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P27586

- NSP3_ROTPC

UniProt

P27586 - NSP3_ROTPC

Protein

Non-structural protein 3

Gene
N/A
Organism
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei333 – 3342Cleavage; by autolysisSequence Analysis

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 3
    Short name:
    NSP3
    Cleaved into the following 2 chains:
    OrganismiRotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
    Taxonomic identifieri10916 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiSus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000008175: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Non-structural protein 3PRO_0000149544Add
    BLAST
    Chaini1 – 333333p38PRO_0000369888Add
    BLAST
    Chaini334 – 40269p8PRO_0000369889Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP27586.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini334 – 40269DRBMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus C NSP3 family.Curated
    Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR014720. dsRNA-bd_dom.
    IPR002873. Rotavirus_NSP3.
    [Graphical view]
    PfamiPF01665. Rota_NSP3. 1 hit.
    [Graphical view]
    SUPFAMiSSF69903. SSF69903. 1 hit.
    PROSITEiPS50137. DS_RBD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P27586-1 [UniParc]FASTAAdd to Basket

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    MATQASVEWI FNIAGSAASA SIAKAIKDAG GSEDFAKYVI ARFYDNYKDS    50
    VDDTGVYNAC IGRARTVDKA LDDSRKAERN EDWHTNLETI SRLDLELAEL 100
    KLILSNLGIK REDRVLNSMF SVVREEGKSS NTVMLKQNAV RMIEEGKLKI 150
    RVERNENYTA SLKNKIEELE CMIDAFEKGK EIIISLDAMN GEVKRDGNSC 200
    SYNSTAAFVS TIVGNPIKMY DESGKPLFDV GDYLNPKHII DKMIENEIPI 250
    FKSDYRNNES PDFDVWNERS NLKIVSINDC HAICVFKFEN AWWCFDDGVL 300
    NKYSGNGNPL IVANAKFQID KILISGDVEL NPGPDPLIRL NDCKTKYGID 350
    IICRFYIVLD NDGSIIHMCY MRTGSAEAVA KGRSKKEAKR IAAKDILDQI 400
    GL 402
    Length:402
    Mass (Da):45,125
    Last modified:August 1, 1992 - v1
    Checksum:i8B11F7AC7FB5135C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69115 Genomic RNA. Translation: AAA47087.1.
    PIRiA41040. MNXRPC.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69115 Genomic RNA. Translation: AAA47087.1 .
    PIRi A41040. MNXRPC.

    3D structure databases

    ProteinModelPortali P27586.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR014720. dsRNA-bd_dom.
    IPR002873. Rotavirus_NSP3.
    [Graphical view ]
    Pfami PF01665. Rota_NSP3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69903. SSF69903. 1 hit.
    PROSITEi PS50137. DS_RBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the gene 6 from a porcine group C rotavirus that encodes the NS34 equivalent of group A rotaviruses."
      Qian Y.A., Jiang B.M., Saif L.J., Kang S.Y., Ojeh C.K., Green K.Y.
      Virology 184:752-757(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR."
      Langland J.O., Pettiford S., Jiang B., Jacobs B.L.
      J. Virol. 68:3821-3829(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA-BINDING, PROTEOLYTIC CLEAVAGE.

    Entry informationi

    Entry nameiNSP3_ROTPC
    AccessioniPrimary (citable) accession number: P27586
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3