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P27586

- NSP3_ROTPC

UniProt

P27586 - NSP3_ROTPC

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Protein
Non-structural protein 3
Gene
N/A
Organism
Rotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei333 – 3342Cleavage; by autolysis Reviewed prediction

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 3
Short name:
NSP3
Cleaved into the following 2 chains:
OrganismiRotavirus C (strain Pig/United States/Cowden/1980) (RV-C)
Taxonomic identifieri10916 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000008175: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Non-structural protein 3
PRO_0000149544Add
BLAST
Chaini1 – 333333p38
PRO_0000369888Add
BLAST
Chaini334 – 40269p8
PRO_0000369889Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP27586.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini334 – 40269DRBM
Add
BLAST

Sequence similaritiesi

Belongs to the rotavirus C NSP3 family.

Family and domain databases

InterProiIPR014720. dsRNA-bd_dom.
IPR002873. Rotavirus_NSP3.
[Graphical view]
PfamiPF01665. Rota_NSP3. 1 hit.
[Graphical view]
SUPFAMiSSF69903. SSF69903. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27586-1 [UniParc]FASTAAdd to Basket

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MATQASVEWI FNIAGSAASA SIAKAIKDAG GSEDFAKYVI ARFYDNYKDS    50
VDDTGVYNAC IGRARTVDKA LDDSRKAERN EDWHTNLETI SRLDLELAEL 100
KLILSNLGIK REDRVLNSMF SVVREEGKSS NTVMLKQNAV RMIEEGKLKI 150
RVERNENYTA SLKNKIEELE CMIDAFEKGK EIIISLDAMN GEVKRDGNSC 200
SYNSTAAFVS TIVGNPIKMY DESGKPLFDV GDYLNPKHII DKMIENEIPI 250
FKSDYRNNES PDFDVWNERS NLKIVSINDC HAICVFKFEN AWWCFDDGVL 300
NKYSGNGNPL IVANAKFQID KILISGDVEL NPGPDPLIRL NDCKTKYGID 350
IICRFYIVLD NDGSIIHMCY MRTGSAEAVA KGRSKKEAKR IAAKDILDQI 400
GL 402
Length:402
Mass (Da):45,125
Last modified:August 1, 1992 - v1
Checksum:i8B11F7AC7FB5135C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69115 Genomic RNA. Translation: AAA47087.1.
PIRiA41040. MNXRPC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69115 Genomic RNA. Translation: AAA47087.1 .
PIRi A41040. MNXRPC.

3D structure databases

ProteinModelPortali P27586.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR014720. dsRNA-bd_dom.
IPR002873. Rotavirus_NSP3.
[Graphical view ]
Pfami PF01665. Rota_NSP3. 1 hit.
[Graphical view ]
SUPFAMi SSF69903. SSF69903. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of the gene 6 from a porcine group C rotavirus that encodes the NS34 equivalent of group A rotaviruses."
    Qian Y.A., Jiang B.M., Saif L.J., Kang S.Y., Ojeh C.K., Green K.Y.
    Virology 184:752-757(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR."
    Langland J.O., Pettiford S., Jiang B., Jacobs B.L.
    J. Virol. 68:3821-3829(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA-BINDING, PROTEOLYTIC CLEAVAGE.

Entry informationi

Entry nameiNSP3_ROTPC
AccessioniPrimary (citable) accession number: P27586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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