P27602 (PUR7_CANMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:

ADE1

Organism

Candida maltosa (Yeast)

Taxonomic identifier

5479 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Phosphoribosylaminoimidazole-succinocarboxamide synthase		PRO_0000100924

Sequences

	Sequence		Length	Mass (Da)
	P27602 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: A1DF09E65E9A9117	FASTA	291	32,941
	10 20 30 40 50 60 MTSTNLEGTF PLIAKGKVRD IYQVDDNTLL FVATDRISAY DVIMSNGIPN KGKILTKLSE 70 80 90 100 110 120 FWFDFLPIEN HLIKGDIFQK YPQLEPYRNQ LEGRSLLVRK LKLIPLEVIV RGYITGSGWK 130 140 150 160 170 180 EYQKSKTVHG IPIGDVVESQ QITPIFTPST KAEQGEHDEN ITKEQADKIV GKELCDRIEK 190 200 210 220 230 240 IAIDLYTKAR DYAATKGIII ADTKFEFGLD GDNIVLVDEV LTPDSSRFWN AAKYEVGKSQ 250 260 270 280 290 DSYDKQFLRD WLTSNGVAGK DGVAMPEDIV TETKSKYVEA YENLTGDKWQ E

References

[1]	"Molecular cloning of the Candida maltosa ADE1 gene." Sasnauskas K., Jomantiene R., Geneviciute E., Januska A., Lebedys J. Gene 107:161-164(1991) [PubMed: 1743515] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: VSB-899.
[2]	Sasnauskas K. Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Isolation and sequencing of a gene, C-ADE1, and its use for a host-vector system in Candida maltosa with two genetic markers." Kawai S., Hikiji T., Murao S., Takagi M., Yano K. Agric. Biol. Chem. 55:59-65(1991) [PubMed: 1368674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M58322 Genomic DNA. Translation: AAA34318.1. D00855 Genomic DNA. Translation: BAA00731.1.
PIR	JH0489. S55291. S55292. S55293.
3D structure databases
ProteinModelPortal	P27602.
SMR	P27602. Positions 1-289.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_CANMA

Accession

Primary (citable) accession number: P27602

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
Last sequence update:	February 1, 1996
Last modified:	May 31, 2011
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program