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P27586 (NSP3_ROTPC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 3

Short name=NSP3

Cleaved into the following 2 chains:

  1. p38
  2. p8
OrganismRotavirus C (strain Pig/United States/Cowden/1980) (RV-C) [Complete proteome]
Taxonomic identifier10916 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the rotavirus C NSP3 family.

Contains 1 DRBM (double-stranded RNA-binding) domain.

Ontologies

Keywords
   LigandRNA-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Non-structural protein 3
PRO_0000149544
Chain1 – 333333p38
PRO_0000369888
Chain334 – 40269p8
PRO_0000369889

Regions

Domain334 – 40269DRBM

Sites

Site333 – 3342Cleavage; by autolysis Potential

Sequences

Sequence LengthMass (Da)Tools
P27586 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: 8B11F7AC7FB5135C

FASTA40245,125
        10         20         30         40         50         60 
MATQASVEWI FNIAGSAASA SIAKAIKDAG GSEDFAKYVI ARFYDNYKDS VDDTGVYNAC 

        70         80         90        100        110        120 
IGRARTVDKA LDDSRKAERN EDWHTNLETI SRLDLELAEL KLILSNLGIK REDRVLNSMF 

       130        140        150        160        170        180 
SVVREEGKSS NTVMLKQNAV RMIEEGKLKI RVERNENYTA SLKNKIEELE CMIDAFEKGK 

       190        200        210        220        230        240 
EIIISLDAMN GEVKRDGNSC SYNSTAAFVS TIVGNPIKMY DESGKPLFDV GDYLNPKHII 

       250        260        270        280        290        300 
DKMIENEIPI FKSDYRNNES PDFDVWNERS NLKIVSINDC HAICVFKFEN AWWCFDDGVL 

       310        320        330        340        350        360 
NKYSGNGNPL IVANAKFQID KILISGDVEL NPGPDPLIRL NDCKTKYGID IICRFYIVLD 

       370        380        390        400 
NDGSIIHMCY MRTGSAEAVA KGRSKKEAKR IAAKDILDQI GL 

« Hide

References

[1]"Molecular analysis of the gene 6 from a porcine group C rotavirus that encodes the NS34 equivalent of group A rotaviruses."
Qian Y.A., Jiang B.M., Saif L.J., Kang S.Y., Ojeh C.K., Green K.Y.
Virology 184:752-757(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR."
Langland J.O., Pettiford S., Jiang B., Jacobs B.L.
J. Virol. 68:3821-3829(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA-BINDING, PROTEOLYTIC CLEAVAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M69115 Genomic RNA. Translation: AAA47087.1.
PIRMNXRPC. A41040.

3D structure databases

ProteinModelPortalP27586.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR014720. dsRNA-bd_dom.
IPR002873. Rotavirus_NSP3.
[Graphical view]
PfamPF01665. Rota_NSP3. 1 hit.
[Graphical view]
SUPFAMSSF69903. SSF69903. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNSP3_ROTPC
AccessionPrimary (citable) accession number: P27586
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families