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Reviewed, UniProtKB/Swiss-Prot P27604 (SAHH_CAEEL)

Last modified February 9, 2010. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adenosylhomocysteinase
      Short name=AdoHcyase
    EC=3.3.1.1
Alternative name(s):
    S-adenosyl-L-homocysteine hydrolase
    Protein dumpy-14
Gene names
Name: ahcy-1
Synonyms: ahh, dpy-14
ORF Names: K02F2.2
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactor

Binds 1 NAD per subunit.

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.

Subunit structure

Homotetramer.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

C08B11.9Q092271EBI-314690,EBI-314686

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Adenosylhomocysteinase
PRO_0000116910

Regions

Region185 – 352168NAD binding By similarity

Sites

Binding site581Substrate By similarity
Binding site1331Substrate By similarity
Binding site1581Substrate By similarity
Binding site1881Substrate By similarity
Binding site1921Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P27604-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 53ADAB24507CFCD6

FASTA43747,536
        10         20         30         40         50         60 
MAQSKPAYKV ADIKLADFGR KEIILAENEM PGLMAMRSKY GPSQPLKGAR IAGCLHMTIQ 

        70         80         90        100        110        120 
TAVLIETLTA LGAEVQWSSC NIFSTQDHAA AAIAQTGVPV YAWKGETDEE YEWCIEQTIV 

       130        140        150        160        170        180 
FKDGQPLNMI LDDGGDLTNL VHAKYPQYLA GIRGLSEETT TGVHNLAKML AKGDLKVPAI 

       190        200        210        220        230        240 
NVNDSVTKSK FDNLYGIRES LPDGIKRATD VMLAGKVAVV AGYGDVGKGS AASLKAFGSR 

       250        260        270        280        290        300 
VIVTEIDPIN ALQAAMEGYE VTTLEEAAPK ANIIVTTTGC KDIVTGKHFE LLPNDAIVCN 

       310        320        330        340        350        360 
VGHFDCEIDV KWLNTNATKK DTIKPQVDRY TLKNGRHVIL LAEGRLVNLG CATGHPSFVM 

       370        380        390        400        410        420 
SNSFTNQVLA QVELWTKFGT PQEYKLGLYV LPKTLDEEVA YLHLAQLGVK LTKLSDEQAS 

       430 
YLGVPVAGPY KPDHYRY 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization in the dpy-14 region identifies the adenosylhomocysteine hydrolase gene in Caenorhabditis elegans."
Prasad S.S., Starr T., Rose A.M.
Genome 36:57-65(1993) [PubMed: 8458573] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64306 Genomic DNA. Translation: AAA28062.1.
S57284 Genomic DNA. Translation: AAB25906.1.
AF043699 Genomic DNA. Translation: AAB97565.1.
PIRT32918.
RefSeqNP_491955.1.
UniGeneCel.7612

3D structure databases

SMRP27604. Positions 5-437.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-25388N.
IntActP27604. 6 interactions.
STRINGP27604.

Genome annotation databases

EnsemblK02F2.2.1; K02F2.2.1; K02F2.2; Caenorhabditis elegans. [Genome view]
K02F2.2.2; K02F2.2.2; K02F2.2; Caenorhabditis elegans. [Genome view]
GeneID172408.
KEGGcel:K02F2.2.
UCSCK02F2.2.1. c. elegans.

Organism-specific databases

CTD172408.
WormBaseWBGene00019322. ahcy-1.
WormPepK02F2.2. CE17154. [WorfDB]

Phylogenomic databases

eggNOGmeNOG04936.
HOGENOMHBG352029.
InParanoidP27604.
OMAVITHDHM.
PhylomeDBP27604.

Enzyme and pathway databases

BRENDA3.3.1.1. 672.

Gene expression databases

ArrayExpressP27604.

Family and domain databases

InterProIPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR000043. S-Ado-L-homoCys_hydrolase.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
TIGRFAMsTIGR00936. ahcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio875391.

Entry information

Entry nameSAHH_CAEEL
AccessionPrimary (citable) accession number: P27604
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 9, 2010
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents