SIMILARITY: Contains 1 PUL domain.
CC   -!- SIMILARITY: Contains 7 WD repeats.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA39943.1; Type=Miscellaneous discrepancy; Note=Several frameshifts and contaminating sequence;
CC       Sequence=Ref.3; Type=Frameshift; Positions=697;
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DR   EMBL; AK075934; BAC36064.1; -; mRNA.
DR   EMBL; AL732597; CAM19635.1; -; Genomic_DNA.
DR   EMBL; CH466527; EDL30936.1; -; Genomic_DNA.
DR   EMBL; BC139355; AAI39356.1; -; mRNA.
DR   EMBL; BC139356; AAI39357.1; -; mRNA.
DR   EMBL; BC139773; AAI39774.1; -; mRNA.
DR   EMBL; M57958; AAA39943.1; ALT_SEQ; mRNA.
DR   IPI; IPI00226234; -.
DR   PIR; A40963; A40963.
DR   RefSeq; NP_766283.2; NM_172695.2.
DR   UniGene; Mm.370954; -.
DR   UniGene; Mm.485102; -.
DR   ProteinModelPortal; P27612; -.
DR   SMR; P27612; 6-306, 386-794.
DR   MINT; MINT-220705; -.
DR   STRING; P27612; -.
DR   PhosphoSite; P27612; -.
DR   PRIDE; P27612; -.
DR   Ensembl; ENSMUST00000107107; ENSMUSP00000102724; ENSMUSG00000028577.
DR   GeneID; 18786; -.
DR   KEGG; mmu:18786; -.
DR   CTD; 9373; -.
DR   MGI; MGI:104810; Plaa.
DR   eggNOG; roNOG04126; -.
DR   GeneTree; ENSGT00550000074944; -.
DR   HOGENOM; HBG395734; -.
DR   HOVERGEN; HBG008204; -.
DR   InParanoid; P27612; -.
DR   OrthoDB; EOG4DJJVW; -.
DR   PhylomeDB; P27612; -.
DR   NextBio; 295052; -.
DR   ArrayExpress; P27612; -.
DR   Bgee; P27612; -.
DR   CleanEx; MM_PLAA; -.
DR   Genevestigator; P27612; -.
DR   GermOnline; ENSMUSG00000028577; Mus musculus.
DR   GO; GO:0016005; F:phospholipase A2 activator activity; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0006954; P:inflammatory response; IDA:MGI.
DR   InterPro; IPR015155; PLAA_fam_Ub-bd_PFU.
DR   InterPro; IPR013535; PUL.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR011046; WD40_repeat-like_dom.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   KO; K14018; -.
DR   Pfam; PF09070; PFU; 1.
DR   Pfam; PF08324; PUL; 1.
DR   Pfam; PF00400; WD40; 7.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40_like; 1.
DR   PROSITE; PS50176; ARM_REPEAT; FALSE_NEG.
DR   PROSITE; PS51394; PFU; 1.
DR   PROSITE; PS51396; PUL; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; FALSE_NEG.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Complete proteome; Phosphoprotein; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN         1    794       Phospholipase A-2-activating protein.
FT                                /FTId=PRO_0000051131.
FT   REPEAT       17     56       WD 1.
FT   REPEAT       63    107       WD 2.
FT   REPEAT      110    148       WD 3.
FT   REPEAT      149    188       WD 4.
FT   REPEAT      190    227       WD 5.
FT   REPEAT      229    268       WD 6.
FT   REPEAT      270    307       WD 7.
FT   DOMAIN      366    465       PFU.
FT   DOMAIN      533    793       PUL.
FT   REPEAT      546    588       ARM 1.
FT   REPEAT      589    620       ARM 2.
FT   REPEAT      621    668       ARM 3.
FT   REPEAT      669    714       ARM 4.
FT   REPEAT      715    754       ARM 5.
FT   REPEAT      755    794       ARM 6.
FT   MOD_RES      50     50       Phosphoserine (By similarity).
FT   MOD_RES     529    529       N6-acetyllysine (By similarity).
FT   CONFLICT     60     60       C -> Y (in Ref. 2; AAA39943).
FT   CONFLICT     70     70       C -> Y (in Ref. 2; AAA39943).
FT   CONFLICT    300    301       SE -> AD (in Ref. 6).
FT   CONFLICT    528    528       S -> T (in Ref. 1; BAC36064).
FT   CONFLICT    546    546       A -> T (in Ref. 6).
FT   CONFLICT    593    593       A -> R (in Ref. 6).
SQ   SEQUENCE   794 AA;  87221 MW;  7D8B1D55B07563CC CRC64;
     MASGASRYRL SCSLPGHELD VRGLVCCLYP PGAFVSVSRD RTTRLWAPDS PNRGFTEMHC
     MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKDTVCSLSS
     GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH TAAVWAVKIL PEQGLMLTGS ADKTIKLWKA
     GRCERTFLGH EDCVRGLAIL SETEFLSCAN DASIRRWQIT GECLEVYFGH TNYIYSISVF
     PNSKDFVTTA EDRSLRIWKH GECAQTIRLP AQSIWCCCVL ENGDIVVGAS DGIIRVFTES
     EERTASAEEI KAFERELSQA TIDSKTGDLG DINAEQLPGR EHLSEPGTRE GQTRLIRDGE
     RVEAYQWSVS DGRWIKIGDV VGSSGANQQT SGKVLYEGKE FDYVFSIDVN EGGPSYKLPY
     NVSDDPWLVA YNFLQKNDLN PMFLDQVAKF IIDNTKGQTL GLGNTSFSDP FTGGGRYVPG
     TSGPSNTVQT ADPFTGAGRY MPGSAGMDTT MTGVDPFTGN SAYRSAASKT VNIYFPKKEA
     LTFDQANPTQ ILGKLKELNG TAPEEKKLTE DDLVLLEKIL SLICNNSSEK PTAQQLQILW
     KAINWPEDIV FPALDILRLS IKHPNVNENF CNEKGDQFSS HLINLLNPKG KPANQLLALR
     TFCNCFVSQA GQKLMMSQRE SLMSHAIELK SGSNKNIHIA LATLTLNYSV CFHKDHNIEG
     KAQCLSVIST ILEVVQDLEA TFRLLVALGT LISDDSNAIQ LAKSLGVDSQ IKKYVSVSEP
     AKVSECCRLV LHLL
//