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Protein

Non-structural protein 3

Gene
N/A
Organism
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei333 – 3342Cleavage; by autolysisSequence Analysis

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 3
Short name:
NSP3
Cleaved into the following 2 chains:
OrganismiRotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Taxonomic identifieri10916 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000008175: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Non-structural protein 3PRO_0000149544Add
BLAST
Chaini1 – 333333p38PRO_0000369888Add
BLAST
Chaini334 – 40269p8PRO_0000369889Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP27586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini334 – 40269DRBMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus C NSP3 family.Curated
Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR014720. dsRNA-bd_dom.
IPR002873. Rotavirus_NSP3.
[Graphical view]
PfamiPF01665. Rota_NSP3. 1 hit.
[Graphical view]
SUPFAMiSSF69903. SSF69903. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQASVEWI FNIAGSAASA SIAKAIKDAG GSEDFAKYVI ARFYDNYKDS
60 70 80 90 100
VDDTGVYNAC IGRARTVDKA LDDSRKAERN EDWHTNLETI SRLDLELAEL
110 120 130 140 150
KLILSNLGIK REDRVLNSMF SVVREEGKSS NTVMLKQNAV RMIEEGKLKI
160 170 180 190 200
RVERNENYTA SLKNKIEELE CMIDAFEKGK EIIISLDAMN GEVKRDGNSC
210 220 230 240 250
SYNSTAAFVS TIVGNPIKMY DESGKPLFDV GDYLNPKHII DKMIENEIPI
260 270 280 290 300
FKSDYRNNES PDFDVWNERS NLKIVSINDC HAICVFKFEN AWWCFDDGVL
310 320 330 340 350
NKYSGNGNPL IVANAKFQID KILISGDVEL NPGPDPLIRL NDCKTKYGID
360 370 380 390 400
IICRFYIVLD NDGSIIHMCY MRTGSAEAVA KGRSKKEAKR IAAKDILDQI

GL
Length:402
Mass (Da):45,125
Last modified:August 1, 1992 - v1
Checksum:i8B11F7AC7FB5135C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69115 Genomic RNA. Translation: AAA47087.1.
PIRiA41040. MNXRPC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69115 Genomic RNA. Translation: AAA47087.1.
PIRiA41040. MNXRPC.

3D structure databases

ProteinModelPortaliP27586.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR014720. dsRNA-bd_dom.
IPR002873. Rotavirus_NSP3.
[Graphical view]
PfamiPF01665. Rota_NSP3. 1 hit.
[Graphical view]
SUPFAMiSSF69903. SSF69903. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular analysis of the gene 6 from a porcine group C rotavirus that encodes the NS34 equivalent of group A rotaviruses."
    Qian Y.A., Jiang B.M., Saif L.J., Kang S.Y., Ojeh C.K., Green K.Y.
    Virology 184:752-757(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR."
    Langland J.O., Pettiford S., Jiang B., Jacobs B.L.
    J. Virol. 68:3821-3829(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING, PROTEOLYTIC CLEAVAGE.

Entry informationi

Entry nameiNSP3_ROTPC
AccessioniPrimary (citable) accession number: P27586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.